Description
Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells by binding to feline junctional adhesion molecule A (F11R) and/or to alpha-2,6-linked sialic acid. Once attached, the virion is endocytosed. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).
Family
Belongs to the caliciviridae capsid protein family.
Species
Feline calicivirus (strain Cat/United States/Urbana/1960)
Sequence
MCSTCANVLKYYNWDPHFKLVINPNKFLSIGFCDNPLMCCYPELLPEFGTVWDCDQSPLQIYLESILGDDEWSSTYEAIDPVVPPMHWNEAGKIFQPHPGVLMHHIIGEVAKAWDPNLPLFRLEADDGSITAPEQGTVVGGVIAEPSSQMSTAADMASGKSVDSEWEAFFSFHTSVNWSTSETQGKILFKQSLGPLLNPYLEHLSKLYVAWSGSVEVRFSISGSGVFGGKLAAIVVPPGVDPIQSTSMLQYPHVLFDARQVEPVIFTIPDLRSTLYHLMSDTDTTSLVIMVYNDLINPYANDSNSSGCIVTVETKPGSDFKFHLLKPPGSMLTHGSVPSDLIPKTSSLWIGNRFWSDITDFVIRPFVFQANRHFDFNQETAGWSTPRFRPITVTISEKNGAKLGVGVATDFIVPGIPDGWPDTTIGEKLVPAGDYAITNGSGNDITTANQYDAADIIRNNTNFKGMYICGSLQRAWGDKKISNTAFITTATVEGNDLIPSNVIDQTKIAIFQDNHVQDEVQTSDDTLALLGYTGIGEEAIGANRERVVRISTLPETGARGGNHPIFYKNSIKLGYVIRSIDVFNSQILHTSRQLSLNHYLLPPDSFAVYRIIDSNGSWFDVGIDFDGFSFVGVSDVGKLEFPLTASYMGIQLAKIRLASNIRSTMTKL
Simulated SDS-PAGE
(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)
Safety
Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.
Protein synthesis service