The capsid polyprotein VP90 self-assembles and undergoes a proteolytic cleavage by host caspases to yield the VP70 virions. This immature virion is composed of 180 VP70 subunits with 90 dimeric spikes and displays a T=3 icosahedral symmetry. The mature virion is obtained by further cleavages resulting in three structural proteins VP25, VP27 and VP34. This forms contains only 30 spikes located on the icosahedral 2-fold axes. Plays a role in the attachment to target host cell. This attachment induces virion internalization through clathrin-dependent endocytosis (By similarity).

Belongs to the astroviridae capsid polyprotein family.

791 amino acids

MASKSDKQVTVEVNNNNGRSRSRSRGRSQSRGRGRSFKITVNSKNRGRRQNGRNKLQSNQRVRNIVNKQLRKQGVTGPKPAICQRATATLGTIGSNTSGSTEIEACILLNPVLVKDATGSTQFGPVQALGAQYSMWKLKYLNVKLTSMVGSSAVNGTAVRISLNPTSTPSSTSWSGLGARKHLDVTVGKNAVFRLKPADLGGPRDGWWLTNTNDNASDTLGPSIEIHTLGKTMSSYLNQQFTGGLFLVELASEWCFTGYAANPNLVNLMKSTDKQVNVSFEGDNGTPLIMKVPDTSHFARTAVARSSLPTTLARAGQNTTSDTVWQVLNTAVSAAEIVTPPPFNWLIKGGWWFVKLIAGRSRAGMRSFYVYPSYQDALSNKPALCTGSVPGGMRVRAAIPTTLQFTQMNQPSLGHGEVTATLGRSIPTPGDTFKVVLTIGQPLAPNTLNNQTWVNKTTTAPQGQHVVKIAKDTSNYTTMQGFTPISNVTWYTEDFQPSEEPPPISGLQVLVDSRKKADVYAVQQYLNHPSNTKDQLTSIFLVKVTTSFQVNNHLSYFYRAAGTGTAVENFKIRGATSEQNISFSEGWYLMTNTATFNPPAPPGWIWKNVELDNNTPYIVDQGMMHLIMSPPVGTQLLFEMKTTVSGTRNVSHFDHDENPSPVWCDALDAADVWELPTETDTESEEDEDEDDEADRFDLHSSYGSEPEDDDENNRVTLLSTLINQGMTVERATMITKRAFPTCADKQKRSVHMDLLASGLSPGNVWSHACEEARTMGTNHMPNVSGDRGHAE

86.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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