Description
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Family
Belongs to the thymidylate synthase ThyX family.
Species
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Sequence
MVKVKLINYTPKPLETVTWAALISYWDGWSTEAFEKISPNDVEIHLPRILSYGHESILEHATFTFSIEGCSRVCTHQLVRHRIASYTQQSQRYIKINPEDVEETFVIPESIKKDSELLKEWKELLKRSLELYEKSIERGIHQEDARFILPQSVKTKIVVTMNLRELKHFFGLRLCERAQWEIREVAWKMLEEIAKRKELKPIIEWAKLGPRCIQLGYCPERELMPPGCLKRTRERWKNLLEKY
Simulated SDS-PAGE

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)
Safety
Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.
Protein synthesis service