Description
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Family
Belongs to the thymidylate synthase ThyX family.
Species
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Sequence
MKIKLVSYSKDGERIVAIAAKMSRSRKGWDYHEKEMTDDEIETWIRDSITHGYWSVLEHSVYTFSIEGISRVASHQLVRHRIASYTQMSHRFAKPVDKYYKPITPPSIEKRGKEVVDKAYQDAYNYFYQLLEKGVPEEDARYVLPNGVNTNIVVTMNARELYNFFGLRLCSRAQWEIRAIAWKMLDEVKRVHPRLFKYAGPNCIIHENFIRENPITLDDIDNTVFISQRCIEGVTREGIPKCVKNARSILVSEDGVVMGK
Simulated SDS-PAGE

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)
Safety
Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.
Protein synthesis service