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thyX

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Length
325 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
36.562 kDa
Sequence
MAASLEKAGLGISVRLLEYTGDGERIVAVASKVSLSRSPAERLLAIGEDEVETWILETFRRQHFSPWEHSVYTFMVEGLSRVASHQLVRHRVASYTQLSHRYSEGYLREAALKACESIGLDCPSKPAETEGGRKAAYRLYSQALERAARDFGASERFAIAAKAFVIPPTILARGDGGDGVVEAYLRSAAIYYSLLSRGARREDARYILPDALRTRIVVTMNARELIQVFFPLRMCTRAQWEIRHIAWLLWRELSRVHPRLFRWAGPSCVLRENTLRTTPASLYSYLEGVERFTQPRCPELVENKAIPGCLRQAASVAPPGDGEYE

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Aquifex aeolicus (strain VF5)
Length
317 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
37.642 kDa
Sequence
MMKIYLMGSDQRIVRCARVSFAKDSYVDEKRDKRLIRYLFKHRHASPFEHNIIAFEWKKEKWIELLSKLENPTVQVYYSNGFVFLNLRNAINVWELLPDAVKERIKEAFPTTYGVIQRRGEIEDEELYSLPYTKDKAYVKEKIETSSGWIGLVDKLELETDMDFYTFVVECPLFVARQWMRHRFGSYNEVSKRYVGKEFLEFYLPKYIRKQAEKNKQASVDEPISESEVFIKKIENLISKSVKLYEEIIEKGGAKELARGVLPQFMKTRFYWTVPRISLDNFITLRTHEGAQKEIREFAEAIKEMVGYRGTDKKNVI

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Treponema pallidum (strain Nichols)
Length
305 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
34.186 kDa
Sequence
MTLRTLQAGVAVSIALDRVCFFCYNGAVAHCVVEAAEDILDRRFSVLDKGFVRLIDYLGGDARIVQAARVSYGAGTRTARDDAALIDFLLRNKHTSPFEQVVLTFHVRAPIFVARQWMRHRTARISEVSSRYSLLSHDCYVPQETSVAVQSTRNKQGRASEGISPEQQQEVRAAFEAQQKAACAAYDALIQKNIARELARINVPLSLYTEWYWQIDLHNLFHFLRLRASAHAQAEIRAYAEVIIEITRAVAPCATASFENHEKDGVQFSGREFAALKALLAGEGLSLEGKERARFEEKLRSGLQQ

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Gluconobacter oxydans (strain 621H)
Length
303 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
34.609 kDa
Sequence
MALTSEQRAEIEAQRSEPQLTSRPTVAAMENLLFTPFEVLDHGFLRVVDYMGDDGAVVQAARVSYGRGTKKVSEDAGLIRYLMRHRHSTPFEMCEIKFHVKLPVFVARQWIRHRMASVNEYSARYSILDREFYLPAMDQVAAQSSSNRQGRSDALDADTAHQVLEILRRDASQCYDDYESLLNPEGRGLARELARINLTLNTYTQWYWKIDLHNLMHFLALRADPHAQYEIRVYAEKMIEILKAWVPATAAAFEEYRLGAFTLSAGMLKVVRRRLAGETVTQENSGLTKREWSEMAAVLDGAS

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)
Length
302 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
34.619 kDa
Sequence
MPLSSEQLAEIDAQRAHTAPTRRVVSPGMESHLYRAHPVLDHGFVRVIDYMGDDAAICQAARVSYGTGTKSVQNDEGLIRYLMRHWHSTPFEMCELKLHVKLPVFVARQWIRHRTANVNEYSARYSILDREFYIPAPEHVAAQSAVNNQGRGEALQGEEAARVLEILKADSARCYDNYEAMIGQEGQQGLARELARMNLPANIYTQWYWKVDLHNLFHFLRLRADAHAQYEIRVYAETMCRLVADWVPFAYKAFEDYRLGAVNLSAQMVDSLRRMLAGEAVTQETSGLSAREWREFQDVIGR

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Ehrlichia ruminantium (strain Welgevonden)
Length
298 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
34.876 kDa
Sequence
MLVLSIRIKVWQTMESEITKRIVVPELEDILYKEHKVLDKGFVRLVDYMGSDESVVQAARISYGRGTKSVSQDAALINYLMRHSHTTPFEMCEIKFHIKLPIFVARQWVRHRTANVNEYSARYSVLDHEFYIPELDHVATQSEDNAQGRGNSLSNEDAQYVTDLLKRDSDMVYETYNKFLIKGVSREISRISLTLNYYTEWYWKIDLHNLLHFLRLRSDVHAQYEIRVYAETMLEIVKKWVPLTYAAFVEYCLESQSFSKSALSVVKKLIAGEDVAREDTGIGKREWRELMDVLADNK

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Ehrlichia ruminantium (strain Gardel)
Length
297 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
34.762 kDa
Sequence
MLVLSIRIKVWQTMESEITKRIVVPELEDILYKEHKVLDKGFVRLVDYMGSDESVVQAARISYGRGTKSVSQDAALINYLMRHSHTTPFEMCEIKFHIKLPIFVARQWVRHRTANVNEYSARYSVLDHEFYIPELDHVATQSEDNAQGRGNSLSNEDAQYVTDLLKRDSDMVYETYNKFLIKGVSREISRISLTLNYYTEWYWKIDLHNLLHFLRLRSDVHAQYEIRVYAETMLEIVKKWVPLTYAAFVEYCLESQSFSKSALSVVKKLIAGEDVAREDTGIGKREWRELMDVLADK

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Rickettsia bellii (strain RML369-C)
Length
294 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
34.486 kDa
Sequence
MNNATKRVVVPALEEILYEPIKVLDHGFIRVIDYMGDDSAIVQAARVSYGKGTKQLNQDKGLINYLLRHYHTTPFEMCDIKFHIKLPIFIARQWIRHRTASVNEYSARYSILGNEFYLPEPQNIAPQSSTNKQCRESDSLPKEVAEKVLNILEEDARNCYKHYTKLMNTDEEGNIIDDNNTGIARELARMNLTLNYYTEWYWKINLHNLLHFLRLRADPHAQYEIRVYAEKMLDIVKAWVPFTYEAFEEYRMCGANISRKGLEVIKKMISGEKVTHETSGMTKREWEELTKILK

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Rickettsia conorii (strain ATCC VR-613 / Malish 7)
Length
294 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
34.431 kDa
Sequence
MHNTTKRVTVPALEEILYEPIKVLDYGFIRVIDYMGDDSAIVQAARVSYGKGTKQLNQDKGLINYLLRHYHTTPFEMCDIKFHIKLPIFIARQWIRHRTASVNEYSARYSILGNEFYLPEPANIASQSAVNKQCREGDSLPKEVAEKVLAILEEDARQCYGHYKELMNADEEGNIIDENATGIARELARMNLTLNYYTEWYWKINLHNLLHFLRLRADPHAQYEIRVYAEKMLEIVKAWVPFVYEAFEEYRLQGANISRKGLDVIKRMINGEKVTHETSDMTKREWEELMKIFG

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)
Length
294 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
34.308 kDa
Sequence
MHNTTKRVTVPALEEILYEPIKVLDHGFIRVIDYMGDDSAIVQAARVSYGKGTKQLNQDKGLINYLLRHYHTTPFEMCDIKFHIKLPIFIARQWIRHRTASVNEYSARYSILGNEFYLPEPANIASQSAVNKQCREGDSLPKEGAEKVLAILEEDAKQCYGHYKELMNADEDGNIIDENNTGIARELARMNLTLNYYTEWYWKINLHNLLHFLRLRADPHAQYEIRVYAEKMLEIVKAWVPFTYEAFEEYRLQGANISRKGLDVIKRMIKGEKVTHESSGMTKREWEELMKIFG

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Rickettsia prowazekii (strain Madrid E)
Length
294 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
34.505 kDa
Sequence
MHNTTKRVTVPALEAMLYETIKVLDHGFIRVIDYMGDDSSIVQAARVSYGKGTKQLNQDKGLINYLLRHYHTTPFEMCDIKFHIKLPIFIARQWIRHRTASVNEYSARYSILGNEFYLPDPANIASQSVVNKQCRAGDSVPKKVSEKVLAILEEDARRCYRHYKELMNADEDGNILDENVSGIARELARINLTLNYYTEWYWKINLHNLLHFLRLRTDPKAQYEIRVYAEKILDIVKAWVPFTYEAFEEYRLQGANISRKGLEVIKRMIKGEKVIHETSGMNKREWEELVKIFR

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Length
294 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
34.445 kDa
Sequence
MHNTTKRVTVPALEAMLYETIKVLDHGFIRVIDYMGDDSSIVQAARVSYGKGTKQLNQDKGLINYLLRHYHTTPFEMCDIKFHIKLPIFIARQWIRHRTASVNEYSARYSILGNEFYLPEPTDIASQSAINKQCRAGDSLPKKVSEKVLAILEEDARRCYMHYKELMNADEDGNIIDENVAGIARELARMNLTLNYYTEWYWKINLHNLLHFLRLRTDSKAQYEIRVYAGKILDIVKAWVPFTYEAFEEYRLQGANISRKGLEVIKRMIQGEKVIHETSGMNKREWEELVKIFR

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Anaplasma marginale (strain St. Maries)
Length
291 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
33.62 kDa
Sequence
MEEGTGEYTKRVVVHALEDILHQELRVLDKGFVRVVDYMGSDESVVQAARVSYGRGTKRTSQDAALIGYLMRHAHTSPFEMCEIKLHVKLPIFVARQWVRHRTASINEYSARYSVLDREFYIPDEKQIAEQSTNNAQGRGTPLPADAAKRIMELFRRNSELMYEDYEALLEQGLARELARMNLTINCYTQWYWKVNLHNLLRFLALRSGAGAQYEIREYASRILEIVRLWVPMVHAAFVEYHLESSTISRSALVVVRKMLQGEKVSMEESGLGRREWGELMSVLYPDGEPE

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Wolbachia pipientis wMel
Length
284 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
33.247 kDa
Sequence
MNEATKRTIVKEIDAILYEEHKVLDHGFIRVVDYMGSDSAIVQAARVSYGKGTKQISQDEALIKYLMRHHHTTPFEMCEIKFHVKLPIFVARQWIRHRTANVNEYSARYSILDNEFYTPKPEQVAKQSDNNKQGSGEAFDPDTSKEIIDSLINDSNLVYSHYEKFIEQGLAREIARTNLMLNYYTQFYWKIDLHNLLHFLKLRADKHAQYEIRVYAEVMLDIIKKWVPLAYNAFVEYCLESACISRTGLEIIRKLIKGENVTREESNIGKREWGELMSILDKQS

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Length
270 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
31.007 kDa
Sequence
MEGPLTIPVLDKGFVRLVDQMGDDRAIVQAARVSYGEGTKTVREDAALIDYLMRHRHTSPFEMVVFKFHVKAPIFVARQWFRHRTASVNEISGRYSILKEEFYEPEAFRKQAKRNKQASEGALLDEEALALLRKVEQEAYGAYRALLEKGVAREMARMVLPLNLYTEFYWKQDLHNLFHFLKLRLAPEAQWEIRQYARAIAEIVKERVPLAWAAFEEHLLEGAFLSRTELRALRGLLTPEVYEKALSSLGLGGSRLKEALEKVFGPGEAL

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Length
270 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
31.006 kDa
Sequence
MEGPLTIPVLDKGFVRLVDQMGDDRAIVQAARVSYGEGTKTVREDAALIDYLMRHRHTSPFEMVVFKFHVKAPIFVARQWFRHRTASVNEISGRYSILKEEFYEPEAFRKQAKRNKQASEGALLDEEALALLRKVQQEAYGAYRALLEKGVAREMARMVLPLNLYTEFYWKQDLHNLFHFLKLRLAPEAQWEIRQYARAIAEIVKERVPLAWAAFEEHLLEGAFLSRTELRALRGLLTPEVYEKALSSLGLGGSRLKEALEKVFGPGEAL

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Length
266 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
30.847 kDa
Sequence
MDKEFKVLDKGFIRLVDYMGTDARIVQSARVSYGEGTKTVREDAALIDYLLRNKHTSPFEQVVFTFHVKLPIFVARQWIRHRTARLNEISGRYSILKAEFYVPAGKDIALQSSDNKQGRMNEAVPQDLQNEVITSLQKQQEEIYAGYSKLLDKNIARELARINLPLSTYTEWYWQIDLHNLFHFLRLRMDAHAQKEIRDYAEVMFEICKTVTPLACASFERHEKNGVNFSAEELEAIRNLIAGKDSGLKGKELERFNEKLKSGRQV

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Length
265 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
31.277 kDa
Sequence
MNKEYKILDNGFLKLIDFMGDDRRIVKAARISYREESVKRKDAELIDYLIRNGHTSPLEQVVFTFHVKAPIFVARQWMRHRTARINEVSGCYSLAREEFYVPLEEDLKCQTSSNSSEKEFKSLEKLSDKIKHHQKHSYELYQDMINANIPKELSRIVLPLSLYTEWYWQIDLNNLFHFIKLRLALDSPKEIKENSPKEMREYAKALISIVREIVPIAFNSFENHFLRGKRFSHEEIIAIINALDLNKLSMDAEKLNLLKDKLGID

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Length
260 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
30.568 kDa
Sequence
MISVKLVSYTNDGEKVIAIAAKMSRSRKGWDYHEKDMTDDEIETWIRDAILHGYWSVLEHSVYTFSIEEISRVASHQLVRHRIASYTQMSHRFAKPIDEYYKPIIPPSAKKRSKELVEKAYKEAYDNYYTLLESGVPEEDARYVLPNGVNTNIVVTMNARELYNFFSLRLCSRAQWEIRAIAWKMLEEVKKVHPRLFKYTGPNCIIHENFIRNENESITLEDIFKDYKLEFISQRCIEGVLRDGIKKCIINSRSVLDNIK

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Length
260 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
30.242 kDa
Sequence
MKIKLVSYSKDGERIVAIAAKMSRSRKGWDYHEKEMTDDEIETWIRDSITHGYWSVLEHSVYTFSIEGISRVASHQLVRHRIASYTQMSHRFAKPVDKYYKPITPPSIEKRGKEVVDKAYQDAYNYFYQLLEKGVPEEDARYVLPNGVNTNIVVTMNARELYNFFGLRLCSRAQWEIRAIAWKMLDEVKRVHPRLFKYAGPNCIIHENFIRENPITLDDIDNTVFISQRCIEGVTREGIPKCVKNARSILVSEDGVVMGK

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Length
257 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
30.344 kDa
Sequence
MNVKLVSYTRDGEKVVAIASKMSRSRKGWDYHEKTMTDEEIEVWIRDAILHGYWSVLEHSIYTFSIEGISRVASHQLVRHRVASYTQMSHRFAKPIDEYYKPITPPSIEKRAKEIIEKAYQEAYENYFKLLQDGVPEEDARYVLPNGVNTNIVVTMNARELYNFFALRLCSRAQWEIRAIAWKMLEEVKKVHPRLFRYVGPNCIIHENFIRNEPITLDEVLQKDNIEFISQRCIEGVMRDGILKCIRNSKHVLEYLK

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Mycobacterium leprae (strain Br4923)
Length
254 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
27.967 kDa
Sequence
MAQIAPLRVQLIAKTEFLAPPDVSWTTDADGGSALVEFAGRACYQSWSKPNPRTATNAAYIKHIIDVGHVAVLEHASVSFYISGISRSCTHELIRHRHFSYSQLSQRYVPEKDAQVVVPPDMEDDDELQQILIAAVEASRATYTELLVKLNAKLMAGELGGNRAVLRRKQARQAAHAVLPNANETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIVCLRRLVDVAPAVFADFEITALADGTEVATSPLATEA

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Mycobacterium leprae (strain TN)
Length
254 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
27.967 kDa
Sequence
MAQIAPLRVQLIAKTEFLAPPDVSWTTDADGGSALVEFAGRACYQSWSKPNPRTATNAAYIKHIIDVGHVAVLEHASVSFYISGISRSCTHELIRHRHFSYSQLSQRYVPEKDAQVVVPPDMEDDDELQQILIAAVEASRATYTELLVKLNAKLMAGELGGNRAVLRRKQARQAAHAVLPNANETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIVCLRRLVDVAPAVFADFEITALADGTEVATSPLATEA

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Mycobacterium sp. (strain JLS)
Length
254 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
28.01 kDa
Sequence
MAETAPLRVQLIARTEFTVPPDVPWETDAEGGAALVEFAGRACYQSWSKPNPRTATNASYLRHIIEVGHLSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPENDSQVVVPPGIEGDAELEGLFTAAADASRAAYAELLAKLEAKLMGDEPREGRATLRRKQARQAARSVLPNATETRIVVTGNYRAWRHFIAMRASEHADLEIRRLAIACLRELVAVAPAVFADFEIYPLADGTEVATTPLVTEA

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Mycobacterium sp. (strain KMS)
Length
254 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
27.996 kDa
Sequence
MAETAPLRVQLIARTEFTVPPDVPWETDAEGGAALVEFAGRACYQSWSKPNPRTATNASYLRHIIDVGHLSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPENDSQVVVPPGIEGDAELEGLFTAAADASRAAYAELLAKLEAKLMGDEPREGRATLRRKQARQAARSVLPNATETRIVVTGNYRAWRHFIAMRASEHADLEIRRLAIACLRELVAVAPAVFADFEIYPLADGTEVATTPLVTEA

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Mycobacterium sp. (strain MCS)
Length
254 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
27.996 kDa
Sequence
MAETAPLRVQLIARTEFTVPPDVPWETDAEGGAALVEFAGRACYQSWSKPNPRTATNASYLRHIIDVGHLSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPENDSQVVVPPGIEGDAELEGLFTAAADASRAAYAELLAKLEAKLMGDEPREGRATLRRKQARQAARSVLPNATETRIVVTGNYRAWRHFIAMRASEHADLEIRRLAIACLRELVAVAPAVFADFEIYPLADGTEVATTPLVTEA

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Length
252 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
28.323 kDa
Sequence
MAQQSLLDVQLVACSTFTTPSGVDWKVDSAATDSEALVEFAGRACYETFDKPNPRTAANDAYIRHIMEVGHMALLEHPTATVYIRGLSRSATHELVRHRHFSFSQLSQRFVHSDETHVVIPPLIDNDPQLRELFLSTVDEVRFAYSELMTALDNKLADEPNAILRRKQARQAARSILPNATESRIVVTGNFRAWRHFIGMRATEHADVEIRSLAVRCLEILKEKAPTVFSDFETSVLSDGSIMATSPYVTDY

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Mycobacterium avium (strain 104)
Length
250 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
27.503 kDa
Sequence
MAEIAPLRVQLIAKTDFLAPPDVPWSTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYIKHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPENDSRVVVPPGLDDDPELQQILAAAADASRATYTELLARLEAKFADQPSAVLRRKQARQAARAVLPNATETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRRLADVAPAVFADFEIATLADGTEVATSPLATEA

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Mycobacterium abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543)
Length
250 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
27.687 kDa
Sequence
MAEIVPLRVQLIAKTDFIAPPDIDWSTDADGGPALVEFAGRACYQSWSKPNPRTATNESYLRHVIEVGHLSVLEHASATFYITGISRSCTHELIRHRHFSYSQLSQRFVPEDDSNVVLPPAVEDDPELVALVRKATDASRAAYVELLEKLESTLADVPNAVLRRKQARQAARSVLPNATETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIACLRQLADLAPSIFGDFDIATLADGTEVAISPLVYEG

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Length
250 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
27.591 kDa
Sequence
MAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYLRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPPGMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEVATSPLATEA

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Mycobacterium bovis (strain BCG / Pasteur 1173P2)
Length
250 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
27.591 kDa
Sequence
MAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYLRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPPGMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEVATSPLATEA

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019)
Length
250 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
27.591 kDa
Sequence
MAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYLRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPPGMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEVATSPLATEA

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Mycobacterium gilvum (strain PYR-GCK)
Length
250 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
27.604 kDa
Sequence
MAEIAPLRVQLIAKTEFSAPPDVEWSTDADGGAALVEFAGRACYQSWSKPNPRTATNATYVRHIIDVGHFSVLEHASVSFYITGLSRSCTHELIRHRHFSYSQLSQRYVPENDAEVVAPPGIEDDPELLALFTAATDASRAAYTELLNRLEAKLADQGTSTLRRKQARQAARAVLPNATETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRRLVAVAPQVFSDFEITALADGTEVATSPLATEV

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Mycobacterium marinum (strain ATCC BAA-535 / M)
Length
250 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
27.606 kDa
Sequence
MAETAPLRVQLIAKTEFLAPPDVPWTTDADGGEALVEFAGRACYQSWSKPNPKTATNAGYLRHIIDVGHFAVLEHASVSFYISGISRSCTHELIRHRHFSYSQLSQRYVPEGDSRVVVPPGLEDDPELREILIAAADASRATYTELLTKLEARFADQPNAVLRRKQARQAARAVLPNATETRIVVSGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLVAVAPAVFADFEVTTLADGSEVATSPLATEV

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Length
250 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
27.503 kDa
Sequence
MAEIAPLRVQLIAKTDFLAPPDVPWSTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYIKHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPENDSRVVVPPGLDDDPELQQILAAAADASRATYTELLARLEAKFADQPSAVLRRKQARQAARAVLPNATETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRRLADVAPAVFADFEIATLADGTEVATSPLATEA

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Length
250 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
27.591 kDa
Sequence
MAEIAPLRVQLIAKTEFMAPPGVPWETDADGGEALTEFAGRACYQSWSKPNPKTATNAGYISHIIDVGHFSVLEHASVSFYISGISRSATHELIRHRHFSYSQLSQRYVPEHDSEVVVPPGFEDDPELVEIFTSAVDASRATYTELLKRLEAKFADQPNAVLRRKQARQAARAVLPNATETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIACLRELVTVAPAVFSDFVISTLADGSEVATSPLATEA

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Length
250 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
27.591 kDa
Sequence
MAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYLRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPPGMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEVATSPLATEA

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Length
250 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
27.591 kDa
Sequence
MAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYLRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPPGMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEVATSPLATEA

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
250 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant (PubMed:18493582). Is essential for growth of the pathogen on solid media in vitro; the essential function is something other than dTMP synthase (PubMed:12657046) (PubMed:22034487).
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
27.591 kDa
Sequence
MAETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNPKTATNAGYLRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEKDSRVVVPPGMEDDADLRHILTEAADAARATYSELLAKLEAKFADQPNAILRRKQARQAARAVLPNATETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEVATSPLATEA

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Length
250 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
27.73 kDa
Sequence
MAEIAPLRVQLIAKTEFSAPPDVPWSTDADGGAALVEFAGRACYQSWDKPNPRTATNAGYVRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYSQLSQRYVPEHDSQVVAPPGIEDDPELLEIFTEAADAGRAAYTELLTRLEARLADQPNATLRRKQARQAARAVLPNATETRIVVTGNYRAWRHFIAMRASEHADLEIRRLAIECLRQLVDAAPQVFSDFEIVVLADGTEVATSPLATEV

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Length
250 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
28.054 kDa
Sequence
MTEPVELSVELIACSSFTPPASVAWDTDAHGAEALVEFAGRACYETFDKPNPRTATNAAYLRHIMEVGHTALLEHASATMYIRGISRSATHELVRHRHFSFSQLSQRFVHEGEQEVIIPELINEDPQLRSLFLRAMDDNRFVYNELLNALEEKLEGEPNALLRKKQARQAARAVLPNATESRIVVTGNFRSWRHFLGMRASEHADVEIRAVAVACLEKLKQQAPTVFGDFQVETLADGTQMATSPYVTDF

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Length
250 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
28.065 kDa
Sequence
MAEQVKLSVELIACSSFTPPADVEWSTDVEGAEALVEFAGRACYETFDKPNPRTASNAAYLRHIMEVGHTALLEHANATMYIRGISRSATHELVRHRHFSFSQLSQRFVHSGESEVVVPTLIDEDPQLRELFMHAMDESRFAFNELLNALEEKLGDEPNALLRKKQARQAARAVLPNATESRIVVSGNFRTWRHFIGMRASEHADVEIREVAVECLRKLQVAAPTVFGDFEIETLADGSQMATSPYVMDF

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Clostridium tetani (strain Massachusetts / E88)
Length
249 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
28.439 kDa
Sequence
MRGKTMGVKVKLLEYTPNPEKVVASAAKLCYSPVGVEEMAKDLSEEKVNKFLNMLMSYGHESPIEHVSFTFAAEGVSRSLTHQLVRHRIASYSQQSQRYVKLDQFQYIIPPEIDKDNNTRSIFIEAMENSQKAYDKIASTLEQKYISEGMKRKEAEKKAIEDARYVFPNACETKIIFTMNARTLMNFFRHRCCTRAQWEIRNLANEMLSEVKKVAPNLFKYSGPSCVNGNCPEGAMSCGKAAEMKKIYL

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Corynebacterium aurimucosum (strain ATCC 700975 / DSM 44827 / CN-1)
Length
249 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
27.986 kDa
Sequence
MAKVSELDVQLIAATAFHAPQGVDWEVDEGASESEALVEFAGRACYESFDKPNPRTASNQAYLHHILEVGHDALLEHATATLYIRGLSRSASHELVRHRHFSFSQLSQRFVHSEEAEVVLPKFIAEDEQLTRLTLQAADEARFVYEELLDALESKLEEEPNALLRKKQARQAARAVLPNLTESRIVVTGNYRAWRHFIGARATEQADTEMRQLAVTCLKLLREQSPVLFDDFHITTLADGTEMASSPYA

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)
Length
247 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
27.984 kDa
Sequence
MDVKLLEATDDPEDLICKAARNDYSDTSVGSQSFEATMAEVDGDSLEEKKETLIGHLLDHGHFGPFEHAQATFAVEGVSRSCMAQITRHRHVSFDVQSMRYVSFDDVDPEAVREGELVVTPPSATDPDWIGRNQQKASVSDEEFEERAEIFKDTIEQAVESYQELLELGMPPEDARFVLPIGTKVNIVMSMNARMLMHVADMRAAADAQWEIREMTEEMLELAADWCPKTFEYYEQEMKGRKNRLAP

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
Length
247 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
27.622 kDa
Sequence
MRVRLLEATENPEELICQSARNDYMSDWVGDTPLDTAMASVDGDTTDEKLSNLIAQLLTRGHYGPFEHPSATFAIEGVSRSCMAQLTRHRHASFDVQSMRYVAFDDVDPAAVAEGELVVTPPSATDPDWVGRNQDAGDIDEETMAEREAVFQASVRRAVEDYQELLGLGMPPEDARFVLPIGTEVNVVITLNPRSLMHVADMRAAADAQWEIRELTEQLLDAAAQWCPHTFEYYDAEMKHRKNRLAP

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Length
246 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
28.002 kDa
Sequence
MTDTPADDLKPSFRSDVTVELVKHSAADSDVLWAARVSTAGEQSLDELKKDPERSKGLINYLMRDRHGSPFEHNSMTFFISAPIFVFREFMRHRVGWSYNEESGRYRELEPVFYVPGESRKLVQEGRPGKYVFVEGTQAQQELTGRVMEDSYRQAYEAYQEMLAAGVAREVARAVLPVGLFSSMYATCNARSLMHFLGLRTQHELAKVPSFPQREIEMVGEKMEAEWAKLMPLTYAAFNTNGRVAP

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Length
246 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
27.785 kDa
Sequence
MTDIPADDPKIELRSDITVELVKSAATDSDVLFAARVSTAGEQSLDELKKDPERSKGLINYLMRDRHGSPFEHNSMTFFVSAPIFVFREFMRHRVGWSYNEESGRYRELQPVFYAPDASRKLVQQGRPGKYVFVEGTPEQHELVGSAMEDSYRQAYATYQQMLAAGVAREVARAVLPVGLYSSMYATCNARSLMHFLGLRTQHELAKVPSFPQREIEMAGEKMEAEWARLMPLTHAAFNANGRVAP

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
Length
245 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
28.671 kDa
Sequence
MDNGIRVKLVNYTKKPLETVTWAALISYWDEWETETFGRMSDKDVEMHLPRVLGYGHESILEHATLTFAIEGCSRVCSHQLVRHRLASYTQQSQRYIVLNPEDVEETFVIPSGIKEDPELLAEWKELMKKSIELYKKSVERGQHQEDARFILPQAVRTKIVVTMNLRELKHFLGLRACERAQWEIREVAWKMLEEIAKNDELRPIIKWAKLGPRCVQLGYCPEGELMPPGCWKRTGEKWKTLFEG

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Clostridium perfringens (strain 13 / Type A)
Length
245 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
27.854 kDa
Sequence
MLKVKLLQYTPEPEKTIAAAAKLCYSPVGVDDILENLTDEGAEKFLNMLMSYGHMSPIEHVSFTFAVEGVSRSLTHQLVRHRIASYSQQSQRYVKLDQFEYIVPPAIENDEVAKKLFIDQMQGAQKAYDEIVERLKDKYISEGIGEKPAEKKAIEDARYVFPNACETKIVFTMNARSLMNFFHHRCCDRAQWEIRTMAEKMVNEVKKVAPILFKNAGPSCVAGPCPEGKMCCGKLKEMRTLYLGK

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)
Length
245 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
27.652 kDa
Sequence
MPRTEPRVELLAHTPEPLSLLYAAFRQCYHAGFVADMWPRLLSGEIEREKQGAFIASILESGHSSPIEHVSFTFAIEGVSRALTHQLVRHRIASFSQQSQRYVDGSHFDYVMPPAIARNAAAKARFEQFMEDVGSAYRDIKALLEQDGRTGSRANEDARFVLPQAAASKIVVTMNCRALVHFFEERCCMRAQWEIRAVADVMLGLCREVLPELFAHAGAKCERLGYCPEGERFTCGRYPLRQSMP

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Thermococcus onnurineus (strain NA1)
Length
245 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
28.939 kDa
Sequence
MRDGIKVRLVNYTKKPLETVTWAALISYWDEWETEAFERLGEKDVEMHLPRILGYGHESILEHAVLTFAIEGCSRVCSHQLVRHRIASYTQQSMRYIKINPRDVEETFVIPESVKKNPELYEKWKKLMRETIQLYEETYKAGVHQEDARFILPQAVRTKIVVTMNLRELKHFLGLRACERAQWEIRDVAWKMLGEIAKNEELRPIIRWAKLGPRCVQLGYCPEGELMPPGCWKRTREKWKEVALG

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Length
244 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
29.193 kDa
Sequence
MVRVTLVNYTRRPLETITWAALVSYWDEWSTESFEKINEDDVKAHLPRILGYGHESILEHATFTFSIEGCSRVCTHQLVRHRIASYTQQSQRYIVLNEENVEETFVIPESIKKDRELYEKWKKAMAETIKLYKESLKRGIHQEDARFILPQAVRSKIVVTMNLRELKHFFGLRLCERAQWEIREVAWKMLEEIAKREELRPIIKWAKLGPRCIQLGYCPERELMPPGCFKRTRERWMKLLEKPL

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Length
244 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
28.439 kDa
Sequence
MVILETPRVFLIASWGSEAVISAFTDALYRGVPWEEAVKAQAPDVIIKRISAFYRQGHWSVFEFMGAQFLVECSRACHTQFIRHRMASYWSESQRYVDYTKREIRFVVPKGFPADLLKRAYEDYARLREGFRPEYARMILPNATAVLFAVQMNARELLLNFAPLRCAYAAQAEIRHVCWQMFAHAWRLWPNLARLVWEDLPSLHRDFCTKVPRGEDCRLYAIKDAEEKHGPLPETPWLSALVHG

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Length
244 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
28.964 kDa
Sequence
MVRVTLVNYTKRPLETITWAALISYWGEWSTESFERISENDVEKHLPRILGYGHESILEHATFTFSIEGCSRVCTHQLVRHRIASYTQQSQRYIVLDEENVEETFVIPESIKKDRELYEKWKKVMAETISLYKESINRGVHQEDARFILPQAVKTKIIVTMNLRELKHFFGLRLCERAQWEIREVAWKMLEEMAKRDDIRPIIKWAKLGPRCIQFGYCPERDLMPPGCLKKTRKKWEKVAESKS

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Tropheryma whipplei (strain Twist)
Length
244 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
27.959 kDa
Sequence
MLQCLFFVMDPVFLSEITVELVKHSASDSDVVFSARVSTLGSFVAVTDCLSNRDIGLITFLMRERHGSPFEHSHMTFRISAPIFVFREFMRHRIASYNEESGRYKNLDPVFYIPDEKRKLVQIGAPGAYKFEEGTSEQYGLLIEEMKELSLAAYDTYKRLLACGIAREVARMILPLNLYSTMYVTINARSLMNFLSVRTSRANSAFHSYPQREIELCADRIEEIWKGLMPETHAAFEKQGRVAP

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Length
243 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
28.896 kDa
Sequence
MVKVKLINYTPKPLETVTWAALISYWDGWSTEAFEKISPNDVEIHLPRILSYGHESILEHATFTFSIEGCSRVCTHQLVRHRIASYTQQSQRYIKINPEDVEETFVIPESIKKDSELLKEWKELLKRSLELYEKSIERGIHQEDARFILPQSVKTKIVVTMNLRELKHFFGLRLCERAQWEIREVAWKMLEEIAKRKELKPIIEWAKLGPRCIQLGYCPERELMPPGCLKRTRERWKNLLEKY

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Tropheryma whipplei (strain TW08/27)
Length
240 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
27.502 kDa
Sequence
MFFVMDPVFLSEITVELVKHSASDSDVVFSARVSTLGSFVAVTDCLSNRDIGLITFLMRERHGSPFEHSHMTFRISAPIFVFREFMRHRIASYNEESGRYKNLDPVFYIPDEKRKLVQIGAPGAYKFEEGTSEQYGLLIEEMKELSLAAYDTYKRLLACGIAREVARMILPLNLYSTMYVTINARSLMNFLSVRTSRANSAFHSYPQREIELCADRIEEIWKGLMPETHAAFEKQGRVAP

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Length
232 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
25.383 kDa
Sequence
MKIALLQHTPDPEAAVALAARLCYASVGIDELREKLSASDVTAFLDKIMSLGHQSVLEHASFTFGIEGISRAASHQLVRHRIASYSQQSQRYVTFRGDGFPRVVPGSVSATEKRRQVFESAMQACADAYRALVDDGVPAEDARFVLPNAAETKIIVTMNARELIHFFGLRCCERAQWEIRALAVEMLRLVKGVAPTIFRDAGPGCLTGPCPEGGMTCGKAAEVKRLFREMSI

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Kosmotoga olearia (strain ATCC BAA-1733 / DSM 21960 / TBF 19.5.1)
Length
230 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
26.912 kDa
Sequence
MEIKVLEKGFIRLVEVMGDDFSAVQAARVSYGKGLTTPERDKKLIFYLMEHGHHSPFEHIIFKFHIKLPIFVMRQLVRHRIASINERSGRYTEFSDEWYIPERIRTPDKVNRQGSVFVDDDDLNSEGIRLIEETIEKTYQAYKRLLEMGVARELARIVLPTSMYTECYWTINARSMMNFLNLRADSHAQYEMQQYALAVAKIFKSKCPVTYEAFLNFAYTGDLLKTEGCL

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Thermosipho melanesiensis (strain DSM 12029 / CIP 104789 / BI429)
Length
229 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
27.389 kDa
Sequence
MEFKVLDKGFLRLVDILGDDYSAVKAARVSYGKGIKTPEKDKNLIFYLMEHKHETPFEHIVFTFHVKTPIFVARQWFRHRIGSFNEASLRYTELKDEFYLPDHIRKNIVEDKQKAVRVEELKLKEQALELIYNSIEDSYKVYRKLLELGVAREMARIVLPMSSYTQFYWTVNARSLMNFLNLRADSHAQWEIQQYAIKIAKIFKEKCPWTFESFLKFNYRGDILREVEL

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Thermosipho africanus (strain TCF52B)
Length
228 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
26.827 kDa
Sequence
MEYKILDKGFLRLVDMMGDDYAAVKAARVSYGKGIKTPEKDKNLIFYLMEHGHETPFEHIVFTFHVKAPIFVARQWFRHRIGSFNEASLRYTELKDEFYIPDHVRKNVVEDKQKAIKVDDEQLKQKALDLIESSIENSYKVYKELLEMGVAREMARIVLPMSSYTQFYWTVNARSLMNFLNLRADSHAQWEIQQYALNIANIFKEKCPWTFEAFLKFAYKGDLLKGGE

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Pseudothermotoga lettingae (strain ATCC BAA-301 / DSM 14385 / NBRC 107922 / TMO)
Length
221 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
26.173 kDa
Sequence
MTIEVLDRGFVKLLDHMGDDFSAVKAARISHGRDLIDEERDRKLIEYLLRSGHESPFEHIVFTFHIKCPIFVARQWMRHRIASYNELSGRYTELAEEFYLPDLYKRYGERLNENDLQKASKLIEESYKKSHEAYKCLIDMKIPKELARVVLPFATYTQFIWSVNARSLMNFLSLRADSHSQWEMQQFALAVAQVFKSICPWTYESFIRYRYEGDLLKGVNP

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Length
220 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
26.004 kDa
Sequence
MKIDILDKGFVELVDVMGNDLSAVRAARVSFDMGLKDEERDRHLIEYLMKHGHETPFEHIVFTFHVKAPIFVARQWFRHRIASYNELSGRYSKLSYEFYIPSPERLEGYKTTIPPERVTEKISEIVDKAYRTYLELIESGVPREVARIVLPLNLYTRFFWTVNARSLMNFLNLRADSHAQWEIQQYALAIARIFKEKCPWTFEAFLKYAYKGDILKEVQV

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Thermotoga petrophila (strain RKU-1 / ATCC BAA-488 / DSM 13995)
Length
220 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
25.976 kDa
Sequence
MKIDILDKGFVELVDVMGNDLSAVRAARVSFDMGLKDEERDRHLIEYLMKHGHETPFEHIVFTFHVKAPIFVARQWFRHRIASYNELSGRYSKLSYEFYIPSPERLEGYKTTIPPEQVTEKISEIVDKAYRTYLELIESGVPREVARIVLPLNLYTRFFWTVNARSLMNFLNLRADSHAQWEIQQYALAIARIFKEKCPWTFEAFLKYAYKGDILKEVQV

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Thermotoga sp. (strain RQ2)
Length
220 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
26.03 kDa
Sequence
MKIDILDKGFVELVDVMGNDLSAVRAARVSFDMGLKDEERDRHLIEYLMRYGHETPFEHIVFTFHVKAPIFVARQWFRHRIASYNELSGRYSKLSYEFYIPSPERLEGYKTTIPPEQVTEKISEIVDKAYRTYLELIESGVPREVARIVLPLNLYTRFFWTVNARSLMNFLNLRADSHAQWEIQQYALAIARIFKEKCPWTFEAFLKYAYKGDILKEVQV

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NS-E)
Length
216 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
25.659 kDa
Sequence
MKIPVLDKGFVELVDVMGNDLSAVRAARVSFNMELKDEEKDRRLVEYLMRHGHESPFEHIVFTFHVKAPIFVARQWFRHRIASYNELSGRYSKLTYEFYIPPLQRFGQTRIVPEKVIEKISHVVNESYQTYMELLEAGVPREVARIVLPLNLYTRFYWTVNARSLMNFLNLRADSHAQWEIQQYAVAIAKIFREKCPWTYEAFIKYAYKGDLLREV

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Length
215 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
25.067 kDa
Sequence
MDVRFISLTKPEIVIDGEPLSPEGLIAYCARVSSPNQENPNYTKLLQFCIREGHWSIFEMVDMTLEITTTRAIAPQILRHRSFSFQEFSLRYSCATEYECYEARRQDVKNRQNSLDDFDESTKKWFNQAQAAVWEKSHQLYEEALAKGIAKECARSILPLNTVTRLYMKGSVRSWIHYFSVRCDQATQKEHREIALAARKIFMKHFPTVAAALEW

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Helicobacter pylori (strain J99 / ATCC 700824)
Length
208 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
24.203 kDa
Sequence
MEVICKHYTPLDIASQAIRTCWQSFEYSDDGGCKDRDLIHRVGNIFRHSSTLEHLYYNFEIKGLSRGALQELSRHRIASLSVKSSRYTLRELKEVESFLPLNETNLERAKEFLVFVDDEKVNEMSVLALENLRVLLSEHNIKNDLAKYAMPESYKTHLAYSINARSLQNLLTLRSSNKALKEMQDLAKALFDALPYEHQYLFEDCLKH

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Helicobacter pylori (strain ATCC 700392 / 26695)
Length
208 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
24.071 kDa
Sequence
MEVICKHYTPLDIASQAIRTCWQSFEYSDDGGCKDKELIHRVGNIFRHSSTLEHLYYNFEIKGLSRGALQELSRHRIASLSVKSSRYTLRELKEVESFLPLNETNLERAKEFLVFVDNEKVNAMSVLALENLRILLSEHNIKNDLAKYAMPESYKTHLAYSINARSLQNFLTLRSSNKALKEMQDLAKALFDALPGEHQYLFEDCLKH

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Length
207 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
23.809 kDa
Sequence
MQITLLFHTPLSVCSHATRTCWQSFEKGDCGGEKDKELIDRVGNKFKHASTLEHLNYTFYIQGISRACLQEVARHRHTSPSVKSTRYTLKELRNEAEFKIGDFENASRYLVLCGNEEVDNASIKALENLRTILQKSISLDIAKYCLPESYKTELTLTINARSLQNFISLRSSKSALWEIRNLANALFEALPQEHKFIFEHCLHKDIE

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Campylobacter jejuni (strain RM1221)
Length
207 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
23.809 kDa
Sequence
MQITLLFHTPLSVCSHATRTCWQSFEKGDCGGEKDKELIDRVGNKFKHASTLEHLNYTFYIQGISRACLQEVARHRHTSPSVKSTRYTLKELRNEAEFKIGDFENASRYLVLCGNEEVDNASIKALENLRTILQKSISLDIAKYCLPESYKTELTLTINARSLQNFISLRSSKSALWEIRNLANALFEALPQEHKFIFEHCLHKDIE

Gene
thyX
Protein
Flavin-dependent thymidylate synthase
Organism
Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W)
Length
204 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
23.506 kDa
Sequence
MTVTLMQHTSLTICAHAIRTCWQSFEKSDGGGEKDRELIDRVGNKNKHASTLEHLVYTFYIQGISRACLQELARHRIASLSVKSSRYTLKELKAEEEFKEGDWERAKRYLVETESEAVNLASLKALENLRQVLLLGISNDMAKYCLPESYKTELTWTINARALQNFLTLRSSKSALWEIRKLAKTLHEALPKEHRYLFCLNQEG