ORF2

Replication polyprotein

2104 amino acids

The peptidase activity is involved in polyprotein maturation, possibly along with hosts proteases. Transmembrane protein may be surface viral glycoprotein. RNA-directed RNA polymerase replicates the viral genome (Probable).

239.183 kDa

MLIEAFINSLLQNLGIMMSFRDLVASPWILLVIAIPLCAFASSASMVREMLFRHKITENILKGTGVEELFNPFGIIIKYFLYFAILYAFIKYIRNNINVITEKVNFIRRVVSNPTGTTGRRGVLGRCVEQIVEYPTFFITMVYELQQIKNKKDLISKITMISSILKLPLGIWESTVGRMLDRPAIEGTEEMLEDVLPIVAMGLTITKTQIGDVPVESFLVNLDRNQKACENIIKRMQPLMIKMGMMKDSSYDTILQVAKEVNELSEAETWMKTTLKLNPNEFLQTQGAVRVGEIREKVATLRNKLNTLQTKELRSDKVVTECQKHLASLEVLLIEVKVLENSNQTRVKPVGVTIQGEKQIGKTNLVAILSRKICEYVQEHGDISFRNATKWTTWSRQCRDEFDTGYTGQEITYVDDAFQQKDNKDHLMWFTFISNTAVGTNQADLKQKGLPYRSKLVFTTCNKSPDKSVTIEDIEALHARFPHTICLRRNKNKMPKRGAIDESYDWVDFYYGPMSKAVSAIGSNTTSTLKTMSLSEIVKIIGDDLIIQNNFYNSTIKDVGITGQEQMDGAQLERRQRMRELRDHLLRIRSGDENMPFLDETFELNSRPIQTDEKFIPLKDNLDEEVMYGGISDQLLTRFDNIIERSLEGYDVESRELGVEPLTTLNHVRSNMLSYRAWNLINSMCINKTETFSAWLGRYITECVEGVAENLVTTKVKIRINPFTGLQLIAAKRMLQENKLIDMDEIPSTSANSYETVYDQIKNFVNDELSLMETDVVDLALAKISLSQIRSNIKRSTWLDVNDWILALKHKISGKSFAKHMDLYPSSLDSFLLTLKDWEVEDRIKFNSIYKQKVLFVQSRFSLYCWSPFISRGTRFVKVTSRFRELVDKLETGILFHEIKSVTNGIRWLGGAGNNGHVGERVRVIAHTAQFPKKSYPQNGFPINEELHREWIQLVINSDYKYHSLIGEEKVNILWNLIRLQPQREVENFKVYLEDLQASPPKTGTICAKVVNDIKAEVTSSYRQFNNYYTRLTKDGMHTLLSMLSRIGVPISDYWNDLLVDKAPAITAVTVGAITSLAIITIVKTFQYAIAGEEQSKGEKRAKQKNIATTKLQKLKFTLGKEQAEGDSIEHVKEFDGDVKFETIEKLFDHIDEHPNLNIVGLNLVAPENPIAIYAAREESYDFSFSEPRPPQWKKVVTFKEDSKRIISLQLRGEDTEDNILDEIEHAIKVSHGMPYAEWIFNGWFKKESNDNILYCVELDLVTAKTQSGPVGWTRAQTKNLKDLEIQLNKGKPIDVKSVVLGAPQASTQATDTMDVLVNKHLVKVHCLSYENLNNLALNGTQVFALASDNILIVPAHAARQNKWIRFSRATQTGHYGVAKVDERRIDFTRDIAIAIILTRAEAEQKLCELGYSIQLTNISKEKFHFPLITKYLLTADQSEVEWMNCTTLHYFAKNKTVGLGRTTSFQVSEFLCGNEYISKKLVACAQGLQSSVELSRLGDCGSPIVLASGKKAGKLIGFHGYHSPNLQTWYGAMLTVEDLGIINGVEEHFDDPWAKLITQGLPVDLPIGPEVEYVGNLIRPSLPVTNDSLDHWHKSPFADQFEEQLAPGRLNPYDSYIEGDLPTNLEGRKSLILGPNSEMAKTLPELDQGILDWIVDQLVVEQVATFKAENLLTKVSDDIDEMLDYALNGNVDNTYVRGMEVNKASGLPWSLSGSPKKSDFIDVDEATGVRSFKVNANGDALKNRVILKLQQAKMGNRILSFSSSKLKDQPIKIAQAKSGRTRVFHCIPVDLILFSGALYGPYKEAYTKAGLKCYHAVGIDPKSVGWQQLATYMTKHPNYFDADYKNYDKYLHRQVFKAVRKIQRSVIQQVCPDKWDKARAVEELDAIDTYVVDYQTVYKTNRGNKSGSYTTTIDNCLANDIYGLYAWVKTTGLRSLWDYRQNVSSVAFGDDIIKSVSDEYKDKYNYCTYRDVLNATGHIMTPGSKDGEEKPFTSFENLQFLKRGFKLENGMVLAPLLQRSIEGPFVWTDIREDQITVWVNLVQEQLIEAALWGEEYYNELCQKLKCGTNRTLNGALAVLLNTSWEVTFQKFCNRYYGIKRGDL

ORF2

RNA-directed RNA polymerase

965 amino acids

RNA-dependent RNA polymerase that plays an essential role in the virus replication.

Belongs to the tombusviridae RNA polymerase family.

110.88 kDa

MATLPSIHAFWKLWWPTFSEERKMTVVQALRNGLTRKLFQITQIAQQILRWPPYIRERMTSSLGQSLVKTFQTLLGIRKALSRLCLTRNMNVDIFTMLLIPFKFLSQLCSQIVASANFVIQTFRHGLSRGLCLARCRNPETMRSGWSKHTLQMQNCSSTSPLMTPFQPQIARDLSNPHGLWMSTRNKLTRTGGSAIQQTSRYVRLAVRFSLLAAGAYISCVLARKALKEYVYRWELKSDQELPTREQSQISQVEQAMEQNGAMMVMKLNGPTAPILSLQDCLTKHVLVPEIVDEEGTVTQKEQSTFLIREFGPAVRNLVTLAKLEFGGIPKKTTANELTVWRFLVRKCEHANMNPTDSRTAISMALPYVFMPCRTDVGRASIPLRDESIEICRQYRAQFVEETPLRRVFNNPLSGKAWRNWVRHLGGLDDPALFQELKXGCLEEWLGVQSRRTRARHPKLRSHFKDTRHKTRRVFRIAGLGNLYEFGVHNNSAVNLERGLMERVFYVKDDKGELVSCPEPISGIFWKNLKGFRNSIVHHVGHRHPVSRETFLAYYTGPKRTMYEKAVNSLYEMPVSYDDAKLKTFVKAEKINLTKKADPVPRVIQPRAPRYNVELGRYLRPVEHPIYHAIDKIWGGPTIMKGYSVEQIGRHIENAFRSFTDPVAIGFDASRFDQHVSVEALRWEHSVYSRIYGYPELLTQLLRWQIHNRGTAYASDGAFNYQVDGKRMSGDMNISLGNCILATAITHDFVTKLGIPARLINNGDDNVLICPAVEVGRVRQELYRHWLNYGFEVISEEPVYILEQVEFCQMRPVFDGTQYTMMRDPRTTMSKDAYAVTPFNTPTAARRWMRAVGECGLSLTGGLPVKQEYYTALVKHGLDPKNIKQGKDFDSGLYYLSKLSNRKWQEVQESARYSFWLAFGYTPDEQRALEEYFKSWTPTFEWSTTGILAEIPECLLLKHNPLPPT

ORF2

Structural polyprotein

904 amino acids

Protein VP3: Forms, together with protein VP1 and protein VP2, an icosahedral capsid protecting the viral RNA genome. The icosahedral capsid has a pseudo-T=3 symmetry with a diameter of approximately 300 Angstroms, and is composed of 60 copies of each capsid proteins.

Belongs to the picornaviruses polyprotein family.

100.879 kDa

ADQETNTSNVHNTQLASTSEENSVETEQITTFHDVETPNRINTPMAQDTSSARSMDDTHSIIQFLQRPVLIDHIEVIAGSTADDNKPLNRYVLNRQNPQPFVKSWTLPSVVLSAGGKGQKLANFKYLRCDVKVKIVLNANPFIAGRLYLAYSPYDDRVDPARSILNTSRAGVTGYPGIEIDFQLDNSVEMTIPYASFQEAYDLVTGTEDFVKLYLFTITPILSPTSTSASSKVDLSVYMWLDNISLVIPTYRVNTSIVPNVGTVVQTVQNMTTRDSETIRKAMVALRKNNKSTYDYIVQALSSAVPEVKNVTMQINSKKNNSNKMATPVKEKTKNIPKPKTENPKIGPISELATGVNKVANGIERIPVIGEMAKPVTSTIKWVADKIGSVAAIFGWSKPRNLEQVNLYQNVPGWGYSLYKGIDNSVPLAFDPNNELGDLRDVFPSGVDEMAIGYVCGNPAVKHVLSWNTTDKVQAPISNGDDWGGVIPVGMPCYSKIIRTTENDTTRTNTEIMDPAPCEYVCNMFSYWRATMCYRIAIVKTAFHTGRLGIFFGPGKIPITTTKDNISPDLTQLDGIKAPSDNNYKYILDLTNDTEITIRVPFVSNKMFMKSTGIYGGNSENNWDFSESFTGFLCIRPITKFMCPETVSNNVSIVVWKWAEDVVVVEPKPLLSGPTQVFQPPVTSADSINTIDASMQINLANKADENVVTFFDSDDAEERNMEALLKGSGEQIMNLRSLLRTFRTISENWNLPPNTKTAITDLTDVADKEGRDYMSYLSYIYRFYRGGRRYKFFNTTALKQSQTCYVRSFLIPRYYTADNTNNDGPSHITYPVLNPVHEVEVPYYCQYRKLPVASTTDKGYDASLMYYSNVGTNQIVARAGNDDFTFGWLIGTPQTQGITRTETK

ORF2

Capsid polyprotein VP90

796 amino acids

The capsid polyprotein VP90 self-assembles and undergoes a proteolytic cleavage by host caspases to yield the VP70 virions. This immature virion is composed of 180 VP70 subunits with 90 dimeric spikes and displays a T=3 icosahedral symmetry. The mature virion is obtained by further cleavages resulting in three structural proteins VP25, VP27 and VP34. This forms contains only 30 spikes located on the icosahedral 2-fold axes. Plays a role in the attachment to target host cell. This attachment induces virion internalization through clathrin-dependent endocytosis (By similarity).

Belongs to the astroviridae capsid polyprotein family.

87.839 kDa

MASKSDKQVTVEVNNNGRNRSKSRARSQSRGRGRSVKITVNSHNKGRRQNGRNKYQSNQRVRKIVNKQLRKQGVTGPKPAICQRATATLGTIGTNTTGATEIEACILLNPVLVKDATGSTQFGPVQALGAQYSMWKLKYLNVKLTSMVGASAVNGTVLRISLNPTSTPSSTSWSGLGARKHMDVTVGRNAVFKLRPSDLGGPRDGWWLTNTNDNASDTLGPSIEIHTLGKTMSSYKNEQFTGGLFLVELASEWCFTGYAANPNLVNLVKSTDHEVNVTFEGSKGTPLIMNVAEHSHFARMAEQHSSISTTFSRAGGDATSDTVWQVLNTAVSAAELVAPPPFNWLIKGGWWFVKLIAGRTRTGTKQFYVYPSYQDALSNKPALCTGGVTGGVLRTTPVTTLQFTQMNQPSLGHGEHTATIGSIVQDPSGELRVLLTVGSIMSPNSADRQVWLNKTLTAPGTNSNDNLVKIAHDLGHYLIMQGFMHIKTVEWYTPDFQPSRDPTPIAGMSVMVNITKKADVYFMKQFKNSYTNNRHQITSIFLIKPLADFKVQCYMSYFKRESHDNDGVANLTVRSMTSPETIRFQVGEWYLLTSTTLKENNLPEGWVWDRVELKSDTPYYADQALTYFITPPPVDSQILFEGNTTLPRISSPPDNPSGRYMESHQQDCDSSDDEDDCENVSEETETEDEEDEDEDDEADRFDLHSPYSSEPEDSDENNRVTLLSTLINQGMTVERATRITKRAFPTCAEKLKRSVYMDLLASGASPSSAWSNACDEARNVGSNQLAKLSGDRGHAE

ORF2

Capsid polyprotein VP90

794 amino acids

The capsid polyprotein VP90 self-assembles and undergoes a proteolytic cleavage by host caspases to yield the VP70 virions. This immature virion is composed of 180 VP70 subunits with 90 dimeric spikes and displays a T=3 icosahedral symmetry. The mature virion is obtained by further cleavages resulting in three structural proteins VP25, VP27 and VP34. This forms contains only 30 spikes located on the icosahedral 2-fold axes. Plays a role in the attachment to target host cell. This attachment induces virion internalization through clathrin-dependent endocytosis (By similarity).

Belongs to the astroviridae capsid polyprotein family.

87.096 kDa

MASKSDKQVTVEVKNNNNGRNRSRSRARSQSRGRGKSVKITVNSRSRGRRQNGRDKYQSNQRVRNIVTKQLRKQGVTGPKPAICQRATATLGTIGSNTSGTTEIEACILLNPVLVKDATGSTQFGPVQALGAQYSMWKLKYLNVKLTSMVGASAVNGTVVRVSLNPTSTPSSTSWSGLGARKHLDVTVGKNAVFKLKPADLGGPRDGWWLTNTNDNASDTLGPSVEIHTLGMTMSSYKNEQFTGGLFLVELASEWCFTGYAANPNLVNLEKSTDKQVNVTFEGSNGTPLIMKVPEASHFARTAVARSSLPTTLARAGQNTTSDTVWQVLNTAVSAAELVTPPPFNWLVKGGWWFVKLIAGRARTGTRSFYVYPSYQDALSNKPALCTGSAPSGMRSRAAVMTTLQFTQMNQPSLGHGEMTATLGRAIPSPGDTFNVVLTIGQPLAPNTLTKQSWLNKTTVSPQNHHVVKIAKDVNNYTTMQGFTPISSVDWYTTDFQPSEEPTPIPGLQVLVNSSKKADVYAIQQYLNNQTNNKVQLTSIFLVKVTTSFQVNNYLSYFYRSYGTGTTVENLKVRSDTTAQDVNFPVGWYLMTNTAIFNAPAPPGWIWQNVELLNDTAYLIDQGMMHLIMPPPANTQLLFEMRTSVTGSRSMISSEEPDTHEPGDEWCDALDASDSRVFLEETDYEDEEDEDEDDEADRFDLHSSYGSEPEDDDENNRVTLLSTLINQGMTVERATRITKRAFPTSADKTKRSVYMDLLASGLSPGNAWSHACEEARIMGTNQMPNVSGDRGHAE

ORF2

Capsid polyprotein VP90

791 amino acids

The capsid polyprotein VP90 self-assembles and undergoes a proteolytic cleavage by host caspases to yield the VP70 virions. This immature virion is composed of 180 VP70 subunits with 90 dimeric spikes and displays a T=3 icosahedral symmetry. The mature virion is obtained by further cleavages resulting in three structural proteins VP25, VP27 and VP34. This forms contains only 30 spikes located on the icosahedral 2-fold axes. Plays a role in the attachment to target host cell. This attachment induces virion internalization through clathrin-dependent endocytosis (By similarity).

Belongs to the astroviridae capsid polyprotein family.

86.569 kDa

MASKSDKQVTVEVNNNNGRSRSRSRGRSQSRGRGRSFKITVNSKNRGRRQNGRNKLQSNQRVRNIVNKQLRKQGVTGPKPAICQRATATLGTIGSNTSGSTEIEACILLNPVLVKDATGSTQFGPVQALGAQYSMWKLKYLNVKLTSMVGSSAVNGTAVRISLNPTSTPSSTSWSGLGARKHLDVTVGKNAVFRLKPADLGGPRDGWWLTNTNDNASDTLGPSIEIHTLGKTMSSYLNQQFTGGLFLVELASEWCFTGYAANPNLVNLMKSTDKQVNVSFEGDNGTPLIMKVPDTSHFARTAVARSSLPTTLARAGQNTTSDTVWQVLNTAVSAAEIVTPPPFNWLIKGGWWFVKLIAGRSRAGMRSFYVYPSYQDALSNKPALCTGSVPGGMRVRAAIPTTLQFTQMNQPSLGHGEVTATLGRSIPTPGDTFKVVLTIGQPLAPNTLNNQTWVNKTTTAPQGQHVVKIAKDTSNYTTMQGFTPISNVTWYTEDFQPSEEPPPISGLQVLVDSRKKADVYAVQQYLNHPSNTKDQLTSIFLVKVTTSFQVNNHLSYFYRAAGTGTAVENFKIRGATSEQNISFSEGWYLMTNTATFNPPAPPGWIWKNVELDNNTPYIVDQGMMHLIMSPPVGTQLLFEMKTTVSGTRNVSHFDHDENPSPVWCDALDAADVWELPTETDTESEEDEDEDDEADRFDLHSSYGSEPEDDDENNRVTLLSTLINQGMTVERATMITKRAFPTCADKQKRSVHMDLLASGLSPGNVWSHACEEARTMGTNHMPNVSGDRGHAE

ORF2

Capsid polyprotein VP90

786 amino acids

The capsid polyprotein VP90 self-assembles and undergoes a proteolytic cleavage by host caspases to yield the VP70 virions. This immature virion is composed of 180 VP70 subunits with 90 dimeric spikes and displays a T=3 icosahedral symmetry. The mature virion is obtained by further cleavages resulting in three structural proteins VP25, VP27 and VP34. This forms contains only 30 spikes located on the icosahedral 2-fold axes (PubMed:22743104). Plays a role in the attachment to target host cell. This attachment induces virion internalization through clathrin-dependent endocytosis (By similarity).

Belongs to the astroviridae capsid polyprotein family.

85.539 kDa

MASKSNKQVTVEVSNNGRSRSKSRARSQSRGRDKSVKITVNSRNRARRQPGRDKRQSSQRVRNIVNKQLRKQGVTGPKPAICQRATATLGTVGSNTSGTTEIEACILLNPVLVKDATGSTQFGPVQALGAQYSMWKLKYLNVKLTSMVGASAVNGTVSGVSLNPTTTPTSTSWSGLGARKHLDVTVGKNATFKLKPSDLGGPRDGWWLTNTNDNASDTLGPSIEIHTLGRTMSSYKNEQFTGGLFLVELASEWCFTGYAANPNLVNLVKSTDNQVSVTFEGSAGSPLIMNVPEGSHFARTVLARSTTPTTLARAGERTTSDTVWQVLNTAVSAAELVTPPPFNWLVKGGWWFVKLIAGRTRTGSRSFYVYPSYQDALSNKPALCTGSTPGGMRTRNPVTTTLQFTQMNQPSLGHGEAPAAFGRSIPAPGEEFKVVLTFGAPMSPNANNKQTWVNKPLDAPSGHYNVKIAKDVDHYLTMQGFTSIASVDWYTIDFQPSEAPAPIQGLQVLVNSSKKADVYAIKQFVTAQTNNKHQVTSLFLVKVTTGFQVNNYLSYFYRASATGDATTNLLVRGDTYTAGISFTQGGWYLLTNTSIVDGAMPPGWVWNNVELKTNTAYHMDKGLVHLIMPLPESTQMCYEMLTSIPRSRASGHGYESDNTEYLDAPDSADQFKEDIETDTDIESTEDEDEADRFDIIDTSDEEDENETDRVTLLSTLVNQGMTMTRATRIARRAFPTLSDRIKRGVYMDLLVSGASPGNAWSHACEEARKAAGEINPCTSGSRGHAE

ORF2

Capsid polyprotein VP90

783 amino acids

The capsid polyprotein VP90 self-assembles and undergoes a proteolytic cleavage by host caspases to yield the VP70 virions. This immature virion is composed of 180 VP70 subunits with 90 dimeric spikes and displays a T=3 icosahedral symmetry. The mature virion is obtained by further cleavages resulting in three structural proteins VP25, VP27 and VP34. This forms contains only 30 spikes located on the icosahedral 2-fold axes. Plays a role in the attachment to target host cell. This attachment induces virion internalization through clathrin-dependent endocytosis (By similarity).

Belongs to the astroviridae capsid polyprotein family.

86.018 kDa

MASKPSKQVTVEVNNGRSRSRSRPRSQSRGRDKSVKITVNSRNKGRRQNGRNKHQSNQRVRNIVNKQLRKQGVTGPKPAICQRATATLGTVGSNTSGTTEIEACILLNPVLVKDATGSTQFGPVQALGAQYSMWKLKYLNVKLTSMVGSSAVNGTVVRVSLNPTSTPSSTSWSGLGARKHLDVTVGKNAVFKLKPADLGGPRDGWWLTNTNDNASDTLGPSIEIHTLGRTMSSYQNQQFTGGLFLVELASEWCFTGYAANPNLVNLMKSTDKQVNVTFNGSAGEPLVMSVPATSHFVRAVVARSTLPTSLARAGERTTSDTVWQVLNTAVSAAELVTPPPFNWLVKGGWWFVKLIAGRTRNGTRSFYVYPSYQDALSNKPAICTGGLPSGLRAASAVATTLQFTQMNQPSLGHGENTATLGRSIATAGDRLKVILTVGQPVTPNENNKQTWVGKTNTPTEEVVKIGVNTQNYNVMNGFTMISSIDWYDEEMQPLEVPVPMSELLVMKGINKKADVYAAQQYKNSISNNKHQITSVYLVRVKENFQVTNHLSYFFREKVDTTATELMKIRPQTYYTTVNFVQNNWYLLTSTVLHTGSLPSGWVWMNQELMNNENYIVDQGMKHLMTTPPVSSQLYFEMLTSLPQAMAEHFDQGDQAVVAHDSPGQALFSAEETDSDFESTEDETDEVDRFDLHLSSESDDDDVENNRVTLLSTLINQGMSVERATRITSNAFPTRAARLRRSVYNDLLVSGLGPDAAWSHACEQARKVGDNHDLQASGSRGHAE

ORF2

Capsid polyprotein VP90

782 amino acids

The capsid polyprotein VP90 self-assembles and undergoes a proteolytic cleavage by host caspases to yield the VP70 virions. This immature virion is composed of 180 VP70 subunits with 90 dimeric spikes and displays a T=3 icosahedral symmetry. The mature virion is obtained by further cleavages resulting in three structural proteins VP25, VP27 and VP34. This forms contains only 30 spikes located on the icosahedral 2-fold axes. Plays a role in the attachment to target host cell. This attachment induces virion internalization through clathrin-dependent endocytosis.

Belongs to the astroviridae capsid polyprotein family.

85.731 kDa

MASKSDKQVTVEVNNNGRSRSKSRARSQSRGRGRSVKITVNSHNKGRRQNGRNKYQSNQRVRKIVNKQLRKQGVTGPKPAICQTATATLGTIGSNTTGATEIEACILLNPVLVKDATGSTQFGPVQALGAQYSMWKLKYLNVRLTSMVGASAVNGTVVRISLNPTSTPSSTSWSGLGARKHLDVTVGKNAVFKLKPSDLGGPRDGWWLTNTNDNASDTLGPSIEIHTLGQTMSSYQNTQFTGGLFLVELSSAWCFTGYAANPNLVNLVKSTDKSVNVTFEGSAGTPLIMNVPEHSHFARTAVEHSSLSTSLSRAGGESSSDTVWQVLNTAVSAAELVTPPPFNWLVKGGWWFVKLIAGRARTGARRFYVYLSYQDALSNKPALCTGGVPASARQSNPVRTTLQFTQMNQPSLGHGATPMTFGRSIPEPGEQFRVLLTVGPPMAPNTANSQNWVNKTIVPPENQYTVKIGIDLEHYTTMQGFTPVESVSWYTADFQPSDEPSPIPGLYARVNNTKKADVYGVQQFKSSHTNNRHQITSVFLVRVTTSFQVINYTSYFIRGAESGSNVSNLKIRDQTYHTPLQFTQGKWYLLTSTVMHDGPTSSGWVWMNQELTNNIAYRVDPGMMYLITPPPAASQLYFELHTVLPQARSEEPETYVDAPLPEEPPIEEEETDSDFESTEDENDEVDRFDLHPSSESDDDDVENDRATLLSTLLNQGISVERATRITNGAFPTRAARVRRSVYNDLLVSGLSPGAAWSHACEQARRAGDNHDLQLSGSRDHAE

ORF2

Capsid polyprotein VP90

778 amino acids

The capsid polyprotein VP90 self-assembles and undergoes a proteolytic cleavage by host caspases to yield the VP70 virions. This immature virion is composed of 180 VP70 subunits with 90 dimeric spikes and displays a T=3 icosahedral symmetry. The mature virion is obtained by further cleavages resulting in three structural proteins VP25, VP27 and VP34. This forms contains only 30 spikes located on the icosahedral 2-fold axes. Plays a role in the attachment to target host cell. This attachment induces virion internalization through clathrin-dependent endocytosis (By similarity).

Belongs to the astroviridae capsid polyprotein family.

85.264 kDa

MASKSDKQVTVEVNNTGRGRSKSRARSQSRGRGRSVKITVNSQNKGRRQNGRNKRQSNQRVRNIVNKQLRKQGVTGPKPAICQKATATLGTIGSNTSGTTEIEACILLNPVLVEDATGSTQFGPVQALGAQYSMWKLKYLNVRLTSMVGASAVNGTVVRVSLNPTSTPSSTSWSGLGARKHLDVTVGKNAIFKLKPSDLGGPRDGWWLTNTNDNASDTLGPSVEIHTLGRTMSSYQNQQFTGGLFLVELASEWCFTGYAANPNLVNLVKSTDKQVNVTFEGSAGTPLVMNVPAASHFARTVAQRSTLPTSMARAGENTASDTVWQVLNTAVSAAELVTPPPFNWLVKGGWWFVKLIAGRVRNGNRSFYVYASYQDALSNKPALCTGSTSGSMRTRPAVMTTLQFTQMNQPSLGHGETPATLGRSIPTSGETLKVLLTVGNPISPNETNKQTWVNKTIEPPGAVVRIGRDTQHYCTLNGFTLITKVDWFTEEFQPSEEPAPVQGLMVLGDNHKKADVYAAQQYKNPITNDKQEVTSVFLVRVNEGFQVTNHLSYFYRNSVNTDAVENIKIRSATRHTTVRFYQGSWYLLTSTVLHTGPPVSGWLWMNQELQNDQAYIIDQGIMHLITPPPVSSQIYFEMATLVPQTRSGGGETGLELVMGLSDDEYPISHVNDEEETEYETESDEDETDEVDRFDLCCTSDSEDDIENNRVTLLSTLINQGVTVDRATMITNRAFPTPNYKPRREPSNDLLAPSDCLATARSHACNETCQLSGSRGHAE

ORF2

Capsid polyprotein VP90

776 amino acids

The capsid polyprotein VP90 self-assembles and undergoes a proteolytic cleavage by host caspases to yield the VP70 virions. This immature virion is composed of 180 VP70 subunits with 90 dimeric spikes and displays a T=3 icosahedral symmetry. The mature virion is obtained by further cleavages resulting in three structural proteins VP25, VP27 and VP34. This forms contains only 30 spikes located on the icosahedral 2-fold axes. Plays a role in the attachment to target host cell. This attachment induces virion internalization through clathrin-dependent endocytosis (By similarity).

Belongs to the astroviridae capsid polyprotein family.

84.231 kDa

MASKSGKDVTVKVENTNGRGRSRSRSRSRSRARNKNVKITINSKPGASGGQRRRGKPQSDKRVRSIVKQQLDKSGVTGPKPAIRQRATATLGTIGSNSSGKTELEACILTNPILVKDNTGNNTFGPIVALGAQYSLWRIRFLRIKFTPMVGQSAVTGTVVRASLNPTATPSSTGWSGLGARRHIDIVVGKAATFNLKASDLSGPREGWWLTNTNDSGDSTLGPSIEIHTLGTTMSAYQNGPFTGGLFLCELQAEWEFSGYAANPALLSLEKNRDDDAEVSFDGQQGEPLTMVVAEDSLFNKVATRRSTFTRGIARDGQTKSETIWQVVDTAVSAAETVVPPPFGWLIRGGYWFVKKLAGRTKLRNGKQTSSYVCYASYQDALSDKPAICTGVAANFYAGRTETARANLHFTQMNEPSTGVGETPTAFRMYRAAPDDIVYLRFKPETVNISVSPAARLFLARKYTAHSLKVKGNSGTTRIHCVVKVNDPMWYSPDWEQVAQPGPIPGVSLLGGTTTIGIVTAAYQAHMWGLHIATAFIVQVTKDINPACSTSCVLTKELNDQHLKTVAGQTSFNWSLRAGETYLMMSFGAHTSAVGEWVWNDADISVGYTIYNSPLTPCLLLTEGSFHIVLPAKRGLIPLASTELFTVRDQDSIPQTTEPPAEEDVGDNETEDESDDEDLDHFDLHDSSGSEPEDEDVENNRVTLLNTLVNQGVDLARAAKISKRAYPTLAEKTRRSVFMDSLIAGCGPSSAWSEACKAARKVSFKEPISESRGHAE

ORF2

Capsid polyprotein VP90

775 amino acids

The capsid polyprotein VP90 self-assembles and undergoes a proteolytic cleavage by host caspases to yield the VP70 virions. This immature virion is composed of 180 VP70 subunits with 90 dimeric spikes and displays a T=3 icosahedral symmetry. The mature virion is obtained by further cleavages resulting in three structural proteins VP25, VP27 and VP34. This forms contains only 30 spikes located on the icosahedral 2-fold axes. Plays a role in the attachment to target host cell. This attachment induces virion internalization through clathrin-dependent endocytosis (By similarity).

Belongs to the astroviridae capsid polyprotein family.

84.161 kDa

MASANQAAKAEAKKVIEKVAKEVIKETKNSAQRNQGPGKRWNSKKGRHMPKNNNNKGMKRTVDNEVKQKLKKEGLEGPRSRFSVRVSATIGKIGPNKEQGPELQIATFLHPSLMKEPNDGTNFGPLQAAAAQWGLWRLSSLEVKCTPLVGSSAVTGSIYRMSLNLTQSPGNASWGGLGARKHKDIPAGKSVSWKLQRGDLAGPRQTWWMTDTNEEGGQSCGPMLEIHGLGKTSSTYQSQDWTGDLFIVEVLGRWEFTNYNAKPALGTLDRKSEDYASDATGPGIMVGDDGVMKMTLPTASSLARFMSDASERSPVNEGSVGETIWHIVDEGAGLASSVAPTPFSWLIKGAWWFVKKLAGRSGANADEQYVVYASLADAQNNKPVMANRFDHTKKATTLTVTQVNSPNTGPGVTQAAYHTENPFPLVPATQPPPPRSIVVVNATARPFGYVKYNTGDSNVKSHGKFDGTQYHFTLKRGSTVSYASAAYILTDVSMLTYEGNRVTGCYDPGWMEPTGITVHYRNESSAFGRVLAYEIDQWGSTSDNHFTIGVWLVQTIKDLPAHDTTVWPYIPLPYVSAGNCTAPPVQVALDKACVPYLTKVGVTSHQQCTVRQPQVRSGTFMLVYSIGTNTPATTAGFTTGQPLGEATNASALPEGKISTSGFWERALSAVAPYQDFISVKFTLPQGPHADPRVDALLDLIQQRFNLKPVDASESEDEDEDSPSGSEEEPCGEEPTPPQPTPRLKLAKEMMYEALRDSDWTHVDAEALLAAISSKN

ORF2

Capsid polyprotein VP90

771 amino acids

The capsid polyprotein VP90 self-assembles and undergoes a proteolytic cleavage by host caspases to yield the VP70 virions. This immature virion is composed of 180 VP70 subunits with 90 dimeric spikes and displays a T=3 icosahedral symmetry. The mature virion is obtained by further cleavages resulting in three structural proteins VP25, VP27 and VP34. This forms contains only 30 spikes located on the icosahedral 2-fold axes. Plays a role in the attachment to target host cell. This attachment induces virion internalization through clathrin-dependent endocytosis (By similarity).

Belongs to the astroviridae capsid polyprotein family.

85.125 kDa

MASKSDKQVTVEVNNNGRSRSKSRARSQSRGRGRSVKITVNSNNKGRRQNGRNKYQSNQRVRKIVNKQLRKQGVTGPKPAICQTATATLGTIGSNTTGATEIEACILLNPVLVKDATGSTQFGPVQALGAQYSMWKLKYLNVRLTSMVGASAVDGTVVRISLNPTSTPSSTSWSGLGARKHLDVTVGKNAVFKLKPSDLGGPRDGWWLTNTNDNASDTLGPSIEIHTLGQTMSSYQNTQFTGGLFLVGLSSAWCFTGYAANPNLVNLVKSTDKSVDVTFEGSAGTPLIMNVPEHSHFARMAVEHSSLSTTLSRAGGESSSDTVWQVLNTAVSAAELVTPPPFNWLVKGGWWFVKLIAGRARTGARRFYVYPSYQDALSNKPALCTGGVSTYTRQSNPVRTTLQFTQMNQPSLGRGATPATLGRSIPEPGDQFKVIMTVGALVQPNRSDTQNWLFKTVTPPTGHDAARVGWNTQHYLTIQGFLLIDSLEWLTPNLQESQEPPLIPELGVYIGIHKKALVYFMQQYVNPHTNNKHQVSSIFLIKPTENFSVTNYMSYFFRESQSDQNVANLKIRPQTWQQTVNFQRGKWYLVTNTAIRNGPPPSGWVWDNIELTNESIYYADQVLAHFINPPPQNSKIYFEVHTTMPQSRARSIGLEEDQTDNWQEPDEDLQTSTEESDYETDSLEDESDDEDSNTCRELVINTLVNQGISRERATYIGMSAYPNVEWGSGEQSTSQHIQEISSDDVGAGAHYSCVCERKQQSLNQGSRGHAE

ORF2

Capsid polyprotein VP90

762 amino acids

The capsid polyprotein VP90 self-assembles and undergoes a proteolytic cleavage by host caspases to yield the VP70 virions. This immature virion is composed of 180 VP70 subunits with 90 dimeric spikes and displays a T=3 icosahedral symmetry. The mature virion is obtained by further cleavages resulting in three structural proteins VP25, VP27 and VP34. This forms contains only 30 spikes located on the icosahedral 2-fold axes. Plays a role in the attachment to target host cell. This attachment induces virion internalization through clathrin-dependent endocytosis (By similarity).

Belongs to the astroviridae capsid polyprotein family.

82.366 kDa

MAEKPQQKAVASAAKQLAKEVVKLDKITKSNGKQHPQKNVPARKWRPRQAKPNNRRVTHKIKRELHKQGLEGPASRFRVTVSATIGKVGPNKEQGPELQIATFLHPSLVKEPNDGSNFGPLQAAAAQWGLWRISDLEVRFTPLVGSSAVTGSVTRASLNLTQSPGATSWGGLGARKHLDVPTGVSKVWKLRRGDLTGPRQTWWVTDTNEEGGQSCGPMLEVHGLGKTTSTYKDSDWTGDLFIVELHGTWEFSNYNAKPALGMLERVTDQTNVELGVDTEGQITMTIPENSPMARHMGERFERASASNASSVGETIWQIVDEGAGLASSVAPAPFGWLIKGGWWFVKKILGRAANAGSQYLVYASLADAQNGKPAMSTSRGYVREVKQTILSSTQLNAPNTGPGASQPALAAYEMFPYFPHGEPAVGQPFYLMSTVSTGVYREAMPVWVKYNYPGAPSNQAPFEVTIGQTTYQAQTYFKLTEPVAYGADIPEVTSEVKPALNGWYTLDTLPAIGTFQAIFTLPGTKSKYGDVVAASHFSITPQLMLVAYLVRVTTALPNALRGSPWSDNADNSILYYTPLVNAYAAATSDANPIQFTPNRACVSECRSHCGHPTIVAADVGEYILALVWCRGNGFSAGVINSYGALADTSFNLDSLRADSNGVMTLLNRAVPYSSLCALRMTRGVPPTSDDELVARILGQLQTRLKFAAGSGSSSEDDLSDDDDFECLRSTPLQQIYEGVRGLRGHAEAVAVVKSLQSRGHAE

ORF2

Major capsid protein

741 amino acids

Binds and removes 5' cap structures from cellular mRNA.

Belongs to the totivirus major capsid protein family.

81.749 kDa

MSDTPNSDKVACGRKPMFCEIIKLANRKRLILDTTGERVYDARINYCSTADATVQADCHIYWRLKLRRTDAVFEEYTGQGYALDTASYPQQYADIIRGYYSKHVSSALAANTQHFVNVLAMLRHAGACIAHYCMTGKIDFDILSKKKHKNKEVVTLSSADSLSFLPHSALYLPSALRASDPEIFNVLYLLGCACDASIAMDNIANTSGAAKYAMPHYNPLQLSHALHVTIFYMLGLMDSCGYGEDAVLALTAGLHSVTTVIAHSDEGAITRDALRELSYTQPYGTMPVPIAGYFQHINVLFTTQPAWDQFAGIWDYVILATAALVHLSDPGMTVNDVTYPTTLTTKVASVDGRNSDIAAQMMHSATRFCDIYIENLCLFWGVVANPDGNASQALLHAFNVVACGTEPNRHLEMNVMAPWYWVESSALFSDYSQFRSPISSAGYGPQSIYGARLVLAATNSLEFTGEAGDYSAYRFEWTTMRHNPLFNILNKRVGDGLANVDFRLRPFNEWLLEGQPSRRSCDAVGHGTPTATCNHKTPNRNTVDEFIWGSTSCDLFHPAELTSYTAVCVRFRNYLSEADGDVRVLNTPTREVIEGNVVTRCDGIRCLDSNKRIQHVPEVARRYCMMARYLQARTFGALTIGDDIIRGFDKVDKVVKMHKSNNRLGQMPLIDVTGLCQPMIETSTARASMTTRIDPNRLAAATARIELPLAPRCTSSLIPSSDAVPEPEPHVGEPGNGSGCA

ORF2

Capsid polyprotein VP90

724 amino acids

Capsid polyprotein VP90: self-assembles to form an icosahedral T=3 capsid.

Belongs to the astroviridae capsid polyprotein family.

80.266 kDa

MAAMADKVVVKKTTTRRRGRSNSRSRSRSRSRSRTKKTVKIIEKKPEKSILKKIDQAERRDAKQLRRIRKKVQGPPVNSRMTTVVTLGQITGNKDNTLERKHKCFLNPLLMKSQETGQTATPLSVRASQYNLWKLSRLHVRLIPLAGKANILGSVVFLDLEQEANTAGPESVDTIKARPHVEVPIGSKTVWKVHPRSALGPRQGWWNVDPGDSPTDSLGPALNMWTYLQTVNALQSAGGTQTPYTSALFLVEVLVTYEFSNYGPKPALSQMVSDSFPPASGSTATLKNTSDGAVAIQLSGAIARKMEEVEPKGRRSNAQTSGVGEVFWAVSTEVVNTVADAIPGWGWLLKGGWFVLRKIFGAANDQNGTYLIYSSVADAQGDNRIYTSVKQTQLTSSRINLVQLTQPNVNQAAVGGSVGAANSIYLPLPQADDQYTPYFVYNFQGERVSTTETGVFCLAAIPAATTSSRYNNQITTPSIGYRNASGTGTSFLLDAASWWNILDVTQTGVLFGQPRLGVGVMQTMKTLKQHIKDYTEPAIQKYYPGTTNLDEQLKQRLNLAEGDPVISMGDTNGRRAALFYRTSDEKYILFFSTTEDPGAQYQNLKMLYFWNWSYSDTKQQFLDHLRTVQFANLDDSQPAPYDSDDDDLSDVTSLFEQADLGDETDFKFNMSIQTSKHLEEEKNYWKNQCERMMMEKALSGTSQPLVRFEKAGPRADQSSASGHS

ORF2

Capsid protein

703 amino acids

Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells by binding to feline junctional adhesion molecule A (F11R) and/or to alpha-2,6-linked sialic acid. Once attached, the virion is endocytosed. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).

Belongs to the caliciviridae capsid protein family.

77.721 kDa

MATTHTLLSFDDLEFLLHRKDLTDLYGERCGTLNLVINPYELFLPDELDDDCCDDPFNCCFPDVYASIGTEYSYIDPPELIHEEHCATNGTWPNGDPCEPILPPFTITGTHHYYATKPGEVVSGILSKLGSSWDPSLRSTADVSNSFTFRAESDGPGSAEIVTEEQGTVVQQQPAPAPTALATLATASTGKSVEQEWMTFFSYHTSINWSTVESQGKILYSQALNPSINPYLDHIAKLYSTWSGGIDVRFTVSGSGVFGGKLAALLVPPGVEPIESVSMLQYPHVLFDARQTEPVIFTIPDIRKTLFHSMDETDTTKLVINPYENGVENKTTCSITVETRPSADFTFALLKPPGSLIKHGSIPSDLIPRNSAHWMGNRWWSTISGFSVQPRVFQSNRHFDFDSTTTGWSTPYYVPIEIKIQGKVGSNNKWFHVIDTDKALVPGIPDGWPDTTIPDETKATNGNFSYGESYRAGSTTIKPNENSTHFKGTYICGTLSTVEIPENDEQQIKTEAEKKSQTMYVVTADFKDTIVKPQHKISPQKLVVYFDGPEKDLTMSATLSPLGYTLVDEQPVGSVSSRVVRIATLPEAFTQGGNYPIFYVNKIKVGYFDRATTNCYNSQILMTSQRLAEGNYNLPPDSLAVYRITDSSSQWFDIGINHDGFSYVGLSDLPNDLSFPLTSTFMGVQLARVKLASKVKAHTITAK

ORF2

Capsid protein

702 amino acids

Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells by binding to feline junctional adhesion molecule A (F11R) and/or to alpha-2,6-linked sialic acid. Once attached, the virion is endocytosed. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).

Belongs to the caliciviridae capsid protein family.

77.85 kDa

MATTHTLLSFDDLEFLLHKKDLTDLYGERCGTLNLVINPYDLFLPDDLDDDWCDDPFNCCFSDVYTSIGTEYSYIDPPDLIYEEHCATNGHWPDGTPCEPILPPFVIEGTHHYYATKPGEAVSGILSKLGSAWDPDLQSTVDTKPDFVFRAESDGPGGADIVTEEQGTVVQQQPVPAQSALTTLAAASTGKTVDCEWTTFFSYHTAVNWSTTEAQGKILFSRALSPELNPYLRHISSLYSTWSGGIDVRFTVSGSGVFGGKLAALIVPPGIEPVESPTMLQYPHVLFDARQTEPVIFTIPDIRKTLYHSMDDTDTTRLVIMVYNELINPYEQSEPKSSCSITVETRPSSDFTFSLLKPPGSLLKHGSIPSDLIPRNSRHWMGNRWWSTIDGFVVQPRVFQSNRHFDFDSTTTGWSTPYYIPIEVTLEKLDRGGQYFKVTDTEKSLVPGLPDGWPDTTIPTAMTASNGNYDYTVAEYRITNNGTHFKGFYIMGNLTTKVKGSDNLGETQQTSRTLFASVGNYKDQNTINPTHKITSNSLVVYDANNVSAATAKTTTWHSTMSHLGYVLVDESPVGSDSTKVVRIATLPEAFTNGGNFPVFFTNKIQIGHFDRAHTKCFNSQVLMTSQKLAENHYTLPPDSLLVYRITDAASSWFDLGINHDGFSYVGISTIPELDFPLTFNLHGVQLAKVKLASKVKTSKTTI

ORF2

Capsid protein

701 amino acids

Capsid protein self-assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulates the genomic RNA and VP2 proteins. Attaches virion to target cells. Once attached, the virion is endocytosed. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).

Belongs to the caliciviridae capsid protein family.

77.477 kDa

MATTHTLLSFDNLEFLLHRKDLTDLYGKRCGTLNLVINPYELFLPDELDDDCCDDPFNCCFSDVYASIGTEYSYIDPPDLIYEEHCATNGTWPDGTPCEPILPPFTITGTHHYYATKPGEVVSGILSKLRVFLGSLLRSTADVNSNFTFRAESDGPGSTEIVTEEQGTIVQQQPAPAPTALATLATASTGKSVEQEWMTFFSYHTSINWSTVESQGKVLYSQALNPSINPYLDHISKLYSTWSGGIDVRFTVSGSGVFGGKLAALLVPPGVEPIESVSMLQYPHVLFDARQTEPVIFTIPDIRKTLFHSMDETDTTKLVIMVYKNGADTKTTCSITVETRPSADFTFALLKPPGSLIKHGSIPSDLIPRNSAHWLGNRWWSMISGFSVQPRVFQSNRHFDFDSTTTGWSTPYYIPIEITITAKVKGNNHWYHVIAHDKALVPGIPDGWPDTTIPSEVHASNGNFDYAKGFHDDKEIVNPANNNTHFKGTYICGTLSTIKDPEKAENQSESQKKSSTMYVATADLGDNKVKPQHKISSQKLVVYFDGPEKDLTMNATLSPLGYTLVDDQPIGSNSSTVVRIATLPEAFTQGGNYPIFYVNKTNKGYFDKATTDCYNSQILMTSQRLAEGNYSLPPDSLAVYRITDSSSQWFDIGINHDGFSYVGLPDLPADLTFPLTSTFMGVQLARVKLASKVKVTRNSIK

ORF2

Capsid protein

691 amino acids

Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells by binding to specific cellular receptor. Once attached, the virion is endocytosed. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).

Belongs to the caliciviridae capsid protein family.

76.181 kDa

MARYLELNPQNYSDEEYDYDSYNPFPNFEKNLASHYGTDFVPRINLDDFFLDDEDFEFCDDPLNCCFPDYLASLGEEEFIYEGDEPYIVLKHQLVSSTMWDDGTFTYPILPPFKTSSISYFLPKPGEVLHRCLMAVAKGMDPDLQVAVGTEFQFRAESDSSHPPDITTEDQGTVVATGPQPSAPAMATLATAATGTMPEEWKNFFSYYTTINWATTDETGKVLFVQNLAPRMNPFLDHIAKMYTGWSGSMEVRFTISGSGVFGGKVAAVLVPPGISTEGGTNLLQFPHVLVDARQTEPVIFTIPDIRTQLWHDMHDTSTSHLVILVYNDLVNPFQGGENGTSCTITVETRGGTDFEFHLLKPPTRKMIFGADPSRLIPRRSQFWEGNRLPGVITSFVCLPRMFQANRHFDCKRQTFGWSRPVHKGIEVRVDATNKDAANTTDIGIHVVTARNAIKSDIPDGWPDYYRTGEQVYNNTTQTFQEVKESVMGSAVPDSTATAMTWHHLPTVVFGHGTAVGSKTTNSKVLSGNFYAIGNFDQSGNIKLYPSYWIAKEQSAGGAPIGAYEDMVKRIDVLPTAQTTGGNFPVAFVSKFASSHNGNGVSVYNSQILTTSALLAQDVYDIGPNALAVFKIKGSGGYWFDLGISADGFSYVGGGNLNFSSLQFPLEATYVGMASLHNKLQYNLGGSATTL

ORF2

Capsid polyprotein VP90

683 amino acids

Capsid polyprotein VP90: self-assembles to form an icosahedral T=3 capsid.

Belongs to the astroviridae capsid polyprotein family.

73.909 kDa

MAGGATAPAGAKPKQPKQKQKKPSSQARKKPSQKQKAMKPVKQELRKVEKQVRVLKARTNGPKVNDTMKTTVTVGTLVGQTQSGLNRQLRVSFNPLLMKSTEGGSTTPLSIRASMYEMWKPLSVEIFATPLSGFSSVVGSVGFMVITLNGLEASADSIDTIKARRHVQMALGRPYRLKLSARELAGPREGWWLVDTSEAPADAYGPAVDLMLAYATENLLGTSSGSTTSYTGTLWQVEMRVTYAFSTYNPKPGLQTLVSQSITGGQTVTIQPSPDDGSLIMTTNSQQVLALLTPRVAGQRKGKSQTIWAIAGSAVDAAATVLGPWGYLLKGGFWLVRLIFGGSSARNTTTRQYQIYPSVESALTDQPIFGNSTGTQSVTVPICHITEVVNPNAESNNLPPPTTGAQPQPQPPAPIEEILLPLAELTGQPGVPPLYTFDGSSYTPPTNWLGSTILLTGIPAHKRVTGNLAKFGVTNLQMSKVAATALEIYDFTDFGVFFGTGSYLSEGGIHTGKTLIYSLMSGQTPNPWLAANQSGTTWYMPSWAGFPQPGQGDYFLQMQDVTDTTTHTTSVNVYFLVAYRQSRRLIAFFNTGGTARPAPTSMLCLYNVDCGRAPQTPYPTFQSTLQSLNQIGVDAKSDPDSDDDISLAGSVIGDEFDSVDHLEREREDLMRRLRDLDLRRFQI

ORF2

Capsid protein

672 amino acids

Major viral capsid protein that encapsidates the viral genome. Binds to the 5' end of the genomic RNA (By similarity).

Belongs to the hepevirus capsid protein family.

72.316 kDa

MNNMFFCSVHGDATMRSRALLFLLFVLLPMLPAPPAGQPSGRRRGQAGCGGGFWGDRVDSQPFALPYIHPTNPFASDIPAAAGTGARPRQPIRPLGSAWRDQSQRPAASTRRRPAPAGASPLTAVAPAPDTAPVPDADSRGAILRRQYNLSTSPLTSTIATGTNFVLYAAPLSPLLPLQDGTNTHIMATEASNYAQYRVVRATIRYRPLVPNAVGGYAISISFWPQTTTTPTSVDMNSITSTDVRILVQPGIASELVTPSERLHYRNQGWRSVETSGVAEEEATSGLVMLCIHGSPVNSYTNTPYTGALGLLDFALELEFRNLTPGNTNTRVSRYSSSARHKLRRGPDGTAELTTTAATRFMKDLHFTGTNGVGEVGRGIALTLFNLADTLLGGLPTELISSAGGQLFYSRPVVSANGELTVKLYTSVENAQQDKGVAIPHDIDLGESRVVIQDYDNQHEQDRPTPSPAPSRPFSVLRANDVLWLSLTAAEYDQTTYGSSTNPMYVSDTVTFVNVATGAQGVSRSLDWSKVTLDGRPLTTIQQYSKTFYVLPLRGKLSFWEAGTTKAGYPYNYNTTASDQILIENAAGHRVCISTYTTNLGSGPVSVSAVGVLAPHSALAALEDTADYPARAHTFDDFCPECRALGLQGCAFQSTVGELQRLKMKVGKTREY

ORF2

Capsid polyprotein VP90

671 amino acids

Capsid polyprotein VP90: self-assembles to form an icosahedral T=3 capsid.

Belongs to the astroviridae capsid polyprotein family.

72.514 kDa

MSAPAGKAGPKAQKKCKVVTQKTKTVPKKTKQQKPRKVRLQKVERQVKTLKAKTRGPKISDTFSTVVTVGRIIGNNDDSLTRQLKVFVNPLLMKNQDSGSTSSPLSIRASQYGLWKIAKLHVYFTPLAGSANVIGTVSFASLEQESGVATAESPDTIKAKYHAEVPIGSRFVWKVPPRMLTGPREGWWNMDSGDDPTNSVGPSISFWTYLKTILALSTATTTSYLGSLFLIEIRCTYLFSNYAPKPNLAIMVNEKITTTQPVTLTNLSDGSLVMTTTDTRLCALLDNDRGPRGPNAQTNGPGEKFWAVSTLVVDTVAASIGPWGWLLKGGWWVIRKIFGAANTTSTYAIYASVEDAAKDSRIYQPVSGTQTLAAGDVYVTQLTQPNVNEAGSTSLGFSPPTPPAPTGSYLPLPQAAGVPGIPPQYTFSDGQYTAATTWSGTQLYLTGVPATKTVSGSNEMFGVENNTMSRANIDRVQIYDFTTTGIIFLGGQNRSGGAIHTAKTLIVALKTATTKAPWLAADATGTNWAMPSWVGFPVPGAGDHFLQMQNSTDRTTHTTPVGVYFLVAYGATNKLVAFWAAPTDVQAEPTSLMTLYNVDAGRAPITAGLNFTTAMTEYSDDDDDAESDISSLFAPDEVDWKFKIEASSSRHLEEELQFWKSKATQLMLEKN

ORF2

Capsid protein

668 amino acids

Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells by binding to feline junctional adhesion molecule A (F11R) and/or to alpha-2,6-linked sialic acid. Once attached, the virion is endocytosed. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).

Belongs to the caliciviridae capsid protein family.

73.55 kDa

MCSTCANVLKYYDWDPHIKLVINPNKFLHVGFCDNPLMCCYPELLPEFGTMWDCDQSPLQVYLESILGDDEWSSTHEAIDPVVPPMHWDEAGKIFQPHPGVLMHHLICKVAEGWDPNLPLFRLEADDGSITTPEQGTMVGGVIAEPNAQMSTAADMATGKSVDSEWEAFFSFHTSVNWSTSETQGKILFKQSLGPLLNPYLTHLAKLYVAWSGSVDVRFSISGSGVFGGKLAAIVVPPGIDPVQSTSMLQYPHVLFDARQVEPVIFSIPDLRSTLYHLMSDTDTTSLVIMVYNDLINPYANDSNSSGCIVTVETKPGPDFKFHLLKPPGSMLTHGSIPSDLIPKSSSLWIGNRFWSDITDFVIRPFVFQANRHFDFNQETAGWSTPRFRPITITISVKESAKLGIGVATDYIVPGIPDGWPDTTIPGELVPVGDYAITNGTNNDITTAAQYDAATEIRNNTNFRGMYICGSLQRAWGDKKISNTAFITTGTVDGAKLIPSNTIDQTKIAVFQDTHANKHVQTSDDTLALLGYTGIGEEAIGADRDRVVRISVLPERGARGGNHPIFHKNSIKLGYVIRSIDVFNSQILHTSRQLSLNHYLLSPDSFAVYRIIDSNGSWFDIGIDNDGFSFVGVSSIGKLEFPLTASYMGIQLAKIRLASNIRSVMTKL

ORF2

Capsid protein

668 amino acids

Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells by binding to feline junctional adhesion molecule A (F11R) and/or to alpha-2,6-linked sialic acid. Once attached, the virion is endocytosed. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).

Belongs to the caliciviridae capsid protein family.

73.589 kDa

MCSTCANVLKYYDWDPHFRLIINPNKFLPIGFCDNPLMCCYPDLLPEFGTVWDCDQSPLQIYLESILGDDEWASTHEAIDPSVPPMHWDSAGKIFQPHPGVLMHHLIGEVAKAWDPNLPLFRLEADDGSITTPEQGTAVGGVIAEPSAQMSTAADMASGKSVDSEWEAFFSFHTSVNWSTSETQGKILFKQSLGPLLNPYLEHLSKLYVAWSGSIEVRFSISGSGVFGGKLAAIVVPPGVDPVQSTSMLQYPHVLFDARQVEPVIFTIPDLRSTLYHVMSDTDTTSLVIMVYNDLINPYANDSNSSGCIVTVETKPGPDFKFHLLKPPGSVLTHGSIPSDLIPKSSSLWIGNRYWTDITDFVIRPFVFQANRHFDFNQETAGWSTPRFRPITITISEKNGSKLGIGVATDYIIPGIPDGWPDTTIADKLIPAGDYSITTGEGNDIKTAQAYDTAAVVKNTTNFRGMYICGSLQRAWGDKKISNTAFITTAIRDGNEIKPSNTIDMTKLAVYQDTHVEQEVQTSDDTLALLGYTGIGEEAIGSNRDRVVRISVLPEAGARGGNHPIFYKNSIKLGYVIRSIDVFNSQILHTSRQLSLNHYLLPPDSFAVYRIIDSNGSWFDIGIDSEGFSFVGVSDIGKLEFPLSASYMGIQLAKIRLASNIRSRMTKL

ORF2

Capsid protein

668 amino acids

Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells by binding to feline junctional adhesion molecule A (F11R) and/or to alpha-2,6-linked sialic acid. Once attached, the virion is endocytosed. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).

Belongs to the caliciviridae capsid protein family.

73.518 kDa

MCSTCANVLKYYNWDPHFKLVINPNKFLSIGFCDNPLMCCYPELLPEFGTVWDCDQSPLQIYLESILGDDEWSSTYEAIDPVVPPMHWNEAGKIFQPHPGVLMHHIIGEVAKAWDPNLPLFRLEADDGSITAPEQGTVVGGVIAEPSSQMSTAADMASGKSVDSEWEAFFSFHTSVNWSTSETQGKILFKQSLGPLLNPYLEHLSKLYVAWSGSVEVRFSISGSGVFGGKLAAIVVPPGVDPIQSTSMLQYPHVLFDARQVEPVIFTIPDLRSTLYHLMSDTDTTSLVIMVYNDLINPYANDSNSSGCIVTVETKPGSDFKFHLLKPPGSMLTHGSVPSDLIPKTSSLWIGNRFWSDITDFVIRPFVFQANRHFDFNQETAGWSTPRFRPITVTISEKNGAKLGVGVATDFIVPGIPDGWPDTTIGEKLVPAGDYAITNGSGNDITTANQYDAADIIRNNTNFKGMYICGSLQRAWGDKKISNTAFITTATVEGNDLIPSNVIDQTKIAIFQDNHVQDEVQTSDDTLALLGYTGIGEEAIGANRERVVRISTLPETGARGGNHPIFYKNSIKLGYVIRSIDVFNSQILHTSRQLSLNHYLLPPDSFAVYRIIDSNGSWFDVGIDFDGFSFVGVSDVGKLEFPLTASYMGIQLAKIRLASNIRSTMTKL

ORF2

Secreted protein ORF2

660 amino acids

Isoform Capsid protein ORF2: Forms an icosahedral capsid with a T=1 symmetry and a 34 nm diameter. The capsid is composed of 60 copies linked to each other. Binds to the 5' end of the genomic RNA to mediate genome encapsidation (By similarity). Binds to heparin surface proteoglycans (HSPGs) to mediate viral entry. Additionally, the interactions with host ASGR1 and ASGR2 facilitate viral infection of hepatocytes (By similarity).

Belongs to the hepevirus capsid protein family.

70.98 kDa

MRPRPILLLLLMFLPMLPAPPPGQPSGRRRGRRSGGSGGGFWGDRVDSQPFAIPYIHPTNPFAPDVTAAAGAGPRVRQPARPLGSAWRDQAQRPAAASRRRPTTAGAAPLTAVAPAHDTPPVPDVDSRGAILRRQYNLSTSPLTSSVATGTNLVLYAAPLSPLLPLQDGTNTHIMATEASNYAQYRVARATIRYRPLVPNAVGGYAISISFWPQTTTTPTSVDMNSITSTDVRILVQPGIASELVIPSERLHYRNQGWRSVETSGVAEEEATSGLVMLCIHGSPVNSYTNTPYTGALGLLDFALELEFRNLTPGNTNTRVSRYSSTARHRLRRGADGTAELTTTAATRFMKDLYFTSTNGVGEIGRGIALTLFNLADTLLGGLPTELISSAGGQLFYSRPVVSANGEPTVKLYTSVENAQQDKGIAIPHDIDLGESRVVIQDYDNQHEQDRPTPSPAPSRPFSVLRANDVLWLSLTAAEYDQSTYGSSTGPVYVSDSVTLVNVATGAQAVARSLDWTKVTLDGRPLSTIQQYSKTFFVLPLRGKLSFWEAGTTKAGYPYNYNTTASDQLLVENAAGHRVAISTYTTSLGAGPVSISAVAVLAPHSVLALLEDTMDYPARAHTFDDFCPECRPLGLQGCAFQSTVAELQRLKMKVGKTREL

ORF2

Capsid protein

660 amino acids

Major viral capsid protein that encapsidates the viral genome. Binds to the 5' end of the genomic RNA (By similarity).

Belongs to the hepevirus capsid protein family.

70.965 kDa

MRPRAVLLLLFVLLPMLPAPPAGQPSGRRRGRRSGGAGGGFWGDRVDSQPFALPYIHPTNPFAADVVSQPGAGTRPRQPPRPLGSAWRDQSQRPSAAPRRRSAPAGAAPLTAVSPAPDTAPVPDVDSRGAILRRQYNLSTSPLTSSVASGTNLVLYAAPLNPLLPLQDGTNTHIMATEASNYAQYRVVRATIRYRPLVPNAVGGYAISISFWPQTTTTPTSVDMNSITSTDVRILVQPGIASELVIPSERLHYRNQGWRSVETTGVAEEEATSGLVMLCIHGSPVNSYTNTPYTGALGLLDFALELEFRNLTPGNTNTRVSRYTSTARHRLRRGADGTAELTTTAATRFMKDLHFAGTNGVGEVGRGIALTLFNLADTLLGGLPTELISSAGGQLFYSRPVVSANGEPTVKLYTSVENAQQDKGITIPHDIDLGDSRVVIQDYDNQHEQDRPTPSPAPSRPFSVLRANDVLWLSLTAAEYDQTTYGSSTNPMYVSDTVTLVNVATGAQAVARSLDWSKVTLDGRPLTTIQQYSKTFYVLPLRGKLSFWEAGTTKAGYPYNYNTTASDQILIENAAGHRVAISTYTTSLGAGPTSISAVGVLAPHSALAVLEDTIDYPARAHTFDDFCPECRTLGLQGCAFQSTIAELQRLKMKVGKTRES

ORF2

Genome-linked protein precursor

660 amino acids

Precursor from which the VPg molecule is probably released at the onset of the RNA synthesis. Essential for virus replication (By similarity).

Belongs to the peptidase S39B family.

72.353 kDa

MALLGIKLMTLVFAAWLSCCHSSSALPSSGLSGPCLNHSCLLRNSLNGASQWGTILHSPAVGSNCPPCPMMSIMGCSPPKPLQSNSYGVLCSTIASKAKQDLKLCWKEVQTRSEMYSKRISAALIDSLHQAVGMLLMIIIWIWSSIFLVVYHVLAYMTTYHLSSAVCVGFLIFCTICAFRLISWICGDLLAFNVSGLTPIWVNFSESSCPAGLSLRRYKNEKTVEGYKPFIIPQKSPKKSVIELSFSNGSHLGYATCVRLWDGSICLMTAKHCLVKEALLKGRVAGHSLPVKNFDLFLTCDEIDFSLLRGPKQWEAYLGVKGADLITSNRIGRSPVTFYNLSKDGEWLANSAQITGRHGKLCSVLSNTSPGDSGTPYYSGKNVVGIHKGTSELENYNLMIPIPNIPGLTSPDFKFETTNVRGNLYNDEGFRLSVGEDDKAEHWTDRLMKSITFKTKRWADWAEEESESDDERGKVVPPAKPSNYGEGCPPEHNQYLSDVGDLLTKVIGPEQNEKCVDILMGIMGVDKNEVAPHKEEKAEKGNEAVVSATVKTVKEPTTQCDEDIISEIVKRVVDKMNLKAIEKSVVEILAEKAMTKAPRGKRKNSKDTSRPSTPGSYIIPAKRTPDSGPVEKSLNSTGRAKEESPSGARTLPGNIPAWVR

ORF2

Secreted protein ORF2

660 amino acids

Isoform Capsid protein ORF2: Forms an icosahedral capsid with a T=1 symmetry and a 34 nm diameter. The capsid is composed of 60 copies linked to each other. Binds to the 5' end of the genomic RNA to mediate genome encapsidation (PubMed:14671114, PubMed:15557331). Binds to heparin surface proteoglycans (HSPGs) to mediate viral entry. Additionally, the interactions with host ASGR1 and ASGR2 facilitate viral infection of hepatocytes (By similarity).

Belongs to the hepevirus capsid protein family.

70.978 kDa

MRPRPILLLLLMFLPMLPAPPPGQPSGRRRGRRSGGSGGGFWGDRVDSQPFAIPYIHPTNPFAPDVTAAAGAGPRVRQPARPLGSAWRDQAQRPAVASRRRPTTAGAAPLTAVAPAHDTPPVPDVDSRGAILRRQYNLSTSPLTSSVATGTNLVLYAAPLSPLLPLQDGTNTHIMATEASNYAQYRVARATIRYRPLVPNAVGGYAISISFWPQTTTTPTSVDMNSITSTDVRILVQPGIASELVIPSERLHYRNQGWRSVETSGVAEEEATSGLVMLCIHGSLVNSYTNTPYTGALGLLDFALELEFRNLTPGNTNTRVSRYSSTARHRLRRGADGTAELTTTAATRFMKDLYFTSTNGVGEIGRGIALTLFNLADTLLGGLPTELISSAGGQLFYSRPVVSANGEPTVKLYTSVENAQQDKGIAIPHDIDLGESRVVIQDYDNQHEQDRPTPSPAPSRPFSVLRANDVLWLSLTAAEYDQSTYGSSTGPVYVSDSVTLVNVATGAQAVARSLDWTKVTLDGRPLSTIQQYSKTFFVLPLRGKLSFWEAGTTKAGYPYNYNTTASDQLLVENAAGHRVAISTYTTSLGAGPVSISAVAVLAPHSALALLEDTLDYPARAHTFDDFCPECRPLGLQGCAFQSTVAELQRLKMKVGKTREL

ORF2

Secreted protein ORF2

660 amino acids

Isoform Capsid protein ORF2: Forms an icosahedral capsid with a T=1 symmetry and a 34 nm diameter. The capsid is composed of 60 copies linked to each other (By similarity). Binds to the 5' end of the genomic RNA to mediate genome encapsidation (By similarity). Binds to heparin surface proteoglycans (HSPGs) to mediate viral entry (PubMed:19812150). Additionally, the interactions with host ASGR1 and ASGR2 facilitate viral infection of hepatocytes (PubMed:27155063).

Belongs to the hepevirus capsid protein family.

70.98 kDa

MRPRPILLLLLMFLPMLPAPPPGQPSGRRRGRRSGGSGGGFWGDRADSQPFAIPYIHPTNPFAPDVTAAAGAGPRVRQPARPLGSAWRDQAQRPAAASRRRPTTAGAAPLTAVAPAHDTPPVPDVDSRGAILRRQYNLSTSPLTSSVATGTNLVLYAAPLSPLLPLQDGTNTHIMATEASNYAQYRVVRATIRYRPLVPNAVGGYAISISFWPQTTTTPTSVDMNSITSTDVRILVQPGIASEHVIPSERLHYRNQGWRSVETSGVAEEEATSGLVMLCIHGSLVNSYTNTPYTGALGLLDFALELEFRNLTPGNTNTRVSRYSSTARHRLRRGADGTAELTTTAATRFMKDLYFTSTNGVGEIGRGIALTLFNLADTLLGGLPTELISSAGGQLFYSRPVVSANGEPTVKLYTSVENAQQDKGIAIPHDIDLGESRVVIQDYDNQHEQDRPTPSPAPSRPFSVLRANDVLWLSLTAAEYDQSTYGSSTGPVYVSDSVTLVNVATGAQAVARSLDWTKVTLDGRPLSTTQQYSKTFFVLPLRGKLSFWEAGTTKAGYPYNYNTTASDQLLVENAAGHRVAISTYTTSLGAGPVSISAVAVLAPHSALALLEDTMDYPARAHTFDDFCPECRPLGLQGCAFQSTVAELQRLKMKVGKTREL

ORF2

Secreted protein ORF2

660 amino acids

Isoform Capsid protein ORF2: Forms an icosahedral capsid with a T=1 symmetry and a 34 nm diameter. The capsid is composed of 60 copies linked to each other. Binds to the 5' end of the genomic RNA to mediate genome encapsidation (By similarity). Binds to heparin surface proteoglycans (HSPGs) to mediate viral entry. Additionally, the interactions with host ASGR1 and ASGR2 facilitate viral infection of hepatocytes (By similarity).

Belongs to the hepevirus capsid protein family.

70.937 kDa

MGPRPILLLFLMFLPMLLAPPPGQPSGRRRGRRSGGSGGGFWGDRVDSQPFAIPYIHPTNPFAPNVTAAAGAGPRVRQPVRPLGSAWRDQAQRPAAASRRRPTTAGAAPLTAVAPAHDTPPVPDVDSRGAILRRQYNLSTSPLTSSVATGTNLVLYAAPLSPLLPLQDGTNTHIMATEASNYAQYRVARATIRYRPLVPNAVGGYAISISFWPQTTPTPTSVDMNSITSTDVRILVQPGIASELVIPSERLHYRNQGWRSVETSGVAEEEATSGLVMLCIHGSPVNSYTNTPYTGALGLLDFALELEFRNLTPGNTNTRVSRYSSTARHRLRRGADGTAELTTTAATRFMKDLYFTSTNGVGEIGRGIALTLFNLADTLLGGLPTELISSAGGQLFYSRPVVSANGEPTVKLYTSVENAQQDKGIAIPNDIDLGESRVVIQDYDNQHEQDRPTPSPAPSRPFSVLRANDVLWLSLTAAEYDQSTYGSSTGPVYVSDSVTLVNVATGAQAVARSLDWTKVTLDGRPLSTIQQYSKIFFVLPLRGKLSFWEAGTTRPGYPYNYNTTASDQLLVENAAGHRVAISTYTTSLGAGPVSISAVAVLGPHSALALLEDTLDYPARAHTFDDFCPECRPLGLQGCAFQSTVAELQRLKMKVGKTREL

ORF2

Capsid protein

660 amino acids

Major viral capsid protein that encapsidates the viral genome. Binds to the 5' end of the genomic RNA (By similarity).

Belongs to the hepevirus capsid protein family.

70.992 kDa

MRPRAVLLLLFVLLPMLPAPPAGQPSGRRRGRRNGGAGGGFWGDRVDSQPFALPYIHPTNPFAADVVSQPGAGARPRQPPRPLGSAWRDQSQRPSTAPRRRSAPAGAAPLTAVSPAPDTAPVPDVDSRGAILRRQYNLSTSPLTSSVAAGTNLVLYAAPLNPLLPLQDGTNTHIMATEASNYAQYRVVRATIRYRPLVPNAVGGYAISISFWPQTTTTPTSVDMNSITSTDVRILVQPGIASELVIPSERLHYRNQGWRSVETTGVAEEEATSGLVMLCIHGSPVNSYTNTPYTGALGLLDFALELEFRNLTPGNTNTRVSRYTSTARHRLRRGADGTAELTTTAATRFMKDLHFTGTNGVGEVGRGIALTLFNLADTLLGGLPTELISSAGGQLFYSRPVVSANGEPTVKLYTSVENAQQDKGITIPHDIDLGDSRVVIQDYDNQHEQDRPTPSPAPSRPFSVLRANDVLWLSLTAAEYDQTTYGSSTNPMYVSDTVTLVNVATGAQAVARSLDWSKVTLDGRPLTTIQQYSKTFYVLPLRGKLSFWEAGTTKAGYPYNYNTTASDQILIENAAGHRVAISTYTTSLGAGPTSISAVGVLAPHSALAVLEDTVDYPARAHTFDDFCPECRTLGLQGCAFQSTIAELQRLKMKVGKTRES

ORF2

Secreted protein ORF2

660 amino acids

Isoform Capsid protein ORF2: Forms an icosahedral capsid with a T=1 symmetry and a 34 nm diameter. The capsid is composed of 60 copies linked to each other. Binds to the 5' end of the genomic RNA to mediate genome encapsidation (By similarity). Binds to heparin surface proteoglycans (HSPGs) to mediate viral entry. Additionally, the interactions with host ASGR1 and ASGR2 facilitate viral infection of hepatocytes (By similarity).

Belongs to the hepevirus capsid protein family.

70.998 kDa

MRPRPILLLLLMFLPMLPAPPPGQPSGRRRGRRSGGSGGGFWGDRVDSQPFAIPYIHPTNPFAPDVTAAAGAGPRVRQPARPLGSAWRDQAQRPAVASRRRPTTAGAAPLTAVAPAHDTPPVPDVDSRAAILRRQYNLSTSPLTSSVATGTNLVLYAAPLSPLLPLQDGTNTHIMATEASNYAQYRVVRATIRYRPLVPNAVGGYAISISFWPQTTTTPTSVDMNSITSTDVRILVQPGIASELVIPSERLHYRNQGWRSVETSGVAEEEATSGLVMLCIHGSPVNSYTNTPYTGALGLLDFALELEFRNLTPGNTNTRVSRYSSTARHRLRRGADGTAELTTTAATRFMKDLYFTSTNGVGEIGRGIALTLFNLADTLLGGLPTELISSAGGQLFYSRPVVSAHGEPTVKLYTSVENAQQDKGIAIPHDIDLGESRVVIQDYDNQHEQDRPTPSPAPSRPFSVLRANDVLWLSLTAAEYDQSTYGSSTAPVYVSDSVTLVNVATGAQAVARSLDWTKVTLDGRPLSTIQQYPKTFFVLPLRGKLSFWEAGTTKAGYPYNYNTTASDQLLVENAAGHRVAISTYTTSLGAGPVSISAVAVLAPHSALALLEDTLDYPACAHTFDDFCPECRPLGLQGCAFQSTVAELQRLKMKVGKTREL

ORF2

Capsid protein

659 amino acids

Major viral capsid protein that encapsidates the viral genome. Binds to the 5' end of the genomic RNA (By similarity).

Belongs to the hepevirus capsid protein family.

70.641 kDa

MRPRPLLLLFLLFLPMLPAPPTGQPSGRRRGRRSGGTGGGFWGDRVDSQPFAIPYIHPTNPFAPDVAAASGSGPRLRQPARPLGSTWRDQAQRPSAASRRRPATAGAAALTAVAPAHDTSPVPDVDSRGAILRRQYNLSTSPLTSSVASGTNLVLYAAPLNPPLPLQDGTNTHIMATEASNYAQYRVARATIRYRPLVPNAVGGYAISISFWPQTTTTPTSVDMNSITSTDVRILVQPGIASELVIPSERLHYRNQGWRSVETSGVAEEEATSGLVMLCIHGSPVNSYTNTPYTGALGLLDFALELEFRNLTTCNTNTRVSRYSSTARHSARGADGTAELTTTAATRFMKDLHFTGLNGVGEVGRGIALTLLNLADTLLGGLPTELISSAGGQLFYSRPVVSANGEPTVKLYTSVENAQQDKGVAIPHDIDLGDSRVVIQDYDNQHEQDRPTPSPAPSRPFSVLRANDVLWLSLTAAEYDQSTYGSSTGPVYISDSVTLVNVATGAQAVARSLDWSKVTLDGRPLPTVEQYSKTFFVLPLRGKLSFWEAGTTKAGYPYNYNTTASDQILIENAAGHRVAISTYTTRLGAGPVAISAAAVLAPRSALALLEDTFDYPGRAHTFDDFCPECRALGLQGCAFQSTVAELQRLKVKVGKTREL

ORF2

Putative serine protease

657 amino acids

Putative serine protease.

Belongs to the peptidase S39B family.

73.415 kDa

MSKYLATSVRLCLMVCIVGWLLMPSYKELDGWCSSLSSLERDKSNWLLTGLSTWFCIVPSGTDQSSLVSYFSPLEKLSKFVQDLDLDFVKLWWLETITLINTLNTTEKLLSGVTFSVVLWYPRILVTVLMLVWKLWFPVRFLVVASSLLCLRILVWPFEVIADVILETCAWFTRKYHKLMDVIEDLMMIPQRVMEWCSGNTAKMVVPTVASCVSESIESKLDRILMALGRKGTVLEAAQPGSDFVECEQWPNGLVAIRRHDGRIVGMGFLVVLNGKWRLVTAAHVARECKRGIMLSAGIDSKTVTFQDLDVVLQTQVDACIMNVPAGTAASLGVRKVVINRTPSESKVVRTYGYNSGKFCMSEGLVGTTSANMGFRHGCSTLRGWSGTPIYRDNKVVGIHSRCNGIYENFGLSLDLLVGRLESEETDRYARTMEEFNTEDRPVTPPMEFSWEFEEKFERVRSTRKSFARIESEVATFTATKLSGFDWTDDAPMDFDELPVFESTMVSVFQERPLGGLPISNGNKAEEKKITSEALEPSKSSTPEAAKHTRRRRRNKKKSKNSETGHGPEEQSQQQSRPSSPIPDDSAPVSSPPVSPPSTGSVPKSWTQAYTQKLVLLLGSMDGQSKEKVDLAILEAKSFASALFPPSKPKSSEESEK

ORF2

Capsid protein

606 amino acids

Major viral capsid protein that encapsidates the viral genome. Binds to the 5' end of the genomic RNA (By similarity).

Belongs to the hepevirus capsid protein family.

65.005 kDa

MSLCRLLLMLAMCCGVSRGSQTLPAGGRRGQRRRDNSAQWSTQQRPEGAVGPAPLTDVVTAAGTRTVPDVDQAGAVLVRQYNLVTSPLGLATLGSTNALLYAAPVSPLMPLQDGTTSNIMSTESSNYAQYRVQGLTVRWRPVVPNAVGGFSISMAYWPQTTSTPTSIDMNSITSTDVRVVLQPGSAGLLTIPHERLAYKNNGWRSVETVSVPQEDATSGMLMVCVHGTPWNSYTNSVYTGPLGMVDFAIKLQLRNLSPGNTNARVTRVKVTAPHTIKADPSGATITTAAAARFMADVRWGLGTAEDGEIGHGILGVLFNLADTVLGGLPSTLLRAASGQYMYGRPVGNANGEPEVKLYMSVEDAVNDKPIMVPHDIDLGTSTVTCQDYGNQHVDDRPSPAPAPKRALGTLRSGDVLRITGSMQYVTNAELLPQSVSQGYFGAGSTMMVHNLITGVRAPASSVDWTKATVDGVQVKTVDASSGSNRFAALPAFGKPAVWGPQGAGYFYQYNSTHQEWIYFLQNGSSVVWYAYTNMLGQKSDTSILFEVRPIQASDQPWFLAHHTGGDDCTTCLPLGLRTCCRQAPEDQSPETRRLLDRLSRTFPSPP

ORF2

Capsid protein VP1

546 amino acids

Soluble capsid protein may play a role in viral immunoevasion.

Belongs to the caliciviridae capsid protein family.

58.774 kDa

MMMASKDAPQSADGASGAGQLVPEVNTADPLPMEPVAGPTTAVATAGQVNMIDPWIVNNFVQSPQGEFTISPNNTPGDILFDLQLGPHLNPFLSHLSQMYNGWVGNMRVRILLAGNAFSAGKIIVCCVPPGFTSSSLTIAQATLFPHVIADVRTLEPIEMPLEDVRNVLYHTNDNQPTMRLVCMLYTPLRTGGGSGNSDSFVVAGRVLTAPSSDFSFLFLVPPTIEQKTRAFTVPNIPLQTLSNSRFPSLIQGMILSPDASQVVQFQNGRCLIDGQLLGTTPATSGQLFRVRGKINQGARTLNLTEVDGKPFMAFDSPAPVGFPDFGKCDWHMRISKTPNNTGSGDPMRSVSVQTNVQGFVPHLGSIQFDEVFNHPTGDYIGTIEWISQPSTPPGTDINLWEIPDYGSSLSQAANLAPPVFPPGFGEALVYFVSAFPGPNNRSAPNDVPCLLPQEYITHFVSEQAPTMGDAALLHYVDPDTNRNLGEFKLYPGGYLTCVPNGVGAGPQQLPLNGVFLFVSWVSRFYQLKPVGTASTARGRLGVRRI

ORF2

Capsid protein

539 amino acids

Soluble capsid protein may play a role in viral immunoevasion.

Belongs to the caliciviridae capsid protein family.

58.775 kDa

MKMASNDANPSDGSAANLVPEVNNEVMALEPVVGAAIAAPVAGQQNVIDPWIRNNFVQAPGGEFTVSPRNAPGEILWSAPLGPDLNPYLSHLSRMYNGYAGGFEVQVILAGNAFTAGKVIFAAVPPNFPTEGLSPSQVTMFPHIIVDVRQLEPVLIPLPDVRNNFYHYNQANDSTLKLIAMLYTPLRANNAGDDVFTVSCRVLTRPSPDFDFIFLVPPTVESRTKPFTVPVLTVEEMSNSRFPIPLEKLYTGPSSAFVVQPQNGRCTTDGVLLGTTQLSAVNICNFRGDVTHIAGSHDYTMNLASQNWSNYDPTEEIPAPLGTPDFVGKIQGLLTQTTRADGSTRAHKATVSTGSVHFTPKLGSVQFTTDTNNDFQAGQNTKFTPVGVIQDGDHHQNEPQQWSLPNYSGRTGHNVHLAPAVAPTFPGEQLLFFRSTMPGCSGYPNMNLDCLLPQEWVLHFYQEAAPAQSDVALLRFVNPDTGRVLFECKLHKSGYITVAHTGPYDLVLPPNGYFRFDSWVNQFYTLAPMGNGTGRRRAL

ORF2

Capsid protein VP1

530 amino acids

Soluble capsid protein may play a role in viral immunoevasion.

Belongs to the caliciviridae capsid protein family.

56.589 kDa

MMMASKDATSSVDGASGAGQLVPEVNASDPLAMDPVAGSSTAVATAGQVNPIDPWIINNFVQAPQGEFTISPNNTPGDVLFDLSLGPHLNPFLLHLSQMYNGWVGNMRVRIMLAGNAFTAGKIIVSCIPPGFGSHNLTIAQATLFPHVIADVRTLDPIEVPLEDVRNVLFHNNDRNQQTMRLVCMLYTPLRTGGGTGDSFVVAGRVMTCPSPDFNFLFLVPPTVEQKTRPFTLPNLPLSSLSNSRAPLPISSMGISPDNVQSVQFQNGRCTLDGRLVGTTPVSLSHVAKIRGTSNGTVINLTELDGTPFHPFEGPAPIGFPDLGGCDWHINMTQFGHSSQTQYDVDTTPDTFVPHLGSIQANGIGSGNYVGVLSWISPPSHPSGSQVDLWKIPNYGSSITEATHLAPSVYPPGFGEVLVFFMSKMPGPGAYNLPCLLPQEYISHLASEQAPTVGEAALLHYVDPDTGRNLGEFKAYPDGFLTCVPNGASSGPQQLPINGVFVFVSWVSRFYQLKPVGTASSARGRLGLRR

ORF2

Capsid protein

485 amino acids

Major viral capsid protein that encapsidates the viral genome. Binds to the 5' end of the genomic RNA (By similarity).

Belongs to the hepevirus capsid protein family.

52.318 kDa

single

RRQYNLSTSPLTSSVATGTNLVLYAAPLSPLLPLQDGTNTHIMATEASNYAQYRVVRATIRYRPLVPNAVGGYAISISFWPQTTTTPTSVDMNSITSTDVRILVQPGIASELVIPSERLHYRNQGWRSVETSGVAEEEATSGLVMLCIHGSPVNSYTNTPYTGALGLLDFALELEFRNLTPGNTNTRVSRYSSTARHRLRRGADGTAELTTTAATRFMKDLYFTSTNGVGEIGRGIALTLFNLADTLLGGLPTELISSAGGQLFYSRPVVSAHGEPTVKLYTSVENAQQDKGIAIPHDIDLGESRVVIQDYDNQHEQDRPTPSPAPSRPFSVLRANDVLWLSLTAAEYDQSTYGSSTAPVYVSDSVTLVNVATGAQAVARSLDWTKVTLDGRPLSTIQQYPKTFFVLPLRGKLSFWEAGTTKAGYPYNYNTTASDQLLVENAAGHRVAISTYTTSLGAGPVSISAVAVLAPHSALALLEDTLDYP

ORF2

61 kDa protein homolog

474 amino acids

Probably plays an important role in the persistence and survival of the virus. May be a structural component in the envelope of the polyhedron or the envelope of the polyhedra-derived virus (PDV) (By similarity).

52.01 kDa

MMERQYQSVRSYLINNQHNAIAAGPFLQRVAGPEAHSVGRNVGDRAVRLNRQAVLDLLKLAEDIYADTAYMQADQPEASSRHFATLNRMRLLLIGVQDPDARRNLNSVLARIEALLRVDVVNDAEVNVLSGDFYEEYSKYISYQQTFAQTPTASASQQTQTSLPRPQTSLPRQTQASLPQQTPFDQPEMVSPPSFVHTTPAILPQTTQPPATDTFSRPSDEFVYVPGKERAVPDTRFKPPVPPKPEHLKSRPSSVATNAAGATPVAPPPPPFPSADVTTSMPPPPPPFPSADVTTSMPPPPPMVDLATSMPPPPPPPPPMVDLATSMPPPINNAINNLLIDAMVAETNKNAGDNRSALLDQIKQGKTLKKTQPADGAPATDPRSTLLSEIRQGKTLKKLRKIEDQSSTQTLLKDVDTTDKTKTILKNFVTNIDRISKQEQEEKDRLDTITKRRPAVEHTDGNSTGNNSDDWRDD

ORF2

Capsid protein

454 amino acids

Capsid protein self-assembles to form an icosahedral capsid with a T=3 symmetry, about 28-34 nm in diameter, and consisting of 180 capsid proteins.

Belongs to the icosahedral plant coat protein family.

48.116 kDa

MTLNLRKVPAYLPGKVDGALTNLVHAAVDHVVPGLGKAEKAAAVYNIKQVVKKLGTYTEQGVKKIAKKTLGELGYLNYTPSSHLGMAITGRGTKQINMSRSTNAGGFALGGTTAAPVSISRNINRRSKPSIKMMGDAVVISHSEMLGAINSGTPSSNVTAFRCTGYRANPGMSTIFPWLSATAVNYEKYKFRRLSFTLVPLVSTNYSGRIGVGFDYDSSDLVPGNRQEFYALSNHCENMPWQESTVEIKCDNAYRFTGTHVAADNKLIDLGQVVVMSDSVSNGGTISAALPLFDLIVNYTVELIEPQQALFSSQLYSGSTTFTSGIPLGTGADTTTVVGPTVVNSTTVTNCVVTFKLPAGVFEVSYFIAWSTGTAAVVPTVPTTGAGSKLSNTSTGSNSYGVCFINSPVECDLLLTATVLLIIPTLPSSTCVFHAPARRCTTPMCHRLLTSLAG

ORF2

Putative movement protein

419 amino acids

Cell-to-cell movement.

43.354 kDa

MPLTPTPSIRPSRPTSFSMSGPTTLGVRQTSCSSSLRSSPSSSPDSPTSPTSSTTGSCPKTPPGTPPLPRTSRTARPSSCMMLSCITPQGRSLTSSSSVPSSRRSMPPLSFRLSRASRISRSIRKFTASVFRVLTLSTSRRATQPPTTRSRVRPSTGSRPPVSPLVTSSSPSPFSTLSARSIPSSSSVAALPSFRPKTLLPSAFRTPSPSPLPPPSTRTFVTGWSPARCTTRSSIMSEPSAFGLPTPPASSGLRSASLSTAGSPLPPGTTFSTSRSRPPPFVPTPRIPFSSRPSLACPTGFAPTLGRSGAWLPPRPLSLPGPLPVPSAGSSPFTPTVSGCSASTSSAGGSGLVSHSMAPSQGFFGRPIQPAARQCSLPTPPLSAKSLLVWQTGVLPPPSGRVCSPRPLRRPGSPTQPWP

ORF2

Uncharacterized protein ORF2

407 amino acids

44.741 kDa

MTGRHSPHRQTSPSPRPVEKMPRFQREHGASHRYTPMGKRPAAPANTGSHRGALLGRLNGDPERKGEFTAVSKLLKSRGYIPEARTALIEWVEKEGARRGGFEVMCGSILLPGHDESGRAIDDIFRDMSRSVRGEVASPIDELLFRVGNLLEVYVETTTGKPVPAKGLWGVVQVESTVTGIPKMIHVCLDRSLGVGYKCSFAKLWKKTIEELLGTGVGTTNPHCWFTRTIHSDAIQASFDGLNMIFELFGGRVRTGRVSPEGERRVFHTRCLGDDSFNALFAATVHDPTVSRAVFEARVRTVQTSYPAWYTFGDMWTPAPNNVGWVTTPEGSWCYDIRVRDLYNDPNKMSVTPAAAAPPGVPKPEHGEELEADPWKPSSTIGSPAPNLCALYTSGDSVELHAPLLPL

orf2

Uncharacterized protein Orf2

397 amino acids

46.325 kDa

MRLHVHINDKLGELFKKRVHLVYGDRRGALSHAIEEAIILWLLHTDYIVKLQKVNAMSLQTQRIDSDSSHYLPISRLPQTIDEFRAFYNRFGAKATLLVYLLVRGKPLRLYDLFRFHQAIAGVSSDNSTRKVLKRLLRDGLIYRKGKLYYPSPDALLLMWDSIDWSRVRTKRYTGNGVVSKPSKRRVRGVGSQVRRVVRIARSLARRGDTLRAVSLLTHTLLGVRQTGVLLYRKGGLFIVYEHKDRSVRVLFSERIGKLFDDLGLPEGSLYMHMYYRAGRIIHNVFGGYRVARRMFYFLREHGFFYVPASEVDRVGEYRYDPHSGKLIVRIGNWTYEVDADLDAIDSYVENLNSRRTRKSKKKSSSLVSYPRERFGIVRVSKHTKVENDVYYLNYTP

ORF2

Capsid protein

388 amino acids

Capsid protein self-assembles to form an icosahedral capsid with a T=3 symmetry, about 32-35 nm in diameter, and consisting of 180 capsid proteins.

Belongs to the icosahedral plant coat protein family.

40.911 kDa

MAMTTRNNNNVLAISKKQLGVLAASAAVGALRNHISESSPALLQSAVGLGKKALNKVRNRRKQGNQQIITHVGGVGGSIMAPVAVSRQLVGSKPKFTGRTSGSVTVTHREYLTQVNNSSGFVVNGGIVGNLLQLNPSNGTLFSWLPAIASNFDQYSFNSVVLHYVPLCGTTEVGRVALYFDKDSQDPEPADRVELANFGVLKETAPWAEAMLRIPTDKVKRYCNDSATVDQKLIDLGQLGIATYGGAGTNAVGDVFISYSVTLYFPQPTNTLLSTRRLDLTGSLADATGPGYLVLTRTPTVLTHTFRVTGTFNLSGGLRCLTSLTLGATGAVVINDILAIDNVGTASAYFLNCTVSSLPATVTFTTTGISSATVNVVRGTRANVVNLL

ORF2

Capsid protein

388 amino acids

Capsid protein self-assembles to form an icosahedral capsid with a T=3 symmetry, about 32-35 nm in diameter, and consisting of 180 capsid proteins.

Belongs to the icosahedral plant coat protein family.

41.151 kDa

MAMVKRNNNTGMIPVSTKQLLALGAAAGATALQGFVKNNGMAIVEGAVDLTKRAYKAVRRRGGKKQQMINHVGGTGGAIMAPVAVTRQLVGSKPKFTGRTSGSVTVTHREYLSQVNNSTGFQVNGGIVGNLLQLNPLNGTLFSWLPAIASNFDQYTFNSVVLHYVPLCSTTEVGRVAIYFDKDSEDPEPADRVELANYSVLKETAPWAEAMLRVPTDKIKRFCDDSSTSDHKLIDLGQLGIATYGGAGTNAVGDIFISYSVTLYFPQPTNTLLSTRRLDLAGALVTASGPGYLLVSRTATVLTMTFRATGTFVISGTYRCLTATTLGLAGGVNVNSITVVDNIGTDSAFFINCTVSNLPSVVTFTSTGITSATVHCVRATRQNDVSLI

ORF2

Capsid protein

388 amino acids

Capsid protein self-assembles to form an icosahedral capsid with a T=3 symmetry, about 32-35 nm in diameter, and consisting of 180 capsid proteins.

Belongs to the icosahedral plant coat protein family.

41.164 kDa

MAMVKRNNNTGLIPVSTKQLMALGAAAGASALQGFVRNNGAAIVGKVVDVGQKVYKAVKKRGGKKQQQIKHVGGTGGAIMAPVAVTRQLTGSKPKFTGKTSGSVTVTHREYLSQVNMSTGFQVNGGIVGNLLQLNPLNGTLFSWLPAIASNFDQYSFNSVLLHYVPLCATTEVGRVAMYFDKDSEDPEPADRVELANYSVLAETAPWAERALWVPTDRIKRFCDDSSTLDHKLIDLGQLGVATYGGAGTNAVGDIFISYSVTLYFPQPTNTLLSTRRLDLAGTPVTASGPGYILLTRTPTVLTMTFRATGTFVISGAYRCLTSTVLGLTGGVNVNSITVVDNVGTSSSFFINCTVSNLPSVITFTTTGITSATIQCNRATRQNDVSLI

ORF2

Capsid protein

380 amino acids

Capsid protein self-assembles to form an icosahedral capsid with a T=3 symmetry, about 32-35 nm in diameter, and consisting of 180 capsid proteins.

Belongs to the icosahedral plant coat protein family.

40.878 kDa

MALVSRNNNMRTLAKLAAPLATAGTRTIVDNKEAIWNGVKWIWGKLPKGKKGKNGNGALIAHPQAFPGAIAAPISYAYAVKGRKPRFQTAKGSVRITHREYVSVLSGTNGEFLRNNGTGPNNDFSINPLNPFLFPWLVNIAANFDQYKFNSLRFEYVPLVNTTTNGRVALYFDKDSEDPGPDDRAALANYAHLSEISPWAITKLTVPTDNVKRFISDTSSGDPKLINLGQFGWVAYSGPTAELGDIFVEYTVDLFEAQPTSPLLESLFRESASSVQTRMGLPYFSLEVASATDLVWQARVPGTYVVTIIFNSTVGGLTPSISGGGTINSSFSVSTAGSSAYVANITIRVNANLSLSGLTGATNAQLFAVRAITENAVQVV

ORF2

Capsid protein

380 amino acids

Capsid protein self-assembles to form an icosahedral capsid with a T=3 symmetry, about 32-35 nm in diameter, and consisting of 180 capsid proteins.

Belongs to the icosahedral plant coat protein family.

40.566 kDa

MAMTTTNNNRAMTRAAKQALPALGALATSGMGQQLFMSGVNYAIEKGKQFVPNRRGGKKNRNTDMVAHPGALSGSMAAPVAISRIVRGSKPRFIRSKGSVTITHRELVGQFNSSSALVVNGGITGNLYKINPANAVLFPWLQTLASNFDQYMFNTLRLQYVPMCASTETGRVAIYFDKDSQDLEPVDRIELANMRHLTETAPWCEGSLRVPVDSVKRFMNDNSTVDPKLIDLGQVGLATYGGPGTNAVGDLFIHYTVTFYEPQPSSGLTSTLQTGTGSANAGPTLVAVATTATTTTVTFRSPGTYLVSMVQRATTFTGVTPIALTFNSNTNTTAAGTNYSANYNVTVPVPGAQMRFVGTGFGNYTLQVTRAKITNAATLL

ORF2

Capsid protein

372 amino acids

Capsid protein self-assembles to form an icosahedral capsid with a T=3 symmetry, about 32-35 nm in diameter, and consisting of 180 capsid proteins.

Belongs to the icosahedral plant coat protein family.

39.788 kDa

MALVKRNNNMALIATEAGKLAAVKAGQVMLSPAGRELIWNGVNWVRRKLGRSKKSDVILHPGVLPGAIAAPVANTRIIRASKPKFTRSKGSVTIAHRELLGQFNNSSGLVVNGGVSGNLYRINPSNPVVFPWLQGIAASFDQYKFDRVQLQYVPMCATTETGRVAIYFDKDQQDVEPADRVELANMGHWTESAPWCESTLNVPVDNVKRFMNDNTTTDRKLVDLGQIGLATYGGGSTNPVGDLFIHYTITLFEPQPLASLVETEQSGAGAAPFGTNLVTVSSNATTTIITFRGPGVYLLALSQRAASFTTLVTAGGAVVNSHTTLFSGPAYQSIANITATIPGGSITYNGTLFGNYTLQVTRAKISNNATLI

ORF2

Putative movement protein

362 amino acids

Suppressor of viral-induced RNA silencing.

40.208 kDa

MASLINVSSLVNRVKLDQSIIGSDEINKLYGSDAPLVFKDEVKMVIPGNAEGEAIKLQANILTADRLQSIRNAKVNGKEAAYLHLGFVPIAIRSLLPSGNEQIWGRCALVDTSRTRAETAVIDEFEFKFTKKQPFAAKLLTINAAVDINCKVSVGSIQVLLELHGVDLREERSVAAIITGLTCTPTNKMVLLHKIECDTPKWSLCNIIEQVEDEEESKKAFENMFNASSSNLIDLGQEQWLDEGKRTPLIGSLAIKGFGRKVMPVRRRNLTTRNLMKDYVSHVKSETASLKRSQSGRDWGNDRLRKYLEEQALEQARSSTDHQLVKAPKFKTIEVTGLETVHDLKDKIDKAESSTASDTGTK

ORF2

Capsid protein

345 amino acids

Capsid protein self-assembles to form an icosahedral capsid with a T=3 symmetry, about 31-34 nm in diameter, and consisting of 180 capsid proteins.

Belongs to the icosahedral plant coat protein family.

37.921 kDa

MTSRQSRKSKMALVPKQRQNLARTVKTVKIPYATTQIVTTSNPPKKGQIKVSGRQLFMSLITSSSFVVNNGLPTPSLLSLNPSNQYLFPSLAYEAANYDLYRFAKLRLSYVHDTNATVSGRVSLMWDRDSQDVPPNSRVSIPQCTKSVSTAVYESCAIDLPIDDVWRFVRDTDVVDRKLSDYGQIFTAVHSGSTTDEVGDVYLDYTIELKDRQPTASMVQTAYWDVSGVLAKSEGPRYFSPSSDVTFTSTMAAISLQLSGIFNVQVVVTCTTAGTLVVGPNISVIGAMYSQFTTPRYFAQPVLACTGVPNGTPSVSMTGFAGITRITLVITRLPPETRCRNRQFP

ORF2

Capsid protein

339 amino acids

Capsid protein self-assembles to form an icosahedral capsid with a T=3 symmetry, about 31-34 nm in diameter, and consisting of 180 capsid proteins. Plays an essential role in virion formation by interacting, via its N-terminal region, with the bipartite viral RNA genome and specifically with the 3' terminus of RNA-1 and the TA element on RNA-2. Participates also in symptom development, viral RNA accumulation and systemic movement within the host.

Belongs to the icosahedral plant coat protein family.

36.583 kDa

MSSKAPKKSKQRSQPRNRTPNTSVKTVAIPFAKTQIIKTVNPPPKPARGILHTQLVMSVVGSVQMRTNNGKSNQRFRLNPSNPALFPTLAYEAANYDMYRLKKLTLRYVPLVTVQNSGRVAMIWDPDSQDSAPQSRQEISAYSRSVSTAVYEKCSLTIPADNQWRFVADNTTVDRKLVDFGQLLFVTHSGSDGIETGDIFLDCEVEFKGPQPTASIVQKTVIDLGGTLTSFEGPSYLMPPDAFITSSSFGLFVDVAGTYLLTLVVTCSTTGSVTVGGNSTLVGDGRAAYGSSNYIASIVFTSSGVLSTTPSVQFSGSSGVSRVQMNICRCKQGNTFILG

ORF2

Uncharacterized protein ORF2

337 amino acids

Belongs to the plectrovirus ORF2 family.

39.996 kDa

MKKFIFFFKNYCYISGSMLLFSLIDLLLWIISLYCVGLVFWILFALQCVYFVWWLWKNIFYQLNAFRLVNFVWDNPLSVIIGKLGTGKTLLLTYLSQTMKLLTDEIYSNYPLEDDKVKVLTFKNLDFTDRTKPVPPDDSVILFDESYLYIDGTSPHDEKKVHSGKIPWIVLARHFRHRALFTAQREGMIWNNIRQLASGIIIPISLKKPVAKKGFNFFNRFFIMRMGIFQDITDYEIWKTKSVERTAEGKRAKHKSDVGLGIRFFKIIIPLEFANKYDSEWLKFVRDLKNDEIVNEKFYYWSEITKLSVKERLELFDIDILKKNLKPRKEKGNGKDD

ORF2

Uncharacterized protein ORF2

337 amino acids

Belongs to the plectrovirus ORF2 family.

39.809 kDa

MKKFIFFFKNYCYISGSMLLFSLIDLLLWIISLYCVGLVFWILFVLQCIYFVWWLWKNIFYQLNSFGLVNFVWDNPLSVIIGKLGTGKTLLLTYLSQTMKLLTDEIYSNYPLEDDKVKVLTFKNLDFTDRTKPVPPDDSVILFDESYLYIDGTSPHDEKKVHSGKIPWIVLARHFGNRALFTAQREGMIWNNIRQLASGIIIPISLKKPVIKKGFNFFNRFFIMQIGIFQDITDYEIWKTKSVERTAEGKRVKHKSDVGLGIRFFKIIIPLEFANKYDSQWLKFVRDLKNDEIVNKKEYYWSEITKLSVKERLELFDIDILKKNLKPKKEKGNGKDD

ORF2

Replication-associated protein ORF2

320 amino acids

Plays an essential role in viral DNA replication. Binds the origin of replication and cleaves the dsDNA replicative form I (RFI) and becomes covalently bound to it via phosphotyrosine bond, generating the dsDNA replicative form II (RFII). In turn, viral DNA replication initiates at the 3'-OH of the cleavage site. After one round of rolling circle synthesis, protein ORF2 is linked to the newly synthesized ssDNA and joins the ends of the displaced strand to generate a circular single-stranded molecule ready to be packed into a virion.

Belongs to the microviridae Rep protein family.

38.09 kDa

MACLRPLQVHNLKKGEKVNFKHYSNGDVARYDMNKNYIVNDSVPCRKCVGCRLDNSAEWGVRASLEIKSNPKHNWFVTLTYSDEHLVYNALGRPNCVPEHITKFIKSLRKYFERRGHIGIKYLASNEYGTKRMRPHYHICFFNLPLDDLEKTIDSQKGYQQWTSKTISRFWDKGFHTIGELTYHSANYTARYTTKKLGVKDYKALQLVPEKLRMSKGIGLKYFMENKERIYKEDSVLISTDKGIKRFKVPKYFDRRMEREWQDEFYLDYIKEKREKVAKRTLFQRQIVSSRSYTDYLGDEQKKLNNIVKRLTRPLKTGKK

ORF2

Capsid protein

302 amino acids

Capsid protein self-assembles to form a flexuous, filamentous capsid (Potential). The capsid encapsulates the single-stranded RNA genome.

32.081 kDa

MTTSRFATFDIESETGLTPGAYPAPLPTLEQQLHDRNAILAAIPSLARAKLDAATLKRRFANFLLTLGMVGTTSKGSYEELIIPPVKGMGSSTGFRARELVQIITSSPAPPGFDGNQTLRQFARPYAPQVQNMIAQGKFKTNLYDKYGKSVGAPPHVCIDFNDAMDLQMFHSTAEFESAHKVRELAIAEASARENAPRPAANPRAAKPIIGQTAPAFHSGDAAKQSGGQPVNIKPSLAQSAGFDSHRPPPETPPRAGTPSSQKSGQSGQTTIQPPASHGILSGMLGSHKSTPHSSPQQTPKK

ORF2

Uncharacterized ORF2 protein

278 amino acids

30.105 kDa

MSVTPDPTVGQALHPFSVPPTPAELDHIAAFYNVHPTPPLIGFSLIGSVNIRPGGTSQRLTGIFDATPNSLPDAVASLSAHNFHHLLDWHHSIDPAHIAAAPHPHTPAIKAALQRLTLIPNVIIYAPPTPSPPPPPAPTQPTRPTPGPAFFPQPFKVELHHPTPKTSSLPAPSLPTSLPPIITNQYLRLQISTPTGARQTYLRALIPKSPDLTDFILRIDLTEYHAHLIFTAELTRDHSITLARGPYVWPTFLPPSINNLIKLTHAAAEPSLQLTEIS

ORF2

Movement and silencing protein TGBp1

268 amino acids

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Increases plasmodesma size exclusion limit. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (By similarity).

Belongs to the Tymovirales TGBp1 protein family.

30.474 kDa

MEDFFNCLRSRGFERTDEPLPSDSRRIVVHGVGGSGKTSLIEAFAIANEWVRAYTLTSHERFDISGRGISQYKGQPIDEKLWTILDEYGQTDNPETLPPFNVLATDPYQAFRCQPLRAHFVSLRSYRVPHHIAQAITQYTGFPIEAAGTDLHEGKYTVGPWTDKLRQQILVEDGEIHYQLSRRQCPHKLITDAIGEQWPTVTVVFDRSISPESARPLRCLFYIAATRSSNELNIRTYVPTRTPGLIKASLPHTSCRLCCRPRDLPSEN

ORF2

Minor spike protein H

263 amino acids

Probably triggers with protein G the injection of the phage DNA into the host upon conformational changes induced by virus-host receptor interaction.

Belongs to the microviridae H protein family.

28.549 kDa

MSFAENVGRFIGNSVNSVGSVIGDGLKGFNSTQSISSAKQANLLNNLPLPSLDNVLNIGMFGGLASGLLSYRAAKKQNKVMQDIANRQMAFQERMSSTAVRRHVEDLKKAGLNPLLALGGSASTPQGAFYSPVNPMESGLNSAISVADKVFDYQRLAHADFQGRLNSAMSVVQLASAVQDYKRNYGKFGEVAYWFDRYAGKLLPAMLFYLFRKHPVGRAVSAANSGYAVAKGAKGVNFKFSNMSSTAVQRHNSRYNVSKGWRR

ORF2

Movement and silencing protein TGBp1

241 amino acids

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Increases plasmodesma size exclusion limit. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (By similarity).

Belongs to the Tymovirales TGBp1 protein family.

26.334 kDa

MKTDLLLQILSNNNFTRTSEPIKEPLIIHGVPGSGKSTLVRALVTYRSTVACTLGAPYGSNLAFPGVTSPGLTQSLTDHETRILDEYQLGTESDLKPFNVLVGDPFQGNLHLKAHYVKSFSHRVPRIICNFLQSLGYEIAGSKPGELAQLPIYGPNPSGPTGQVLHLGPLSRRLTQSHGVCSKLPSEVQGLEFEEVTLVYHSSEFERNRVGFYIAATRALGRLNLITDTTLEIPHELCPTS

ORF2

Membrane protein 2

238 amino acids

Belongs to the varicellovirus ORF2 protein family.

25.984 kDa

MHVISETLAYGHVPAFIMGSTLVRPSLNATAEENPASETRCLLRVLAGRTVDLPGGGTLHITCTKTYVIIGKYSKPGERLSLARLIGRAMTPGGARTFIILAMKEKRSTTLGYECGTGLHLLAPSMGTFLRTHGLSNRDLCLWRGNIYDMHMQRLMFWENIAQNTTETPCITSTLTCNLTEDSGEAALTTSDRPTLPTLTAQGRPTVSNIRGILKGSPRQQPVCHRVRFAEPTEGVLM

ORF2

Membrane protein 2

238 amino acids

Belongs to the varicellovirus ORF2 protein family.

25.984 kDa

MHVISETLAYGHVPAFIMGSTLVRPSLNATAEENPASETRCLLRVLAGRTVDLPGGGTLHITCTKTYVIIGKYSKPGERLSLARLIGRAMTPGGARTFIILAMKEKRSTTLGYECGTGLHLLAPSMGTFLRTHGLSNRDLCLWRGNIYDMHMQRLMFWENIAQNTTETPCITSTLTCNLTEDSGEAALTTSDRPTLPTLTAQGRPTVSNIRGILKGSPRQQPVCHRVRFAEPTEGVLM

ORF2

Movement and silencing protein TGBp1

236 amino acids

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Increases plasmodesma size exclusion limit. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (By similarity).

Belongs to the Tymovirales TGBp1 protein family.

26.356 kDa

MDHIHLLLSAHGFTRTRLAKSKPIVVHAIAGSGKSTVIRKILSDLPTPKAYTLGKPDPYSLSNPTIKAFAQFKRGTLDILDEYGQLPLTDLDSSFEFIFTDPYQAPTDNLFEPHYTLETTYRFGPNTCNLLNQAFQSNITSLVTKDNISFGSPYLVDPVGTILAFQPDTYLILCLHQASFFKVSDVIGYQWPTVTLYLACKISEIPEEERHLLFIGLTRHTESLLILGPDAFDSSP

ORF2

Movement and silencing protein TGBp1

236 amino acids

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Increases plasmodesma size exclusion limit. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (By similarity).

Belongs to the Tymovirales TGBp1 protein family.

26.451 kDa

MDHIHHLLSSHGFTRTRLAKSKPIVVHAIAGSGKSTVIRKILSDLPNARAYTLGKPDPYSLSNPTIKAFAQFKRGTLDILDEYGQLPFADLDSSFEFIFTDPYQAPTDNLFEPHYTLEITYRFGPNTCNLLNQAFQSNITSLVTQDNISFGSPYLVDPVGTILAFQPDTYLILCLHQAPFFKVSEVIGYQWPTVTLYLACKISEIPEEERHLLFIGLTRHTESLLILGPDAFDSSP

ORF2

Movement and silencing protein TGBp1

236 amino acids

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Increases plasmodesma size exclusion limit. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (By similarity).

Belongs to the Tymovirales TGBp1 protein family.

26.313 kDa

MDSEIVERLTKLGFVKTSHTHIAGEPLVIHAVAGAGKTTLLRSLLELPGVEVFTGGEHDPPNLSGKYIRCAAPPVAGAYNILDEYPAYPNWRSQPWNVLIADNLQYKEPTARAHYTCNRTHRLGQLTVDALRRVGFDITFAGTQTEDYGFQEGHLYTSQFYGQVISLDTQAHKIAVRHGLAPLSALETRGLEFDETTVITTKTSLEEVKDRHMVYVALTRHRRTCHLYTAHFAPSA

ORF2

Movement and silencing protein TGBp1

233 amino acids

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Increases plasmodesma size exclusion limit. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (By similarity).

Belongs to the Tymovirales TGBp1 protein family.

25.846 kDa

MDCKYLLELLDSYSFIRSSRSFSSPIIIHGVAGCGKSTIIQKIALAFPELLIGSFTPALLDSNSGRKQLAVTSDPLDILDEYLGGPNPVVRLAKFCDPLQYSCEQPEVPHFTSLLTWRFCVRTTALLNGIFGCQIKSRREDLCHLTHENPYTTDPKGVVVAHEQEVINLLLQHGCPVTPTQHLWGLTIPVVSVYITSIASLSTVDRANLFLSLTRDSKALHIFEFDAWSHATC

ORF2

Movement and silencing protein TGBp1

233 amino acids

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Increases plasmodesma size exclusion limit. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (By similarity).

Belongs to the Tymovirales TGBp1 protein family.

26.25 kDa

MNHFINLLVAEGFVRTNEPLTDQLVVHSVAGSGKSTLIRKFLEEQPLARAYTHCRADPPNLEGRFIQPFKGPCPDHFNILDEYCKEPISAKFQVLIADPLQYRTQHLRPHYVNHKSHRLGPETCKLLSSLGIKVESHRRDRDVVTLSGIFGSPILGQAIALDRSASDLLRAHGIQALCPIESIGQEYPVVTVVSSEPLRNVRFKDQVYIALSRHTEQLHVLSPEFPHTTSRPQ

ORF2

Movement and silencing protein TGBp1

232 amino acids

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Increases plasmodesma size exclusion limit. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (By similarity).

Belongs to the Tymovirales TGBp1 protein family.

25.754 kDa

MDVLINKLASCNFSRTRNQVGKPCIINCVPGAGKSTLIRELLNSDSRFRAYTFGEADPKNLSGRRILPASELQNAPQGALIIIDEYTEGSWEPGKICAAFGDPIQSRGPGIVADFVCNKTKRFGSSTCELLNGFGFEIHSEKEDICLVRDFFEVEPEGTVIAFESEVKDILARHFVEFEDICSIRGKTFEEVTFFTASNSIPEHLRADFFQCLTRHKNKLTIACPDATFAPS

ORF2

Movement and silencing protein TGBp1

231 amino acids

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Increases plasmodesma size exclusion limit. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (By similarity).

Belongs to the Tymovirales TGBp1 protein family.

25.824 kDa

MDVFVKILSDFGFTRLSSSLHVPIVVHCMPGAGKSSCIRALLKADSRFVAYTLGVPDPCNLDGLCIKAFTGSVDLKYFNILDEYARYNGDASDFFALFGDPVQSPPRNLYRAHFKAVLSKRFGSCTAQLLRELGFEVESTKEDLVSIRGLYDFDPVGTVIYYEKEIGCLLRAHSIEAYEPEEVVGKTFETVTFVTAENHIPAESRHLVYQCLTRHRSVLHLMTPDASYTST

ORF2

Movement and silencing protein TGBp1

230 amino acids

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Increases plasmodesma size exclusion limit. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (By similarity).

Belongs to the Tymovirales TGBp1 protein family.

24.687 kDa

MDSIINALTSNNFQRTNTPISKPLVVHAVAGAGKTTLIQNLLPEHPNLAAQTAGSPQTPNLTGAFIRKLTCPESNKINLLDEYAALQPLKGSWDVVLADPLQHPGLALRPHFIKSVSHRLCPATTRLISKLVCPCTSSRTEESTIQFSGLFEGPLLGTVIALDQTTQALLTAHGAHFLCPTAALGLEFDTVTVVSALPLEEVADKVGLYISLSRHRSQLHVRSPPPHPSH

ORF2

Movement and silencing protein TGBp1

229 amino acids

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Increases plasmodesma size exclusion limit. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (By similarity).

Belongs to the Tymovirales TGBp1 protein family.

25.391 kDa

MVEFTKRLLLERNFERTNRPITGPIVVHAVAGAGKSSVINTVSLTFQLICWTTLPEEKASFNCLHLRHLDGPAFPGAFVDEYQLADTDLSEAAFLFGDPLQYPGPAAQVPHFVKLFSHRCGLNSASLIRELGIAFEASKLDSVQHLDPYSSDPEGTILAFEPEVQAALASHSLDFLCLDEFRGKQWPVCTLYVSTKNLCDLDRPSVYVALTRHYERLLIMSFDAADTSA

ORF2

Movement and silencing protein TGBp1

229 amino acids

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Increases plasmodesma size exclusion limit. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (By similarity).

Belongs to the Tymovirales TGBp1 protein family.

25.439 kDa

MDVIVDLLYKYKFERLSNKLVCPIVVHCVPGAGKSSLIRELLELDSRFCAYTAGVEDQPRLSGNWIRKWSGQQPEGKFVVLDEYTLLTEVPPVFALFGDPIQSNTSAVQRADFVCSVSRRFGSATCGLLRELGWNVRSEKADLVQVSDIYTKDPLGKVVFSEEEVGCLLRSHGVEALSLQEITGQTFEVVTFVTSENSPVINRAAAYQCMTRHRTALHILCPDATYTAA

ORF2

Movement and silencing protein TGBp1

228 amino acids

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Increases plasmodesma size exclusion limit. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (By similarity).

Belongs to the Tymovirales TGBp1 protein family.

25.374 kDa

MDVLLSLLSEFGFERLSSELSLPIVVHSVPGGGKSSLIRKLINKDRRFSAYTFGLEDCESITGVRIKKAHASIPRSEFVVFDEYIEGDTPPWAFAVFADPLQGGPGPVLRAHFIKRRSHRFGKCTAQLLNDLSYEVESDLADVVQIQGLYETDLQGTVVYYEACVGNLLRAHSVPAYYISEIRGQTFESVTFVTSENYPVDRALAFQCLTRHRSSLLILSPNATYTAS

ORF2

Movement and silencing protein TGBp1

227 amino acids

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Increases plasmodesma size exclusion limit. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (By similarity).

Belongs to the Tymovirales TGBp1 protein family.

25.107 kDa

MDVFLQVLNKYKFERVSSTLNKPIVVHSVPGAGKSSAIRELLKLDSRFECITRGRPDIPNLEGAFIKAERSGESKLLLVDEYIEGPIPEDAFAIFADPLQSTAVSPHRAHFIKTLSHRFGKCTDSLLRDLGWDVQAEGQDSVQIADIFTVDPRETIVYFEPEVGELLRSHGVEASCIGEVRGATFEHVTFVTSENSPLIDKASAFQCLTRHTKSLLILCPDATYTAA

ORF2

Movement and silencing protein TGBp1

226 amino acids

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Increases plasmodesma size exclusion limit. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (By similarity).

Belongs to the Tymovirales TGBp1 protein family.

24.462 kDa

MDILIISLKSLGYSRTSRPLDSGPLVVHAVAGAGKSTALRKLLARHSTFTIHTLGVPDKISIRTRGIQKPGPIPKGNFAILDEYTLDATTREAYQALFADPYQAPELSLEPHFYLETSFRTPKKAAALIASCGFDFETNSQEEGHLEVTGIFKGPLLGKVIAIDSEAETTLSRHGVEFVKPCQVTGLEFPVVTIVSAAPIEEIGQSTLFYNAITRSKGLTYVRAGT

ORF2

Movement and silencing protein TGBp1

226 amino acids

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Increases plasmodesma size exclusion limit. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs.

Belongs to the Tymovirales TGBp1 protein family.

24.596 kDa

MDILISSLKSLGYSRTSKSLDSGPLVVHAVAGAGKSTALRKLILRHPTFTVHTLGVPDKVSIRTRGIQKPGPIPEGNFAILDEYTLDNTTRNSYQALFADPYQAPEFSLEPHFYLETSFRVPRKVADLIAGCGFDFETNSQEEGHLEITGIFKGPLLGKVIAIDEESETTLSRHGVEFVKPCQVTGLELKVVTIVSAAPIEEIGQSTAFYNAITRSKGLTYVRAGT

ORF2

Movement and silencing protein TGBp1

226 amino acids

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Increases plasmodesma size exclusion limit. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs.

Belongs to the Tymovirales TGBp1 protein family.

24.664 kDa

MDILIISLKSLGYSRTHKSLDSGPLVVHAVAGAGKSTALRKLILRHPTFTVHTLGVPDKVSIRTRGIQKPGPIPEGNFAILDEYTLDNTTRNSYQALFADPYQAPEFSLEPHFYLETSFRVPRKVADLIAGCGFDFETNSQEEGHLEITGIFKGPLLGKVIAIDEESETTLSKHGVEFVKPCQVTGLEFKVVTVVSAAPIEEIGQSTAFYNAITRSKGLTYVRAGT

ORF2

Movement and silencing protein TGBp1

226 amino acids

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Increases plasmodesma size exclusion limit. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (By similarity).

Belongs to the Tymovirales TGBp1 protein family.

24.42 kDa

MDILIISLKSLGYSRTARPLDSSPLVVHAVAGAGKSTALRKLLARHSTFTVHTLGVPDKISIRTRGIQKPGPIPEGNFAILDEYTLDATTREAYQALFADPYQAPELSLEPHFYLETSFRTPTKAAALIASCGFDFETNSQEEGHLEITGIFKGPLLGKVIAIDSEAETTLSRHGVEFVKPCQVTGLEFPVVTIVSAAPIEEIGQSTLFYNAITRSKGLTYVRAGA

ORF2

Protein VP2

225 amino acids

Minor structural protein present in one or two copies per virion. Does not seem to play a role in capsid assembly, but is essential for production of infectious virus (By similarity).

23.645 kDa

MASAATAGLTLLSGGASIAADIASIVTEQQRLALQKEQIRNNYELGKQSLSLQQQAMENSRDRIRLSAAQIKELGLDPKSELNMLMGLTAGAQPPISTPISSEQLFLNSSNLARSVRWDARNFGEAINTFAGLRAKHQANPNRPDMMLGSDNPNWGARATGDALSVSGLSVRSNHFGSGPSSLGSLSSVRSNPFSSISSGSVGGISLRTVGSRPSIRSVFSTTSV

ORF2

Protein VP2

225 amino acids

Minor structural protein present in one or two copies per virion. Does not seem to play a role in capsid assembly, but is essential for production of infectious virus (By similarity).

23.552 kDa

MASAATAGLTLLSGGAGIAADIASIVTEQQRLALQKEQIRNNYELGKQTLSLQQQAMENSRDRIRLSAAQIKELGLDPKSELSMIMGLTAGAQPSISAPISSEQLFLNSSNLARSVRWDARNFGEAINTFAGLRAKHQANPSRPDMMLGSDNPNWGARVTGDALSVSGLSVRSNHFGSGSSSLGSLSSVRTNPFSSVSSGSVGGISLRTVGSRPSIRSVFSTTSV

ORF2

Movement and silencing protein TGBp1

225 amino acids

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Increases plasmodesma size exclusion limit. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (By similarity).

Belongs to the Tymovirales TGBp1 protein family.

24.954 kDa

MDFAELLESKAFTRTRLPLSKPIVVHAVAGAGKTSLLENYARINPAARIYTPIAQQSNSLLLSPFTQSLEQADIVDEYPLSTLHPGVEYVLADPIQYLGSKDLLKPHYICPTTHRFGHSTAEFLTSLGIETYAHKPDRLTIANIFKTEPHGQVIACDLDTQQLAARHSLDYLRPCQSIGKTFKDTTILISHELNRDTLTKEIYIALTRHTNSVTILTPDAPSTSS

ORF2

Movement and silencing protein TGBp1

223 amino acids

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Increases plasmodesma size exclusion limit. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (By similarity).

Belongs to the Tymovirales TGBp1 protein family.

25.21 kDa

METVLSLLNEFGFERTVEPLSDPIVVHAVPGSGKTTLIKQALIRNNNIEAVTFGVPEKANIHGTYIKKARQGQRGRGNYSILDEYLSGEYSTGFNCLFSDPYQNHGDCLRAHFIGRCSHRFGRQTVQILRDLGYNIASSKEDIVEKKNIFQLIEPEGVIICLEKGVEDFLKWHSVEYKFPCQVRGATFDIVTFIHEKPLEELVGPDLFVALTRHRSKLVLVSN

ORF2

Movement and silencing protein TGBp1

216 amino acids

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Increases plasmodesma size exclusion limit. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (By similarity).

Belongs to the Tymovirales TGBp1 protein family.

23.575 kDa

MEFCGGTLRTRFQRTSVPNSPVTVVHTVAGSGKTTFIRNLLIDHPQLVARTYGTPDVPNLLGYGIRDRHGDAHIVDEYPAADLRSHPSVSIVFADPLQHHGEVRPAHFTCSHTHRFGKSTCSLLGTLGVYCTSDKEDSVTFAGAYLAEPVGTLIALGEDAELVLDNHRVEYFTPCQALGLTFPSVTLLTDAPIEDQPPVSRYIALTRHTDSLLILN

ORF2

Uncharacterized ORF2 protein

202 amino acids

21.48 kDa

MAEFSTPVRSGEATEGDLRVPRAGAEGEFTHRSQGAIRARDWPGYGQGSEKSMFIGRHYRKKRALSLCAVRTTKKACKLLIVMWTPPRNDQHYLNWQWYSSILSSHAAMCGCPDAVAHFNHLASVLRAPQNPPPPGPQRNLPLRRLPALPAAPEAPGDRAPWPMAGGAEGEDGGAGGDADHGGAAGGPEDADLLDAVAAAET

ORF2

Minor spike protein H

199 amino acids

Probably triggers with protein G the injection of the phage DNA into the host upon conformational changes induced by virus-host receptor interaction.

Belongs to the microviridae H protein family.

21.481 kDa

MALPALVAAAAPAVIGGIASYFGQQETNAANAKLAVWQTRENQAEAARNRKWQEQMSNSAHQREANDLQTAGLNRLLTATGGASTPSGGQGQAAGATMENSLKAGITTAFEAKQLGMQIERQEKELQNLAAQTRKLNIDAKVAEKRIPESDLKTKFTTNFSPVIDRVINLEDSNGPRLSNLREEKKPNQMPLKNGKLNT

ORF2

Uncharacterized ORF2 protein

177 amino acids

19.198 kDa

MTSRDCTGLSEFLGHGSDSCDSGSGSLGSLSYVQCVNLLSDLKSLGYQSIDSILYILGGGEAERFEIYRIFRRHGIGIGEALQLGVKKSLCNSPRSLLAILDDLLSRLGRGSAFLPSDLGAVKGELVATFHSSRLSVDLYVNNKKVVTRSVQAEGDYSYVARRFSGYKGLILRATRY

ORF2

Uncharacterized protein ORF2

167 amino acids

19.82 kDa

MHIGRREMPRHRKARHCQRFVADSCRSTETHSQVEDRVVRALMEDDVDLWRKMKYMVISSKNNDDKTMDTMRKFCERVTMAEESVEDLYYEKKYVKRFDKDTDDYMGQVTLPSARELAAAMKVGGRIGERRRKRDERVNELERKELELCGYDLVDGQCVLTGNLTRE

ORF2

Protein VP2

166 amino acids

Minor structural protein present in one or two copies per virion. Does not seem to play a role in capsid assembly, but is essential for production of infectious virus (By similarity).

Belongs to the vesivirus VP2 protein family.

17.697 kDa

MSWFTGASLAAGSLVDMAGTISSIVAQQRQIDLMAEANRIQADWVRRQEALQIRGQDISRDLAVNGTAQRVESLVNAGFTPVDARRLAGGTETVSYGLLDRPILQRGILSGITETRHLQAMQGALSAFKNGASYGAPPAPSGFVNPNYQPSPPRLKLGPRPPSTNV

ORF2

Protein VP2

165 amino acids

May be a minor structural protein present in one or two copies per virion. May play a role in RNA genome packaging (By similarity).

Belongs to the sapovirus VP2 family.

17.847 kDa

MSWLVGALQTFGSLADVAGTVSNIVYQQRQAAQLEKQNELMETWMNKQEALQKSQMELTRDLSINGPAARVQSALDAGFDEVSARRIAGSGERVIWGNLDRPIMHAGTMDSIRQTKHLDSLSHSLATFKNGTPFGKPAPPTTKFGKPQATTAQINIGHNPGSSSV

ORF2

Protein VP2

165 amino acids

Minor structural protein present in one or two copies per virion. Does not seem to play a role in capsid assembly, but is essential for production of infectious virus (By similarity).

Belongs to the vesivirus VP2 protein family.

17.814 kDa

MSWLVGALQTFGSLADVAGTVSNIVYQQRQAAQLEKQNELMETWMNKQEALQKSQMELTRDLSINGPAARVQSALDAGFDEVSARRIAGSGERVIWGNLDRPIMHAGTMDSIRQTRHLDSLSHSLATFKNGTPFGKPAPPTAKSGRPQATTAQITIGHNPGSTSV

ORF2

Protein VP2

164 amino acids

May be a minor structural protein present in one or two copies per virion. May play a role in RNA genome packaging (By similarity).

Belongs to the sapovirus VP2 family.

17.65 kDa

MSWIAGAMQGAGLLGDLAGTIGQIVLHNKQLNIMNSFNQAQIQLAKDQLKQNQQLANQYYEFNANLPVNQYNSAVSAGFDSVSARQLAGSREVRYLGGQQTPLVHQGQIHQMMFSPKHLMQAQHVVGTFSRGMPGVTPSKGLPRPQGVTAKVPVAGATTTHSKV

ORF2

Uncharacterized ORF2 protein

152 amino acids

15.82 kDa

MHFSKLSRRKKGKVPLPPLPTAPLPPHRPRMSGTWCPPVHNVPGLERNWYESCLRSHAAFCGCGDFVSHLNNLANRLGRPPAPRPPGAPQPPAVRALPALPAPEDRFPNPPGWPGPGGGAAGAGAAAGRDGGDGGDAEPGDEDLDALFAADE

ORF2

Uncharacterized ORF2 protein

150 amino acids

15.958 kDa

MFIGRHYRKKRALSLLAVRTTQKARKLLIVMWTPPRNDQQYLNWQWYSSVLSSHAAMCGCPDAVAHFNHLASVLRAPQNPPPPGPQRNLPLRRLPALPAAPEAPGDRAPWPMAGGAEGEEGGAGGDADHGGAAGGPEDADLLDAVAAAET

ORF2

Uncharacterized ORF2 protein

136 amino acids

14.088 kDa

MTNQWEPTTLNAWGREEAWLRSVVDSHQSFCGCNDPGFHLGLLLHSAGRHLGGPGGPQPPPAPGGPGVGGEGPRRFLPLPGLPANPEEPGHQRPPCPGGPGDAGGAGGVDAETGEGEWRPEDIAELLDGLEDAEKR

ORF2

Uncharacterized ORF2 protein

130 amino acids

13.841 kDa

MGDWFMQGSPPDFAVQEDRWLKAVESCHQLFCSCSSAWDHLRNILQTRGYWPQGPPPYRSEPHTEHSRPPPPKKRRPWCGGDGGGDAGAGPSGVAGTAAGGAGGDGAVGPVEEDDPTVADLIAAMEEDER

ORF2

Uncharacterized protein 2

126 amino acids

14.073 kDa

MSKSKTPNFDDMEVLDDTNDEYDDSESEWIDLDRGESVVGEIREINPDCGDYGTTVLELSRGLGDNVCMWSNRQIDNKIEQHGLGVGEVVGIKHTDREQTFTPDGSDEPVKFDVYEVRAVNVGGND

ORF2

Suppressor of RNA silencing

124 amino acids

Suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that performs sequence-specific inhibition of viral mRNAs expression.

Belongs to the virgaviridae suppressor of RNA silencing family.

14.573 kDa

MPKSEFFREERKRRVALLGEDAVCKLNGVCGYSCGMPPAVEKVSVPADTEEDVYMLIFPYEQFCGEKHFKLYESLKDVSDDELKLRRLERQRETLLASFQQKLKRYDEKIALLSEKFKNLRSKL

ORF2

Protein VP2

117 amino acids

Minor structural protein present in one or two copies per virion. Does not seem to play a role in capsid assembly, but is essential for production of infectious virus (By similarity).

Belongs to the lagovirus VP2 protein family.

12.652 kDa

MAFLMSEFIGLGLAGAGVLSNALLRRQELQLQKQALENGLVLKADQLGRLGFNPNEVKNVIVGNSFSSNVRLSNMHNDASVVNAYNVYNPASNGIRKKIKSLNNSVKIYNTTGESSV

ORF2

Protein VP2

117 amino acids

Minor structural protein present in one or two copies per virion. Does not seem to play a role in capsid assembly, but is essential for production of infectious virus (By similarity).

Belongs to the lagovirus VP2 protein family.

12.71 kDa

MAFLMSEFIGLGLAGASVLSNALLRRQELQLQRQALENGLVLKADQLGRLGFNPNEVKNVIVGNSFSSNVRLSNMHNDASVVNAYNVYNPASNGIRKKIKSLNNSVKIYNTTGESSV

ORF2

Protein VP2

117 amino acids

Minor structural protein present in one or two copies per virion. Does not seem to play a role in capsid assembly, but is essential for production of infectious virus (By similarity).

Belongs to the lagovirus VP2 protein family.

12.67 kDa

MAFLMSEFIGLGLAGAGVLSNALLRRQELQLQKQAMENGLVLKADQLGRLGFNPNEVKNVIVGNSFSSNVRLSNMHNDASVVNAYNVYNPASNGIRKKIKSLNNSVKIYNTTGESSV

ORF2

ORF2 protein

117 amino acids

12.227 kDa

MWQPPTQNGTQLERHWFESVWRSHAAFCSCGDCIGHLQHLATNLGRPPAPQPPRDQHPPHIRGLPALPAPPSNRNSWPGTGGDAAGGEAGGSRGAGDGGDGELADEDLLDAIALAAE

ORF2

Uncharacterized protein V2

114 amino acids

13.463 kDa

MRGVKIPELSKIMRELKTKELKKLLRYELDESTSVDSDEEQDDPGVPFYYEELEKCKTMKELYKFAREYDLQIPRIDKNDIFLKACKELNKNNIFDPNEDIIFEGVIIDPVVIG

orf2

Uncharacterized protein SPD_2302 homolog

109 amino acids

12.93 kDa

MSISFRTNTSMMNIAYKNRDLSDEEFKEEAHQFRDKEIKILEEKLKELNISCKVVGINSIKDMNEYKEIMENVNQAKEELKRIDELIAVRSSRIDFLEDKTLRITGNQR

orf2

Uncharacterized protein SPD_2302

109 amino acids

12.93 kDa

MSISFRTNTSMMNIAYKNRDLSDEEFKEEAHQFRDKEIKILEEKLKELNISCKVVGINSIKDMNEYKEIMENVNQAKEELKRIDELIAVRSSRIDFLEDKTLRITGNQR

ORF2

Uncharacterized ORF2 protein

100 amino acids

10.424 kDa

MQRRTQELIWKELVDNSHKLFCNCMDPQNHYRLICQNLNREPGEPWRTAGGIGEGGAGGDGAAAGGEGDVHGRPAGAEDGEDGADAAMAAALAAFEDATG

ORF2

Uncharacterized ORF2 protein

91 amino acids

10.242 kDa

MSSFLTPAVYSKNGLENQWINTIWNTHDLMCGCNNAIKHLFDILKKKGEQLCLPSTTEDAGTQTHGEEKDYDLEEGDLDALFANDFEEDDG

ORF2

Uncharacterized protein ORF2

88 amino acids

10.245 kDa

MRVKLEHSERGMVTYSQVKKIRENDMYMKIYQEGGYHRINLVNIRKRFIVSGDKEKVSLCLGGCKPIFKGEYDSCPECGAEVRIKEVK

ORF2

Probable movement protein p8

73 amino acids

Cell-to-cell movement.

Belongs to the carmovirus/necrovirus/panicovirus movement protein p8 family.

7.93 kDa

MSTVETPAQDTLATKEPNKTGAKDRQQARSARLSVAAGAGRTALSQRDAQEDRFSLGIVQTADKIENTFNFNF

ORF2

Double gene block protein 1

72 amino acids

Cell-to-cell movement. Displays RNA-binding activity (By similarity).

Belongs to the carmovirus double gene block protein 1 family.

7.774 kDa

MDPERIPYNSLSDSDATGKRKKGGEKSAKKRLVASHAASSVLNKKRNEGSASHGGTWVIVADKVEVSINFNF

ORF2

Probable movement protein p8

72 amino acids

Cell-to-cell movement.

Belongs to the carmovirus/necrovirus/panicovirus movement protein p8 family.

7.921 kDa

MDYQTDVTEDNVQIRGRARSVEGKKHNGSGLTGVKRHAVSETSQKSQQGTGNGTMTNIAEEQTITVTYNFNF

ORF2

Double gene block protein 1

65 amino acids

Cell-to-cell movement. Displays RNA-binding activity.

Belongs to the carmovirus double gene block protein 1 family.

7.121 kDa

MDSQRTVELTNPRGRSKERGDSGGKQKNSMGRKIANDAISESKQGVMGASTYIADKIKVTINFNF

ORF2

Probable movement protein p8

65 amino acids

Cell-to-cell movement.

Belongs to the carmovirus/necrovirus/panicovirus movement protein p8 family.

7.492 kDa

MENTENVRSGRNQREYSKERQQEGGYKEVSKAAVRKEGDVKQDMGPSVSMTVVGEKVEFTQHFHF

ORF2

Double gene block protein 1

61 amino acids

Cell-to-cell movement. Displays RNA-binding activity.

Belongs to the carmovirus double gene block protein 1 family.

6.831 kDa

MDIEPEVPVVEKQMLAGNRGKQKTRRSVAKDAIRKPASDSTNGGNWVNVADKIEVHIHFNF

ORF2

Double gene block protein 1

61 amino acids

Cell-to-cell movement. Displays RNA-binding activity (By similarity).

Belongs to the carmovirus double gene block protein 1 family.

6.749 kDa

MDIESEVPVVGKQMLAGNRGKQKTRRSVAKDAIRKPASDSTNGGNWVNVADKIEVHIHFNF

ORF2

Uncharacterized ORF2 protein

59 amino acids

6.615 kDa

MDPAKIWWHSCLLSHKSWCNCTEPRNHLPGWPTSEGTSTEDGDIITDAEMLTLAEDTEG

ORF2

Movement protein p6

54 amino acids

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Two movement proteins, p6, Hsp70h and three structural proteins, CP, CPm, and P64 are essential for cell-cell movement. Also plays a role in virion formation. Together with CPm and p64, encapsidates the 5'-terminal portion of the viral genome (By similarity).

6.389 kDa

MDCVLRSYLLLAFGFLICLFLFCLVVFIWFVYKQILFRTTAQSNEARHNHSTVV

ORF2

Uncharacterized 6 kDa protein

51 amino acids

5.895 kDa

MYSRGSFFKSRVTLPTLVGAYMWEFELPYLTDKRHISYSAPSVATFSLVSR