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thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Haloferax volcanii
Length
342 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
38.449 kDa
Sequence
MTTTPNQGTSHAPIFDLVTDVFGTGRHKPNRTGVDTISGFSKHYTVDLQEGFPLLTTKDLSGFRWNSLIHELLWYFSGEEHIRTLREETGIWDAWADEEGHLDTAYGRFWRRYPVPEEGLAGEAWPDDGHRWMNDEGTFDQLAYVLDTLDENPNSRRLVINAWHPANAAVSTLPPCHYTFVFNVQGDELNLHLTQRSGDIALGVPFNLAAYAILAQVVAQRAGFELGSFAHTIVDAHVYCGAGERGAWYGDHLDELQSRLADVQSPDEYLDVREWLLDAAPEEADGEEDYDHVPGLLLQASREPRERPALDVADVPLEDLSFEDIVLRDYDPADGIRFAVAE
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)
Length
323 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.406 kDa
Sequence
MKQYLDLVQSILDQGAWQENRTGVRTLSLPGAALRFDLQQGFPAVTTKKLAFKSAIGEMVGFLRATRSAAQFRALGCKVWDQNANENEQWLANPYREGPDDLGPVYGVQWRHWPAYKLLPRSAGGQVADALARGYRQVAEVAENGAPHVLLYKAVDQLRQCLDTIHQSPGDRRILFHGWNWAQIEEMALPPCHLLYQFLPNAGTREISLCLYIRSNDVGLGTPFNLTEGAALLHLVGRLTGYKPRWFSYFIGDAHVYENHLPMLREQLTREPYPAPQLVLSDRIPDFAVTGKYEPQWLEQVEPGDFTLSGYQHHAPLTAPMAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
Length
323 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.406 kDa
Sequence
MKQYLDLVQSILDQGAWQENRTGVRTLSLPGAALRFDLQQGFPAVTTKKLAFKSAIGEMVGFLRATRSAAQFRALGCKVWDQNANENEQWLANPYREGPDDLGPVYGVQWRHWPAYKLLPRSAGGQVADALARGYRQVAEVAENGAPHVLLYKAVDQLRQCLDTIHQSPGDRRILFHGWNWAQIEEMALPPCHLLYQFLPNAGTREISLCLYIRSNDVGLGTPFNLTEGAALLHLVGRLTGYKPRWFSYFIGDAHVYENHLPMLREQLTREPYPAPQLVLSDRIPDFAVTGKYEPQWLEQVEPGDFTLSGYQHHAPLTAPMAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Length
323 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.37 kDa
Sequence
MKQYLDLVQSILDQGAWQENRTGVRTLSLPGAALRFDLQQGFPAVTTKKLAFKSAIGEMVGFLRATRSAAQFRALGCKVWDQNANENEQWLANPYREGPDDLGPVYGVQWRHWPAYKLLPSSAGGQVADALARGYRQVAEVDENGAPHVLLYKAVDQLRQCLDTIRQSPGDRRILFHGWNWAQIEEMALPPCHLLYQFLPNAGTREISLCLYIRSNDVGLGTPFNLTEGAALLHLVGRLTGYKPRWFSYFIGDAHVYENHLPMLREQLAREPYPAPQLVLSDRIPDFAVTGKYEPQWLEQVEPGDFTLSGYQHHAPLTAPMAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Length
323 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.772 kDa
Sequence
MKQYLDLVRDVIDNGTLQGNRTGIRTISLPGAMLRFDLQKGFPAITTRKLAFKSAIGEMVGFLRGVKNAGEFRELGCKVWDQNANENAQWLANPFRQGHDDLGEIYGVQWRQWPGYKRIPLSNPAAIEMAEQAGFRRIAQDEEDGVAFVILYKAIDQVRQCLDTIANDPGSRRILFHGWNCAQLDEMALPPCHLLYQFHPNVETREISLTLYIRSNDLGLGTPFNLTEGAALLSLFGRLTGYTPRWFTYFIGDAHVYENHLDMLNEQLKREPLEAPKLVISDRVPAFAETGKYEPEWLEKIEPSDFWLEGYEHHAPMTAPMAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)
Length
323 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.724 kDa
Sequence
MKQYLELVAHVIKHGTLQANRTGVNTISFPGAMLRYDLQEGFPAITTRRMAFKSAIGEMVGFLRGVSNAAEFRELGCKVWDQNANENAQWLNNPFRKGEDDLGEIYGVQWRKWPAYKRIDTGNVAAIELALGQGYRQIAESEEDGQSFVVLYKAIDQIRQCIDTIINDPGSRRILFHGWNCAQLDEMALPPCHLLYQLHPNPQTREISLTLYIRSNDLGLGTPFNLTEGAALLSLIGRLTGYTPRWFTYFIGDAHVYENHLDMLNEQMTREPYPMPKLVISDRVPEFAKTGVYQPEWLELIEPSDFSLEGYQHHPAMTAPMAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / NCDO 523)
Length
322 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
37.165 kDa
Sequence
MSQNEQQYLDLAQKILDEGSHKGDRTGTGTRSLFGTQMRFNLAEGFPLLTTKKVFFGLIKSELLWFLRGDNNIRFLLEHNNHIWDEWAFKKWIESDKYTGPDMTNFGLRSQTDENFAKIYKEQKDIFVNNILNDDEFKEEFGYIGNVYGKLWRSWETNSLTAGDETVDQVARLIDQIKETPNSRRLILTAWNAETTPQAPLPSCHVLSQFYVADGKLSLQMYQRSGDFFLGVPFNIASYSLLLHMVAAQTGYEVGEFIHTIGDTHIYNNHVDQITEQLSRPMHKLPKLWLNPEVKSLFDYTMDDIKILDYDSEPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Lactobacillus reuteri (strain DSM 20016)
Length
320 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.982 kDa
Sequence
MATNVNEEQYLDLIRYVLANGHQKGDRTGTGTKSVFGYQMRFDLSKGFPILTTKKVPFGLIKSELLWFLRGDTNIRFLLQHKNHIWDEWAFKKWVESDEYQGPDMTDFGHRWLKDPEFKQVYLQEKKAFCQRILEDDDFAQKYGDLGLVYGSQWRKWKTSQGDTIDQIANVIQQIKTTPDSRRMIVSAWNPEDVPSMALPPCHTMFQFYVNDGKLSCQLYQRSADIFLGVPFNIASYALLTHMIAHQCGLEPGEFVHTLGDAHIYLNHLDQVKEQLTRTPHEAPKLILPAEPKPIDQYEMTDIKLEGYTHEPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Oenococcus oeni (strain ATCC BAA-331 / PSU-1)
Length
319 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.992 kDa
Sequence
MSRNEEQYLNLARRILETGASKMDRTKTGTHSIFGAQMRFDLSEGFPLLTSKKVAFGRIKSELLWFLRGDNNIRFLLQHHNHIWDEWPFKKWVESNEYKGPDMTDFGLRTQKDPIFAEQYKEQKKIFVDRILNDDEFSKKFGTIGDVYGKLWRHWPDANDDGSVDQITRLINEIKVNPNSRRLILTAWDPETTPFATLPSCHVMSQFYVVDGKISLQMYQRSADYFLGVPFNIASYSLLLSMVAAQTGLEVGEFIHTIGDAHIYNNHVDQIKEQLSKPTHKLPTLKLNPDVKSIFDYEMSDIKLENYIHEDVIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bacillus thuringiensis (strain Al Hakam)
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.893 kDa
Sequence
MKHAENEYLNLCRHVMEHGTKKEDRTGTGTVSVFGYQMRFDLSKGFPLLTTKRVPFRLVASELLWFMKGDTNIRYLLQHNNNIWNEWAFKSWVESDEYTGPDMIDFGLRSQQDEEFKVQYDEQMELFKKNVLEDDEFSNKYGYLGDVYGKQWRAWKTTAGETLDQLKDVIEMIKKTPDSRRLIVSAWNPEDVPSMALPPCHTLFQFYVADGKLSCQLYQRSGDIFLGIPFNIASYSLLTHLIAHECGLEVGEFVHTIGDAHIYTNHFEQVEKQLAREPRPFPKLTLNPDVKSVFDFEMEDLTIEGYDPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bacillus anthracis
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.893 kDa
Sequence
MKHAENEYLNLCRHVMEHGTKKEDRTGTGTVSVFGYQMRFDLSKGFPLLTTKRVPFRLVASELLWFMKGDTNIRYLLQHNNNIWNEWAFKSWVESDEYTGPDMIDFGLRSQQDEEFKVQYDEQMELFKKNVLEDDEFSNKYGYLGDVYGKQWRAWKTTAGETLDQLKDVIEMIKKTPDSRRLIVSAWNPEDVPSMALPPCHTLFQFYVADGKLSCQLYQRSGDIFLGIPFNIASYSLLTHLIAHECGLEVGEFVHTIGDAHIYTNHFEQVEKQLAREPRPFPKLTLNPDVKSVFDFEMEDLTIEGYDPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bacillus cereus (strain ATCC 10987 / NRS 248)
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.867 kDa
Sequence
MKHAENEYLNLCRHVMEHGTKKEDRTGTGTVSVFGYQMRFDLSKGFPLLTTKRVPFRLVASELLWFMKGDTNIRYLLQHNNNIWNEWAFKSWVESDEYTGPDMTDFGLRSQQDEEFKVQYDEQMELFKKNVLEDDDFSNKYGYLGDVYGKQWRAWKTTAGETLDQLKDVIEMIKKTPDSRRLIVSAWNPEDVPSMALPPCHTLFQFYVADGKLSCQLYQRSGDIFLGIPFNIASYSLLTHLIAHECGLEVGEFVHTIGDAHIYTNHFEQVEKQLAREPRPFPKLTLNPDVKSVFDFEMEDLTIEGYDPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.81 kDa
Sequence
MKHAEYEYLNLCRHVMEHGTKKEDRTGTGTVSVFGYQMRFDLSKGFPLLTTKRVPFRLVASELLWFMKGDTNIRYLLQHNNNIWNEWAFKNWVESDEYKGPDMTNFGLRSQEDEAFKTQYDEQMEIFKKNVLEDDEFARKYGYLGDVYGKQWRAWKTAAGETIDQLKDVIEMIKKTPDSRRLIVSAWNPEDVPNMALPPCHTLFQFYVADGKLSCQLYQRSGDIFLGIPFNIASYSLLTHLIAHECGLAVGEFVHTIGDAHIYTNHFEQVKKQLAREPRPFPTLKLNSDVKSVFDFEMGDLTIEGYDPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.881 kDa
Sequence
MKHAENEYLNLCRHVMEHGTKKEDRTGTGTVSVFGYQMRFDLSKGFPLLTTKRVPFRLVASELLWFMKGDTNIRYLLQHNNNIWNEWAFKSWVESDEYTGPDMTDFGLRSQQDEEFKVQYDEQMELFKKNVLEDDEFSNKYGYLGDVYGKQWRAWKTTAGETLDQLKDVIEMIKKTPDSRRLIVSAWNPEDVPSMALPPCHTLFQFYVADGKLSCQLYQRSGDIFLGIPFNIASYSLLTHLIAHECGLEVGEFVHTIGDAHIYTNHFEQVEKQLAREPRPFPKLTLNPDVKSVFDFEMEDLTIEGYDPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bacillus cereus (strain ZK / E33L)
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.866 kDa
Sequence
MKHAENEYLNLCRHVMEHGTKKEDRTGTGTVSVFGYQMRFDLSKGFPLLTTKRVPFRLVASELLWFMKGDTNIRYLLQHNNNIWNEWAFKSWVESDEYTGPDMTDFGLRSQQDEEFKVQYDKQMELFKKNVLEDDDFSNKYGYLGDVYGKQWRAWKTTAGETLDQLKDVIEMIKKTPDSRRLIVSAWNPEDVPSMALPPCHTLFQFYVADGKLSCQLYQRSGDIFLGIPFNIASYSLLTHLIAHECGLEVGEFVHTIGDAHIYTNHFEQVEKQLAREPRPFPKLTLNPDVKSVFDFEMEDLTIEGYDPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bacillus thuringiensis subsp. konkukian (strain 97-27)
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.893 kDa
Sequence
MKHAENEYLNLCRHVMEHGTKKEDRTGTGTVSVFGYQMRFDLSKGFPLLTTKRVPFRLVASELLWFMKGDTNIRYLLQHNNNIWNEWAFKSWVESDEYTGPDMIDFGLRSQQDEEFKVQYDEQMELFKKNVLEDDEFSNKYGYLGDVYGKQWRAWKTTAGETLDQLKDVIEMIKKTPDSRRLIVSAWNPEDVPSMALPPCHTLFQFYVADGKLSCQLYQRSGDIFLGIPFNIASYSLLTHLIAHECGLEVGEFVHTIGDAHIYTNHFEQVEKQLAREPRPFPKLTLNPDVKSVFDFEMEDLTIEGYDPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081 / JCM 1002 / NBRC 13953 / NCIMB 11778)
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.371 kDa
Sequence
MANQDQAYLDLLKKIMTEGNDKNDRTGTGTRSLFGAQMRFDLSQGFPILTTKRVPFGLIKSELLWFLRGDTNIRFLLEHKNHIWDEWAFKNWVTSPEYQGPDMTDFGLRSQKDPGFKAVYDEEMQKFCQRILDDEAFAQKYGNLGDVYGAQWRHWGKRDGGFIDQIADVIEQIKTNPDSRRLIVTAWNPEDVPSSALPPCHVLFQFYVADGKLSLQLYQRSGDMFLGVPFNIASYSLLLSLIARETGLEVGEFVHTIGDAHIYKNHFAQVEEQLKRKPFDAPTLWLNPGKKKVADFEMADIKLVNYQHGSTIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365)
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.371 kDa
Sequence
MANQDQAYLDLLKKIMTEGNDKNDRTGTGTRSLFGAQMRFDLSQGFPILTTKRVPFGLIKSELLWFLRGDTNIRFLLEHKNHIWDEWAFKNWVTSPEYQGPDMTDFGLRSQKDPGFKAVYDEEMQKFCQRILDDEAFAQKYGNLGDVYGAQWRHWGKRDGGFIDQIADVIEQIKTNPDSRRLIVTAWNPEDVPSSALPPCHVLFQFYVADGKLSLQLYQRSGDMFLGVPFNIASYSLLLSLIARETGLEVGEFVHTIGDAHIYKNHFAQVEEQLKRKPFDAPTLWLNPGKKKVADFEMADIKLVNYQHGSTIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Lactobacillus gasseri (strain ATCC 33323 / DSM 20243 / JCM 1131 / NCIMB 11718 / AM63)
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
37.111 kDa
Sequence
MATLEQPYLDLLNKIMIEGHDKEDRTGTGTRSIFGAQMRFNLSEGFPILTTKRVPFGLIKSELLWFLRGDTNIRFLLEHNNHIWDEWAFKNWVESDEYHGPDMTNFGLRSQEDAKFKQVYQEEMKKFDERILADRDFAVKFGNLGDVYGAQWRHWQKREGGFIDQIQNVIDQIKKTPYSRRLIVSAWNPEDVPNSALPPCHVLFQFYVNDGRLSVQLYQRSGDMFLGVPFNIASYSLLVNLIAQETGLKPGEFIHTLGDAHIYRNHFDQVKELLTRKPYDSPKLWLNPDKKKIEDFEMSDIKLVDYKHHGTIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Lactobacillus helveticus (strain DPC 4571)
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.882 kDa
Sequence
MAILEQPYLDLLQKIMSEGHGKDDRTGTGTRSYFGAQMRFDLSQGFPLLTTKKVPFGLIKSELLWFLRGDTNIRFLLEHNNHIWDEWAFKNWVNSSEYQGPDMTDFGLRSQSDPEFNKIYQAEMKKFDQRILDDEDFAKKYGNLGDVYGAQWRHWEKREGGFIDQIADVIKQIKETPDSRRMIVTAWNPEDVPTSALPPCHVMFQFYVVDGKISVQLYQRSGDMFLGVPFNIASYSLLLNLIARETGLQVGEFIHTLGDAHIYRNHLKQVEELLSRKPYDSPQLWLNPEKKNIADFEMKDIKVVDYQHHGTIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533)
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
37.037 kDa
Sequence
MATLEQPYLDLLSKIMSEGHDKEDRTGTGTRSLFGAQMRFDLNDGFPILTTKKIPFGLIKSELLWFLRGDTNIRFLLEHNNHIWDEWAFKNWVESNEYQGPDMTNFGLRSQQDPEFKRIYQEEMKKFDQKVLEDQTFAEKYGNLGDVYGAQWRHWQKREGGFIDQIQNVIDQIKKTPYSRRLIVSAWNPEDVPTSALPPCHVLFQFYVNDGCLSLQLYQRSGDMFLGVPFNIASYALLVNLVARETGLKPGEFIHTLGDAHIYKNHFNQVKELLNRSAYDAPMLWLNPDKKLVQDFEMKDIKLINYRHHGTIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Lactobacillus salivarius (strain UCC118)
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.978 kDa
Sequence
MSIVEEPYLQLIRDILEKGHEKSDRTGTGTKSLFGYQMRFNLAEGFPLLTTKKVPFGLIKSELLWFLRGDTNIRFLLEHNNHIWDEWAFKNWVESDEYHGPDMTNFGLRAQEDDNFNKVYQDEKKKFCQKIVEDQEFANKFGNLGDVYGAQWRHWQTRNGETIDQIKDVIETIKNNPDSRRMIVTAWNPEDVPLSALPPCHTLFQFYVNDGKLSCQLYQRSADVFLGVPFNIASYALLTHMIARETGLEVGEFVHTLGDAHIYLNHLDQVNEQLQRKPNDAPTLWLNPEKKNIMDFEMEDIKVKNYHSHSAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
37.084 kDa
Sequence
MAILEQPYLDLINKIMIEGHDKNDRTGTGTRSYFGAQMRFDLSKGFPILTTKKVPFGLIKSELLWFLRGDTNIRFLLEHKNHIWDEWAFKNWVNSDEYTGPDMTDFGLRSQSDPEFNKIYQAELKKFDRRILDDENFAKKYGNLGDVYGAQWRHWQKRDGSFIDQIENVIEQIKNNPDSRRMIVTAWNPEDVPTSALPPCHVMFQFYVVDGKISVQLYQRSGDMFLGVPFNIASYALLLNMIARETGLQVGEFIHTLGDAHIYSNHFSQVKEMLSRKPYESPQLWLNPEKKHIEDFDMQDIKLVDYKHHGTIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Staphylococcus aureus (strain JH9)
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.825 kDa
Sequence
MLNSFDAAYHSLCEEVLEIGNTRNDRTNTGTISKFGHQLRFDLSKGFPLLTTKKVSFKLVATELLWFIKGDTNIQYLLKYNNNIWNEWAFENYIKSDEYNGPDMTDFGHRALSDPEFNEQYKEQMKQFKQRILEDDTFAKQFGDLGNVYGKQWRDWVDKDGNHFDQLKTVIEQIKHNPDSRRHIVSAWNPTEIDTMALPPCHTMFQFYVQDGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAKECGLEVGEFVHTFGDAHIYSNHIDAIQTQLARESFNPPTLKINSDKSIFDINYEDLEIVDYESHPAIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Staphylococcus aureus (strain bovine RF122 / ET3-1)
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.839 kDa
Sequence
MLNSFDAAYHSLCEEVLEIGNTRNDRTNTGTISKFGHQLRFDLSKGFPLLTTKKVSFKLVATELLWFIKGDTNIQYLLKYNNNIWNEWAFENYIKSDEYKGPDMTDFGHRALSDPEFNEQYKEQMKQFKQRILEDDTFAKQFGDLGNVYGKQWRDWVDKDGNHFDQLKTVIEQIKHNPDSRRHIVSAWNPTEIDTMALPPCHTMFQFYVQDGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAKECGLEVGEFVHTFGDAHIYSNHIDAIQTQLARESFNPPTLKINSDKSIFDINYEDLEIVDYESHPAIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Staphylococcus aureus (strain COL)
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.839 kDa
Sequence
MLNSFDAAYHSLCEEVLEIGNTRNDRTNTGTISKFGHQLRFDLSKGFPLLTTKKVSFKLVATELLWFIKGDTNIQYLLKYNNNIWNEWAFENYIKSDEYKGPDMTDFGHRALSDPEFNEQYKEQMKQFKQRILEDDTFAKQFGDLGNVYGKQWRDWVDKDGNHFDQLKTVIEQIKHNPDSRRHIVSAWNPTEIDTMALPPCHTMFQFYVQDGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAKECGLEVGEFVHTFGDAHIYSNHIDAIQTQLARESFNPPTLKINSDKSIFDINYEDLEIVDYESHPAIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Staphylococcus aureus (strain Newman)
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.839 kDa
Sequence
MLNSFDAAYHSLCEEVLEIGNTRNDRTNTGTISKFGHQLRFDLSKGFPLLTTKKVSFKLVATELLWFIKGDTNIQYLLKYNNNIWNEWAFENYIKSDEYKGPDMTDFGHRALSDPEFNEQYKEQMKQFKQRILEDDTFAKQFGDLGNVYGKQWRDWVDKDGNHFDQLKTVIEQIKHNPDSRRHIVSAWNPTEIDTMALPPCHTMFQFYVQDGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAKECGLEVGEFVHTFGDAHIYSNHIDAIQTQLARESFNPPTLKINSDKSIFDINYEDLEIVDYESHPAIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.825 kDa
Sequence
MLNSFDAAYHSLCEEVLEIGNTRNDRTNTGTISKFGHQLRFDLSKGFPLLTTKKVSFKLVATELLWFIKGDTNIQYLLKYNNNIWNEWAFENYIKSDEYNGPDMTDFGHRALSDPEFNEQYKEQMKQFKQRILEDDTFAKQFGDLGNVYGKQWRDWVDKDGNHFDQLKTVIEQIKHNPDSRRHIVSAWNPTEIDTMALPPCHTMFQFYVQDGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAKECGLEVGEFVHTFGDAHIYSNHIDAIQTQLARESFNPPTLKINSDKSIFDINYEDLEIVDYESHPAIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Staphylococcus aureus (strain N315)
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.825 kDa
Sequence
MLNSFDAAYHSLCEEVLEIGNTRNDRTNTGTISKFGHQLRFDLSKGFPLLTTKKVSFKLVATELLWFIKGDTNIQYLLKYNNNIWNEWAFENYIKSDEYNGPDMTDFGHRALSDPEFNEQYKEQMKQFKQRILEDDTFAKQFGDLGNVYGKQWRDWVDKDGNHFDQLKTVIEQIKHNPDSRRHIVSAWNPTEIDTMALPPCHTMFQFYVQDGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAKECGLEVGEFVHTFGDAHIYSNHIDAIQTQLARESFNPPTLKINSDKSIFDINYEDLEIVDYESHPAIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Staphylococcus aureus (strain MRSA252)
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.839 kDa
Sequence
MLNSFDAAYHSLCEEVLEIGNTRNDRTNTGTISKFGHQLRFDLSKGFPLLTTKKVSFKLVATELLWFIKGDTNIQYLLKYNNNIWNEWAFENYIKSDEYKGPDMTDFGHRALSDPEFNEQYKEQMKQFKQRILEDDTFAKQFGDLGNVYGKQWRDWVDKDGNHFDQLKTVIEQIKHNPDSRRHIVSAWNPTEIDTMALPPCHTMFQFYVQDGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAKECGLEVGEFVHTFGDAHIYSNHIDAIQTQLARESFNPPTLKINSDKSIFDINYEDLEIVDYESHPAIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Staphylococcus aureus (strain MSSA476)
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.825 kDa
Sequence
MLNSFDAAYHSLCEEVLEIGNTRNDRTNTGTISKFGHQLRFDLSKGFPLLTTKKVSFKLVATELLWFIKGDTNIQYLLKYNNNIWNEWAFENYIKSDEYNGPDMTDFGHRALSDPEFNEQYKEQMKQFKQRILEDDTFAKQFGDLGNVYGKQWRDWVDKDGNHFDQLKTVIEQIKHNPDSRRHIVSAWNPTEIDTMALPPCHTMFQFYVQDGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAKECGLEVGEFVHTFGDAHIYSNHIDAIQTQLARESFNPPTLKINSDKSIFDINYEDLEIVDYESHPAIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Staphylococcus aureus (strain USA300 / TCH1516)
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.839 kDa
Sequence
MLNSFDAAYHSLCEEVLEIGNTRNDRTNTGTISKFGHQLRFDLSKGFPLLTTKKVSFKLVATELLWFIKGDTNIQYLLKYNNNIWNEWAFENYIKSDEYKGPDMTDFGHRALSDPEFNEQYKEQMKQFKQRILEDDTFAKQFGDLGNVYGKQWRDWVDKDGNHFDQLKTVIEQIKHNPDSRRHIVSAWNPTEIDTMALPPCHTMFQFYVQDGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAKECGLEVGEFVHTFGDAHIYSNHIDAIQTQLARESFNPPTLKINSDKSIFDINYEDLEIVDYESHPAIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Staphylococcus aureus
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
37.178 kDa
Sequence
MYNPFDEAYHGLCEEILEIGNRRDDRTHTGTISKFGHQLRFDLTKGFPLLTTKKVSFKLVATELLWFIKGDTNIQYLLKYNNNIWNEWAFENYVQSDDYHGPDMTDFGHRSQQDPEFNEQYKEEMKKFKERILNDDAFAKKYGNLGNVYGKQWRDWEDKNGNHYDQLKSVIQQIKTNPNSRRHIVSAWNPTEIDSMALPPCHTMFQFYVQEGKLNCQLYQRSADIFLGVPFNIASYALLTHLVAKECGLEVGEFIHTFGDAHIYSNHMDAIHTQLSRDSYLPPQLKINTDKSIFDINYEDLELINYESHPAIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Staphylococcus aureus (strain MW2)
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.825 kDa
Sequence
MLNSFDAAYHSLCEEVLEIGNTRNDRTNTGTISKFGHQLRFDLSKGFPLLTTKKVSFKLVATELLWFIKGDTNIQYLLKYNNNIWNEWAFENYIKSDEYNGPDMTDFGHRALSDPEFNEQYKEQMKQFKQRILEDDTFAKQFGDLGNVYGKQWRDWVDKDGNHFDQLKTVIEQIKHNPDSRRHIVSAWNPTEIDTMALPPCHTMFQFYVQDGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAKECGLEVGEFVHTFGDAHIYSNHIDAIQTQLARESFNPPTLKINSDKSIFDINYEDLEIVDYESHPAIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Staphylococcus epidermidis (strain ATCC 12228)
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
37.178 kDa
Sequence
MYNPFDEAYHGLCEEILEIGNRRDDRTHTGTISKFGHQLRFDLTKGFPLLTTKKVSFKLVATELLWFIKGDTNIQYLLKYNNNIWNEWAFENYVQSDDYHGPDMTDFGHRSQQDPEFNEQYKEEMKKFKERILNDDAFAKKYGNLGNVYGKQWRDWEDKNGNHYDQLKSVIQQIKTNPNSRRHIVSAWNPTEIDSMALPPCHTMFQFYVQEGKLNCQLYQRSADIFLGVPFNIASYALLTHLVAKECGLEVGEFIHTFGDAHIYSNHMDAIHTQLSRDSYLPPQLKINTDKSIFDINYEDLELINYESHPAIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Staphylococcus haemolyticus (strain JCSC1435)
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.85 kDa
Sequence
MLNSFDSAYHALCEEILEIGNQRDDRTHTGTFSKFGHQLRFDLSKGFPLLTTKKVSFKLIATELLWFIKGDTNIQYLLKYNNNIWNEWAFEKYVQSNDYHGPDMTNFGHRALQDDEFNELYKEEMSKFKQHILNDDSFAKKYGDLGNVYGKQWRDWVDKEGNHFDQLKTVIEQIKNSPNSRRHIVSAWNPTEIDSMALPPCHTMFQFYVQDGRLSCQLYQRSADIFLGVPFNIASYALLTHLIAKECNLEVGEFVHTFGDAHIYSNHIEAIKTQLSRNSFDPPTLKINSNASIFDINYEDLELIGYNSHPAIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.954 kDa
Sequence
MLNAFDQAYHQLCEEILEIGKQKNDRTNTGTISKFGHQLRFDLSKGFPLLTTKKVSFKLIATELLWFIKGDTNIKYLLQYNNNIWNEWAFEKFVQSKDYNGPDMTDFGHRAQKDESFNLIYKDEMNQFKKRILNDDDFAKKYGDLGNVYGKQWRDWEDKYGNHYDQLKTVINQIKTNPNSRRHIVSAWNPTEIDTMALPPCHTMFQFYVQDGKLSCQLYQRSADIFLGVPFNIASYSLLTHLIAKECGLEVGEFVHTFGDAHIYSNHIEAIETQLARESYNPPTLNINSDASIFDIDYEDLEIVDYESHPAIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Staphylococcus aureus (strain Mu3 / ATCC 700698)
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.825 kDa
Sequence
MLNSFDAAYHSLCEEVLEIGNTRNDRTNTGTISKFGHQLRFDLSKGFPLLTTKKVSFKLVATELLWFIKGDTNIQYLLKYNNNIWNEWAFENYIKSDEYNGPDMTDFGHRALSDPEFNEQYKEQMKQFKQRILEDDTFAKQFGDLGNVYGKQWRDWVDKDGNHFDQLKTVIEQIKHNPDSRRHIVSAWNPTEIDTMALPPCHTMFQFYVQDGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAKECGLEVGEFVHTFGDAHIYSNHIDAIQTQLARESFNPPTLKINSDKSIFDINYEDLEIVDYESHPAIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Staphylococcus aureus (strain JH1)
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.825 kDa
Sequence
MLNSFDAAYHSLCEEVLEIGNTRNDRTNTGTISKFGHQLRFDLSKGFPLLTTKKVSFKLVATELLWFIKGDTNIQYLLKYNNNIWNEWAFENYIKSDEYNGPDMTDFGHRALSDPEFNEQYKEQMKQFKQRILEDDTFAKQFGDLGNVYGKQWRDWVDKDGNHFDQLKTVIEQIKHNPDSRRHIVSAWNPTEIDTMALPPCHTMFQFYVQDGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAKECGLEVGEFVHTFGDAHIYSNHIDAIQTQLARESFNPPTLKINSDKSIFDINYEDLEIVDYESHPAIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Staphylococcus aureus (strain USA300)
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.839 kDa
Sequence
MLNSFDAAYHSLCEEVLEIGNTRNDRTNTGTISKFGHQLRFDLSKGFPLLTTKKVSFKLVATELLWFIKGDTNIQYLLKYNNNIWNEWAFENYIKSDEYKGPDMTDFGHRALSDPEFNEQYKEQMKQFKQRILEDDTFAKQFGDLGNVYGKQWRDWVDKDGNHFDQLKTVIEQIKHNPDSRRHIVSAWNPTEIDTMALPPCHTMFQFYVQDGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAKECGLEVGEFVHTFGDAHIYSNHIDAIQTQLARESFNPPTLKINSDKSIFDINYEDLEIVDYESHPAIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Staphylococcus aureus (strain NCTC 8325)
Length
318 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.839 kDa
Sequence
MLNSFDAAYHSLCEEVLEIGNTRNDRTNTGTISKFGHQLRFDLSKGFPLLTTKKVSFKLVATELLWFIKGDTNIQYLLKYNNNIWNEWAFENYIKSDEYKGPDMTDFGHRALSDPEFNEQYKEQMKQFKQRILEDDTFAKQFGDLGNVYGKQWRDWVDKDGNHFDQLKTVIEQIKHNPDSRRHIVSAWNPTEIDTMALPPCHTMFQFYVQDGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAKECGLEVGEFVHTFGDAHIYSNHIDAIQTQLARESFNPPTLKINSDKSIFDINYEDLEIVDYESHPAIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831)
Length
317 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.834 kDa
Sequence
MLGEQAYLDLCKQIFKTGEQRGDRTNTGTHSIFGHQIRFDLNKGFPLLTTKRVPFRLVASELLWFIKGDTNIRYLLKHNNNIWNEWAFEKWVNSADYQGPDMANFGLRSQKDENFNKQYQEQMELFKTRILEDDSFADKYGDLGSVYGKQWRNWKTTQNETIDQLKDVIHSIKTNPNSRRHIVSAWNPEDIPTMALPPCHTLFQFYVSNGKLSCQLYQRSADVFLGVPFNIASYALLTHLIAHECGLEVGDFVHTFGDAHIYSNHVEQVETQLEREIRDFPQLIINKDKNSIFEMDLDDLVIENYNPHPSIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Lactobacillus casei
Length
316 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.58 kDa
Sequence
MLEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSELLWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHEEMAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAWHTSKGDTIDQLGDVIEQIKTHPYSRRLIVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNIASYALLTHLVAHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDFDMKDIKLLNYDPYPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Lactobacillus paracasei (strain ATCC 334 / BCRC 17002 / CIP 107868 / KCTC 3260 / NRRL B-441)
Length
316 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.522 kDa
Sequence
MLEQPYLDLAQKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSELLWFLRGDTNIRFLLQHKNHIWDEWAFEKWVASPDYHGPDMTDFGHRSQKDPEFAASYREQMAKFDERILTDESFAAKYGDLGLVYGSQWRAWHTSRGDTIDQLGDVIEQIKTHPYSRRLIVSAWNPEDVPTMALPPCHTLFQFYVNDGKLSLQLYQRSADIFLGVPFNIASYALLTHLVAHECGLQVGDFIHTFGDAHLYVNHLDQIKEQLTRTPRQAPTLVLNPDKHDIFDFDMQDIKLLNYDPYPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
Length
316 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.014 kDa
Sequence
MLEDSYLQLARTILEHGTYKDDRTGTGTYSVFGYQMRFDLSQGFPLLTTKKVPFGLIKSELLWFLHGDTNIQYLLQHHNHIWDEWAFKNWVTSADYDGPDMTNFEHRRLDDPDFAPIYQAQMQTFDDQILTDDAFAAKYGNLGDVYGAQWRHWQTRQGKTIDQIANVIEMIKTHPDSRRLIVSAWNPEDVPNMALPPCHTLFQFYVADGKLSCQLYQRSGDVFLGVPFNIASYALLTHLIAKETGLAVGEFVHTLGDAHIYTNHVEQVKTQLTRQPRPAPQLTLSGAHDSIFDYQMSDIKLSGYDPAPAIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Lactobacillus sakei subsp. sakei (strain 23K)
Length
316 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.464 kDa
Sequence
MSEQVYLDLARTILEEGHYKGDRTNTGTYSLFGYQMRFNLQEGFPLLTTKKMPFGLIKSELLWFLKGDSNIRYLLQHNNHIWDEWAFERFVKSTDYTGPDMTDFSHRAQDDADFKVVYQEQMRLFNDRILADEGFAKQYGELGDIYGKQWRAWQTRSGETIDQIKNVIEMIKTNPDSRRLIVSAWNPEDVPSMALPPCHTMFQFYVNDGKLSCQLYQRSGDVFLGVPFNIASYALLTHLIAHETGLEVGEFIHTLGDAHIYSNHVTQVKTQLARSMHAAPKLWLNPDKKSIFDFDVADIKVENYESEPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w)
Length
316 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.392 kDa
Sequence
MLEEQYLNLERYVLENGHLKGDRTQTGTLSTFGYQMRFDLSEGFPLLTTKRVPFGLIKSELLWFLKGDTNIRYLLQHNNHIWDEWAFKKWVESDEYQGPDMTDFGHRSLTDPEFNELYKIEKQRFTEQILEDDTFSAKYGDLGNVYGSQWRAWKTSTGETIDQISNVIDMIKNNPNSRRMIVSAWNPEDVPTSALPPCHSLFQFYVADGKLSCQLYQRSGDIFLGIPFNIASYALLTELIAKATGLEVGEFIHTIGDAHIYSNHLDQVKEQLERTPRPAPKLKFKQVHDSIFDYEPGDIVVEGYDPHPTIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Lactobacillus brevis (strain ATCC 367 / JCM 1170)
Length
316 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
35.955 kDa
Sequence
MLEEAYLDLAKTVLTTGHEKTDRTGTGTISLFGYQMRFNLQEGFPLLTTKKVPFGLIKSELLWFLRGDTNIRFLLQHHNHIWDEWAFQRYVDSPEYHGPDMTDFGRRSLVDADFNQRYQAEKKAFCDRIVTDQAFGDHFGDLGLVYGSQWRAWQGHQGETIDQLANVIETLRTHPDSRRMIVSAWNPADVPSMALPPCHTLFQFYVNDGKLSCQLYQRSADIFLGVPFNIASYALLTSLIAKEVGLEVGDFVHTLGDAHIYSNHVEQIKTQLARTPHAAPQLWLNPDKSSIFDYEMSDIKVTGYDPEPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Length
315 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.344 kDa
Sequence
MEEAYLALGKKILEEGHFKEDRTGTGTYSLFGYQMRFDLAKGFPLLTTKRVPFGLIKSELLWFLKGDTNIRYLLERNNHIWDEWAFERYVKSADYQGPDMTDFGHRVLQDPAFAEQYKEEHQKFCDAILNDAEFAEKYGELGNIYGAQWRHWETKDGSFIDQLANVIEMIKTNPDSRRLIVSAWNPEDVPSMALPPCHTMFQFYVNEGKLSCQLYQRSADVFLGVPFNIASYALLTHLIAHETGLEVGEFVHTLGDAHLYQNHVEQMQEQLSREVRSFPTLVLNPDKASVFDFDMEDIKVEGYDPHPTIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CIP 105152 / NBRC 16084 / F199)
Length
314 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.047 kDa
Sequence
MSILRDSGRHYEWQYLDLMRRIWEHGDERVDRTGVGTRSVFGAELRFDLSDGRMPLLTTKRVYWKTATREFLWFLTGNTNIRPLCAQGVEIWTDWPLDRYRKETGDDISRKDFSARIVADEAFALRWGDLGPVYGKQWVDWPVFEPVGDGLFRRREAGVNQVADVVDSLRHNPGSRRHIIEGWNVAEIDRMALPPCHKTYQFHVSGNRLNGLLYQRSCDVALGLPFNLWGAALLVRLLAQQCDLQPGELVWMGGDTHLYLNHADLVEAQLSREPEGDPRLAILRRPDSIFGYRIEDFEVTGYAPQGHLSAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)
Length
314 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.146 kDa
Sequence
MKQYLDLEKYVLENGTQKGDRTGTGTISTFGYQMRFDLQEGFPIMTTKRVPFKLVVSELLWFLHGDTNIRYLLQHNNNIWNEWAFERFVKSADYKGEDMTDFGLRAERDPAFKEVYQAEMEKFKTRILEDETFANKYGELGNIYGKQWREWKTSQGETIDQLADLIEMIKTNPNSRRLIVSAWNPEDIPNMALPPCHSLFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAREVGLDVGEFIHTMGDAHLYNNHIEQVKEQLSRTPHALPKLVLSDKPATIFDFEVADISLDGYNPDPAIKAPISV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Listeria monocytogenes serotype 4b (strain CLIP80459)
Length
314 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.176 kDa
Sequence
MKQYLDLEKYVLENGTQKGDRTGTGTISTFGYQMRFDLQEGFPIMTTKRVPFKLVVSELLWFLHGDTNIRYLLQHNNNIWNEWAFERFVKSDDYKGEDMTDFGLRAERDSAFKEVYQAEMEKFKARILEDEAFANKYGELGNIYGKQWREWKTSQGETIDQLADLIEMIKTNPNSRRLIVSAWNPKDIPNMALPPCHSLFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAREVGLEVGEFIHTMGDAHLYNNHIEQVKEQLSRTPHKLPKLVLSDKPATIFDFDVADISLDGYNPDPAIKAPISV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Listeria monocytogenes serotype 4b (strain F2365)
Length
314 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.177 kDa
Sequence
MKQYLDLEKYVLENGTQKGDRTGTGTISTFGYQMRFDLQEGFPIMTTKRVPFKLVVSELLWFLHGDTNIRYLLQHNNNIWNEWAFERFVKSDDYKGEDMTDFGLRAERDSAFKEVYQAEMEKFKARILEDEAFANKYGELGNIYGKQWREWKTSQGETIDQLADLIEMIKTNPNSRRLIVSAWNPEDIPNMALPPCHSLFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAREVGLEVGEFIHTMGDAHLYNNHIEQVKEQLSRTPHKLPKLVLSDKPATIFDFDVADISLDGYNPDPAIKAPISV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Listeria monocytogenes serotype 4a (strain HCC23)
Length
314 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.217 kDa
Sequence
MKQYLDLEKYVLENGTQKGDRTGTGTISTFGYQMRFDLQEGFPIMTTKRVPFKLVVSELLWFLHGDTNIRYLLQHNNNIWNEWAFERFVKSDDYKGEDMTDFGLRAERDPAFKEVYQAEMEKFKTRILEDEAFANKYGELGNIYGKQWREWKTSQGETIDQLADLIEMIKTNPNSRRLIVSAWNPEDIPNMALPPCHSLFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAREVGLEVGEFIHTMGDAHLYNNHIEQVKEQLSRTPHKLPKLVLSDKPATIFDFDVADISLDGYNPDPAIKAPISV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Length
314 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.163 kDa
Sequence
MKQYLDLEKYVLENGTQKGDRTGTGTISTFGYQMRFDLQEGFPIMTTKRVPFKLVVSELLWFLHGDTNIRYLLQHNNNIWNEWAFERFVKSDDYKGEDMTDFGLRAERDPAFKEVYQAEMEKFKTRIIEDEAFATKYGELGNIYGKQWREWKTSQGETIDQLADLIEMIKTNPNSRRLIVSAWNPEDIPNMALPPCHSLFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAREVGLDVGEFIHTMGDAHLYNNHIEQVKEQLSRTPHALPKLVLSDKPATIFDFEVADISLDGYNPDPSIKAPISV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / SLCC5334)
Length
314 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
36.127 kDa
Sequence
MKQYLDLEKYVLENGTQKGDRTGTGTISTFGYQMRFDLQEGFPIMTTKRVPFKLVVSELLWFLHGDTNIRYLLQHNNNIWNEWAFERFVKSADYKGEDMTDFGLRAERDPAFKEVYQAEMEQFKTRILEDEGFANKYGELGNIYGKQWREWKTSQGETIDQLADVIEMIKTNPNSRRLIVSAWNPEDIPNMALPPCHSLFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAREVGLDVGEFIHTMGDAHLYNNHIEQVKEQLSRTPHALPKLVLSDKPTTIFDFDVADISLDGYHPDPAIKAPISV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256)
Length
311 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
35.515 kDa
Sequence
MADSIHYELQYLDLMRRIWVDGDERVDRTGVGTRSLFGETMRFSLKDDAIPLLTTKRVYWKTALRELLWFLTGDTNIRPLVAQGVKIWTDWPLEKYRKATGEAISATDFEARIVADADFAAKWGDLGPVYGHQWVNWPRYEPAGGGLFRRADHGYNQIAALIDSLKNNPGSRRHIFTGWNVADLDRMALPPCHMTYQFHVRSDGGLSCLLFQRSCDLGLGFAFNIFEAALLTRMVAEQCGLYAHEVVWTGGDVHLYLNHAELVEQQLARVPEGKPRLRILRRPPSIFEYRFEDFVVEDYAPQAHISAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
Length
308 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
34.966 kDa
Sequence
MTEHPEQQYLDAMARAWYGGDERVDRTGVGTKSLFGVTMRFDLSDGTVPLITTKKIFWKSAIKELIWFLSGDTNIRPLVMQNVHIWTDWPLDKYRKATGEAIDRDAFERRIVDDPAFAAEWGDLGPVYGKQWVDWPRYTPAGDGLFRREEKGVNQIAELVGMLRANPSSRRLIFTGWNVPELPGMALPPCHMTYQYHVAGGRLSGILYQRSCDLGLGFPFNIFEAAVLIRMLAQQADLEPGELVWMGADTHVYSNHGHLVEEQLSRSPRPFPRLSLARKPADMFSYALDDFVIEGYDPHPHIKAEVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Agrobacterium radiobacter (strain K84 / ATCC BAA-868)
Length
307 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
35.275 kDa
Sequence
MVRHPEYQYLDLMAHLLENGDRRIDRTGVGTLSGLGAMMRFDLSKGQLPVFTTKRVYWKLAVKEMLWFLTGDTNIRNLLKQNVRIWTDWPLAAYRKATGEAISQEDFEARILADEAFAETWGDLGPVYGKQWRQWRDADGQVHDQIATVIDQLRHNPSSRRMIFHAWNVGELAGMALPPCHMVYQFHVSNLPSPGETKRPRLSLMVYQRSCDLFLGNPFNICQQAVLLAMVAQQVDMDVGELVWAGGDVHIYLNHLDAIREQLSREPRPFPTLRLLRRPDSIDDYRIEDFEVSDYEPHAAIAAEVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Sinorhizobium fredii (strain NBRC 101917 / NGR234)
Length
305 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
35.464 kDa
Sequence
MTRHPEYQYLDLMSELLETGDRRMDRTGEGTLSLFGKQMRFKLSDGTIPIFTTKKVYWKTSVKEMLWFLTGQTNISSLLRENVRIWTDWPLAKYRKATGETISQEQFEDRIVASDEFASEWGDLGPVYGKQWRRWVDNDGQEHDQIATVISTLKTNPTSRRILFHAWNVGELDRMALHPCHMTYQFHVSWPNGQDGRPQLSMMVHQRSCDIFLGAPFNICQQAVLLAMIAQQVDMDRGELVWLGGDTHLYLNHLDQARLQLSRKPKPFPKLEIKRRPASIDGYTIDDFEVSEYQSHERIEAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Flavin-dependent thymidylate synthase
Organism
Dictyostelium discoideum
Length
303 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Similarity
Belongs to the thymidylate synthase ThyX family.
Mass
35.395 kDa
Sequence
MGLDIQTEIDKIVIEKVKPEVEYYDVMGGSHRWEVKVHDHGKVALVDTMPRLAPVGQTADFSICQAARVSYGAGTKKVTEDKGLIRYLYRHQHTSPFEMVEFKFHCVMPVFIARQWIRHRTANVNEYSARYSVLPDKFYHPSIEEVRKQSTSNRQGGEEALEPKTAQEFLDYLDKVEENYKTYNELLEKGLSRELGRIGLPVSIYTEWYWKIDLHNLFHFLRLRMDSHSQKEIRDYANTIFALIRPIVPVACEAFIDYAFESLKLTRLEIEAIRTGSPLNTTNKREIEEFEEKKKLLFPNTQA
Protein
Flavin-dependent thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Rhodopseudomonas palustris (strain BisA53)
Length
298 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
34.172 kDa
Sequence
MRHPEHQYLDLLAQVLEKGDQRIDRTGVGTRALFGAMIRFDLSDGRVPILTTKRVYWKTAVKEMLWFLTGQTNIQALLKENVRIWSDWPLARYRKETGDSISQEDFEKRVVEDNAFATRWGDLGPVYGKQWRRWLGADGREYDQIAELVQTLKSNPASRRMLFHAWNPPELGAMALPPCHMVYQYHVTSSGKLNCILYQRSCDLLLGAAFNYAAASALQLMLAQQADLTPGEFIWFGGDVHLYLNHLDQAREQISRAPRPFPTMRLTRRPDSIDGYRISDFEVDGYEPHAAIKADVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Rhodobacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)
Length
298 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
33.905 kDa
Sequence
MAHPEQQYLDLLAQTLERGDRRVDRTGVGTLSLFGAMLRFDLSDGQVPILTTKRVYWKTAVKEMLWFLTGGTNIRPLLQENVRIWSDWPLAAYRRESGEEISQAAFEQRILEDEAFAARWGELGPVYGRQWRRWLGPDGREHDQIAALIETLRTNPSSRRMLFHAWNVAEVGQMALPPCHMVYQYHVTSDGRLNALLYQRSVDLLLGAPFNFVGAAALQLMIAQQAGLVPGDLVWVGGDTHLYLNHLDQAREQTGRAPRDWPRMRLLRQADGIDDYRIEDFAVEGYDPHPAIAAEVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Length
298 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
33.843 kDa
Sequence
MAHPEQQYLDLLAQTLERGDRRVDRTGVGTLSLFGAMLRFDLSGGQVPILTTKRVYWKTAVKEMLWFLTGGTNIRPLLQENVRIWSDWPLAAYRRESGEEISQAAFEQRVLEDEAFAARWGELGPVYGKQWRRWLGPDGHEHDQIAALIETLRTNPSSRRMLFHAWNVAEVGQMALPPCHMVYQYHVTSDGRLNALLYQRSVDLLLGAPFNFVGAAALQLMIAQQAGLVPGDLVWVGGDTHLYLNHLDQAREQTGRAPRDWPRMRLLRRADSIDDYRIEDFAVEGYDPHPAIAAEVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Rhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
Length
298 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
33.712 kDa
Sequence
MAHPEQHYLDLLAQVLARGDRRVDRTGVGTLSLFGAMLRFDLSKGAAPILTTKKVYWKTAVKEMLWFLTGGTNIRPLLQQNVRIWTDWPLAAYRRATGEEIGQAEFEARIVADEGFAARWGDLGPVYGKQWRRWLGPDGREHDQIAGLIETLRTNPASRRMLFHAWNVAEVGQMALPPCHMVYQYHVTSDGRLNALLYQRSVDLLLGAPFNFVGAAALQLMIAQQADLLPGELVWVGGDTHLYLNHLEQAREQISRAPRDWPRMQLVRRAESIDDYRIEDFAVEGYESHPAIAAEVAV
Protein
Thymidylate synthase: thyA

Gene
THYA
Protein
Thymidylate synthase
Organism
Pneumocystis carinii
Length
297 amino acids
Similarity
Belongs to the thymidylate synthase family.
Mass
34.362 kDa
Sequence
MVNAEEQQYLNLVQYIINHGEDRPDRTGTGTLSVFAPSPLKFSLRNKTFPLLTTKRVFIRGVIEELLWFIRGETDSLKLREKNIHIWDANGSREYLDSIGLTKRQEGDLGPIYGFQWRHFGAEYIDCKTNYIGQGVDQLANIIQKIRTSPYDRRLILSAWNPADLEKMALPPCHMFCQFYVHIPSNNHRPELSCQLYQRSCDMGLGVPFNIASYALLTCMIAHVCDLDPGDFIHVMGDCHIYKDHIEALQQQLTRSPRPFPTLSLNRSITDIEDFTLDDFNIQNYHPYETIKMKMSI
Protein
Thymidylate synthase: THYA

Gene
thyA
Protein
Thymidylate synthase
Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Length
296 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
33.586 kDa
Sequence
MSEHQYLRLVSDILEKGDQRHDRTGVGTLSLFGAMMRFDLSKGRIPILTTKKVSYRLAIREMLWFLSGDTNIRPLVEQGVSIWSDWPLARYQAETGALLSKKEFEAKILADTEFAKKWGDLGPVYGRQWRRWQGSDGQVYDQIATLIETLKSNPSSRRMLFHGWNVAELKDMALPPCHMVYQYHVTSDGRLNSLLYQRSADVFLGLPFNLVGAAALQAMLADQAGLALGDLVWTGGDVHIYRNHIDQMKEQLAREPRAFPRLELTRHPNSITDYKIEDFAITGYDPHPPIKGAVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Psychrobacter cryohalolentis (strain K5)
Length
290 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.621 kDa
Sequence
MTMNSSIIKNEQAYLDLLRLVLNEGTEKGDRTGTGTLSHFGAQLRFNLADGFPLLTTKKVHLKSITYELLWFLNGSTHVDYLQQNGVRIWNEWATSEQTARFNRPAGDLGPIYGHQWRNYGATTTADGQYNSDGVDQIAQVVEQIKTNPNSRRLIVSGWNPGEADQVALPPCHTLFQFFVADNKLSCQLYQRSADLFLGVPFNIASYAMLTHMVAQVCNLEVGEFIWTGGDCHIYQNHREQVELQLTRSLYTLPTLALNPNVKDIFAFNYEDISVDGYESHPAIKAQVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Length
289 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
33.839 kDa
Sequence
MKTYLDLLEKVMTKGEVKKDRTNTGTISYFGTQSRYDLREGFPLLTTKKMAWKAICHELLWFLKGDTNIKYLVDHNVNIWNEWPYEAFKKSNDFKGESLQDFVEKIKTDNQFAQQYGKLGPVYGKQWRDFNGVDQIEWVINEIKTNPFSRRLIVSAWNPGEIKEMALPPCHSFFQFFVNEKYEISLQLYQRSGDLFLGVPFNIASYSLLLLMVAQVTGLKPAEFIHTIGDTHIYSNHLEQVKIQLQREPKKLPKVTLNPDIKNIFDFRFEDISLENYEHHDPIKGKVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Mycoplasma penetrans (strain HF-2)
Length
289 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
33.89 kDa
Sequence
MKEYKDLLKLVLDNGIMQENRTDTDAIAYFGTQSRYDLTKGFPLLTTKKMAYKAIFHELLWFLKGETNIKYLVDNNVKIWNEWPYENYKKSPYFKNESIDEFILKIKEDDSFAKQFGELGPVYGRQWRNFNGVDQITNLIEEIKKNKYSRRLIVSVWNPSEIKNMLLPPCHCLFQFFVNSKNELSCQLYQRSADLFLGVPFNIASYSLLTYMIAQVTNTTAKEFVHTIGVAHIYNNHIDQVKEQLTREPLQLPTLVLNKNIKNIFDFKIEDIEIKDYNSHPAIKGKVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Mycoplasma synoviae (strain 53)
Length
289 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
33.586 kDa
Sequence
MKQYLHLLEHIKTSGTFKKDRTNIGTISLFGLQARYNLKEGFPLLTTKKMAWKAICHELLWFLKGDTNIKYLVDNNVNIWNEWPYEIFKKSNDYQGESLKEFSQKIKEDSSFAQKYGELGPVYGKQWRDFFGVDQISQVINDIKNNPTSRRLIVSAWNVAQIDKMALPPCHAFFQFYVNDNNELSLHLYQRSGDMFLGVPFNIASYSLLLSMVAQVTNLKVGEFIHTIGDAHIYSNHIDQVNTQLERAPYKLPKLILNKNIKNIFDFTFEDIELENYISHETIKAKVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Aster yellows witches'-broom phytoplasma (strain AYWB)
Length
288 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
33.786 kDa
Sequence
MNTYLDLCRFIFQKGSFRKDRTNTGTKSVFGYQMRFNLEEGFPLLTTKKMNLRSIIHELLWFLKGDTNIFYLVQNNVNIWNEWPYQKYQQSDFFQNETLKEFVKKIKNDPLFATKHGNLGPVYGKQWRDFNGVDQIKFLISEIKANPNSRRLILNSWNPSLLNQMALPPCHVLIQFYVHQGKLSLQLYQRSGDVFLGIPFNIASYSLLLMMVAQVTNLQPYEFIHTLGDAHIYSNHITQVQTQIQRTPKKLPQMILNPDIKNIDDFKFIDFILKNYQCDGILKGDIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Onion yellows phytoplasma (strain OY-M)
Length
288 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
33.649 kDa
Sequence
MNTYLDLCRFILQKGSFRNDRTNTGTKSVFGYQMRFNLEEGFPLLTTKKMNLRSIIHELLWFLKGDTNICYLVQNNVNIWNEWPYQKYQQSAFFQNETLKEFLEKIKNDPLFAIKHGNLGPVYGKQWRDFNGVDQIKFLISEIKTNPNSRRLILNSWNPPLLNQMALPPCHVLIQFYVHQGKLSLQLYQRSGDVFLGIPFNIASYSLLLMMVAQVTNLQPYEFIHTLGDAHIYSNHLAQVQTQIQRTPKKLPQMILNPDIKNIDDFKFSDFTLQNYQCDGILKGDIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Phytoplasma mali (strain AT)
Length
288 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
33.877 kDa
Sequence
MQAYLNLCRDILNYGKKKIDRTKTGTRSIFGYQMRFNLEKGFPLLTTKKMNFKAIIHELLWFIKGDTNIRYLVQNNVNIWNEWPYQKYCNSNFFQNLTLQEFIDKIIIDEKFAKIHGDLGPIYGHQWRNFQGIDQLTDLISEIKKNPHSRRLILTAWDPTVIKDMLLPPCHVMIQCYVEKNKISMQLYQRSGDVFLGIPFNIASYSLLLIIIAQCTGLKPFEFIHTIGDAHIYNNHIEQIQKQIKRIPKKLPIMTLNPHIIDINQFTFNDFNLEKYESYGILKGVVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Mycoplasma mobile (strain ATCC 43663 / 163K / NCTC 11711)
Length
288 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
33.365 kDa
Sequence
MEQYLSLLKEILEKGQKKEDRTNTGTISYFGTQRRYDLSKGFPLVTTKKVHLKSIIFELLWFIKGDTNIKYLVDNGVNIWNEWPYETFKKSKDFNGESLADFVLKIKSDTLFAKKYGELGPVYGKQWRNFNGTDQLFDAIETIKKNPDSRRIIVSAWAANEISKMALPPCHAFFQFYVNNNKLSLQLYQRSGDTFLGVPFNIASYSILLAMVAQITNYEVGEFIHTIGDTHIYLNHLEQVEEQLSRKPLKLPKLVLNKKIKNIDDFKYEDIEIIDYESHPAIKAKVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Mesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1)
Length
288 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
33.889 kDa
Sequence
MKQYLELVNEILKDGEKREDRTNTGTISKFGVQKRYDLREGFPLLTTKKVFYKAIFHEMLWFIKGDTNIKYLVENNVKIWNEWPYENFKKSSEFNNETLQEFVERLKNDNEFCNKWGDLGPVYGKQWRDFGGIDQFAKLINDIKKNPFSRRHIVSAWNPAEVDNMLLPPCHSFWQVYVSKDGWLDLQLYQRSGDVFLGVPFNIASYALLMELIAKECNLKARYFVHTIGDAHIYLNHLEQINEQLKRKPLPLCKIKINSEKSIFDIAFEDIEIEGYESHAKITGEVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Acholeplasma laidlawii (strain PG-8A)
Length
288 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
33.318 kDa
Sequence
MKQYLDLARHIMENGTLKSDRTGTGTKSIFGYQMFFDLKDGFPLLTTKKTFLKGIIHELLWFIKGDTNIKYLVDNNVGIWTDWPYKNYMNSSEYQGESIKEFSDKIRQSDEFAKKWGDLGPVYGSQWRNFNGVDQIEYIINTLKTNPDSRRMVLSAWNPAEIGQMMLPPCHTLIQFYVVDNKLSLQLYQRSGDVFLGIPFNIASYAVFLMMVAQVTGFELGSFVHTIGDAHIYTNHFDQINLQLTRTPRRLPILKINKSITRLEDFKYEDFELVGYDPYPPIKGVVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Length
287 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
33.47 kDa
Sequence
MKQYLDLASYVLANGKKRKNRTDTDTLSVFGYQMKFDLTNSFPLLTTKKVNWKAIVHELLWFIKGDTNIKYLVDNGVNIWNEWPYENFKKSPSFQNETLQEFILKVKTDNEFAKQFADLGPVYGKQWRNFNGVDQLKKVIQEIKENPNSRRLIVSSWNPSELEKMALAPCHSLFQFYVEEDKLSLQLYQRSGDIFLGVPFNIASYALLVYLVAHETKLKPGYFIHTLGDAHIYENHIEQIKLQLTRTTLDPPQVVLKSDKSIFAYSFDDIELVGYNYHPFIYGRVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Length
287 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
33.591 kDa
Sequence
MQQYLDLARYVLEHGKYRPNRTDTAGIGVFGYQMHFDISKHFPLLTTKKVHWKSIVHELLWFIKGDTNIKYLVDNKVNIWNEWPYESFKKSPHFNGESQKEFIERIRQDAKFAQQFGNLGPVYGKQWRDFNGVDQLKKVIAQIKVNPFSRRLIVSSWNPNEVDQMLLPPCHSLYQFYVQDGQLSCQLYQRSGDIFLGIPFNIASYSLLVYLVAKETNLKPGSFVHTIGDAHIYENHLEQIKLQLTRQPKPLPKVVLKSDKSIFDYQFDDIELVDYDHHPTIKGEVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Mycoplasma pulmonis (strain UAB CTIP)
Length
286 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
33.458 kDa
Sequence
MKQYLDFLKWVLEKGKHKENRTSVDTISAFGYQMRFDLSKGFPLVTTKKTNFSAIAHELLWFIKGDTNIKYLVDNKVNIWNQWPYESYKKSQDFQSESLKEFIQKIKDDNEFAQKHGNLGPVYGKQWRDFLGIDQLKKVIEQIKNNPNSRRLIVSSWNPSEIDTMLLPPCHTLFQFYVNDNKLSCHLYQRSADAFLGIPFNIASYALLTFLLAQETNLEVGDFVHSIGDAHIYVNHLEQVKTQLKRNPKELPKLIIKNKNIFEINFEDIELVDYEFDPIIKGEVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Streptococcus thermophilus (strain CNRZ 1066)
Length
286 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
33.384 kDa
Sequence
MTKADTIFKENITKIMEEGVWSEQARPKYKDGTTANSKYITGSFAEYDLSKGEFPITTLRPIAIKSAIKEVFWIYQDQTNSLDVLEDKYNVHYWNDWEVEGVPANNGDKRSIGQRYGAVVKKHDIINRLLAQLEANPWNRRNVISLWDYEAFEETAGLQPCAFQTMFDVRRVGEDVYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKIGKFFYFINNLHIYDNQFEQAEELLKRQPSDCQPRLVLNVPDETNFFDIKPEDFELVDYDPVKPQLKFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
Length
286 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
33.356 kDa
Sequence
MTKADTIFKENITKIMEEGVWSEQARPKYKDGTTANSKYITGSFAEYDLSKGEFPITTLRPIAIKSAIKEVFWIYQDQTNSLDVLEDKYNVHYWNDWEVEGVPANNGDKRSIGQRYGAVVKKHDIINRLLAQLEANPWNRRNVISLWDYEAFEETAGLQPCAFQTMFDVRRVGEDVYLDGTLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNLHIYDNQFEQAEELLKRQPSDCQPRLVLNVPDETNFFDIKPEDFELVDYDPVKPQLKFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9)
Length
286 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
33.37 kDa
Sequence
MTKADTIFKENITKIMEEGVWSEQARPKYKDGTTANSKYITGSFAEYDLSKGEFPITTLRPIAIKSAIKEVFWIYQDQTNSLDVLEDKYNVHYWNDWEVEGVPANNGDKRSIGQRYGAVVKKHDIINRLLAQLEANPWNRRNVISLWDYEAFEETAGLQPCAFQTMFDVRRVGEDVYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNLHIYDNQFEQAEELLKRQPSDCQPRLVLNVPDETNFFDIKPEDFELVDYDPVKPQLKFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Psychrobacter sp. (strain PRwf-1)
Length
286 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.73 kDa
Sequence
MITSKNEAAYLDLIRYVRDHGTEKGDRTGTGTRSHFGAQLRFDLKDGFPLLTTKKVHMKSITYELFWFLKGDTHVKYLQDHGVRIWNEWSTAEQTARFGRPEGELGPIYGHQWRNYGATKAEDGRYNQDGVDQVVEVIEQIKSNPNSRRLIVSGWNPAEATQVALPPCHTLFQFFVADGKLSCQLYQRSADLFLGVPFNIASYSLLTHMIAQVCDLEVGEFIWTGGDCHLYQNHIDQVNEQLSREAYELPKLWLNPEIKDIFDFTFDDIRVEGYQSHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Polaromonas sp. (strain JS666 / ATCC BAA-500)
Length
284 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.301 kDa
Sequence
MNTPPETRPDRPIRSQYEDFMRHVDAHGVFKADRTGTGTKSVFGYQMRFDLNEGFPLVTTKKVHLKSIVQELLWFLTGSSDNNWLKERGVTIWDEWAREDGDLGPVYGVQWRSWPTPDGGHIDQISEVIKTLKTNPDSRRIIVSAWNVADLSKMALMPCHAFFQFYVAPATEAGGKGKLSCQLYQRSADIFLGVPFNIGSYALLTHMVAQQCDLDVGDFIWTGGDCHIYSNHAEQVALQLSRAPFPYPTLHIKRKPESIFDYQFDDFEFLDYQHHAAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Actinobacillus succinogenes (strain ATCC 55618 / DSM 22257 / 130Z)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.542 kDa
Sequence
MRQYLDLCQRIVDEGVWLENQRTGKRCLTVINADLTYNAAANEFPIITTRKSYWKAAIAEFLGYIRGYDNAADFRKLGAKTWDANANENQAWLNNPVRKGVDDMGRVYGVQGRAWRKPNGETVDQLRKIVDDLSRGIDDRGEILTFLNPGEFDLGCLRPCMYSHTFSLLGDTLYLTSYQRSCDVPLGLNFNQIQVFTFLALMAQITGKKPGQAYHKIVNAHIYEDQLDLMRDVQLKRRPFPSPRLEINPDIKTLEDLETWVTLDDFNVVGYECHEPIKYPFSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Aliivibrio fischeri (strain ATCC 700601 / ES114)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.464 kDa
Sequence
MKQYLDLCQRIVDEGTWIENERTGKRCLTVINADLTYDVENGVFPLVTTRKSFWKAAVAEMIGYIRGYDSAEDFRKIGTKTWDANANLNDAWLNNPHRKGDDDMGRVYGVQGRSWAKPNGEFVDQLKKIIDDLSQGIDDRGEILNFYNPGEFDMGCLRPCMYSHHFSLLGDTLYLNSTQRSCDVPLGLNFNMVQVYFLLAIVAQITGHKAGKAYHKIVNAHIYEDQLELMQSVQLKREPLQAPIFKINPEIKSLEDLETWVTMDDFEVIGYESHEAIKYPFSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.432 kDa
Sequence
MKQYLDLVKHVLENGNQKGDRTGTGTKSVFGYQMRFDLSEGFPMVTTKKLHLKSIIYELLWFLKGDTNIKYLKENGVKIWDEWADSNGDLGPVYGHQWRNWNSEEIDQISELITELKTNPNSRRMIVSAWNPSVLPDTKKSFEENVANNKAALPPCHAFFQFYVASPDLEKGETKGKLSCQLYQRSADIFLGVPFNIASYALLTMMIAQVCDLEPGEFIHTFGDAHIYNNHFEQLELQLSREPKPLPKMILNPEIKNIFDFDYDDFTLVDYDPHPAIQGSVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.418 kDa
Sequence
MKQYLDLCHRILNEGKWVKNKRTDKLCLTVINADLTYDVAKGEFPLITTRKSFWKAAIAELLGYIRGYDNAADFRQLGTKSWDANANQNADWLANPYRKGVDDMGLVYGAIGRKFPKADHGSLDLLKQIVDDLSNGIDNRGEIYTFYHPGAFHMGCLRPCLYSHHFSLLDGTLYLNSTQRSADVPLGLNWNMVQCYTFLALMAQITNHKAGQVFHKIVNAHIYEDQLALMRDVQLKREPFATPTLTINPAIKSLEDLEIWVTLDDFKVENYFYHPSIQYPFSI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Haemophilus influenzae (strain 86-028NP)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.416 kDa
Sequence
MKQYLDLCRRIVSEGEWVANERTGKHCLTVINADLEYDVANNQFPLITTRKSYWKAAIAEFLGYIRGYDNAADFRALGTKTWDANANVNAAWLANPHRRGVDDMGRVYGVQGRAWRKPNGETIDQLRKIVNNLTKGIDDRGEILTFFNPGEFDLGCLRPCMHTHTFSLVGDTLHLTSYQRSCDVPLGLNFNQIQVFTFLALMAQITGKKAGKAYHKIVNAHIYEDQLELMRDVQLKREPFPLPKLEINPDIKTLEDLETWVTMDDFKVVGYQSHEPIKYPFSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Haemophilus influenzae (strain PittEE)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.479 kDa
Sequence
MKQYLELCRRIVSEGEWVANERTGKRCLTVINADLEYDVANNQFPLITTRKSYWKAAIAEFLGYIRGYDNAADFRALGTKTWDANANENAAWLANPHRRGVDDMGRVYGVQGRAWRKPNGETIDQLRKIVNNLTKGIDDRGEILTFFNPGEFDLGCLRPCMHTHTFSLVGDTLHLTSYQRSCDVPLGLNFNQIQVFTFLALMAQITGKKAGKAYHKIVNAHIYEDQLELMRDVQLKREPFPLPKLEINPDIKTLEDLETWVTMDDFKVVGYQSHEPIKYPFSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Shewanella frigidimarina (strain NCIMB 400)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.119 kDa
Sequence
MKQYLDLCKRIVDEGEWVNNARTNKKCLTVINADLVYDVGNNQFPLVTTRKSFWKSAIAEILGYLRGYQNAADFRALGTKTWDANANENQAWLDNPNRKGPDDMGLIYGALGRAFPKPDGGHVDLLQQIVDDLSNGIDNRGEILTFYHPGAFDLGCLRPCMYEHHFSLLGDTLYLNSTQRSCDVPLGLNFNMVQVYVLLALMAQITGHKPGKAYHKIVNAHIYEDQLEPMRDVQLAREPFASPKLIINPKIKTLKDIETWVTLDDFSVEDYQHHDAIKYPFAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Shewanella halifaxensis (strain HAW-EB4)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.257 kDa
Sequence
MKQYLDLCQRIIDEGTWVENSRTGKRCLTVINADLVYNVDKNEFPLITTRKSFYKAAIAELLGYIRGYDNAADFRKIGCNTWNANANDNQAWLNNPHRKGVDDMGRVYGVQGRAWSKPDGGTIDQLRKIVDDLSKGIDDRGEILSFYNPGEFHMGCLRPCMHTHNFSLLGDTLHLTSFQRSCDVPLGLNFNQVQVFTLLALMAQITGHKAGTAFHKIVNAHIYEDQLELMRDVQIKREPLSSPKLVINPDIKSLEDLETWVTMDDFEVTGYEHHEAIKYPFSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Shewanella loihica (strain ATCC BAA-1088 / PV-4)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.2 kDa
Sequence
MKQYLALCERIINEGVWVENERTGKRCLTVINADLEYDVAANEFPLITTRKSFWKGAIAELLGYLRGYDNAADFRKLGAKTWDANANENSAWLNNPHRKGHDDMGRVYGVQGRAWAKPDGGVVDQLRKIIDNLSKGVDDRGEILSFYNPGEFHMGCLRPCMHTHNFSLLGDTLYLNSFQRSCDVPLGLNFNQVQVFALLSIVAQITGHKPGKAYHKIVNAHIYEDQLPLMQEVQLKREPFPSPKLSINPDIKSLEDLETWVTMDDFEVTGYQHHEAIQYPFSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Shewanella pealeana (strain ATCC 700345 / ANG-SQ1)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.211 kDa
Sequence
MKQYLDLCQRLIDEGTWVENSRTGKRCLTVINADLVYHVDKNEFPLITTRKSFYKAAIAELLGYIRGYDNAADFRAIGCNTWNANANDNQAWLDNPHRKGIDDMGRVYGVQGRAWSKPDGGCIDQLRKIVDDLSKGIDDRGEILSFYNPGEFHMGCLRPCMHTHNFSLVGDTLHLTSFQRSCDVPLGLNFNQVQVFTLLALMAQITGHKPGTAFHKIVNAHIYEDQLELMQEVQLKREPFTSPKLVINPNIKSLEDLETWVSIDDFEVTGYEHHEAISYPFSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Shewanella piezotolerans (strain WP3 / JCM 13877)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.192 kDa
Sequence
MKQYLELCQRIIDEGTWVENSRTGKRCLTVINADLVYHVDKNEFPLITTRKSFWKAAIAEMLGYIRGYDNAADFRNIGAKTWDANANDNQAWLNNPHRKGADDMGRVYGVQGRGWSKPDGGSIDQLRKIVDNLSKGIDDRGEILSFYNPGEFHMGCLRPCMHTHNFSLLGDTLHLTSFQRSCDVPLGLNFNQVQVFTLLALIAQITGHKAGTAYHKIVNAHIYEDQLELMQSVQLKRSPFPSPQLSINPDIKSLEDLETWVTMDDFEVTGYEHHEGIRYPFSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Pasteurella multocida (strain Pm70)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.577 kDa
Sequence
MKHYLELCQRIVDEGVWVENARTGKRCLTVIDADLTYDVANNQFPLITTRKSYWKAAIAEFLGYIRGYDNAADFRKLGTKTWDANANENSAWLNNPHRKGTDDMGRVYGVQGRAWRKPNGETVDQLRKIVNNLRNGIDDRGEIMTFFNPGEFELGCLRPCMHTHTFSLLGDTLYLTSYQRSCDVPLGLNFNQIQVFTFLALMAQITGKKAGKAYHKIINAHIYEDQLDLMKNVQLKRDPFPLPQLHINPEIKTLEDLETWVTMDDFKVTGYQCHDAIKYPFSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Photobacterium profundum (strain SS9)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.372 kDa
Sequence
MKQYLELCQRIVDDGVWIENKRTNKRCLTVVNADLTFDVANNQFPLITTRKSFWKSAIAELLGYIRGYDNAADFRALGTKTWDMNANDNLAWLNNPHRKGEDDMGRVYGVQGRSWQKPDGSTIDQLRKIVDNLSEGIDDRGEILTFYNPGEFDLGCLRPCMHTHTFSLLGDTLHLTSYQRSCDVPLGLNFNQVQVYTLLALVAQITGKKPGLAYHKIINAHIYEDQLSLLRDVQLTRTPFAAPKLIINPKIKCLEDLETWVTMDDFDVIGYEHHEAIKYPFSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Haemophilus influenzae (strain PittGG)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.537 kDa
Sequence
MKQYLELCRRIVSEGEWVANERTGKRCLTVINADLEYDVANNQFPLITTRKSYWKAAIAEFLGYIRGYDNAADFRELGTKTWDANANENAAWLANPHRRGVDDMGRVYGVQGRAWRKPNGETIDQLRKIVNNLTKGIDDRGEILTFFNPGEFDLGCLRPCMHTHTFSLVGDTLHLTSYQRSCDVPLGLNFNQIQVFTFLALMAQITGKKAGKAYHKIVNAHIYEDQLELMRDVQLKREPFPLPKLEINPDIKTLEDLETWVTMDDFKVVGYQSHEPIKYPFSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.46 kDa
Sequence
MKQYLELCRRIVSEGEWVANERTGKHCLTVINADLEYDVANNQFPLITTRKSYWKAAIAEFLGYIRGYDNAADFRALGTKTWDANANENAAWLANPHRRGVDDMGRVYGVQGRAWRKPNGETIDQLRKIVNNLTKGIDDRGEILTFFNPGEFDLGCLRPCMHTHTFSLVGDTLHLTSYQRSCDVPLGLNFNQIQVFTFLALMAQITGKKAGKAYHKIVNAHIYEDQLELMRDVQLKREPFPLPKLEINPDIKTLEDLETWVTMDDFKVVGYQSHEPIKYPFSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Haemophilus parasuis serovar 5 (strain SH0165)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.205 kDa
Sequence
MKQYLDLCQRIVEQGKWVENERTGKRCLTVINADLTYDVAKGEFPLVTTRKSFWKAAIAELLGYIRGYDNAADFRQLGTKSWDANANENAAWLTNPHRKGEDDMGLVYGAVGRNFPKVGGGSVDLLRQIVDDLKRGVDNRGEIYTFYHPGAFHMGCLRPCLHSHHFSLLDGTLYLNSTQRSADVPLGLNWNMIQCYTFLALMAQITGHQAGQAFHKIVNAHIYEDQLELMRDVQLKRTPFKAPTLKINPDIKSLEDLETWVTLADFEVEGYEYHPSIQYPFSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Haemophilus somnus (strain 129Pt)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.779 kDa
Sequence
MRQYLNLCQRIIDQGHWVENERTGKRCLTVINADLTYDVANNQFPLITTRKSYWKAAIAEFLGYIRGYDNAADFRKLGTKTWDANANENQAWLNNPVRKGTDDMGRVYGVQGRRWRKPNGETVDQLRKIVNNLSKGIDDRGEILTFFNPGEIDLGCLRPCMHTHTFSLLGDTLYLTSYQRSCDVPLGLNFNQIQVFTFLALMAQITGKKAGQAYHKIINAHIYEDQFELMRDVQLKREPFPLPRLEINPDIKTLEDLETWVTMDDFKVIGYQCHEAIKYPFSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Histophilus somni (strain 2336)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.779 kDa
Sequence
MRQYLNLCQRIIDQGHWVENERTGKRCLTVINADLTYDVANNQFPLITTRKSYWKAAIAEFLGYIRGYDNAADFRKLGTKTWDANANENQAWLNNPVRKGTDDMGRVYGVQGRRWRKPNGETVDQLRKIVNNLSKGIDDRGEILTFFNPGEIDLGCLRPCMHTHTFSLLGDTLYLTSYQRSCDVPLGLNFNQIQVFTFLALMAQITGKKAGQAYHKIINAHIYEDQFELMRDVQLKREPFPLPRLEINPDIKTLEDLETWVTMDDFKVIGYQCHEAIKYPFSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.393 kDa
Sequence
MKQYLQLCQRIVDEGVWVKNERTGINCLTVINADLEYDVANNQFPLITTRKSYYKSAIAELLGYLRGYNSAAQFRDIGCKTWDANANENQAWLNNPNRKGEDDMGRVYGVQGRSWQKPDGSHLDQLKKVINNLSKGIDDRGEIVTFYNPGEFELGCLRPCMHTHNFSLLGDTLYLTSYQRSCDVPLGLNFNQIQCFALLALVAQITGHKPGKAYHKIVNAHIYENQLELMRDVQLKREPFPSPQLHINPEIKSLEDIETWVSKDDFIVSGYQCHDPIKYPFAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
31.957 kDa
Sequence
MSALPSPSPRPARSQYEDFLRHVRDHGVVKADRTGTGTTSVFGHQMRFDLREGFPLVTTKKVHLKSIVLELLWFLRGDGNATWLQERGVTIWDEWAAPDGDLGPVYGVQWRSWPTPDGGHVDQIAEVVKQLKTNPDSRRIIVSAWNVADLPKMALMPCHAFFQFYVAPGDSPSARGRLSCQLYQRSADIFLGVPFNIASYALLTHMLAQQCDLEVGDFVWTGGDCHIYSNHREQVELQLSRAPRPYPTLQIKRRPPSIFDYAYEDFEIIGYDPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Colwellia psychrerythraea (strain 34H / ATCC BAA-681)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.347 kDa
Sequence
MRAYLDLCQRIIDQGTWVENERTGKRCLTVINADLEYNVGNNEFPLITTRKSFFKSAIAEFIGYIRGYDSAADFRKLGTKTWDANANLNDAWLNNTHRKGEDDMGRVYGIQGRAWAKPDGGTIDQLKKIVDNLKDGIDDRAEIMTFYNPGEFHMGCLRPCMHTHNFSLLGDTLHLTSFQRSCDVPLGLNFNQVQVFVFLALMAQITGKKAGMAYHKIVNAHIYEDQLPLMKEVQLKREPLALPKLIINPEIKSLEDLETWVTMDDFKVEGYECHEAIKYPFAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Mannheimia succiniciproducens (strain MBEL55E)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.687 kDa
Sequence
MRQYLDLCQRIVNEGCWIENKRTGKRCLTVINADLTYDVANNRFPIITTRKSYWKAAIAEFLGYIRGYDNAADFRKLGAKTWDANANENQVWLNNPHRKGTDDMGRVYGVQGRAWRKPNGETVDQLRKIVNNLSRGIDDRGEILTFLNPGEFDLGCLRPCMYNHTFSLLGDTLYLTSYQRSCDVPLGLNFNQIQVFTFLALMAQITGKKAGQAYHKIVNAHIYEDQLELMRDVQLKREPFPSPKLEINPDIKTLEDLETWVTMDDFNVVGYQCHEPIKYPFSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Marinomonas sp. (strain MWYL1)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.366 kDa
Sequence
MKQYLDLCNRIVNEGEWVSNERTGKRCLTVINADLTYDVSKGEFPLVTTRKSYWKSAIAEIIGYLRGYDNAADFRALGTKTWDANANENEVWLNSPYRKGEDDMGLCYGAIGRNFPKPDGGHIDLLKQIIDDLSRGVDNRGEILTFYHPGAFHMACLRPCMYSHHFSLLGDTLYLNSTQRSCDVPLGLNFNMVQVYVLLAIVAQITGKKPGKAFHKIVNAHIYEDQLELMRDVQLKREPYPLPTLKINPEIKSLKDIETWVTMDDFEIEGYQFHEPIAYPFSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Shewanella sediminis (strain HAW-EB3)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.229 kDa
Sequence
MKQYLELCNRIIDEGTWIENERTGKRCLTVINADLTYNVGNNEFPLITTRKSFWKSAIAEMLGYIRGYDNAADFRALGAKTWDANANENQVWLNNPHRKGVDDMGRVYGVQGRAWSKPDGGTVDQLKKIVDNLKAGVDDRGEILSFYNPGEFHMGCLRPCMHTHNFSLLGDTLYLNSFQRSCDVPLGLNFNQVQVYTLLALIAQITGKKPGMAYHKIVNAHIYEDQLALMRDVQLKREPFEPASLSINPDIKSLEDLETWVTMDDFEVSGYQHHEAIKYPFSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Symbiobacterium thermophilum (strain T / IAM 14863)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.76 kDa
Sequence
MNIEIQYLELCREILAENEQEIAEGRWTPNRTGMGTVGVFGRMLKHDFKEGFPALTTKKLFFNSVKAELLWFLAGRTDLEFLHERGCHIWDKDAARNGGKLGPIYGKQWRAWEGADGRTYDQIAWVIQQIREIAADPERPHPNSRRLVVSPWNVADLEEMALPPCHGPFQFHVKDGRLHLAVWQRSADLFLGVPFNIASYSLLLHMVAQVTGLAVGTYTHYLNDVHIYRNLLDQVRLQLTREPYPLPRLWLNPEVREIDQFTMDDIQLVDYKHHPPIRGELST
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Tolumonas auensis (strain DSM 9187 / TA4)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.445 kDa
Sequence
MKQYLDLCQRIIDEGVWIENQRTNKRCLTVINADLVYDVRNNQFPIITTRKSFWKAAIAELLGYIRGYDNAADFRALGTKSWDANANENEAWLKNPARKGLDDMGRVYGVQGRHWKTHDGTELDQLGKIVANLSKGIDDRGEILTFHNPGEFNLGCLRPCMHTHTFSLLGDTLYLTSYQRSCDVPLGLNFNQIQVFTLLALMAQITGNKPGLAYHKIVNAHIYEDQIELMRDVQLKRKPYPSPKLEINPDIKSLKDLETWVTLDDFNVTGYQHHDAIKYPFSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.545 kDa
Sequence
MKQYLDLCQRIVDQGVWVENERTGKRCLTVINADLTYDVGNNQFPLVTTRKSFWKAAVAELLGYIRGYDNAADFRQLGTKTWDANANLNQAWLNNPYRKGEDDMGRVYGVQGRAWAKPDGGHIDQLKKIVDDLSRGVDDRGEILNFYNPGEFHMGCLRPCMYSHHFSLLGDTLYLNSTQRSCDVPLGLNFNMVQVYVFLALMAQITGKKPGLAYHKIVNAHIYQDQLELMRDVQLKREPFPAPQFHINPKIKTLQDLETWVTLDDFDVTGYQFHDPIQYPFSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.68 kDa
Sequence
MKQYLDLCQRIVDQGTWVENERTGKRCLTVINADLTYDVANNQFPLVTTRKSFWKAAVAELLGYIRGYDNAEDFRKLGTKTWDANANLNEAWLNNPFRKGEDDMGRVYGVQGRSWAKPDGGHIDQLRKIVDDLTRDVDDRGEILNFYNPGEFHIGCLRPCMYSHHFSLLGDTLYLNSTQRSCDVPLGLNFNMVQVYVFLAIMAQITGKKPGQAYHKIVNAHIYEDQLAPMRDIQLKREPLKAATFHINPEIKSLEDLETWVTLDDFWVEGYEHHDPIQYPFSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.573 kDa
Sequence
MRQYLDLCQRIVDQGVWVENERTGKRCLTVINADLTYDVGNNQFPLVTTRKSFWKAAVAELLGYIRGYDNAADFRQLGTKTWDANANLNQAWLNNPYRKGEDDMGRVYGVQGRAWAKPDGGHIDQLKKIVDDLSRGVDDRGEILNFYNPGEFHMGCLRPCMYSHHFSLLGDTLYLNSTQRSCDVPLGLNFNMVQVYVFLALMAQITGKKPGLAYHKIVNAHIYQDQLELMRDVQLKREPFPAPQFHINPKIKTLQDLETWVTLDDFDVTGYQFHDPIQYPFSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Vibrio cholerae serotype O1 (strain M66-2)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.573 kDa
Sequence
MRQYLDLCQRIVDQGVWVENERTGKRCLTVINADLTYDVGNNQFPLVTTRKSFWKAAVAELLGYIRGYDNAADFRQLGTKTWDANANLNQAWLNNPYRKGEDDMGRVYGVQGRAWAKPDGGHIDQLKKIVDDLSRGVDDRGEILNFYNPGEFHMGCLRPCMYSHHFSLLGDTLYLNSTQRSCDVPLGLNFNMVQVYVFLALMAQITGKKPGLAYHKIVNAHIYQDQLELMRDVQLKREPFPAPQFHINPKIKTLQDLETWVTLDDFDVTGYQFHDPIQYPFSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.78 kDa
Sequence
MKQYLDLCQRIVDQGVWVENERTGKRCLTVINADLTYDVANNQFPLVTTRKSFWKAAVAELLGYIRGYDNAEDFRKLGTKTWDANANLNDAWLNNPYRKGEDDMGRVYGVQGRAWAKPDGGHIDQLRKIVDDLTRGVDDRGEILNFYNPGEFHMGCLRPCMYSHHFSLLDDTLYLNSTQRSCDVPLGLNFNMVQVYVFLAIMAQITGKKPGQAFHKIVNAHIYEDQLELMRDVQLKREPLQAPTFHINPEIKSLEDLETWVTLDDFWVEGYEHHDPIRYPFSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Vibrio tasmaniensis (strain LGP32)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.486 kDa
Sequence
MKQYLDLCQRIVNDGTWIENERTGKRCLTVINADLEYDVGNNQFPLVTTRKSFWKAAVAELLGYIRGYDNAEDFRKLGTKTWDANSNLNEAWLNNPYRKGEDDMGRVYGVQGRAWAKPDGGHIDQLKKIVDDLTNGIDDRGEILNFYNPGEFHMGCLRPCMYSHHFSLLGDTLYLNSTQRSCDVPLGLNFNMVQVYVFLAIMAQITGKKAGVAYHKLVNAHIYEDQLAPMRDIQLKREPLAGPTFHINPEIKSLEDLETWVTMDDFWVEGYECHEAIKYPFSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Vibrio vulnificus (strain CMCP6)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.717 kDa
Sequence
MKQYLELCRRIVDEGHWVENERTGKRCLTVINADLTYDVANNQFPLVTTRKSFWKAAVAELLGYIRGYDNAEDFRKLGTKTWDANANLNDAWLNNPYRKGEDDMGRVYGVQGRAWAKPDGGHIDQLRKIVDDLTRGVDDRGEILNFYNPGEFHMGCLRPCMYSHHFSLLGDTLYLNSTQRSCDVPLGLNFNMVQVYVFLAIMAQITGKKPGQAFHKIVNAHIYEDQLALMRDVQLKREPLQAPTFHINPEIKSLEDLETWVTLDDFWVEGYEHHDPIQYPFSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Vibrio vulnificus (strain YJ016)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.703 kDa
Sequence
MKQYLELCRRIVDEGHWVENERTGKRCLTVINADLTYDVANNQFPLVTTRKSFWKAAVAELLGYIRGYDNAEDFRKLGTKTWDANANLNDAWLNNPYRKGDDDMGRVYGVQGRAWAKPDGGHIDQLRKIVDDLTRGVDDRGEILNFYNPGEFHMGCLRPCMYSHHFSLLGDTLYLNSTQRSCDVPLGLNFNMVQVYVFLAIMAQITGKKPGQAFHKIVNAHIYEDQLALMRDVQLKREPLQAPTFHINPEIKSLEDLETWVTLDDFWVEGYEHHDPIQYPFSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.217 kDa
Sequence
MKQYLDLCQRIVDDGKWVNNERTGKKCLTVINADLTYNVGNGEFPLVTTRKSFYKSAIAEMIGYIRGYDNAADFRKIGTSTWDANANQNQAWLDNPHRKGEDDCGLIYGKIGRNFPKPDGGSIDLLAKIIYDLKNGIDDRGEIFTFYHPGAFHMGCLRPCMYSHHFSLLDDTLYLNSTQRSCDVPLGLNFNMVQVYFLLAIVAQITGKKAGMAYHKIVNAHIYEDQLELMRDVQLKREPLGMPKLIINPDIKSLEDLETWVTMDDFSIEGYAHHPAIKYPFSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Pseudoalteromonas haloplanktis (strain TAC 125)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.35 kDa
Sequence
MKQYLQLCQRIVDEGQWVENKRTGTRCLTVINADLEYDVANNQFPMITTRKSYYKAAIAELLGYLRGYDSAAQFREIGCKTWDANANENSAWLNNPHRKGEDDMGRVYGVQGRAWQRPDGSTLDQLAKVINNLKNGIDDRGEIISFYNPGEFELGCLRPCMHTHTFSLLGDTLYLTSIQRSCDVPLGLNFNQIQCFVLLALVAQITGHKAGKAYHKITNAHIYENQLELMRDVQLKREPFASPQLKINPNIKSLNDIETWVTRDDFEVTGYECHEAIQYPFSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Psychromonas ingrahamii (strain 37)
Length
283 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.251 kDa
Sequence
MKQYLGLCQRIVDKGIWIENQRTGKRCLTVINADLEYDVGNNQFPMITTRKSFYKSAIAELIGYLRGYDNAADFRKLGTKTWDANSNLNNAWLNNPYRKGEDDMGRVYGIQGRSWAKPDGGFIDQLKKVVDDLSNGIDDRGEIVTFYNPGEFEMGCLRPCMHTHTFSLLGDTLHLTSYQRSCDVPLGLNFNQVQVFALLALMAQITGKKAGMAYHKIVNAHIYEDQLALMRDVQLPRLPFASPQLKINPKIKSLQDLETWVTMDDFEVEGYQCHDAIKYPFSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
Length
280 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
31.774 kDa
Sequence
MRTYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSQGFPLLTTKKVHFRSIVIELLWFLKGDTNVQYLKDHKVSIWDEWATAEQTARFGRPEGELGPVYGHQWRNFGATQNSDGSYKNDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDGKLSCQLYQRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAQLQLTREPLPLCQLKLNPEITDLFDFKFEDIEIVDYQSHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Acinetobacter baumannii (strain AB307-0294)
Length
280 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
31.826 kDa
Sequence
MRAYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSKGFPLLTTKKVHFRSIVIELLWFLKGDTNVKYLQDNKVTIWDEWATAEQTARFGRPEHELGPVYGHQWRNFGATKNADGTYNQDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDNKLSCQLYQRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAKLQLTREPLPLCQLKLNPEVKDIFDFKFEDIEIVGYESHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Acinetobacter baumannii (strain AB0057)
Length
280 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
31.826 kDa
Sequence
MRAYLDLLQHILDNGGDKGDRTGTGTRSVFGHQMRFDLSKGFPLLTTKKVHFRSIVIELLWFLKGDTNVKYLQDNKVTIWDEWATAEQTARFGRPEHELGPVYGHQWRNFGATKNADGTYNQDGFDQIKWLINEIKTNPNSRRLIVSGWNPNEAGQVALPPCHTLFQFFVQDNKLSCQLYQRSADVFLGVPFNIASYALLTHMIAQVCGLGVGDFVWTGGDTHLYANHFEQAKLQLTREPLPLCQLKLNPEVKDIFDFKFEDIEIVGYESHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.76 kDa
Sequence
MSHYDQQYNAIIQKIIESGISDEEYQVRTKWDSDGTPAHTLSIMSEKMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVQVLNDMGVHIWDQWRLEDGTIGAAYGYQLGKKNRTVNGQKVDQVDYLLHQLKHNPSSRRHLTMLWNPDDLDGMALTPCVYETQWYVKEGKLSLEVRARSNDMALGNPFNVFQYNVLQRMIAQVLGYELGEYIFNIGDCHIYTRHIDNLNIQMKREQYEAPKLWINPDIKNFYDFTIDDFKLIDYKHGDKLTFEVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bacillus licheniformis
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.76 kDa
Sequence
MSHYDQQYNAIIQKIIESGISDEEYQVRTKWDSDGTPAHTLSIMSEKMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVQVLNDMGVHIWDQWRLEDGTIGAAYGYQLGKKNRTVNGQKVDQVDYLLHQLKHNPSSRRHLTMLWNPDDLDGMALTPCVYETQWYVKEGKLSLEVRARSNDMALGNPFNVFQYNVLQRMIAQVLGYELGEYIFNIGDCHIYTRHIDNLNIQMKREQYEAPKLWINPDIKNFYDFTIDDFKLIDYKHGDKLTFEVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bacillus mojavensis
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.91 kDa
Sequence
MTQFDKQYNSIIKEIIKNGISDEEFDVRTKWESDGTPAHTLSIITKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVTELNKMGVHIWDQWKQEDGSIGHAYGFQLAKKNRNLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDSMALTPCVYETQWYVKQGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNIGDCHVYTRHIDNLKIQMEREQFEAPKLWINPEVKDFYDFTIDDFKLINYKHGDRLSFEVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bacillus subtilis subsp. natto
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.823 kDa
Sequence
MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVMSKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNKMGVHIWDQWKQEDGTIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDDLDAMSLTPCVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNIGDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYNFTIDDFKLINYKHGDKLLFEVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Lactococcus lactis subsp. lactis (strain IL1403)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.499 kDa
Sequence
MTYADKIFKQNIQNILDNGVFSENARPKYKDGQTANSKYVTGSFVTYDLQKGEFPITTLRPIPIKSAIKELMWIYQDQTSELAILEEKYGVKYWGEWGIGDGTIGQRYGATVKKYNIIGKLLDGLAKNPWNRRNIINLWQYEDFEETEGLLPCAFQTMFDVRREQDGQIYLDATLIQRSNDMLVAHHINAMQYVALQMMIAKHFSWKVGKFFYFVNNLHIYDNQFEQANELVKRTASDKEPRLVLNVPDGTNFFDIKPEDFELVDYEPVKPQLKFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Lactococcus lactis subsp. cremoris (strain SK11)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.676 kDa
Sequence
MTYADQVFKQNIQNILDNGVFSENARPKYKDGQMANSKYVTGSFVTYDLQKGEFPITTLRPIPIKSAIKELMWIYQDQTSELSVLEEKYGVKYWGEWRIGDGTIGQRYGATVKKYNIIGKLLEGLAKNPWNRRNIINLWQYEDFEETEGLLPCAFQTMFDVRREKDGQIYLDATLIQRSNDMLVAHHINAMQYVALQMMIAKHFSWKVGKFFYFVNNLHIYDNQFEQANELMKRTASEKEPRLVLNVPDGTNFFDIKPEDFELVDYEPVKPQLKFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.831 kDa
Sequence
MSKADFIFKKNIKKILTDGVWSEQARPKYKNGKTANSKYITGAFAEYDLAKGEFPITTLRPIAIKSAIKEVFWIYQDQTNELAILNDKYGVRYWNDWEVKQTGTIGERYGAIVKKHDIMNKILKQLEENPWNRRNVISLWDYEAFEKTEGLLPCAFQIMFDVRRVKGEIYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFVNNLHIYDNQFEQAEELLRREPVVCQPHLVLNVPNKTNFFDIKPEDFELLDYEPVKPQLKFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Streptococcus pyogenes serotype M1
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.663 kDa
Sequence
MTKADQIFKANIQKIINEGSLSEQARPKYKDGRTAHSKYITGAFAEYDLAKGEFPITTLRPIPIKSAIKELFWIYQDQSNSLDVLEAKYNVHYWNEWEVDQTRTIGQRYGAVVKKHDIISKILKQLAENPWNRRNVISLWDYEAFEETKGLLPCAFQIMFDVRRVGEDLYLDASLTQRSNDILVAHHINAMQYVALQMMIAKHFGWKIGKFFYFVNNLHIYDNQFDQAQELLKRQPVASQPKLVLNVPDRTNFFDIKPDDFELQNYDPVKPQLHFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.554 kDa
Sequence
MTKADTIFKENIERILKEGVFSEQARPKYKDGTVANSKYVTGAFSEYDLSKGEFPITTLRPIAIKSAIKEVLWIYQDQSNSLEVLNDKYNVHYWNDWEVGDTGTIGERYGAVVKKHDIINKLLKQLETNPWNRRNIISLWDYQAFEETDGLLPCAFQTMFDVRRVDGEIYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNLHIYDNQFEQAQELLRREPSNCQPRLVLNVPDGTNFFDIKAEDFELVDYDPVKPQLKFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.663 kDa
Sequence
MTKADQIFKANIQKIINEGSLSEQARPKYKDGRTAHSKYITGAFAEYDLAKGEFPITTLRPIPIKSAIKELFWIYQDQSNSLDVLEAKYNVHYWNEWEVDQTRTIGQRYGAVVKKHDIISKILKQLAENPWNRRNVISLWDYEAFEETKGLLPCAFQIMFDVRRVGEDLYLDASLTQRSNDILVAHHINAMQYVALQMMIAKHFGWKIGKFFYFVNNLHIYDNQFDQAQELLKRQPVASQPKLVLNVPDRTNFFDIKPDDFELQNYDPVKPQLHFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.564 kDa
Sequence
MTKADQIFKANIQKIINEGSLSEQARPKYKDGRTAHSKYITGAFAEYDLAKGEFPITTLRPIPIKSAIKELFWIYQDQSNSLDVLEAKYNVHYWNEWEVDQTRTIGQRYGAVVKKHDIISKILKQLAENPWNRRNVISLWDYEAFEETKGLLPCAFQIMFDVRRVGEDLYLDASLTQRSNDILVAHHINAMQYVALQMMIAKHFGWKIGKFFYFVNNLHIYDNQFDQAQELLKRQPVASQPKLVLNVPDGTNFFDIKPDDFELQNYDPVKPQLHFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Streptococcus pneumoniae (strain 70585)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.554 kDa
Sequence
MTKADTIFKENIERILKEGVFSEQARPKYKDGTVANSKYVTGAFSEYDLSKGEFPITTLRPIAIKSAIKEVLWIYQDQSNSLEVLNDKYNVHYWNDWEVGDTGTIGERYGAVVKKHDIINKLLKQLETNPWNRRNIISLWDYQAFEETDGLLPCAFQTMFDVRRVDGEIYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNLHIYDNQFEQAQELLRREPSNCQPRLVLNVPDGTNFFDIKAEDFELVDYDPVKPQLKFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Streptococcus pyogenes serotype M18 (strain MGAS8232)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.564 kDa
Sequence
MTKADQIFKANIQKIINEGSLSEQARPKYKDGRTAHSKYITGAFAEYDLAKGEFPITTLRPIPIKSAIKELFWIYQDQSNSLDVLEAKYNVHYWNEWEVDQTRTIGQRYGAVVKKHDIISKILKQLAENPWNRRNVISLWDYEAFEETKGLLPCAFQIMFDVRRVGEDLYLDASLTQRSNDILVAHHINAMQYVALQMMIAKHFGWKIGKFFYFVNNLHIYDNQFDQAQELLKRQPVASQPKLVLNVPDGTNFFDIKPDDFELQNYDPVKPQLHFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Streptococcus pyogenes serotype M12 (strain MGAS2096)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.598 kDa
Sequence
MTKADQIFKANIQKIINEGSLSEQARPKYKDGRTAHSKYITGAFAEYDLAKGEFPITTLRPIPIKSAIKELFWIYQDQSNSLDVLEAKYNVHYWNEWEVDQTRTIGQRYGAVVKKHDIISKILKQLAENPWNRRNVISLWDYEAFEETKGLLPCAFQIMFDVRRVGEDLYLDASLTQRSNDILVAHHINAMQYVALQMMFAKHFGWKIGKFFYFVNNLHIYDNQFDQAQELLKRQPVASQPKLVLNVPDGTNFFDIKPDDFELQNYDPVKPQLHFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Streptococcus pyogenes serotype M12 (strain MGAS9429)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.598 kDa
Sequence
MTKADQIFKANIQKIINEGSLSEQARPKYKDGRTAHSKYITGAFAEYDLAKGEFPITTLRPIPIKSAIKELFWIYQDQSNSLDVLEAKYNVHYWNEWEVDQTRTIGQRYGAVVKKHDIISKILKQLAENPWNRRNVISLWDYEAFEETKGLLPCAFQIMFDVRRVGEDLYLDASLTQRSNDILVAHHINAMQYVALQMMFAKHFGWKIGKFFYFVNNLHIYDNQFDQAQELLKRQPVASQPKLVLNVPDGTNFFDIKPDDFELQNYDPVKPQLHFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Streptococcus pyogenes serotype M2 (strain MGAS10270)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.564 kDa
Sequence
MTKADQIFKANIQKIINEGSLSEQARPKYKDGRTAHSKYITGAFAEYDLAKGEFPITTLRPIPIKSAIKELFWIYQDQSNSLDVLEAKYNVHYWNEWEVDQTRTIGQRYGAVVKKHDIISKILKQLAENPWNRRNVISLWDYEAFEETKGLLPCAFQIMFDVRRVGEDLYLDASLTQRSNDILVAHHINAMQYVALQMMIAKHFGWKIGKFFYFVNNLHIYDNQFDQAQELLKRQPVASQPKLVLNVPDGTNFFDIKPDDFELQNYDPVKPQLHFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Streptococcus pyogenes serotype M4 (strain MGAS10750)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.564 kDa
Sequence
MTKADQIFKANIQKIINEGSLSEQARPKYKDGRTAHSKYITGAFAEYDLAKGEFPITTLRPIPIKSAIKELFWIYQDQSNSLDVLEAKYNVHYWNEWEVDQTRTIGQRYGAVVKKHDIISKILKQLAENPWNRRNVISLWDYEAFEETKGLLPCAFQIMFDVRRVGEDLYLDASLTQRSNDILVAHHINAMQYVALQMMIAKHFGWKIGKFFYFVNNLHIYDNQFDQAQELLKRQPVASQPKLVLNVPDGTNFFDIKPDDFELQNYDPVKPQLHFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Streptococcus pyogenes serotype M5 (strain Manfredo)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.564 kDa
Sequence
MTKADQIFKANIQKIINEGSLSEQARPKYKDGRTAHSKYITGAFAEYDLAKGEFPITTLRPIPIKSAIKELFWIYQDQSNSLDVLEAKYNVHYWNEWEVDQTRTIGQRYGAVVKKHDIISKILKQLAENPWNRRNVISLWDYEAFEETKGLLPCAFQIMFDVRRVGEDLYLDASLTQRSNDILVAHHINAMQYVALQMMIAKHFGWKIGKFFYFVNNLHIYDNQFDQAQELLKRQPVASQPKLVLNVPDGTNFFDIKPDDFELQNYDPVKPQLHFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.501 kDa
Sequence
MTKADTIFKENIECILKEGVFSEQARPKYKDGTVANSKYVTGAFSEYDLSKGEFPITTLRPIAIKSAIKEVLWIYQDQSNSLEVLNDKYNVHYWNDWEVGDTGTIGERYGAVVKKHDIINKLLKQLETNPWNRRNIISLWDYQAFEETDGLLPCAFQTMFDVRRVDGEIYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNLHIYDNQFEQAQELLRREPSNCQPRLVLNVPDGTNFFDIKAEDFELVDYDPVKPQLKFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Streptococcus pyogenes serotype M28 (strain MGAS6180)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.564 kDa
Sequence
MTKADQIFKANIQKIINEGSLSEQARPKYKDGRTAHSKYITGAFAEYDLAKGEFPITTLRPIPIKSAIKELFWIYQDQSNSLDVLEAKYNVHYWNEWEVDQTRTIGQRYGAVVKKHDIISKILKQLAENPWNRRNVISLWDYEAFEETKGLLPCAFQIMFDVRRVGEDLYLDASLTQRSNDILVAHHINAMQYVALQMMIAKHFGWKIGKFFYFVNNLHIYDNQFDQAQELLKRQPVASQPKLVLNVPDGTNFFDIKPDDFELQNYDPVKPQLHFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.554 kDa
Sequence
MTKADTIFKENIERILKEGVFSEQARPKYKDGTVANSKYVTGAFSEYDLSKGEFPITTLRPIAIKSAIKEVLWIYQDQSNSLEVLNDKYNVHYWNDWEVGDTGTIGERYGAVVKKHDIINKLLKQLETNPWNRRNIISLWDYQAFEETDGLLPCAFQTMFDVRRVDGEIYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNLHIYDNQFEQAQELLRREPSNCQPRLVLNVPDGTNFFDIKAEDFELVDYDPVKPQLKFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Streptococcus pyogenes serotype M3 (strain SSI-1)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.663 kDa
Sequence
MTKADQIFKANIQKIINEGSLSEQARPKYKDGRTAHSKYITGAFAEYDLAKGEFPITTLRPIPIKSAIKELFWIYQDQSNSLDVLEAKYNVHYWNEWEVDQTRTIGQRYGAVVKKHDIISKILKQLAENPWNRRNVISLWDYEAFEETKGLLPCAFQIMFDVRRVGEDLYLDASLTQRSNDILVAHHINAMQYVALQMMIAKHFGWKIGKFFYFVNNLHIYDNQFDQAQELLKRQPVASQPKLVLNVPDRTNFFDIKPDDFELQNYDPVKPQLHFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.554 kDa
Sequence
MTKADTIFKENIERILKEGVFSEQARPKYKDGTVANSKYVTGAFSEYDLSKGEFPITTLRPIAIKSAIKEVLWIYQDQSNSLEVLNDKYNVHYWNDWEVGDTGTIGERYGAVVKKHDIINKLLKQLETNPWNRRNIISLWDYQAFEETDGLLPCAFQTMFDVRRVDGEIYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNLHIYDNQFEQAQELLRREPSNCQPRLVLNVPDGTNFFDIKAEDFELVDYDPVKPQLKFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Streptococcus suis (strain 98HAH33)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.534 kDa
Sequence
MTKADIIFKENIRKIMEEGVFSENARPRYKDGNVANSKYVTGAFAEYDLSKGEFPITTLRPIPIKSAIKEILWIYQDQTNDLSVLQEKYGVQYWNDWEVEGTGTIGERYGAIVKKHDIISKILKQLEENPWNRRNVISLWDYEAFDQSAGLLPCAFQTLFDVRRVDGEIYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNLHIYDNQFEQAEELLRRTPSEVEPRLVLNVPDGTNFFDIRAEDFELVDYNPVKPQLKFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Streptococcus sanguinis (strain SK36)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.562 kDa
Sequence
MTLADTIFKENIKKIMEQGVFSENARPRYKDGNVANSKYITGSFAEYDLSKGEFPITTLRPIAIKSAIKEVLWIYQDQSNSLELLNDKYNVHYWNDWEVGDTGTIGQRYGAVVKKHNIINKILQQLEANPWNRRNIISLWDYEAFEETDGLLPCAFQTMFDVRRVDGDIYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNLHIYDNQFEQAEELLRREPSDCHPRLVLNVPDGTNFFDIKAEDFELLDYNPVKPQLKFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Streptococcus suis (strain 05ZYH33)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.534 kDa
Sequence
MTKADIIFKENIRKIMEEGVFSENARPRYKDGNVANSKYVTGAFAEYDLSKGEFPITTLRPIPIKSAIKEILWIYQDQTNDLSVLQEKYGVQYWNDWEVEGTGTIGERYGAIVKKHDIISKILKQLEENPWNRRNVISLWDYEAFDQSAGLLPCAFQTLFDVRRVDGEIYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNLHIYDNQFEQAEELLRRTPSEVEPRLVLNVPDGTNFFDIRAEDFELVDYNPVKPQLKFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.527 kDa
Sequence
MTKADLLFKDNITKIMSEGVFSEQARPRYKNGEMANSKYITGAFAEYDLSKGEFPITTLRPIPIKSAIKEIFWIYQDQTNDLVVLNDKYGVTYWNDWEVGHTGTIGQRYGAVVKKHNIISKLLKQLEDNPWNRRNVISLWDYEAFEETEGLLPCAFQTMFDVRRVNGELYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWRVGKFFYFINNLHIYDNQFEQAQELLKRQPSECNPKLVLNVPDGTDFFDIKPDDFALVDYDPIKPQLRFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Streptococcus agalactiae serotype III (strain NEM316)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.527 kDa
Sequence
MTKADLLFKDNITKIMSEGVFSEQARPRYKNGEMANSKYITGAFAEYDLSKGEFPITTLRPIPIKSAIKEIFWIYQDQTNDLVVLNDKYGVTYWNDWEVGHTGTIGQRYGAVVKKHNIISKLLKQLEDNPWNRRNVISLWDYEAFEETEGLLPCAFQTMFDVRRVNGELYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWRVGKFFYFINNLHIYDNQFEQAQELLKRQPSECNPKLVLNVPDGTDFFDIKPDDFALVDYDPIKPQLRFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.499 kDa
Sequence
MTKADLLFKDNITKIMSEGVFSEQARPRYKNGEMANSKYITGAFAEYDLSKGEFPITTLRPIPIKSAIKEIFWIYQDQTNDLAVLNDKYGVTYWNDWEVGHTGTIGQRYGAVVKKHNIISKLLKQLEDNPWNRRNVISLWDYEAFEETEGLLPCAFQTMFDVRRVNGELYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWRVGKFFYFINNLHIYDNQFEQAQELLKRQPSECNPKLVLNVPDGTDFFDIKPDDFALVDYDPIKPQLRFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.65 kDa
Sequence
MTKADTIFKENIRRILKEGVFSENARPRYKDGNVANSKYITGSFAEYDLSKGEFPITTLRPIAIKSAIKEVLWIYQDQSNSLELLNDKYNVHYWNDWEVGDTGTIGQRYGAIVKKHDIINKILQQLAANPWNRRNIISLWDYEAFEETEGLLPCAFQTMFDVRRVDEDIYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNLHIYDNQFEQAEELLRREPSDCQPRLVLNVPDGTNFFDIKAEDFELLDYDPVKPQLKFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Caulobacter vibrioides (strain ATCC 19089 / CB15)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
31.462 kDa
Sequence
MSTAVLDAPKAATDHPERQYLTLLADILENGVQRGDRTGTGTLGVFGRQIRFDLAKGFPVLTTKKLHLRSIIIELLWFLKGDTNIAYLKDNGVRIWDEWADENGDLGPVYGKQWRSWATPDGRVIDQISALVENLKANPNSRRHIVTAWNPADVDDMALPPCHCLFQFFVADGKLSCQLYQRSADVFLGVPFNIASYALLTLMVAKVVGLEPGEFVHTFGDAHLYLNHLDQAREQLTREPFDFPTMKIADKRDLFGFEYEDFTLEGYQAHPHIKAEVSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Marinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11845 / VT8)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.173 kDa
Sequence
MKAYLDLMQDVVDNGFDKGDRTGVGTRSVFGRQMRFNLQDGFPLVTTKKVHLRSIIYELLWFLKGSTDNTWLAERKVSIWNEWALENGDLGPIYGKQWRSWQCHDGRVIDQISEVIEQIRTKPNSRRLIVSAWNPAELPDESISPQDNVREGRMALAPCHCLFQFYVADGKLSCQLYQRSADLFLGVPFNIASYALLTHMIAQQCDLDVGEFVHTFGDCHLYRNHLTDDIVFEQLRREPRALPKLVIKRKPESIFGYELEDFEFEGYDPSPVIKAPIAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Acidovorax citrulli (strain AAC00-1)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
31.978 kDa
Sequence
MNAPARPVRSQYEDFMRHVYTHGVAKGDRTGTGTRSVFGYQMRFDLNEGFPLVTTKKVHLKSIITELLWFLTGSSSNHWLKERGVTIWDEWAREDGDLGPVYGVQWRSWPTPDGGHIDQISQVVETLRTHPDSRRIIVSAWNVADLDKMALMPCHAFFQFYVAPPQAAGERGKLSCQLYQRSADIFLGVPFNIASYALLTHMMAQQCNLEVGDFIWTGGDCHIYSNHFEQVELQLSRAPHPYPTLHILRRPDSLFDYRFEDFEVRDYAHHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Streptococcus pneumoniae (strain JJA)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.501 kDa
Sequence
MTKADTIFKENIECILKEGVFSEQARPKYKDGTVANSKYVTGAFSEYDLSKGEFPITTLRPIAIKSAIKEVLWIYQDQSNSLEVLNDKYNVHYWNDWEVGDTGTIGERYGAVVKKHDIINKLLKQLETNPWNRRNIISLWDYQAFEETDGLLPCAFQTMFDVRRVDGEIYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNLHIYDNQFEQAQELLRREPSNCQPRLVLNVPDGTNFFDIKAEDFELVDYDPVKPQLKFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Streptococcus pneumoniae (strain P1031)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.554 kDa
Sequence
MTKADTIFKENIERILKEGVFSEQARPKYKDGTVANSKYVTGAFSEYDLSKGEFPITTLRPIAIKSAIKEVLWIYQDQSNSLEVLNDKYNVHYWNDWEVGDTGTIGERYGAVVKKHDIINKLLKQLETNPWNRRNIISLWDYQAFEETDGLLPCAFQTMFDVRRVDGEIYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNLHIYDNQFEQAQELLRREPSNCQPRLVLNVPDGTNFFDIKAEDFELVDYDPVKPQLKFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Streptococcus pneumoniae (strain Taiwan19F-14)
Length
279 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.554 kDa
Sequence
MTKADTIFKENIERILKEGVFSEQARPKYKDGTVANSKYVTGAFSEYDLSKGEFPITTLRPIAIKSAIKEVLWIYQDQSNSLEVLNDKYNVHYWNDWEVGDTGTIGERYGAVVKKHDIINKLLKQLETNPWNRRNIISLWDYQAFEETDGLLPCAFQTMFDVRRVDGEIYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNLHIYDNQFEQAQELLRREPSNCQPRLVLNVPDGTNFFDIKAEDFELVDYDPVKPQLKFDLAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Acidovorax sp. (strain JS42)
Length
277 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
31.748 kDa
Sequence
MTPRPIRHQYEDLMRHVFEHGTAKGDRTGTGTKSVFGHQMRFDLSEGFPLVTTKKVHLKSIILELLWFLRGDSNVRWLQERGCTIWDEWARDDGSLGPVYGVQWRSWPTPDGGHIDQIQQVIDTLKTHPDSRRIIVSAWNVAELDRMALMPCHAFFQFYVAPSQVAGEPGKLSCQLYQRSADIFLGVPFNIASYALLTHMVAQQCDLQVGDFIWTGGDCHIYSNHFEQVRTQLARQPYAYPTLQIKRRPASIFDYAYEDFEVVGYEHHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Alcanivorax borkumensis (strain ATCC 700651 / DSM 11573 / NCIMB 13689 / SK2)
Length
277 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
31.049 kDa
Sequence
MKQYLDLLRHVREHGTYKEDRTGTGTYAVFGYQMRYDLSQGFPMLTTKKLHLRSIIHELLWFLSGDTNIRYLKENGVSIWDGWATPEGELGPVYGEQWRSWKTADGGVIDQITEVLKEIKRNPDSRRLVVSAWNPAVLPDPSISPDANAAAGKQALPPCHCLFQFYVADGKLSCQLYQRSGDIFLGVPFNIASYALLTLMMAQVCDLQPGDFVHTLGDAHLYSNHLEQADTQLARTPGPLPTMTLNPAVKDLFAFTFDDFTVSNYNPDAHIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Hydrogenovibrio crunogenus (strain XCL-2)
Length
277 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
31.773 kDa
Sequence
MKQYLDLLKHITETGVAKGDRTGTGTRSVFGYQMRFNLEEGFPLVTTKKLHLKSIVYELLWFLNGDTNNQYLKEHGVRIWDEWATETGDLGPIYGRQWVAWEKPNGDTINQIEEVIQTLKKNPNSRRMLVSAWNPADLPDESMSPQENVKQGRMALATCHAFFQFYVANGKLSCQLYQRSADTFLGVPFNIASYALLTHMIAQQTDLEVGEFVWTGGDVHLYNNTLEQAELQMSRTPYALPKLKIKRKPPSIFDYEFDDFEIEGYESHPHIKAVVSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Rhodoferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118)
Length
277 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
31.216 kDa
Sequence
MSSHPIRSQYEDFLRHVSTHGVFKADRTGTGTTSVFGYQMRFDLNEGFPLVTTKKVFLKAIVLELLWFLRGDSNVKWLQERGCTIWDEWARPDGDLGPVYGVQWRSWPTPDGGHIDQIAEAIKTLKTNPDSRRIIVSAWNVAELDKMALMPCHAFFQFYVAPAQTPGGKGKLSCQLYQRSADIFLGVPFNIASYALLTHMVAQQCDLDVGDFIWTGGDCHVYSNHAEQVALQLSRTPFAYPTLSIKRKPASIFDYAYEDFEVLGYECHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Roseobacter denitrificans (strain ATCC 33942 / OCh 114)
Length
277 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
31.544 kDa
Sequence
MQQYHDALRTILECGEESTDRTGTGTISYFGMQMRYPLSDGFPLVTTKKLHLRSIFHELLWFLSGDTNIRYLQDNGVSIWDEWADENGDLGPVYGHQWRAFSALSPTEEVKDGEPLYLGRGVDQVTNLIDMIKSSPDSRRMIVSAWNPADVPRMALPPCHALWQVRVLNGRMHLQLYQRSADMFLGVPFNIASYSLLLVMLAHVTGYEPGDFVHTLGDAHIYSNHMDQVNLQLTRTPKPLPTLRINRQVSSIFDFRYEDFEVIGYDPDPAIRAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Ruegeria sp. (strain TM1040)
Length
277 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
31.557 kDa
Sequence
MQQYHDALQHILDHGVETTDRTGTGTLSCFGMQQRYDLAEGFPLVTTKKLHLRSIIHELLWFLSGDTNIRYLKENGVSIWDEWADENGDLGPVYGYQWRKFPRLELAEGTLGDEPLYRAGTVDQISELLDMIRKSPDSRRLIVTAWNPGDVPDMALPPCHSLWQLRILGGKMHLQLYQRSADMFLGVPFNIASYALLLHMLAHVTGYEVGSFVHTMGDAHIYSNHMEQVKLQLSRSPKSLPQLRIARDVSSIFDFKYEDFEILGYDPDPVIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)
Length
277 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
31.557 kDa
Sequence
MKQYLDLMRHVRDTGTKKEDRTGTGTVSVFGYQMRFDLSEGFPLVTTKKCHLKSIIHELLWFLKGETNTQYLTDNGVRIWNEWATEEGDLGPVYGAQWRSWPTPDGGSLDQFALLVEQIKNKPDSRRHIISAWNPALLPDEGVSPQDNVRNGKMALPPCHTLFQFYVADNKLSCQLYQRSADIFLGVPFNIASYALLTMMVAQVTGLELGDFVHTFGDAHLYLNHLEQVETQLAREPLPLPTMKINPEVKDIFSFKFEDFELVDYQAHPHISAPISI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Teredinibacter turnerae (strain ATCC 39867 / T7901)
Length
277 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
31.412 kDa
Sequence
MKQYLELMRHVRDNGVRKEDRTGTGTVSVFGYQMRFDLSQGFPLVTTKKCHLKSIIHELLWFLNGETNIAYLNNNGVKIWDAWATESGDLGPIYGAQWRSWPAQNGETLDQISQLIEQIKHKPDSRRLIISAWNPALLPDESISPQDNVRNGKMALPPCHTLFQFYVLEGRLSCQLYQRSADIFLGVPFNIASYALLTMMIAQVTGLAPGDFVHTFGDAHLYLNHLEQVDTQLQRQPLPLPTMAINPAVKDIFGFCFDDFELQNYQAHPHIAAPISV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Thioalkalivibrio sulfidiphilus (strain HL-EbGR7)
Length
277 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
31.776 kDa
Sequence
MQPYLDLMRQLLEHGTVKSDRTGTGTRSLFGHQMRFDLSKGFPLVTTKKLHLKSIIHELLWFLKGETNIAYLKDNGVRIWDEWATEDGELGPVYGRQWRAWPTPDGRHIDQISQVVEQIRTRPDSRRLIVSAWNVAELPDEGISPKDNARAGRMALAPCHTFFQFYVADGRLSCQLYQRSADVFLGVPFNIASYALLTLMVAQVTDLEPGDFVHTFGDVHLYSNHVEQAKEQLSREPYPLPKMHLNPEVKSLFDFRYEDFTLEGYQAHPHIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Pseudomonas fluorescens (strain SBW25)
Length
277 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
31.51 kDa
Sequence
MKQYLELLNDVVTNGLTKGDRTGTGTKAVFARQYRHNLADGFPLLTTKKLHFKSIANELIWMLSGNTNIKWLNENGVKIWDEWATEDGDLGPVYGEQWTAWPTKDGGTINQIDYMVHTLKTNPNSRRILFHGWNVEYLPDETKSPQENARNGKQALPPCHLLYQAFVHDGHLSMQLYIRSSDVFLGLPYNTAALALLTHMLAQQCDLIPHEIIVTTGDTHAYSNHMEQIRTQLARTPKKLPELVIKRKPASIYDYKFEDFEIVGYDADPSIKADVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)
Length
277 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
31.541 kDa
Sequence
MKSYLDLLTDVLENGSVKGDRTGTGTISVFGRQYRHDLSKGFPLLTTKKLHFKSIVNELIWFLSGDTNIKWLNENGVKIWNEWATEEGDLGPVYGKQWTAWPTKDGGTINQIDYVVNALKTNPNSRRILFHGWNVEYLPDEKVSPQENAENGKMALPPCHLLYQFYVVDNKLSAHLFIRSSDSFLGLPYNTASLACLTHMLAQQCDMGVGEIVISLSDVHIYSNHMEQVKTQISREPRKLPELKLLRKPESIYDYKFEDFELVGYDPHPHIAAPVSI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Polaromonas naphthalenivorans (strain CJ2)
Length
276 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
31.291 kDa
Sequence
MTRPIRHQYEDLMRLVATQGAFKADRTGTGTKSVFGHQMRFDLNEGFPLVTTKKVHLKSIIQELLWFLTGSSSNHWLTERGVTIWNEWARADGDLGPVYGVQWRSWPTPDGGHIDQIAEVIKTLKTNPDSRRIIVSAWNVADLDKMALMPCHALFQFYVAPATEAGGKGKLSCQLYQRSADIFLGVPFNIASYALLTHMVAQQCDLDVGDFIWTGGDCHIYSNHQEQVALQLGRAPFAYPLLHIRRKPDSIFDYQFEDFEFLDYQHHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
Length
275 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
32.172 kDa
Sequence
MKARFDKIYKDIVDTIAEKGIWSEGNVRTKYADGTAAHYKSYIGYQFRLDNSDDEAHLITSRFAPSKAPIRELYWIWILQSNNVDVLNELGCKFWDEWKMQDGTIGKAYGYQIAQETFGQKSQLHYVINELKKNPNSRRIMTEIWIPNELSEMALTPCVHLTQWSVIGNKLYLEVRQRSCDVALGLVANVFQYSVLHKLVALECGLEPAEIIWNIHNMHIYDRHYDKLIEQVNRETFEPAKIKINNFKSIFDFKPDDIEIIDYKYGEKVSYEVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Flavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)
Length
274 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
31.299 kDa
Sequence
MKQYLDLVKYVLNNGTQKGDRTGTGTKSVFGYQMRFNLAEGFPMVTTKKLHLKSIIHELLWFLKGETNIAYLQQNGVKIWDDWADENGELGPVYGHQWRNWNNEEIDQITELIETLKINPNSRRMLVSAWNPSVLPDTTKSFAENVANAKVALPPCHAFFQFYVSEGKLSCQLYQRSADIFLGVPFNIASYALFTMMIAQVCDLQAGEFIHTFGDAHIYNNHFEQVALQLSREPKPLPKMILNPAVKNIFDFKFEDFKLEGYESHAHIKGAVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Francisella philomiragia subsp. philomiragia (strain ATCC 25017)
Length
274 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
31.416 kDa
Sequence
MREYLNFLKYIKDNGTKKGDRTGTGTTSIFGYQMRFDLQQGFPLVTTKKIHIPSVVHELLWFLSGSTNVKYLNDNKVRIWNEWATEEGELGPIYGKQWRDFNGEGIDQIAEVIEMLKTNPNSRRILVSAWNPCVVPSEKISPQENVAKGNSALPPCHAMFQFYIADNKLSCMLTQRSADAFLGVPFNIASYSLLTHMIAQQCDLDVGEFIWSGGDCHIYNNHIEQVNEQLSREPLDLPTLKILRKPSSIFDYKYEDFEFQNYKHHPAIKAKISV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Francisella tularensis subsp. tularensis (strain FSC 198)
Length
274 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
31.325 kDa
Sequence
MQEYLNFLKYIKENGVLKGDRTGTGTRSIFGYQMRFDLQKGFPLVTTKKIHIPSVVHELLWFLSGSTNIKYLNDNNVRIWNEWATVDGELGPIYGKQWRDFNGQGIDQIADVIQMLKTNPNSRRILVSAWNPCVVPSEKISPQENVVKGNSALPPCHAMFQFYVANNKLSCMLTQRSADAFLGVPFNIASYSLLTNMVAQQCNLDVGEFIWSGGDCHIYNNHIEQVNEQLSREPLALPTLKILRKPNSIFDYKYEDFEFENYNHHPAIKAKISV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Francisella tularensis subsp. holarctica (strain FTNF002-00 / FTA)
Length
274 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
31.415 kDa
Sequence
MREYLNFLKYIKENGVLKNDRTGTGTRSIFGYQMRFDLQKGFPLVTTKKIHIPSVVHELLWFLSGSTNIKYLNDNNVRIWNEWATVDGELGPIYGKQWRDFNGQGIDQIADVIQMLKTNPNSRRILVLAWNPCVVPSEKISPQENVVKGNSALPPCHAMFQFYVANNKLSCMLTQRSADAFLGVPFNIASYSLLTHMVAQQCNLDVGELIWSGGDCHIYNNHIEQVNEQLSREPLALPTLKILRKSNSIFDYKYEDFEFENYNHHPAIKAKISV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Francisella tularensis subsp. holarctica (strain LVS)
Length
274 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
31.415 kDa
Sequence
MREYLNFLKYIKENGVLKNDRTGTGTRSIFGYQMRFDLQKGFPLVTTKKIHIPSVVHELLWFLSGSTNIKYLNDNNVRIWNEWATVDGELGPIYGKQWRDFNGQGIDQIADVIQMLKTNPNSRRILVLAWNPCVVPSEKISPQENVVKGNSALPPCHAMFQFYVANNKLSCMLTQRSADAFLGVPFNIASYSLLTHMVAQQCNLDVGELIWSGGDCHIYNNHIEQVNEQLSREPLALPTLKILRKSNSIFDYKYEDFEFENYNHHPAIKAKISV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Francisella tularensis subsp. novicida (strain U112)
Length
274 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
31.376 kDa
Sequence
MREYLNFLKYIKENGVLKGDRTGTGTRSIFGYQMRFDLQKGFPLVTTKKIHIPSVVHELLWFLSGSTNIKYLNDNNVRIWNEWATVDGELGPIYGKQWRDFNGQGIDQIADVIQMLKTNPNSRRILVSAWNPCVVPSEKISPQENVVKGNSALPPCHAMFQFYVANNKLSCMLTQRSADAFLGVPFNIASYSLLTHMVAQQCNLDVGEFIWSGGDCHIYNNHIEQVNEQLSREPLALPTLKILRKPNSIFDYKYEDFEFENYNHHPAIKAKISV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Francisella tularensis subsp. holarctica (strain OSU18)
Length
274 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
31.415 kDa
Sequence
MREYLNFLKYIKENGVLKNDRTGTGTRSIFGYQMRFDLQKGFPLVTTKKIHIPSVVHELLWFLSGSTNIKYLNDNNVRIWNEWATVDGELGPIYGKQWRDFNGQGIDQIADVIQMLKTNPNSRRILVLAWNPCVVPSEKISPQENVVKGNSALPPCHAMFQFYVANNKLSCMLTQRSADAFLGVPFNIASYSLLTHMVAQQCNLDVGELIWSGGDCHIYNNHIEQVNEQLSREPLALPTLKILRKSNSIFDYKYEDFEFENYNHHPAIKAKISV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Length
274 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
31.325 kDa
Sequence
MQEYLNFLKYIKENGVLKGDRTGTGTRSIFGYQMRFDLQKGFPLVTTKKIHIPSVVHELLWFLSGSTNIKYLNDNNVRIWNEWATVDGELGPIYGKQWRDFNGQGIDQIADVIQMLKTNPNSRRILVSAWNPCVVPSEKISPQENVVKGNSALPPCHAMFQFYVANNKLSCMLTQRSADAFLGVPFNIASYSLLTNMVAQQCNLDVGEFIWSGGDCHIYNNHIEQVNEQLSREPLALPTLKILRKPNSIFDYKYEDFEFENYNHHPAIKAKISV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Francisella tularensis subsp. tularensis (strain WY96-3418)
Length
274 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
31.376 kDa
Sequence
MREYLNFLKYIKENGVLKGDRTGTGTRSIFGYQMRFDLQKGFPLVTTKKIHIPSVVHELLWFLSGSTNIKYLNDNNVRIWNEWATVDGELGPIYGKQWRDFNGQGIDQIADVIQMLKTNPNSRRILVSAWNPCVVPSEKISPQENVVKGNSALPPCHAMFQFYVANNKLSCMLTQRSADAFLGVPFNIASYSLLTHMVAQQCNLDVGEFIWSGGDCHIYNNHIEQVNEQLSREPLALPTLKILRKPNSIFDYKYEDFEFENYNHHPAIKAKISV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Gramella forsetii (strain KT0803)
Length
274 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
31.44 kDa
Sequence
MKQYHDLLKHVLEQGAQKGDRTGTGTKSVFGYQMRFDLSEGFPMVTTKKLHLKSIIYELLWFLKGDTNIEYLKENGVRIWNEWADDNGDLGPVYGHQWRNWNGEEIDQIKEIVHSLKHNPNSRRMLVSAWNPSVLPDTSVSFSENVANGKAALPPCHAFFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTMMMAQVCGYEAGDFIHTFGDAHIYSNHMEQVELQLSREPRQLPIMKINPEVKDIFDFKFEDFTLEDYDPHPGIKAKVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Nocardioides sp. (strain ATCC BAA-499 / JS614)
Length
273 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.593 kDa
Sequence
MRAYLDLLQRVVDEGVPKGDRTGTGTLSVFGHQMRFDLRAGFPLVTTKKVHTRSVFGELLWFLRGDTNVKWLQDRGITIWDEWADEQGDLGPVYGYQWRSWPTPDGRHVDQIAQVVEQIRDSPDSRRHVVSAWNVADIPDMALAPCHTMFQFYVAPPGPGEESGPGRLSCQLYQRSADVFLGVPFNIASYALLTHMVAQVTGLEVGDFVHTLGDAHLYSNHLDQARLQLTREPRPLPRLVLDSSVTELDAFDLEHIAVEGYDPHPGIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Corynebacterium jeikeium (strain K411)
Length
273 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.744 kDa
Sequence
MAPQQQPSSIPTPYEDLLREILETGTPKGDRTGTGTTSLFGRQIRYDLSAGFPLITTKSVHVKSVVGELLWFLRGDSNVRWLQENGIRIWNEWADENGDLGPVYGVQWRSWPTPNGQHIDQIAGALETLQTNPDSRRNIVSAWNVSELDNMALPPCHLLFQLYVANGKLSCQLYQRSADMFLGVPFNIASYSLLTHMFAQQAGLEVGEFIWTGGDCHIYDNHVEQVKLQLSRDARPYPQLKLNKAADMFSYDFSDIEFTGYDPHPVIKAKVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
Length
270 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.835 kDa
Sequence
MSTNNTIKTPYEDLLRTILEQGSHKDDRTGTGTTSLFGQQMRFDLTEAFPLITTKKVYWKGVIGELLWFLQGSSNVRWLQKRNIHIWDEWASEEGELGPVYGVQWRSWPTPDGQHVDQIAQALDILKNNPDSRRNIVSAWNVADLNNMALPPCHLLFQLYVADGKLSCQLYQRSADMFLGVPFNIASYSALTHMLAQQAGLKVGEFIWTGGDCHIYDNHREQVLTQLSREPRPYPQLTLRKASSIFDYDFDDFTIEGYDPHPAIRGEVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Leifsonia xyli subsp. xyli (strain CTCB07)
Length
269 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.672 kDa
Sequence
MTTPIPTPYEDLLRDVLANGSHKSDRTGTGTRSVFGRQLRFDLADGFPLITTKRVHFKSIAYELLWFLRGDSNVGWLRENGVSIWDEWADERGELGPVYGVQWRSWPSPDGTHIDQIQQVVDTLRRDPDSRRIIVSAWNVADIPDMALAPCHAFFQFYVADGKLSCQLYQRSADMFLGVPFNIASYALLTLMVAQQVGLEPGEFVWTGGDVHIYDNHIEQVNEQLSRNPFPAPALRFARRPESVFDYRYEDFVLEGYRHHPAIRAAVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Methylocella silvestris (strain DSM 15510 / CIP 108128 / LMG 27833 / NCIMB 13906 / BL2)
Length
269 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.407 kDa
Sequence
MQAYLDLIDKILREGVRKPDRTGTGTLSIFGYQMRFDLGAGFPLVTTKKLHWKSIVHELIWFLRGDTNIGYLKDNGVGIWDEWADDSGDLGPVYGRQWRSWQAPDGRTIDQIANVIDEIQRDPFSRRLLVSAWNPADLPAMALAPCHCLFQFNVRDDSTGTRRLDLQLYQRSGDAFLGAPFNIASYALLTELVASVCGLTPGDFVHTFGDAHLYLNHIDQAKLQLSRDPRPLPRLRINGNVKSLFDIRFEDLSLENYDPHPVIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Cutibacterium acnes (strain DSM 16379 / KPA171202)
Length
269 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.838 kDa
Sequence
MQIYLDLLRRILDEGVRREDRTGTGTVSVFGHQMVFDLREGFPLVTTKKIYTRSVFGELLWFLRGDTNVGWLHDNNIHIWDEWADENGDLGPVYGHQWRSWPDDDGTIDQIANVVEQIRTNPWSRRHIVSAWNVAEIKEMALPPCHTLFQFYVTPDDRGTPTWLSCQLYQRSGDTFLGVPFNIASYALLTHLVASVTGLKPLRFVHTLGDAHVYLNHLDQVHEQLKRKPRHRPTLTVNPGIRDIDGFELSDITLTGYDPYPALPAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216)
Length
268 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.504 kDa
Sequence
MAEQRIDTQYEDLLRHVLATGTPKSDRTGTGTRSVFGHQLRYDLSAGFPLVTTKRVHFKSIALELLWFLRGDGNVRWLQERGVTIWDEWADENGDLGPVYGVQWRSWPTPDGRHVDQIAQVLHTLRTDPDSRRMVVSAWNVAELDRMALAPCHAFFQFHVADGKLSCQLYQRSADLFLGVPFNIASYALLTHLVAAEVGLEVGDFVWTGGDVHVYDNHVEQVTEQLTRTPYPFPRLAVRPAGLFEHEYEDFEVLDYRHHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Corynebacterium aurimucosum (strain ATCC 700975 / DSM 44827 / CN-1)
Length
268 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.695 kDa
Sequence
MATMIETPYEDLLRRVLEEGAPKGDRTGTGTLSLFGAQLRYNLAESFPLLTTKKVYFHGVIGELLWFLRGDSNVKWLQENKVRIWNEWADEDGELGPVYGVQWRSWPTPDGQHIDQIQVALDTLKNNPDSRRNLVSAWNVSELDKMALMPCHLLFQLYVADGKLSMQVYQRSADMFLGVPFNLASYAALTHMFAQQAGLEVGELIWTGGDCHIYNDHIEQVKEQLSRQPREYPQLKLHKAESLFDYDFDDFEVIGYDPHPTIKAQVSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Arthrobacter sp. (strain FB24)
Length
267 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.447 kDa
Sequence
MSIPTPYEDLLRDVLANGTHKSDRTGTGTLSVFGRQMRFDLSQSFPLITTKRVHFKSVAVELLWFLRGETNVKWMQDQGVTIWNEWADADGELGPVYGVQWRSWPTPDGGHIDQIAELVENLKSNPDSRRHIVSAWNVAELQDMALPPCHAFFQFYVADGKLSCQLYQRSADTFLGVPFNIASYALLTCMLAQQVGLEPGEFVWTGGDVHIYDNHMDQVLKQLKREPYEYPQLKILRKPDSIFDYTLDDFEVVGYQHHPTIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Paenarthrobacter aurescens (strain TC1)
Length
267 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.407 kDa
Sequence
MSIPTPYEDLLRDVMANGTHKSDRTGTGTRSVFGRQLRFDLAESFPLITTKRVHFKSVAVELLWFLRGDSNVKWMQDQGVSIWDEWADADGELGPVYGVQWRSWPTPDGGHIDQISELMTNLAANPDSRRHIVSAWNVSELKDMALPPCHAFFQFYVADGKLSCQLYQRSADTFLGVPFNIASYALLTRMVAQQLGLEPGEFVWTGGDVHVYDNHVDQVAEQLSREPYEYPQLKILRKPDSIFDYTLDDFEVVDYRHHPTIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Length
267 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.569 kDa
Sequence
MTAIPTPYEDLLRTIRDEGAHKDDRTGTGTTSLFGQQIRYNLQEGFPLLTTKKVHFHSVVGELLWFLRGDSNVRWLQDNNIRIWNEWADEDGELGPVYGVQWRSWPTPDGRHIDQISRALEMLKNNPDSRRNIVSAWNVSELENMALPPCHLLFQLYVADGKLSCQLYQRSADMFLGVPFNIASYALLTHMFAQQADLEVGEFIWTGGDCHIYDNHTEQVDEQLSRAARPYPTLELNKAASLFDYTFEDIAVSNYDPHPLIRGKVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Mycobacterium avium (strain 104)
Length
266 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.134 kDa
Sequence
MPIPTPYEDLLRLVLDRGTAKSDRTGTGTRSLFGQQLRYDLSAGFPLITTKKVHLKSVVYELLWFLRGDSNVDWLHRHGVTIWDEWASDTGDLGPIYGVQWRSWPTPSGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIPRMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLSVGEFVWTGGDCHIYDNHVEQVRLQLSREPRPYPELVLAHRDSIFDYTYDDVVVHNYDPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Mycobacterium gilvum (strain PYR-GCK)
Length
266 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.053 kDa
Sequence
MPTATPYEDLLRLVLDTGTPKSDRTGTGTRSLFGHQMRYDLNAGFPLITTKKVHTKSIVYELLWFLRGDSNVRWLQERGVTIWDEWASPTGDLGPVYGVQWRSWPTPSGEHIDQISAALDLLKRDPDSRRNIVSAWNVGEIPQMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLGVGEFIWTGGDCHIYDNHVEQVTEQLSRDPRPYPELVLAPRDSIFDYTYEDVVIKNYEPHPAIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Mycobacterium leprae (strain TN)
Length
266 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.141 kDa
Sequence
MLIATPYEDLLRLVLDCGVAKMDRTGTGTRSLFGQQLRYDLSVGFPLVTTKKVHFKSVVYELLWFLRGDSNVAWLHEHGVNIWDEWASSTGDLGPIYGVQWRSWPTSSGDYIDQISTALDLLRTEPDSRRIIVSAWNVGEIPQMALPPCHAFFQFYVAQGRLSCQLYQRSADMFLGVPFNIASYALLTHMMAAQSGLLVGEFVWTGGDCHIYDNHVEQVQLQLSREPRAYPELFLAQRDSIFDYVYEDVVVTNYDPHPAIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Length
266 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.148 kDa
Sequence
MPIPTPYEDLLRLVLDRGTAKSDRTGTGTRSLFGQQLRYDLSAGFPLITTKKVHLKSVVYELLWFLRGDSNVDWLHRHGVTIWDEWASDTGDLGPIYGVQWRSWPTPSGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIPRMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLSVGEFVWTGGDCHIYDNHVEQVRLQLSREPRPYPELILAHRDSIFDYTYDDVVVHNYDPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Length
266 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.056 kDa
Sequence
MPIDTPYEDLLRLVTERGTPKSDRTGTGTRSLFGHQMRYDLSAGFPLITTKKVHTKSVIYELLWFLRGDSNVRWLQEHGVTIWDEWASETGDLGPIYGVQWRSWPTPSGEHIDQISSALELLKSDPDSRRNIVSAWNVGEIPQMALPPCHAFFQFYVADGKLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLDVGEFIWTGGDCHIYDNHTEQVALQLSREPRPYPELVLAPRDSIFDYTYEDIAIVNYDPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Rhodococcus jostii (strain RHA1)
Length
266 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.152 kDa
Sequence
MTVPTPYEDLLRLVMDTGTPKADRTGTGTKSVFGHQMRWNLADGFPLITTKKVHLKSIVYELLWFLRGDSNVKWLQDNGVTIWDEWADADGELGPVYGVQWRSWPTPSGEHIDQITQTIETLKSNPDSRRIIVSAWNVGDIPQMALAPCHAFFQFYVADGKLSCQLYQRSADLFLGVPFNIASYALLTHMVAQQAGLEPGDFIWTGGDCHIYDNHVDQVTEQLSREPLPYPTLKLNKRESIFDYTFEDVEIVDYRHHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bifidobacterium longum (strain NCC 2705)
Length
266 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.689 kDa
Sequence
MPYEDLVRKILTEGTLKSDRTGTGTISLFGQQMRFDLSKYFPLLTTKTVFFKGLAYELLWFLKGSSNINWLLEHNVHIWDEWADENGDLGPVYGVQWRSWPAPTPEDPNRTIDQISNVLDLIKHHPDSRRMIVSAWNPAEVEKMALPPCHALFQFYVADDKLSCQLYQRSCDMFLGVPFNIASYSLLTMMMAQQAGLKPGEFVWTGGDCHVYDNHVDQFLEQLGRKPYPYPTIEIRKADSLFDYQYEDFKVVGYQHHPTIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Brachyspira hyodysenteriae (strain ATCC 49526 / WA1)
Length
266 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.799 kDa
Sequence
MQNYLDLLKKVLEEGEETKDRTGVGTRRIFGPQLRFKFEGNKIPIITTKRVFMKGVIIELLWFLQGSTNIKFLLENNVHIWDEWADDMGELGPVYGKQWRAWETKEGNKIDQISNIVNTLRNNPASRRIILNAWNVGEIDQMHLPPCHMMCQFSVNSKGGIITHLYQRSADLFLGVPFNISSYAILTRLLAMHSGLHASELIMTFGDAHIYNNHIEQVKLQLSREPLEQTTELFIDNRPNIFSHVYEDFKLEGYKYYPTIKAEVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Corynebacterium glutamicum (strain R)
Length
266 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.23 kDa
Sequence
MTVPTPYEDLLRKIAEEGSHKDDRTGTGTTSLFGQQIRFDLNEGFPLLTTKKVHFHSVVGELLWFLQGDSNVKWLQDNNIRIWNEWADEDGELGPVYGVQWRSWPTPDGRHIDQISGALETLRNNPDSRRNIVSAWNVSELENMALPPCHLLFQLYVADGKLSCQLYQRSADMFLGVPFNIASYALLTHMFAQQAGLEVGEFIWTGGDCHIYDNHKEQVAEQLSREARPYPTLELNKAASMFEYSFDDITVSGYDPHPLIRGKVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Length
266 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.23 kDa
Sequence
MTVPTPYEDLLRKIAEEGSHKDDRTGTGTTSLFGQQIRFDLNEGFPLLTTKKVHFHSVVGELLWFLQGDSNVKWLQDNNIRIWNEWADEDGELGPVYGVQWRSWPTPDGRHIDQISGALETLRNNPDSRRNIVSAWNVSELENMALPPCHLLFQLYVADGKLSCQLYQRSADMFLGVPFNIASYALLTHMFAQQAGLEVGEFIWTGGDCHIYDNHKEQVAEQLSREARPYPTLELNKAASMFEYSFDDITVSGYDPHPLIRGKVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Mycobacterium sp. (strain JLS)
Length
266 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.038 kDa
Sequence
MPIPTPYEDLLRLVFERGTPKSDRTGTGTRSLFGHQMRYDLAAGFPLITTKKVHLKSVVYELLWFLRGESNVRWLQEHGVTIWDEWASETGELGPVYGVQWRSWPTPSGGHVDQISAAVDLLRTDPDSRRNIVSAWNVGEIPQMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLGVGEFVWTGGDCHIYDNHVEQVTEQLSRDPRPYPELVLAQRDSIFDYTYEDVVVKNYDPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Mycobacterium sp. (strain KMS)
Length
266 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.038 kDa
Sequence
MPIPTPYEDLLRLVFERGTPKSDRTGTGTRSLFGHQMRYDLAAGFPLITTKKVHLKSVVYELLWFLRGESNVRWLQEHGVTIWDEWASETGELGPVYGVQWRSWPTPSGGHVDQISAAVDLLRTDPDSRRNIVSAWNVGEIPQMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLGVGEFVWTGGDCHIYDNHVEQVTEQLSRDPRPYPELVLAQRDSIFDYTYEDVVVKNYDPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Mycobacterium sp. (strain MCS)
Length
266 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.038 kDa
Sequence
MPIPTPYEDLLRLVFERGTPKSDRTGTGTRSLFGHQMRYDLAAGFPLITTKKVHLKSVVYELLWFLRGESNVRWLQEHGVTIWDEWASETGELGPVYGVQWRSWPTPSGGHVDQISAAVDLLRTDPDSRRNIVSAWNVGEIPQMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLGVGEFVWTGGDCHIYDNHVEQVTEQLSRDPRPYPELVLAQRDSIFDYTYEDVVVKNYDPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Mycobacterium ulcerans (strain Agy99)
Length
266 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.094 kDa
Sequence
MPIATPYEDLLRRVLETGTAKSDRTGTGTRSLFGQQIRYDLGCGFPLLTTKKVHFKSVVYELLWFLRGDSNVGWLQQHGVTIWDEWASETGDLGPIYGVQWRSWPTPSGEHIDQISAALELLRTDPDSRRIIVSAWNVGQIPQMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLSVGEFIWTGGDCHIYDNHVEQVTEQLRREPRPYPKLSLSQRDSIFDYTYEDVVVQDYDPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
Length
266 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.007 kDa
Sequence
MPIATPYEDLLRLVLDTGTTKSDRTGTGTRSLFGHQMRYDLNAGFPLITTKKVHTKSIVYELLWFLRGDSNVRWLQEHGVTIWDEWASPTGDLGPVYGVQWRSWPTPSGAHIDQISAALDLLRRDPDSRRNIVSAWNVGEIPQMALPPCHAFFQFYVSGGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLGVGEFIWTGGDCHIYDNHVEQVTEQLSREPRPYPELVLAQRDSLFDYIYEDVVIKNYDPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Nocardia farcinica (strain IFM 10152)
Length
266 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.394 kDa
Sequence
MATDRQYEDLLRLVLDTGTAKGDRTGTGTRSIFGHQLRYDLSAGFPLITTKKVHLKSIVYELLWFLRGDSNVGWLREHGVTIWDEWADPQGELGPVYGVQWRSWPTPDGTHIDQISQVLQTLRTDPDSRRMIVSAWNVAELDRMALAPCHAFFQFYVADGKLSCQLYQRSADLFLGVPFNIASYALLTHMVAQQTELEPGEFIWTGGDCHIYDNHVEQVTEQLGREPYPFPRLELRPAPSLFDYRFEDVTVTDYRHHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Neisseria gonorrhoeae
Length
265 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.306 kDa
Sequence
MKAYLDLMRHVLDNGTDKSDRTGTGTLSVFGYQMRFDLGKGFPLLTTKKLHLRSIIHELLWFLKGDTNIKYLKDNNVSIWDDEWADENGDLGPVYGYQWRSWPAPDGRHIDQIANVVEQIKKNPDSRRLIVSAWNPALVDEMALPPCHALFQFYVADGNLSCQLYQRSADIFLGVPFNIASYALLTMMMAQVCGLEAGEFVHTFGDAHLYRNHFEQAALQLEREPRALPVMKINPEVKDLFAFKFEDFELEGYDPHPHIKAVVSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
29.937 kDa
Sequence
MRAYLDLMQKILDEGTVKSDRTGTGTISLFGHQMRFNLAEGFPLVTTKKCHLRSIIHELLWFLNGDTNTAYLKEHGVSIWDEWADENGDLGPVYGAQWRSWPAADGSVIDQIQKAVDDIKHNPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLTHMMAQQCDLEVGDFVWTGGDVHLYSNHMEQTALQLTREPRPLPTLVIKRKPDSIFDYKFEDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Aeromonas salmonicida (strain A449)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
29.95 kDa
Sequence
MRVYLDLMQKILDEGTVKSDRTGTGTVSLFGHQMRFNLAQGFPLVTTKKCHLRSIIHELLWFLNGDTNTAYLKEQGVSIWDEWADENGDLGPVYGAQWRSWPAADGAVIDQIQRAVDDIKHNPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLTHMMAQQCDLEVGDFVWTGGDVHLYSNHMEQTALQLSREPRPLPQLAIKRKPDSIFDYRFEDFEILGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Agrobacterium fabrum (strain C58 / ATCC 33970)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
29.875 kDa
Sequence
MKQYLDLLRHVMETGSDRGDRTGTGTRSVFGYQMRFDLSEGFPVLTTKKLHLRSIIHELLWFLNGDTNIAYLKENGVSIWDEWADENGDLGPVYGAQWRSWPAPDGRHIDQIALLIEALKTNPNSRRHIVSAWNPALVDEMALPPCHCLFQFYVSDGKLSCQLYQRSADIFLGVPFNIASYALLTLMVAQVVGLKPGDFVHTLGDAHIYANHFEQAQLQMTRTPKALPTMRLNPDVKNLFGFKFEDFTLENYEADSSIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Agrobacterium vitis (strain S4 / ATCC BAA-846)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
29.725 kDa
Sequence
MKQYLDLLQHVMENGSDRGDRTGTGTRSVFGYQMRFDLAQGFPVLTTKKLHLRSIIHELLWFLKGDTNIAYLKENGVSIWDEWADENGDLGPVYGAQWRSWPKPGGGHIDQIANLVESIKTNPNSRRHIVSAWNPAEVDEMALPPCHCLFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTMMVAQVTGLKAGDFIHTLGDAHLYANHFEQARLQLTRQPKPLPVMRINPDVKDVFGFAFEDFSLENYSADPVIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.239 kDa
Sequence
MQAYLDLMAHVRHHGTPKSDRTGTGTLSVFGHQMRFDLSRGFPVVTTKKLHLRSIIHELLWFLSGDSNIAYLKANGVSIWDEWADENGDLGPIYGVQWRSWPTPDGRRVDQLAQVLRDLREHPDSRRHLVSAWNVGELPNMALPPCHTLFQFYVAEGRLSCQLYQRSADIFLGLPFNIASYALLTHMVAQVCDLKPGEFIWTGGDCHLYTNHLEQADRQLQREPLPLPRLRLNPEVRDLFAFRYEDIALEGYQHHPPIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Anoxybacillus flavithermus (strain DSM 21510 / WK1)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.746 kDa
Sequence
MKQYLQLLEDILQNGVYKDDRTGTGTLSVFGRQLRFDLREGFPLLTTKKLHIRSIIHELLWFLSGDTNIRYLKENGVTIWDEWADEKGDLGPVYGAQWRSWRGADGRTIDQISEVIEQIKTNPNSRRLLVSAWNVAELDHMKLPPCHYAFQFYVENGTLSCMWQQRSVDTFLGLPFNIASYALLTYMVAQQCDLQPKELIFTGGDVHLYMNHIEQAKLQLTREPRPLPKLIIKRKPASIFEYRFEDFEIVDYDPHPHIKADVSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Aromatoleum aromaticum (strain EbN1)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.134 kDa
Sequence
MKQYLDLMRHVLDHGDRKSDRTGTGTLSIFGWQMRFNLDDGFPLLTTKKLHTRSIIHELLWFLRGDTNIRYLNENGVSIWDDWADENGDLGPVYGKQWRRWETANGATIDQIAQLIDGLKHNPDSRRHLVSAWNPGEVAGMALPPCHALFQFYVAGDRLSCQLYQRSADIFLGVPFNIASYALLTLMVAQVCGLRAGDFVWTGGDCHLYLNHLDQARLQLSRQPRALPRMIVNPGVTDIFGFRFEDFRLEGYDPHPHIKAEVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Azoarcus sp. (strain BH72)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.371 kDa
Sequence
MQQYLDLMRHVLEHGDRKTDRTGTGTVSVFGWQMRFRLAEGFPLLTTKKLHTRSIIHELLWFIRGDTNIRYLKDHGVSIWDEWADENGDLGPVYGKQWRRWETADGRSVDQLAQLIDGIKRNPDSRRHIVSAWNPGEVGSMALPPCHALFQFYVAGGRLSCQLYQRSADIFLGVPFNIASYALLTMMVAQVCDLEPGDFVWTGGDCHLYLNHLQQAEEQLQRTPYPLPRMILNPEVRDLFAFRFEDFTLEGYTAHPHIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Azotobacter vinelandii (strain DJ / ATCC BAA-1303)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.125 kDa
Sequence
MKQYLDLMRLVREHGTFKSDRTGTGTFSVFGHQMRFDLAEGFPLVTTKKCHLKSIVHELLWFLKGDTNIRYLKENGVSIWDEWADGNGDLGPVYGYQWRSWPAPDGRHIDQIANVVNMIRDNPDSRRLIVSAWNPALIDEMKLPPCHALFQFYVADGRLSCQLYQRSADIFLGVPFNIASYALLILMMAQVTGLAPGEFVWTGGDCHLYANHLEQADLQLSREPLPLPTMQLDPDVKDLFAFRFEDFELVGYQSHPHIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.484 kDa
Sequence
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQEGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRSLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.225 kDa
Sequence
MKQYHDLCRHILDQGVVKEDRTGTGTTSVFGYQMRFNLQEGFPLITTKKLHIRSIIHELLWFISGETNVRYLQDNGVRIWNEWADEEGNLGPVYGSQWRSFPRPDGSSVDQLAQVIEQIKTNPDSRRLIVSAWNPGQLEEMALPPCHLLFQFYVADGKLSCQLYQRSADTFLGVPFNIASYALLTHMVAHVTGLEVGDFVHTLGDAHIYHNHLEQVELQLSRDPRPLPKLNIVRDVSSIESFRFEDFEILGYDPHPHIKGEVSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Geobacillus kaustophilus (strain HTA426)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.512 kDa
Sequence
MRQYLQLLEDILENGVEKEDRTGVGTLSVFGRQLRFNLQDGFPLVTTKKLHIRSIIYELLWFLKGDTNVRYLQENGVTIWDEWADENGDLGPIYGAQWRSWKGADGKTIDQIAWVVEEIKRNPNSRRLLVSAWNVAELDEMKLPPCHYAFQFYVANGRLSCMWQQRSVDTFLGLPFNIASYALLTHMIAQQCDLDVGELIFTGGDVHLYKNHLEQAKLQLTREPRPLPKLVIKRKPPSIFDYEYDDFEIVGYNPHPTIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Geobacillus sp. (strain WCH70)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.581 kDa
Sequence
MRQYLQLLEDILENGVEKDDRTGVGTLSVFGRQLRFNLQEGFPLLTTKKLHIRSIIYELLWFLKGDTNVRYLQENGVTIWDEWADENGDLGPIYGAQWRSWKGADGKTVDQISWVIEEIKRNPNSRRLLVSAWNVAELDKMKLPPCHYAFQFYVADGKLSCMWQQRSVDTFLGLPFNIASYALLTHMIAQQCDLDVGELIFSGGDVHLYKNHLEQAKLQLTREPRPLPKLVIKRKPASIFEYEFEDFEIVDYDPHPHIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Geobacillus thermodenitrificans (strain NG80-2)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.345 kDa
Sequence
MRQYLQLLEDILENGVEKEDRTGVGTLSVFGRQLRFNLQDGFPLVTTKKLHIRSIIYELLWFLKGDTNVRYLQENGVTIWDEWADENGDLGPVYGAQWRSWKGADGKTVDQIASVVEEIKRNPNSRRLLVNAWNVAELDKMKLPPCHYAFQFYVANGRLSCMWQQRSVDTFLGLPFNIASYALLTHMIAEQCGLDVGELIFTGGDVHLYKNHIEQAKLQLTREPRPLPKLVLKRKPSSIFDYEYDDFEIVGYDPHPTIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Salmonella paratyphi A (strain ATCC 9150 / SARB42)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.369 kDa
Sequence
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQEGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQIATVLSQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLDVGDFVWTGGDTHLYSNHMEQTHLQLSREPRALPKLVIKRKPDSLFDYRFDDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.369 kDa
Sequence
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQEGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQIATVLSQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLDVGDFVWTGGDTHLYSNHMEQTHLQLSREPRALPKLVIKRKPDSLFDYRFDDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Salmonella paratyphi C (strain RKS4594)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.349 kDa
Sequence
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQEGFPLVTTKHCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQIATVLSQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLDVGDFVWTGGDTHLYSNHMEQTHLQLSREPRALPKLVIKRKPDSLFDYRFDDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Salmonella typhi
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.336 kDa
Sequence
MKQYLELIQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLLEGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQIATVLSQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLDVGDFVWTGGDTHLYSNHMEQTHLQLSREPRALPKLVIKRKPDSLFDYRFDDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.369 kDa
Sequence
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQEGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQIATVLSQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLDVGDFVWTGGDTHLYSNHMEQTHLQLSREPRALPKLVIKRKPDSLFDYRFDDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Serratia proteamaculans (strain 568)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.155 kDa
Sequence
MKQYLDLMNKVLAEGTPKADRTGTGTLSIFGHQMRFNLQEGFPLVTTKKCHLRSIIHELLWFLNGDTNVAYLKENKVSIWDEWADENGNLGPVYGKQWRAWGTADGRQIDQLTTVLNQLKQDPDSRRIIVSAWNVGELDQMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMEQTQLQLTREPRALPKLVIKRKPASLFDYRFEDFEIEGYDPHPAIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.411 kDa
Sequence
MKQYLDLMKHILDKGTDKSDRTGTGTRSVFGYQMRFDLNEGFPLVTTKKCHLRSIIHELLWFLKGETNVDYLHENKVSIWDEWADEKGNLGPVYGAQWRSWPTPDGRHIDQISQVIEQIKATPDSRRLIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLTMMVAQQCNLGLGDFVWTGGDTHLYSNHMEQTQLQLSREPRPLPTMKILRHPESIFDYRFEDFELSGYDPHPHIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Shewanella baltica (strain OS223)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.038 kDa
Sequence
MKQYLDLMKHILAEGVDKSDRTGTGTRSVFGYQMRFDLSKGFPLVSTKKCHMRSIIHELLWFLKGETNVAYLRENKVSIWDEWADDNGDLGPVYGAQWRSWPTQSGDAIDQISQVIAQIKSQPDSRRLIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLTMMVAQQCDLALGDFVWTGGDTHLYSNHMEQTALQLSREPMPLPTMTILRKPESIFDYQFDDFELTNYAPHPHIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Shewanella baltica (strain OS155 / ATCC BAA-1091)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.08 kDa
Sequence
MKQYLDLMKHILAEGVDKSDRTGTGTRSVFGYQMRFDLSKGFPLVSTKKCHMRSIIHELLWFLKGETNVAYLRENKVSIWDEWADENGDLGPVYGAQWRSWPTQSGDAIDQISQVIAQIKSQPDSRRLIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLTMMVAQQCDLALGDFVWTGGDTHLYSNHMEQTALQLSREPMPLPTMTILRRPESIFDYQFDDFELTNYAPHPHIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Shewanella baltica (strain OS185)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.066 kDa
Sequence
MKQYLDLMKHILAEGVDKSDRTGTGTRSVFGYQMRFDLSKGFPLVSTKKCHMRSIIHELLWFLKGETNVAYLRENKVSIWDEWADDNGDLGPVYGAQWRSWPTQSGDAIDQISQVIAQIKSQPDSRRLIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLTMMVAQQCDLALGDFVWTGGDTHLYSNHMEQTALQLSREPMPLPTMTILRRPESIFDYQFDDFELTNYAPHPHIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Shewanella baltica (strain OS195)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.066 kDa
Sequence
MKQYLDLMKHILAEGVDKSDRTGTGTRSVFGYQMRFDLSKGFPLVSTKKCHMRSIIHELLWFLKGETNVAYLRENKVSIWDEWADDNGDLGPVYGAQWRSWPTQSGDAIDQISQVIAQIKSQPDSRRLIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLTMMVAQQCDLALGDFVWTGGDTHLYSNHMEQTALQLSREPMPLPTMTILRRPESIFDYQFDDFELTNYAPHPHIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.183 kDa
Sequence
MKQYLALMEHILAHGAVKTDRTGTGTRSVFGYQMRFDLNQGFPLVTTKKCHLRSIIHELLWFLQGDTNVAYLHEHNVSIWDEWADDKGNLGPVYGAQWRSWPTQSGKAVDQISQIIEQIKTQPDSRRLIVSAWNVGELDKMALAPCHALFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLTMMVAQQCDLALGDFVWTGGDTHLYSNHMEQTKLQLSREPHALPQMNILRKPESIFDYQFDDFELVNYQPHPHIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Shewanella oneidensis (strain MR-1)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.005 kDa
Sequence
MQQYLDLMKHILAEGVDKSDRTGTGTRSVFGYQMRFDLSKGFPLVTTKKCHMRSIIHELLWFLKGDTNIAYLRDNKVSIWDEWADENGDLGPVYGAQWRSWPTQSGEAIDQISQVIAQIKSQPDSRRLIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLTMMVAQQCDLALGDFVWTGGDTHLYSNHMEQTALQLSREPRPLPTMTILRKPASIFDYQFDDFALSNYDPHPHIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Shewanella putrefaciens (strain CN-32 / ATCC BAA-453)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.145 kDa
Sequence
MQQYLDLMKHILAEGVDKSDRTGTGTRSVFGYQMRFDLSKGFPLVTTKKCHMRSIIHELLWFLKGETNIAYLRENKVSIWDEWADDNGDLGPVYGAQWRSWPTQSGDAIDQISQVIAQIKAQPDSRRLIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLTMMVAQQCDLALGDFVWTGGDTHLYSNHMEQTVLQLSREPKPLPLMTILRKPESIFDYQFEDFELTNYNPHPHIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / JCM 11019 / NCTC 9343)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.365 kDa
Sequence
MKQYLDLLDRVLTEGIEKGDRTGTGTISVFGHQMRFNLDEGFPCLTTKKLHLKSIIYELLWFLKGDTNVKYLQDHGVRIWNEWADETGDLGHIYGYQWRSWPTYDGGFIDQISEAVDAIKHNPDSRRIIVSAWNVGDLDHMNLPPCHAFFQFYVANGRLSLQLYQRSADIFLGVPFNIASYALLLQMMAQVTGLQAGDFIHTLGDAHIYLNHLEQVKLQLSREPRPLPQMKINPDVKNIFDFQFEDFELVNYDPHPHIAGKVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bacteroides fragilis (strain YCH46)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.364 kDa
Sequence
MKQYLDLLDRVLTEGIEKGDRTGTGTISVFGHQMRFNLDEGFPCLTTKKLHLKSIIYELLWFLKGDTNVKYLQDHGVRIWNEWADETGDLGHIYGYQWRSWPTYDGGFIDQISEAVDAIKHNPDSRRIIVSAWNVGDLDHMNLPPCHAFFQFYVANGRLSLQLYQRSADIFLGVPFNIASYALLLQMMAQVTGLQAGDFIHTLGDAHIYLNHLEQVKLQLSREPRPLPQMKINPDVKNIFDFQFKDFELVNYDPHPHIAGKVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.457 kDa
Sequence
MEQYLELCRHVLEHGTERSDRTGTGTISVFGYQMRFDLQEGFPVVTTKKLHLRSIIHELLWFLKGETNIAYLQENGVRIWNEWADENGELGPVYGKQWRSWEGANGKTVDQISQVVEAIKHQPDSRRLIVSAWNAAEIEDMALAPCHCLFQFYVQDGKLSCQLYQRSADIFLGVPFNIASYALLTKMIAQVCDLEEGEFVHTFGDAHIYLNHIEQVKLQLTREPRPLPEMRLNPEVRSLFDFTFDDFELVGYDPHPHIKGEVSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bacillus pumilus (strain SAFR-032)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.491 kDa
Sequence
MKQYKELCRHVLQHGDEKGDRTGTGTISTFGYQMRFDLQEGFPLLTTKKLHLKSIIHELLWFLKGDTNVKYLQENGVRIWNEWADENGELGRVYGAQWRSWASGDGETVDQITKLIHDIEHNPNSRRLIVSAWNPGEIDQMALPPCHCLFQFYVSNGKLSCQLYQRSADIFLGVPFNIASYALLTMMIAKVTNLEPGEFVHTLGDAHIYQNHLPQVNMQLEREERALPQLRITRDVKSIFDFTFDDFVLENYDPHPHIKGEVSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bacillus clausii (strain KSM-K16)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.508 kDa
Sequence
MEQYLQLCEHVLQNGSPKSDRTGTGTISVFGYQMRFDLEKGFPIVTTKKLHMRSIIHELLWFLKGDTNIRYLQENGVRIWNEWADENGDLGPVYGKQWRSWEGANGKTVDQITEVVEQIKTNPNSRRLIVNAWNVAEIEEMALAPCHCLFQFYVNDGKLSCQLYQRSADIFLGVPFNISSYALLTMMMAQVCGLKPGEFIHTFGDAHLYNNHIEQTKLQLTRKPKQLPTMHINPEVTDLFAFTYDDFELKHYDPYPHIKAEVSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.392 kDa
Sequence
MKQYLDLLNRVLTEGTEKSDRTGTGTISVFGHQMRFNLDEGFPCLTTKKLHLKSIIYELLWFLQGDTNAKYLQEHGVRIWNEWADENGDLGHIYGYQWRSWPDYDGGFIDQISEAVETIKHNPDSRRIIVSAWNVADLKNMNLPPCHAFFQFYVADGRLSLQLYQRSADIFLGVPFNIASYALLLQMMAQVTGLKAGEFIHTLGDAHIYLNHLDQVKLQLSREPRALPQMKINPDVKSIYDFQFEDFELVNYDPHPHIAGIVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.479 kDa
Sequence
MKQYLDLLNRILTEGVHKEDRTGTGTISVFGHQMRFNLEEGFPLVTTKKLHLKSIIHELLWFLQGDTNVKYLQDNGVRIWNEWADANGDLGHIYGYQWRSWPDYNGGFIDQISEAIETIKHNPDSRRIIVSAWNVADLNNMNLPPCHAFFQFYVANGRLSLQLYQRSADTFLGVPFNIASYALLLQMVAQVTGLQTGDFVHTLGDTHIYTNHLEQVKLQLSREPRPLPQMKINPDIKDIFSFKYEDFELVNYDPWPHIAGKVSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.433 kDa
Sequence
MKQYKDLCRHVLENGEKKGDRTGTGTISTFGYQMRFNLQEGFPMLTTKKLHFKSIAHELLWFLKGDTNVRYLQENGVRIWNEWADENGELGPVYGSQWRSWRGADGETIDQISRLIHDIKTNPNSRRLIVSAWNVGEIDHMALPPCHCLFQFYVADGKLSCQLYQRSADVFLGVPFNIASYALLTMMIAHVTGLEPGEFVHTFGDVHIYQNHVEQVNLQLTRDVRPLPKLRFARNVDSIFDFTFEDFIIEDYDPHPHIKGAVSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bartonella bacilliformis (strain ATCC 35685 / NCTC 12138 / KC583)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.13 kDa
Sequence
MKAYLDLLSHVLNNGTDRSDRTGVGTRSVFGYQMRFNLQEGFPLLTTKKLHLRSIIYELLWFLKGDTNIAWLKEHGVSIWDEWADKDGNLGPVYGYQWRSWPSSDGRYIDQISNLLAMINHNPNSRRLIVTAWNPALIDEMALPPCHCLFQFQVANGKLSCQLYQRSADIFLGVPFNIASYALLTMMIAQVTGLKVGDFIHTLGDAHLYSNHFEQAKQQLSRTPGILPLIRINPKVTDLFSFQFEDFELLNYEAQPHIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.294 kDa
Sequence
MKTYLDLLSHVLNKGIDRTDRTGVGTRSVFGYQMRFDLQAGFPLLTTKKLHLRSIIYELLWFLRGDTNIAWLKEHGVSIWDEWADEKGNLGPIYGYQWRSWPAPDGRHIDQISNLLMMIKKTPDSRRLIVSAWNPASIKEMALPPCHCFFQFYVADGKLSCQLYQRSADIFLGIPFNIASYALLTMMIAQVSGLKVGDFIHTLGDAHLYSNHFEQAQHQLSRIPNALPFMRINPAVTDLFSFKFEDFELLNYDAQPHIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Laribacter hongkongensis (strain HLHK9)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.221 kDa
Sequence
MKAYLELMQHVLDHGTDKADRTGTGTRSVFGYQMRFDLAQGFPLLTTKKLHLRSIVHELLWFLAGDTNIRYLKDNGVRIWDEWADENGDLGPVYGYQWRSWPAPDGRHIDQISGLLDMIRRNPDSRRLIVSAWNPALVDDMALPPCHCLFQFYVADGKLSCQLYQRSADVFLGVPFNIASYALLTLMVAQVTGLQPGEFVHTFGDAHLYSNHFEQARLQLQREPRALPVMKLNPVVTDLFAFRFEDFTLEGYDPHPHIKAEVSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Legionella pneumophila (strain Paris)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.183 kDa
Sequence
MKTYLQLLEHILQQGVEKSDRTGTGTLSVFGYQMRFDLTKGFPLVTTKKLHTRSIVHELLWFLRGDTNISYLKENGVTIWDEWADNNGDLGPVYGKQWRSWPTADGHTIDQLSDVVQQIKSNPDSRRLIVSAWNVGELDKMALMPCHALFQFYVANNKLSCQLYQRSADVFLGVPFNIASYSLLTHMVAQQCNLDVAEFIWTGGDCHLYLNHLEQAQIQLTREPLPLPSLTIKRKPASLFDYAYEDFEFLNYQSHPAIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Legionella pneumophila (strain Corby)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.169 kDa
Sequence
MKTYLQLLEHILQQGVEKSDRTGTGTLSVFGYQMRFDLTKGFPLVTTKKLHTRSIVHELLWFLRGDTNISYLKENGVTIWDEWADNNGDLGPVYGKQWRSWPTADGHTIDQLSDVVQQIKSNPDSRRLIVSAWNVGELDKMALMPCHALFQFYVANNKLSCQLYQRSADVFLGVPFNIASYSLLTHMVAQQCNLDVAEFIWTGGDCHLYLNHLEQAQIQLTREPLPLPSLTIKRKPASLFDYAYEDFEFVNYQSHPAIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.165 kDa
Sequence
MKTYLQLLEHILQHGVEKSDRTGTGTLSVFGYQMRFDLAQGFPLVTTKKLHTRSIVHELLWFLRGDTNISYLKENGVTIWDEWADNNGDLGPVYGKQWRSWPTADGRTIDQLSEVVQQIKSNPDSRRLIVSAWNVGELDKMALMPCHALFQFYVANNKLSCQLYQRSADVFLGVPFNIASYSLLTHMVAQQCNLDVAEFIWTGGDCHLYLNHLEQAQIQLTREPLPLPSLAIKRKPASLFDYAYEDFEFLNYQSHPAIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Legionella pneumophila (strain Lens)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.026 kDa
Sequence
MKTYLQLLEHILQHGVEKSDRTGTGTLSVFGYQMRFDLAKGFPLVTTKKLHTRSIVHELLWFLRGDTNISYLKENGVTIWDEWADNNGDLGPVYGKQWRSWPTADGGTIDQLSDVVQQIKSNPDSRRLIVSAWNVGELDKMALMPCHALFQFYVANNKLSCQLYQRSADVFLGVPFNIASYSLLTHMVAQQCNLDVAEFIWTGGDCHLYLNHLEQAQTQLTREPLPLPSLAIKRKPASLFDYAYEDFEFVNYQSHPAIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / JCM 21032 / NBRC 15819 / NCTC 12168)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.139 kDa
Sequence
MRTYLDLLQHVLDNGTDRGDRTGTGTRSVFGYQMRFNLEEGFPVLTTKKLHLRSIIHELLWFLKGDTNIAYLKENGVSIWDEWADKNGDLGPVYGYQWRSWPAPDGRHIDQIANLLKMLHGNPNSRRLIVSAWNPALVDEMALPPCHCLFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTMMIAQVAGLKPGEFIHTLGDAHIYANHFDQARLQLTRIPKKLPTMWINPDVKDLFAFRFEDFQLEGYEADPTIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Oligotropha carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.062 kDa
Sequence
MHQYQDLLEHILSDGAEKHDRTGTGTLSVFGHQMRFDLAAGFPMLTTKKLPFKAIVHELLWFLAGDTNVRYLQNNGVSIWDEWADANGDLGPVYGKQWRSWQAPDGRSIDQITNLVQMIRTNPDSRRLIVTAWNPADVEQMALPPCHCLFQFYVANGRLSCQLYQRSADVFLGVPFNIASYALLMMMIAQVTDLAPGHFVHTFGDAHLYSNHLDQARLQLTRAPRALPTLRINPAVRDIFGFRYEDFKLENYDPHPHIKAEVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.327 kDa
Sequence
MKQYLELLNRVLTEGVRKEDRTGTGTISVFGHQMRFNLEEGFPLLTTKKLHLKSIIYELLWFLNGDTNVKYLQDHGVRIWNEWADADGSLGHIYGYQWRSWPDYKGGSIDQITEAVETIKHNPDSRRIIVSAWNVADLDNMNLPPCHAFFQFYVANGRLSLQLYQRSADIFLGVPFNIASYALLLQMMAQATGLKAGDFVHTLGDAHIYSNHLEQVKLQLTREPRALPRMEINPDVKSIFDFKFEDFNLTGYDPHPHIKGEVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
29.936 kDa
Sequence
MQQYLDLMRLARDTGVTKTDRTGTGTRSIFGHQMRFDLSEGFPLVTTKKLHLKSIIHELLWFIAGDTNTRYLKANGVSIWDDWADENGELGPVYGHQWRSWPTPDGGKIDQIRNLVEQIKTNPDSRRLIVSAWNVADVDSMALPPCHCLFQFYVAEGKLSCQLYQRSADIFLGVPFNIASYALLTMMVAQVTGLKPGEFIHTFGDAHLYLNHLEQADKQLAREPKKLPVMHINPDVKSLFDFTYDDFTLEGYEAHPHISAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.361 kDa
Sequence
MKQYLDLMKKVLEEGTPKADRTGTGTRSIFGHQMRFNLQDGFPLVTTKKCHLRSIIHELLWFLNGDTNVAYLNENKVSIWDEWADENGDLGPVYGKQWRSWGAADGRQIDQLKNVLTQLRQDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDIFLGLPFNIASYALLVHMVAQQCDLDVGDFVWTGGDTHLYNNHMEQTHLQLSREPRALPKLVIKRRPDTLFDYRFEDFEIEGYDPHPAIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Pectobacterium carotovorum subsp. carotovorum (strain PC1)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.387 kDa
Sequence
MKQYLDLMKKVLEEGTPKADRTGTGTRSIFGHQMRFNLQDGFPLVTTKKCHLRSIIHELLWFLNGDTNVAYLHENKVSIWDEWADENGDLGPVYGKQWRSWGAADGRQIDQLKNVLTQLRQDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDIFLGLPFNIASYALLVHMVAQQCDLDVGDFVWTGGDTHLYNNHLEQTQLQLSREPRALPKLVIKRRPDTLFDYRFEDFEIEGYDPHPTIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.184 kDa
Sequence
MKQYLDLMTRVLAEGTPKADRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHIRSIIHELLWFLNGDTNIKYLHENGVTIWDEWADENGDLGPVYGKQWRAWGTADGRQIDQLKTVLEQLKSDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMEQTKLQLSREPRSLPKLVIKRKPASLFDYKFDDFEIVDYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Polynucleobacter asymbioticus (strain DSM 18221 / CIP 109841 / QLW-P1DMWA-1)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.235 kDa
Sequence
MRQYHNLMKEVLAKGVQKSDRTGTGTISVFGHQMRFNLADGFPMVTTKKLHMKSIVYELLWFLKGSTDNNWLKERGVSIWNEWAAPDGDLGPIYGYQWRSWPAPNGQHIDQISEVVETIKKNPDSRRIIVSAWNVADIPRMALAPCHAFFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTHMVAQQCNLEVGDFIWTGGDCHLYSNHLEQVDLQLSRDFLPLPKLNILRKPDSLFDYEFEDFEIVGYESHPHIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Hahella chejuensis (strain KCTC 2396)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.587 kDa
Sequence
MKQYLDMMRHVREQGAVKTDRTGTGTRSVFGYQMRFDLQQGFPLVTTKKLHLRSIIYELLWFLNGDTNIKYLKDNGVSIWDEWADESGDLGPVYGYQWRSWPAPNGEHIDQISNVLAQIKRNPDSRRHMVVAYNPAFVDQMALPPCHAMFQFYVAEGRLSCQLYQRSADIFLGVPFNIASYALLTHMFAQQCDLDVGDFIWTGGDVHLYNNHLDQAKEQLDREPRPLPQLQIRRKPASLFDYEFEDFEITGYDPHPHIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Halorhodospira halophila (strain DSM 244 / SL1)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.232 kDa
Sequence
MRAYLDLVQHVLEHGHRKEDRTGTGTLSVFGHQMRFDLEAGFPLVTTKRVFWRGVAEELLWFIRGSTNARELEDKGVRIWSPWADPDGELGPVYGAQWRSWRAADGREIDQLQQVLTELRQRPDSRRHLVSAWNVGELERMNLPPCHLLFQFYVAEGRLSCQLYQRSADLFLGVPFNIASYSLLTHLVARHVGLEVGEFIWTGGDCHLYLNHLAQAREQLSRAPRPLPTLHIDPGVTDLFAVRYEHLRLAGYDPHPKLTAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.609 kDa
Sequence
MKQYLHLMKKVLNEGTEKEDRTGTGTVSIFGHQMRFNLKEGFPLVTTKKCHLRSIIHELLWFLKGDTNIAYLRENQVSIWEEWADKTGSLGPIYGKQWRAWGTPDGHQVDQLSQTLELLKNNPDSRRMIVSAWNVGELDKMALAPCHAFFQFYVVKKTLSCQLYQRSCDVFLGLPFNIASYSLLMHMIAQQCDFFLGDFVWTGGDIHLYSNHLDQAHLQLTREPRSLPHLLINRKPDSLFDYHFEDFSLEKYNPYPAIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Hyphomonas neptunium (strain ATCC 15444)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.196 kDa
Sequence
MQQYQALLRDILENGHKRGDRTGVGTIGVFGRQMRFDLSEGFPMVTTKRLHLRSIIVELLWFLRGDTNIAYLKENGVSIWDEWADENGDLGPVYGKQWRSWATPNGEAIDQIQWVLNEIRTNPNSRRLIVSAWNPADVNDMALPPCHCLFQFNVMDGKLNCQLYQRSADVFLGVPFNIASYALLTMMMARATGLQPGEFVHTFGDAHLYLNHLEQAELQLTREPRDLPTIHMNPDKADLFGWEYEDFRVDGYAPHPHIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.307 kDa
Sequence
MKQYLDLMQKVLTEGTPKNDRTGTGTISIFGHQMRFNLQEGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRSWPAPDGRHIDQITTVMNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMVAQQCDLQVGDFVWTGGDTHLYSNHLEQTNLQLSREPRPLPKLVIKRKPASIFDYRFEDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.126 kDa
Sequence
MRAYHDLLRRILDDGVAKHDRTGTGTLSVFGHQMRFDLAEGFPLVTTKRLHLKSIIHELLWFLAGDTNVAYLQSNGVTIWDEWADEHGDLGPVYGRQWRSWAKPDGGSVDQIAWVLDEIRRNPDSRRLVVSAWNPADLDRMALAPCHCLFQFYIAERRLSCQLYQRSADAFLGVPFNIASYALLTAMMAHVLDLEPGDFVHTLGDAHLYSNHVAQARQQLARDERPLPRLRLNPEVRSLFDFRYDDVVIEGYDPHPAIRAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.33 kDa
Sequence
MRTYLDLLQHVLDHGVDRDDRTGTGTRSVFGYQMRFDLEEGFPVLTTKKLHLRSIIHELLWFLKGDTNIAYLKENGVTIWDEWADENGDLGPVYGYQWRSWPAPDGRHIDQIANLLKMLHTNPQSRRLIVSAWNPALVDEMALPPCHCLFQFYVANGRLSCQLYQRSADIFLGVPFNIASYALLTMMIAQVTGLKPGEFIHTLGDAHIYSNHFEQARLQLTRTPKKLPVMHINPDVKDLFAFRFEDFRLDGYEADPTIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.302 kDa
Sequence
MRTYLDLLQHVLDHGVDRDDRTGTGTRSAFGYQMRFDLEEGFPVLTTKKLHLRSIIHELLWFLKGDTNIAYLKENGVTIWDEWADENGDLGPVYGYQWRSWPAPDGRHIDQIANLLKMLHTNPQSRRLIVSAWNPALVDEMALPPCHCLFQFYVANGRLSCQLYQRSADIFLGVPFNIASYALLTMMIAQVTGLKPGEFIHTLGDAHIYSNHFEQARLQLTRTPKKLPVMHINPDVKDLFAFRFEDFRLDGYEADPTIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Brucella suis (strain ATCC 23445 / NCTC 10510)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.33 kDa
Sequence
MRTYLDLLQHVLDHGVDRDDRTGTGTRSVFGYQMRFDLEEGFPVLTTKKLHLRSIIHELLWFLKGDTNIAYLKENGVTIWDEWADENGDLGPVYGYQWRSWPAPDGRHIDQIANLLKMLHTNPQSRRLIVSAWNPALVDEMALPPCHCLFQFYVANGRLSCQLYQRSADIFLGVPFNIASYALLTMMIAQVTGLKPGEFIHTLGDAHIYSNHFEQARLQLTRTPKKLPVMHINPDVKDLFAFRFEDFRLDGYEADPTIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Brucella suis biovar 1 (strain 1330)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.33 kDa
Sequence
MRTYLDLLQHVLDHGVDRDDRTGTGTRSVFGYQMRFDLEEGFPVLTTKKLHLRSIIHELLWFLKGDTNIAYLKENGVTIWDEWADENGDLGPVYGYQWRSWPAPDGRHIDQIANLLKMLHTNPQSRRLIVSAWNPALVDEMALPPCHCLFQFYVANGRLSCQLYQRSADIFLGVPFNIASYALLTMMIAQVTGLKPGEFIHTLGDAHIYSNHFEQARLQLTRTPKKLPVMHINPDVKDLFAFRFEDFRLDGYEADPTIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain 5A)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.705 kDa
Sequence
MKQYIKLIKKIIRVGNQKKDRTGTGTLSIFGYNMKFDLKKGFPLLTTKKCHIASIIYELLWFLKGDTNIAYLNENKISIWNNWANESGDVGPIYGKQWRNWSTPEGHEIDQIKNVLIQLKKNPDSRRMLVSSWNVGDIDKMRLPPCHVLFQFYVFNNTLSCQLYQRSCDVFLGLPFNIASYSILIHMIAQQCDLKVGDFLWTGGDVHLYNNHIELAKKQILRIPRTLPKLTILKKPQSLFQYCFEDFKIIGYHPYPAIKGKISI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.722 kDa
Sequence
MKQYIKLIKKIIRVGNQKKDRTGTGTLSIFGYNMKFDLKKGFPLLTTKKCHIASIIYELLWFLKGDTNISYLNENKISIWNNWANESGDVGPIYGKQWRNWSTPEGHEIDQIKNVLIQLKKNPDSRRMLVSSWNVGDIDKMRLPPCHVLFQFYVFNNTLSCQLYQRSCDVFLGLPFNIASYSILIHMIAQQCDLKVGDFLWTGGDVHLYNNHIELAKKQILRIPRTLPKLTILKKPQSLFQYCFEDFKIIGYHPYPAIKGEISI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.716 kDa
Sequence
MKQYLDLIKKIIKNGNSKKDRTGTGTLSIFGHHMKFDLKKGFPLITTKKCHIPSIIHELLWFLRGETNIKYLNENKISIWDNWADKFGDLGPIYGKQWRSWDTSNGKKIDQIKNVLKQIKEDPDSRRILVSSWNVGEIDKMSLAPCHILFQFYVLKKKLSCQLYQRSCDVFLGLPFNIASYAILIHMIAQQCNLQVGEFLWTGGDVHLYKNHVELAKKQILRIPKKLPELIILKKPQSLFQYSFEDFKIVGYKPYSLIKGKISV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain Tuc7)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.706 kDa
Sequence
MKQYIKLIKKIIRVGNQKKDRTGTGTLSIFGYNMKFDLKKGFPLLTTKKCHIASIIYELLWFLKGDTNIAYLNENKISIWNNWANESGDVGPIYGKQWRNWSTPEGHEIDQIKNVLIQLKKNPDSRRMLVSSWNVGDIDKMRLPPCHVLFQFYVFNNTLSCQLYQRSCDVFLGLPFNIASYSILIHMIAQQCDLKVGDFLWTGGDVHLYNNHIELAKKQILRIPRTLPKLTILKKPQSLFQYCFEDFKIIGYHPYPAIKGEISI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.897 kDa
Sequence
MKSYLVLLKKILKEGSNRKDRTGIGTLSVFGYHMEFNLKLGFPLITTKKCHFPAIVHELLWFLKGDTNIKYLNDHNISIWNPWADERGYLGPIYGEQWRSWKTKDGRVIDQIDNVIHLIKNNPNSRRIVVSSWNVGDLHKMALLPCHVLFQFHVVDHVLHCQLYQRSCDVFLGLPFNIASYSLLTHMIAQQCNLKVGNFIWTGGDVHLYKNHIKQAKKQILRRPYLLPKLVINRKPTQIFNYLLQDFNLLNYKYHPSIHAKIAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Chelativorans sp. (strain BNC1)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.195 kDa
Sequence
MRQYLDLLAHVLENGIDREDRTGTGTRGVFGYQMRFDLSDGFPVLTTKKLHLRSIIYELLWFLKGDTNIRYLQENGVTIWDEWADENGDLGPVYGAQWRSWPAPDGRHIDQIANLLNGLRENPYSRRHIVTAWNPAEIDGMALPPCHCLFQFHVAEGRLSCQLYQRSADIFLGVPFNIASYALLTMMIAQVTGLKPGDFVHTLGDAHLYKNHFDQAREQLTRTPKPLPTMWINPEVDDLFAFGYEDFRLEGYVADPTIRAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.177 kDa
Sequence
MQPYLDLMRHVLENGVEKSDRTGTGTLSVFGHQMRFDLAAGFPLVTTKKLHLRSIIHELLWFLRGDTNIAYLKENRVRIWDEWADENGDLGPVYGYQWRSWPRPDGGHVDQIANVVEQIKRNPDSRRLIVSAWNPALVDEMALPPCHALFQFYVAEGRLSCQLYQRSADIFLGVPFNIASYALLTHMVAQACDLAPGEFVHTLGDAHLYLNHLEQARLQLSREPRALPRLVLNPRVKDVFAFTFDDIAIEDYDPHPHIKAEVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.154 kDa
Sequence
MQQYLDLMRHVLEHGHDKADRTGTGTRSVFGYQMRFDLAAGFPLVTTKKCHLRSIIHELLWFLSGDTNIRYLKENGVSIWDEWADENGDLGPVYGYQWRSWPAPDGRHIDQISQLLDMIKKNPDSRRLIVSAWNPALVDQMALPPCHSLFQFYVANGRLSCQLYQRSADIFLGVPFNIASYALLTMMVAQVCGLQPGDFVHTLGDAHLYSNHLEQARLQLTRDPRPLPTMKLNPEVKDLFAFTFDDFALEGYDPHPHIKAQVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.455 kDa
Sequence
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLREGFPLVTTKRCHLRSIIHELLWFLQGDTNVAYLHENNVTIWDEWADENGNLGPVYGKQWRAWPAPDGRHIDQITTVMNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMEQTHLQLSREPRALPKLVIKRKPDSIFDYRFEDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Clostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.232 kDa
Sequence
MQQYLDLCKHILNNGIKKEDRTGTGTISTFGYQMRFDLQKGFPLLTTKKLHLKSIIHELLWFISGNTNIKYLKDNGVSIWDEWADENGNLGPVYGHQWRSWDTADGRSIDQLKGVIDQIKNNPDSRRLIVSSWNVGEIEKMALPPCHCFYQFYVVNGTLSCMLYQRSADVFIGVPFNIASYALFTMMIAQSCGLRAGEFVHTLGDAHIYLNHVEQVKLQLSRDPRPLPKMNINPDIKDLFQFKYSDFTLTDYDPHPHIKGAVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Rhizobium leguminosarum bv. viciae (strain 3841)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
29.95 kDa
Sequence
MKQYLDLLNHVMEKGSDRGDRTGTGTRSVFGYQMRFDLEEGFPVLTTKKLHLRSIIHELLWFLKGETNIRYLKENGVSIWDEWADENGDLGPVYGAQWRSWPAPDGGHIDQIANLVKGIVNNPNSRRHIVSAWNPAEVDEMALPPCHCLFQFYVADGKLSCQLYQRSADIFLGVPFNISSYALLTMMVAQVVGLKPGDFVHTLGDAHLYHNHFDQAKLQLARRPKPLPFMRIKPDVKDIFGFTFDDFELIGYEADASIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.096 kDa
Sequence
MRQYLDLLQHVLDNGADRSDRTGTGTRSVFGYQMRFDLARGFPVTTTKKLHLKSIIHELLWFLAGDTNIKYLTDHGVTIWDEWADENGDLGPVYGRQWRSWPDGHGGSIDQIAGLLKEIRRNPQSRRLIVSAWNPAEVEAMALPPCHCLFQFYVSEGRLSCQLYQRSADIFLGVPFNIASYALLTLMVAQVTGLKPGDFVHTLGDAHLYSNHFEQAREQLQRTPRALPTMWINPEVKDLFAFRFEDFRLENYVADASIQAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Rhizobium meliloti (strain 1021)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
29.987 kDa
Sequence
MRQYLDLLEHVITTGTDRGDRTGTGTRSVFGYQMRFDLSQGFPVLTTKKLHLRSIIHELLWFLRGDTNVAYLKDNGVSIWDEWADENGELGPVYGYQWRSWPTPDGRHIDQIAALVEGLKTNPNSRRHIVSAWNPALVDEMALPPCHCLFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTMMVAQVTGLEAGDFVHTLGDAHIYRNHFEQAQLQLTRTPKPLPKMEINPAVKDIFSFRFEDFELVGYEADSHIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.191 kDa
Sequence
MQGYLQLLDEVLHDGIDRDDRTGVGTRSLFGRQMRFDLAEGFPLLTTKKLHIRSILHELLWFLRGDTNIGYLKENKVSIWDEWADEAGDLGPVYGHQWRSWEGANGDTVDQIAWVENEIRTNPRSRRLVVSAWNVADVPKMALPPCHLLFQFYVSGGRLSCQLYQRSADLFLGVPFNIASYAMLTSMMAHVTGLKPGEFVHTLGDVHLYSNHFDQAREQLSRTPRPLPTFHIKRDVASVTDFQFDDFELTNYDPHPHIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Rhodopseudomonas palustris (strain HaA2)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
29.751 kDa
Sequence
MIPYHDLLERILSDGAEKHDRTGTGTLSVFGHQLRFDLAAGFPMLTTKRLPLKAIIHELLWFLQGDTNIKYLHDHGVTIWDEWADANGDLGPVYGAQWRSWPTADGRSIDQIAHVVDMIRRNPDSRRLIVTAWNPADVEKMALPPCHCLFQFYVANGRLSCQLYQRSADVFLGVPFNIASYALLTMMVAQVTGLKPGDFIHTLGDAHLYSNHLEQARLQLTRAPRALPAMAINPAVTDIFGFRYEDFTLHGYDPHPHIKAEVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
29.662 kDa
Sequence
MIQYQDLLERILSDGAEKHDRTGTGTLSVFGHQMRFDLAAGFPMLTTKRLPLKAIVHELLWFLQGDTNIKYLHDHGVTIWDEWADANGDLGPVYGAQWRSWPTADGGSIDQIANVVEMIKRNPDSRRLMVTAWNPADVEKMALPPCHCLFQFYVANGKLSCQLYQRSADVFLGVPFNIASYALLTLMVAQVTGLKPGEFVHTLGDAHLYSNHLEQARLQLTRAPRALPVMTINPAVKDIFGFRYEDFTLTGYDPHPHIKAEVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Rhodopseudomonas palustris (strain BisB18)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.055 kDa
Sequence
MNQYHDLLQRILGEGAEKHDRTGTGTLSVFGHQMRFALDAGFPMLTTKRLPLKAIVHELLWFLKGDTNIKYLKDHGVSIWDEWADENGDLGPVYGSQWRSWPAADGRSIDQIADVVEMIKRNPDSRRLIVTAWNPAEIDQMALPPCHCLFQFYVARGRLSCQLYQRSADVFLGVPFNIASYALLTMMVAQVTGLKPGEFIHTLGDAHLYSNHLEQARLQLTRTPRDLPVMTINPQVTDIFGFRFEDFTLHNYDPHPHIKAEVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Rhodopseudomonas palustris (strain BisB5)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
29.806 kDa
Sequence
MIQYHDLLERILSDGTEKHDRTGTGTLSVFGHQMRFNLAAGFPMLTTKRLPLKAIVHELLWFLQGDTNIKYLRDNGVTIWDEWADANGDLGPVYGAQWRSWPAADGRSIDQIANIVEMIKRNPDSRRLIVTAWNPADVDRMALPPCHCLFQFYVAGGKLSCQLYQRSADVFLGVPFNIASYALLTMMIAQVTGLKPGEFIHTLGDAHLYSNHLEQARLQLTRAPRALPEMVIDPAVKDVFGFRYEDFTLQGYDPHPHIKAEVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Ruthia magnifica subsp. Calyptogena magnifica
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.326 kDa
Sequence
MKQYLDFLRLVKNTGTNKTDRTGIGTTSLFGYQMRFDLSDGFPLITTKRVHLPSVVHELLWFLSGATNIKYLQENGVRIWNEWADKNGDLGPIYGVQWRNWQNVRGESIDQIMQVIEQIKNTPDSRRIIVSAWNVGELENMALPPCHAFFQFYVALGKLSCQLYQRSADVFLGVPFNIASYALLTHMMAQQCDLEVGDFIWSGGDCHIYSNHTKQVEIQLARTPKTLATLKINNKPDSIFDYNFEDFEFINYVFDAYIKATVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.479 kDa
Sequence
MKQYLELMKKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQEGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGHHIDQITTVLSQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADRKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEAGDFIWTGGDTHLYSNHMEQTHLQLSREPRALPKLVIKRKPDSLFDYRFDDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Salmonella choleraesuis (strain SC-B67)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.369 kDa
Sequence
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQEGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQIATVLSQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLDVGDFVWTGGDTHLYSNHMEQTHLQLSREPRALPKLVIKRKPDSLFDYRFDDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bartonella quintana (strain Toulouse)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.36 kDa
Sequence
MKTYLDLLSHVLNKGIDRTDRTGVGTRSVFGYQMRFDLQIGFPLLTTKKLHLRSIIYELLWFLRGDTNVAWLKEHGVSIWDEWADEKGNLGPIYGYQWRSWPASDGRYIDQISRLLTMIKKTPDSRRLIVSAWNPALIEEMALPPCHCFFQFYVADDKLSCQLYQRSADIFLGVPFNIASYALLTMMIAQVSGLKAGDFIHTLGDAHLYSNHFEQARYQLSRIPNALPSMLINPSVTDLFSFKFEDFELLNYEAQPHIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bartonella tribocorum (strain CIP 105476 / IBS 506)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.378 kDa
Sequence
MKSYLALLSHVLNQGIDRTDRTGVGTRSIFGYQMRFDLQAGFPLLTTKKLHLRSIIYELLWFLKGDTNIAWLKEHGVSIWDEWADKQGNLGPVYGYQWRSWPAPDGRHIDQIDNLLRMIKEKPDSRRLIVSAWNPALIEEMALPPCHCLFQFYIDEGKLSCQLYQRSADIFLGVPFNIASYALLTMMIAQVSGLKVGDFIHTFGDAHLYSNHFEQAQYQLSRIPNALPCMRINPAVTDLFSFKFEDFELLNYEAHPHIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Baumannia cicadellinicola subsp. Homalodisca coagulata
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.768 kDa
Sequence
MKQYLELMRLVRTQGISKVDRTNTGTLSIFGHQMRFNLSHGFPLITTKRCHLRSIIYELLWFLNGDTNINYLRKHHVTIWDEWINEKGDLGPIYGRQWRAWGTADGSYIDQLSDVMLQLKHNPDSRRIIVSAWNVGEIKQMALAPCHVLFQFYVANGVLSCQLYQRSCDMFLGLPFNISSYALLIHMVAQQCDLQLGEFIWTGGDIHLYRNHLKQTDLQLKRNPRPLPQLIIKRRPASLFQYQFDDFYLSGYDPHPAIKAQVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.443 kDa
Sequence
MKQYHDLIKTVLEHGVKKEDRTGTGTISMFGYQMRYNLQEGFPLLTTKKLHTRSIFHELLWFLKGETNIKYLHDNKVTIWDEWADENGNLGPVYGKQWRSWETADGRTIDQITNVVEQIKKNPNSRRMLVVAFNPGDVDKMALPPCHAFFQFYVANGKLSCQLYQRSADIFLGVPFNIASYALLTHMIAQVCDLEVGDFVHTLGDAHLYLNHLEQANLQLTREFRPLPQLKLNPAKKDLFDFTYEDIEIIGYDPHPAIKAEVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
29.941 kDa
Sequence
MHQYQDLLERILSDGAEKTDRTGTGTLSVFGHQMRFNLSAGFPMLTTKRLPLKAIVHELLWFLKGDTNIKYLRDNGVTIWDEWADANGDLGPVYGHQWRSWPAPDGRSIDQIANVVDMIKRNPDSRRLIVSAWNPAEVDKMALPPCHCLFQFYVANGKLSCQLYQRSADVFLGVPFNIASYALLTMMVAQVTGLKPGDFVHSFGDTHLYSNHLEQAKLQLTRAPRALPVMRINPDVKDIFSFRFEDFELVGYDPHPHIKAEVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
29.922 kDa
Sequence
MHQYHDLLERILSDGAEKHDRTGTGTLSVFGHQMRFNLGAGFPLVTTKRLPLKAIVHELLWFLRGDTNIKYLHDHGVTIWDEWADANGDLGPVYGYQWRSWPTPDGGHIDQIANVIDMIKRNPDSRRLIVTAWNPADVEKMALPPCHCLFQFYVVNGKLSCQLYQRSADVFLGVPFNIASYALLTMMVAQVTGLKPGEFVHSFGDVHLYSNHVEQARLQLTRAPRSLPTMTLNPDVKDIFAFRYEDFALAGYDPHPHIKAEVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bradyrhizobium sp. (strain ORS 278)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
29.964 kDa
Sequence
MHQYHDLLERILSDGAQKHDRTGTGTLSVFGHQMRFNLAAGFPMVTTKRLPLKAIVHELLWFLKGDTNIKYLHDHGVTIWDEWADANGDLGPVYGYQWRSWPTSDGGQIDQISNVVDMIRRNPDSRRLIVTAWNPADVEKMALPPCHCLFQFYVANGKLSCQLYQRSADVFLGVPFNIASYALLTMMVAQVTGLKLGEFVHSFGDVHLYSNHIEQARLQLSRTPRPLPTMTLNPDVKDIFAFRYEDFALAGYDPHPHIKAEVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.186 kDa
Sequence
MKQYLDLCQRILDEGVIKEDRTGTGTTSVFGHQMRFDLSEGFPMVTTKKLHMKSIIHELLWFLSGDTNVRYLQENGVRIWNEWADENGDLGPVYGSQWRSFTGRDGKTVDQIQWVIDEIKRNPDSRRLIVSAWNPAELDKMALPPCHLLFQFYVANGKLSCQLYQRSGDTFLGVPFNIASYALLTHMVAHVTGLEVGDFVHTIGDAHLYLNHIEQVKLQLTREPKPLPKLVLNPDVTSIFDFKYEDIEIVGYESHPHIKGEVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Brucella abortus (strain 2308)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.33 kDa
Sequence
MRTYLDLLQHVLDHGVDRDDRTGTGTRSVFGYQMRFDLEEGFPVLTTKKLHLRSIIHELLWFLKGDTNIAYLKENGVTIWDEWADENGDLGPVYGYQWRSWPAPDGRHIDQIANLLKMLHTNPQSRRLIVSAWNPALVDEMALPPCHCLFQFYVANGRLSCQLYQRSADIFLGVPFNIASYALLTMMIAQVTGLKPGEFIHTLGDAHIYSNHFEQARLQLTRTPKKLPVMHINPDVKDLFAFRFEDFRLDGYEADPTIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Brucella abortus biovar 1 (strain 9-941)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.33 kDa
Sequence
MRTYLDLLQHVLDHGVDRDDRTGTGTRSVFGYQMRFDLEEGFPVLTTKKLHLRSIIHELLWFLKGDTNIAYLKENGVTIWDEWADENGDLGPVYGYQWRSWPAPDGRHIDQIANLLKMLHTNPQSRRLIVSAWNPALVDEMALPPCHCLFQFYVANGRLSCQLYQRSADIFLGVPFNIASYALLTMMIAQVTGLKPGEFIHTLGDAHIYSNHFEQARLQLTRTPKKLPVMHINPDVKDLFAFRFEDFRLDGYEADPTIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Brucella canis (strain ATCC 23365 / NCTC 10854)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.261 kDa
Sequence
MRTYLDLLQHVLDHGVDRDDRTGTGTRSVFGYQMRFDLEEGFPVLTTKKLHLRSIIHELLWFLKGDTNIAYLKENGVTIWDEWADENGDLGPVYGYQWRSWPAPDGRHIDQIANLLKMLHTNPQSRSLIVSAWNPALVDEMALPPCHCLFQFYVANGRLSCQLYQRSADIFLGVPFNIASYALLTMMIAQVTGLKPGEFIHTLGDAHIYSNHFEQARLQLTRTPKKLPVMHINPDVKDLFAFRFEDFRLDGYEADPTIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Brucella melitensis biotype 2 (strain ATCC 23457)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.33 kDa
Sequence
MRTYLDLLQHVLDHGVDRDDRTGTGTRSVFGYQMRFDLEEGFPVLTTKKLHLRSIIHELLWFLKGDTNIAYLKENGVTIWDEWADENGDLGPVYGYQWRSWPAPDGRHIDQIANLLKMLHTNPQSRRLIVSAWNPALVDEMALPPCHCLFQFYVANGRLSCQLYQRSADIFLGVPFNIASYALLTMMIAQVTGLKPGEFIHTLGDAHIYSNHFEQARLQLTRTPKKLPVMHINPDVKDLFAFRFEDFRLDGYEADPTIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Magnetospirillum magneticum (strain AMB-1 / ATCC 700264)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
29.721 kDa
Sequence
MHQYLDLLRRIQAEGVTKTDRTGTGTTSVFGHQMRFDLSRGFPLVTTKKLHTRSIFVELLWFLRGDTNIGWLKDNKVSIWDEWADANGDLGPVYGKQWRSWACPDGSTVDQITQVVEMIRKSPDSRRLIVSAWNPADIESMALPPCHCLFQFYVADGKLSCQLYQRSADVFLGVPFNIASYALLTHMVAQVTGLEVGAFVHTFGDAHLYSNHMEQAALQLSRAPLPLPRLELNPEVKDLFAFTMDDIKVVDYQCHAHIAAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Methylobacterium extorquens (strain CM4 / NCIMB 13688)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
29.93 kDa
Sequence
MRAYHDLLTRILSEGVRKEDRTGTGTLSVFGHQMRFDLADGFPLVTTKQLHLRSIIHELLWFLKGDTNVAYLKENGVTIWDEWADANGDLGPVYGKQWRSWAKPEGGTVDQIAWILDEIARNPDSRRLIVSAWNPADLDRMALAPCHCLFQFYVADGRLSCQLYQRSADAFLGVPFNIASYALLTAMMAQVTGLKAGDFVHTFGDAHLYANHLEQTHLQLSREPRPLPRLRLNPEVRSLFDFRFEDIVIEGYEPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Shewanella sp. (strain ANA-3)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.129 kDa
Sequence
MQQYLDLMKHILAEGVDKSDRTGTGTRSVFGYQMRFDLSKGFPLVTTKKCHMRSIIHELLWFLKGDTNIAYLRENKVSIWDEWADENGDLGPVYGAQWRSWPTQSGDAIDQIAQVIAQIKSQPDSRRLIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLTMMVAQQCDLALGDFVWTGGDTHLYSNHMEQTALQLSREPRQLPTMTILRKPASIFDYQFEDFELTHYDPHPHIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Shewanella sp. (strain MR-4)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.061 kDa
Sequence
MQQYLDLMKHILAEGVDKSDRTGTGTRSVFGYQMRFDLSKGFPLVTTKKCHMRSIIHELLWFLKGDTNIAYLRDNKVSIWDEWADENGDLGPVYGAQWRSWPTQSGDAIDQIAQVIAQIKSQPDSRRLIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLTMMVAQQCDLALGDFVWTGGDTHLYSNHMEQTALQLSREPRPLPTMTILRKPASIFDYQFEDFELTNYDPHPHIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Shewanella sp. (strain MR-7)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.061 kDa
Sequence
MQQYLDLMKHILAEGVDKSDRTGTGTRSVFGYQMRFDLSKGFPLVTTKKCHMRSIIHELLWFLKGDTNIAYLRDNKVSIWDEWADENGDLGPVYGAQWRSWPTQSGDAIDQIAQVIAQIKSQPDSRRLIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLTMMVAQQCDLALGDFVWTGGDTHLYSNHMEQTALQLSREPRPLPTMTILRKPASIFDYQFEDFELTNYDPHPHIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Shewanella sp. (strain W3-18-1)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.145 kDa
Sequence
MQQYLDLMKHILAEGVDKSDRTGTGTRSVFGYQMRFDLSKGFPLVTTKKCHMRSIIHELLWFLKGETNIAYLRENKVSIWDEWADDNGDLGPVYGAQWRSWPTQSGDAIDQISQVIAQIKAQPDSRRLIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLTMMVAQQCDLALGDFVWTGGDTHLYSNHMEQTVLQLSREPKPLPLMTILRKPESIFDYQFEDFELTNYNPHPHIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Shigella boydii serotype 4 (strain Sb227)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.436 kDa
Sequence
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYAPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Shigella dysenteriae serotype 1 (strain Sd197)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.493 kDa
Sequence
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQEGFPLVTTKRCHLRSIIHELLWFLQGNTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Shigella flexneri serotype 5b (strain 8401)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.466 kDa
Sequence
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGVKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Shigella flexneri
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.466 kDa
Sequence
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGVKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Shigella sonnei (strain Ss046)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.48 kDa
Sequence
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Sinorhizobium medicae (strain WSM419)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.026 kDa
Sequence
MRQYLDLLEHVIETGTDRGDRTGTGTRSVFGYQMRFDLSQGFPVLTTKKLHLRSIIHELLWFLKGDTNIAYLKEHGVRIWDEWADENGDLGPVYGYQWRSWPTPDGGHIDQIATLVEGLKTNPNSRRHIVSAWNPALVDDMALPPCHCLFQFYVADGKLSCQLYQRSGDIFLGVPFNIASYALLTMMVAQVTGLEAGDFVHTLGDAHIYRNHFEQAQLQLTRTPKPLPRMEINPAVKDLFSFRFEDFELTGYEADSHIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Sodalis glossinidius (strain morsitans)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.25 kDa
Sequence
MKQYLDLMRRVRAQGTPKADRTGTGTLSIFGHQMRFDLRQGFLLVTTKRCHLRSIIHELLWFLNGDTNIAYLQQNNVSIWDEWADDNGDLGPVYGRQWRAWGTSDGRQIDQLAEVVRQLKQDPDSRRIIVSAWNVGELDKMALAPCHALFQFYVANGTLSCQLYQRSCDIFLGLPFNIASYALLVHMLAQQCDLQVGDFVWTGGDTHLYSNHLQQADLQLTRDPLPLPQLLIKRRPATLFDYRFEDFELTGYDPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Escherichia coli O127:H6 (strain E2348/69 / EPEC)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.48 kDa
Sequence
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Escherichia coli O45:K1 (strain S88 / ExPEC)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.48 kDa
Sequence
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Escherichia coli (strain 55989 / EAEC)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.48 kDa
Sequence
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Escherichia coli O157:H7
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.48 kDa
Sequence
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Escherichia coli O7:K1 (strain IAI39 / ExPEC)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.48 kDa
Sequence
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Escherichia coli O81 (strain ED1a)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.48 kDa
Sequence
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Escherichia coli O8 (strain IAI1)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.48 kDa
Sequence
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Escherichia coli (strain K12 / MC4100 / BW2952)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.48 kDa
Sequence
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Escherichia coli O9:H4 (strain HS)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.479 kDa
Sequence
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGNTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Escherichia coli O1:K1 / APEC
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.48 kDa
Sequence
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Escherichia coli O6:K15:H31 (strain 536 / UPEC)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.48 kDa
Sequence
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.48 kDa
Sequence
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.479 kDa
Sequence
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGNTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Escherichia coli (strain K12)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product (PubMed:3286637, PubMed:2223754, PubMed:9826509). This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation (PubMed:7708505).
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.48 kDa
Sequence
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.48 kDa
Sequence
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Escherichia coli (strain UTI89 / UPEC)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.48 kDa
Sequence
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Edwardsiella ictaluri (strain 93-146)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.248 kDa
Sequence
MKQYLDLMRKVLAEGTPKADRTGTGTLSIFGHQMRFNLQQGFPLVTTKKCHLRSIIHELLWFLNGETNVSYLHENNVTIWDEWADDNGDLGPVYGKQWRAWGCADGRQVDQISQVMEQLRQEPDSRRIIVSAWNVGELDQMALAPCHAFFQFYVADGRLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQLDLQVGDFVWTGGDTHLYSNHMEQTALQLTREPRALPRLVLARRPASIFDYRFEDFIIEGYDPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Enterobacter sp. (strain 638)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.45 kDa
Sequence
MKQYLELMKKVLDEGTPKNDRTGTGTLSIFGHQMRFNLQEGFPLVTTKRCHLRSIIHELLWFLQGDTNVAYLRENNVSIWDEWADENGNLGPVYGHQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMEQTHLQLTREPRALPKLVIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Thiobacillus denitrificans (strain ATCC 25259)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
29.887 kDa
Sequence
MKPYLDLMRHVLEHGTRKDDRTGTGTLSVFGWQTRYDLAAGFPLVTTKKCHLRSIVHELLWFLQGDTNIRYLKENGVSIWDEWADENGDLGPVYGHQWRSWPKADGGVIDQIAEAVKTLRTNPDSRRIIVSAWNVADLDRMALAPCHAFFQFYVAEGRLSCQLYQRSADIFLGVPFNIASYALLTLMMAQVTGLKPGDFVHTLGDAHLYVNHLEQAREQLSREPRPLPTMTLNPDVTDIFGFRFEDFTLGGYDPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Vesicomyosocius okutanii subsp. Calyptogena okutanii (strain HA)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.587 kDa
Sequence
MKQYLDFLKLVKNIGVYKTDRTNTGTTSMFGYQMRFDLSKGFPLVTTKHVHLPSVVYELLWFLNGDTNIKYLQDNGVRIWNEWADENGDLGPVYGTQWRHWKNIKDKSIDQISKVVEQIKNTPNSRRIIVSAWNVGELENMALPPCHVFFQFYVADGKLSCQLYQRSADIFLGVPFNIASYSLLTHMMAQQCDLEVGDFIWSGGDCHIYSNHYKQVEIQLSRTPKALATLKIKRKPENIFDYSFEDFEFVNYIFDAPIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Coxiella burnetii (strain Dugway 5J108-111)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.439 kDa
Sequence
MKEYLNFLQFILDHGVAKTDRTGIGTKSVFGYEMRFNLREGFPLVTTKKIHLKSVIYELLWFLRGDTNIQFLNDNGVTIWDEWADENGDLGPIYGKQWRRWHCPDGRTVDQMQRLIREIKTNPDSRRLIVSAWNVGELDQMALPPCHLLFQFYVADGFLSCKLTQRSADAFLGVPFNIASYSLLTHLIARQCNLKAGEFIWSGGDCHIYNTHQDQVSTQLSREPRALPQLIINRDPSSLYDYNFNDFSIVNYHPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Coxiella burnetii (strain RSA 331 / Henzerling II)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.439 kDa
Sequence
MKEYLNFLQFILDHGVAKTDRTGIGTKSVFGYEMRFNLREGFPLVTTKKIHLKSVIYELLWFLRGDTNIQFLNDNGVTIWDEWADENGDLGPIYGKQWRRWHCPDGRTVDQMQRLIREIKTNPDSRRLIVSAWNVGELDQMALPPCHLLFQFYVADGFLSCKLTQRSADAFLGVPFNIASYSLLTHLIARQCNLKAGEFIWSGGDCHIYNTHQDQVSTQLSREPRALPQLIINRDPSSLYDYNFNDFSIVNYHPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.439 kDa
Sequence
MKEYLNFLQFILDHGVAKTDRTGIGTKSVFGYEMRFNLREGFPLVTTKKIHLKSVIYELLWFLRGDTNIQFLNDNGVTIWDEWADENGDLGPIYGKQWRRWHCPDGRTVDQMQRLIREIKTNPDSRRLIVSAWNVGELDQMALPPCHLLFQFYVADGFLSCKLTQRSADAFLGVPFNIASYSLLTHLIARQCNLKAGEFIWSGGDCHIYNTHQDQVSTQLSREPRALPQLIINRDPSSLYDYNFNDFSIVNYHPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Cronobacter sakazakii (strain ATCC BAA-894)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.473 kDa
Sequence
MKQYLELMNKVLHEGAQKDDRTGTGTLSIFGHQMRFNLQEGFPLVTTKRCHLRSIIHELLWFLKGDTNVAYLHENNVTIWDEWADENGDLGPVYGKQWRSWATPDGRHIDQLETVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVANGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEPGDFVWTGGDTHLYSNHLEQARLQLTREPRPLPKLVIKRKPESLFDYRFEDFEIEGYDPHPAIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.509 kDa
Sequence
MKQYLDFMRHVYEHGTEKSDRTGTGTRSVFGYQMRFDLNEGFPVVTTKKLHLKSIIHELLWFLQGSTNIKYLKDNGVTIWDEWADANGELGPIYGYQWRAWPTPDGRHIDQITEVVQQIRDNPDSRRLIVSAWNVGEIPQMKLPPCHAFFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTHMIAQQCDLGVGDFVWTGGDCHIYSNHFEQVETQLSREPMKLPTLRIKHRPDSIFDYKYDDFELVGYESHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.429 kDa
Sequence
MKQYLDFMRHVYEHGTDKADRTGTGTRSVFGYQMRFDLRAGFPVVTTKKLHLKSIIYELLWFLQGSTNVRWLQEHGVTIWDEWADENGELGPVYGSQWRSWPTPDGRHIDQITDLVAQIRANPDSRRLIVSAWNVADIPRMKLPPCHAFFQFYVADGRLSCQLYQRSADIFLGVPFNIASYALLTHMMAQQTGLEVGDFVWTGGDCHLYNNHFEQVQTQLAREPLALPQLKILRKPDSIFDYRYEDFELAGYQSHAAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.31 kDa
Sequence
MKQYHDLMQHILDQGVKKEDRTGTGTVSVFGYQMRFNLQEGFPLLTTKKLHMRSITHELLWFLQGDTNIKYLKDNNVSIWDEWADENGNLGPVYGYQWRSWPTPDGKHIDQITNVVNMIKNNPDSRRLIVSAWNVGEIEKMKLPPCHAFFQFYVADGKLSCQLYQRSADVFLGVPFNIASYALLTMMVAQVCGLQAGDFVHTLGDAHLYSNHLEQAKLQLSRDFRPLPAMKINPDVKSIFDFKFEDFTLEGYDPHPHIKAAVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Dechloromonas aromatica (strain RCB)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.507 kDa
Sequence
MQPYLDLMRHVLDNGNDKSDRTGTGTRSVFGWQMRFDLSQGFPVMTTKKLHLKSIIHELLWFIQGDTNIKYLQENGVKIWDEWADENGDLGPVYGKQWRRWETPDGRVIDQITQLVNSLKNNPDSRRHIVSAWNPGDVDNMALPPCHCLFQFYVANGKLSCQLYQRSADIFLGVPFNIASYALFTMMLAQVCGYQPGEFVHTFGDAHLYSNHFEQAKLQLSRDTRPLPTMWINPEVKDLFAFRFEDFRLEGYDPHPHIPAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Deinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.291 kDa
Sequence
MQQYLDFMRHVLEHGTEKTDRTGTGTLSVFGHQMRFDLQEGFPLVTTKRTHLKSIIHELLWFLQGSSNVAYLREHGVTIWDEWADPDGELGPVYGVQWRSWPTPDGRHIDQIAQVVEQIRRTPDSRRLIVSAWNVGEIEQMALPPCHAFFQFYVADGRLSCQLYQRSADIFLGVPFNIASYALLTLMVAQVTGLKPGEFIWTGGDCHLYTNHLEQARKQLTREPRTLPVMRLNPDVRELDGFRFEDFTLEGYDPHPGIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Escherichia coli O139:H28 (strain E24377A / ETEC)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.48 kDa
Sequence
MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.248 kDa
Sequence
MKAYLDLMRHVLDNGTDKSDRTGTGTRSVFGYQMRFDLGKGFPLLTTKKLHLRSIIHELLWFLKGDTNIKYLKDNNVSIWDEWADENGDLGPVYGYQWRSWPAPDGRHIDQIANVVEQIKKNPDSRRLIVSAWNPALVDEMALPPCHALFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTMMMAQVCGLEAGEFVHTFGDAHLYRNHFEQAALQLEREPRALPVMKINPEVKDLFAFKFEDFELEGYDPHPHIKAVVSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.261 kDa
Sequence
MKAYLDLMRHVLDNGTDKSDRTGTGTRSVFGYQMRFDLGKGFPLLTTKKLHLRSIIHELLWFLKGDTNIKYLKDNNVSIWDEWADENGDLGPVYGYQWRNWPAPDGRHIDQIANVLEQIKKNPDSRRLIVSAWNPALVDEMALPPCHALFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTMMMAQVCGLEAGEFVHTFGDAHLYRNHFEQAALQLEREPRALPVMKINPEVKDLFAFKFEDFELEGYDPHPHIKAAVSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Neisseria meningitidis serogroup B (strain MC58)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.277 kDa
Sequence
MKAYLDLMRHVLDNGTDKSDRTGTGTRSVFGYQMRFDLGKGFPLLTTKKLHLRSIIHELLWFLKGDTNIKYLKDNNVSIWDEWADENGDLGPVYGYQWRNWPAPDGRHIDQIANVLEQIKKNPDSRRLIVSAWNPALVDEMALPPCHALFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTMMMAQVCGLEAGEFVHTFGDAHLYRNHFEQAALQLEREPRALPVMKINPEVKDLFSFKFEDFELEGYDPHPHIKAAVSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.263 kDa
Sequence
MKAYLDLMRHVLDNGTDKSDRTGTGTRSVFGYQMRFDLGKGFPLLTTKKLHLRSIIHELLWFLKGDTNIKYLKDNNVSIWDEWADENGDLGPVYGYQWRNWPAPDGRHIDQIANVVEQIKKNPDSRRLIVSAWNPALVDEMALPPCHALFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTMMMAQVCGLEAGEFVHTFGDAHLYRNHFEQAALQLEREPRALPVMKINPEVKDLFSFKFEDFELEGYDPHPHIKAAVSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Nitrosomonas eutropha (strain DSM 101675 / C91)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.373 kDa
Sequence
MHPYLDLMRHVLQYGHKKTDRTGTGTLSIFGYQMRFDLQQGFPLVTTKQCHVKSIIHELLWFLRGDTNIDYLKKNGISIWNEWADKSGELGPVYGHQWRSWTVSGDKSIDQIAQVIQQIKATPDSRRMIISAWNVGDLDKMALAPCHVLFQFYVVDGKLSCQLYQRSADIFLGVPFNIASYSLLTLMIAQCCNLKPGEFIHTFGDAHLYLNHLEQARLQLTREPKSLPIMELNPAIRNILDFRYEDFTLHNYDPHPPIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.428 kDa
Sequence
MYQYLDLMRHVLQYGHKKSDRTGTGTLSVFGYQMRFDLQTGFPLVTTKKCHVKSIIHELLWFLRGETNIDYLKRNGVSIWDEWADENGDLGPIYGHQWRSWAASDGTVIDQISQVIQQIKETPDSRRMIVSAWNVGDLDKMKLAPCHVLFQFYVADGRLSCQLYQRSADIFLGVPFNIASYSLLTLMIAQCCDLQPGEFVHTFGDAHLYLNHLEQARLQLEREPRALPAMQLNSTVRNIFDFGYEDFTLHDYDPYPPIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Nitrobacter hamburgensis (strain DSM 10229 / NCIMB 13809 / X14)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
29.896 kDa
Sequence
MNQYHDLLERILSDGAEKHDRTGTGTLSIFGHQMRFNLASGFPMLTTKKLPLKSIVHELLWFLKGETNVRYLREHGVSIWDEWADANGDLGPVYGSQWRSWPAPDGRSIDQIANVVDMIGRSPDSRRLIVSAWNPADVDKMALPPCHCLFQFYVADGKLSCQLYQRSADVFLGVPFNIASYALLTMMVAQVTGLKPGDFVHSLGDAHLYLNHLDQARLQLTRPTRSLPTMTINPEVKSIFAFRYEDFKLENYDPHPHIKAEVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Nitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / NCIMB 11848 / C-107)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.665 kDa
Sequence
MKPYLELIQKILDTGVERDDRTGTGTWSIFGHQMRFDLRQGFPLITTKKLHIRAIFIELLWFLRGETNVKYLHDHGVTIWDEWADEQGELGPIYGYQWRSWPLPDGGYLDQMAKTLTQIRNHPHSRRHVVVAYNPACVDEMALPPCHALFQFYVAQGRLSCQLYQRSADVFLGVPFNIASYALLTHLIAQQCDLDVGEFVWTGGDVHLYRNHLEPARLQLTREPLSLPHLRIKRRPPSLFEYQYDDLEIVDYQSYPAIKAAISV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Nitrobacter winogradskyi (strain ATCC 25391 / DSM 10237 / CIP 104748 / NCIMB 11846 / Nb-255)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.027 kDa
Sequence
MNQYHDLLERILGEGTEKHDRTGTGTLSVFGHQMRFDLASGFPMLTTKKLPFRSIVHELLWFLRGETNIKYLKDNGVSIWDEWADANGDLGPVYGSQWRSWPARDGRGIDQIANVIDLIQRNPDSRRLIVSAWNPADVDRMALPPCHCLFQFYVAGGKLSCQLYQRSADVFLGVPFNIASYALLTMMVAQVTGLKPGDFVHSLGDAHLYSNHLDQARLQLSRPTRPLPTMTINPEVKDIFAFRYEDFRLENYDPHPHIKAEVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Wigglesworthia glossinidia brevipalpis
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.804 kDa
Sequence
MKEYLDLLNLILKNGYPKIDRTKTGTLSMFGYQIRINLNEGFPLLTTKYCHFKSIVYELLWFLRGDTNISFLKKNNISIWNKWADKNGNLGPIYGKQWRAWEDKKNNTIDQIEIALNKLKKEPSSRRILVSSWNVGELDLMSIPPCHVLFQLYVINNKLSCQVYQRSCDIFLGLPFNIGSYALLTHIFANQCDLLVEDLIWTGGDIHLYKNHLNQAKLQLTRSPLPLPKIFIKKKPKNLFNYAFNDFLLIDYNHHPKIKAPISI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Xanthomonas axonopodis pv. citri (strain 306)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.129 kDa
Sequence
MKPYLELLQHVLDHGAEKSDRTGTGTRSVFGWQMRFDLNDGFPLVTTKKLHLRSIIHELLWFLKGDTNIGYLSDHQVRIWDEWADDNGDLGPVYGKQWRRWTGPDGVEIDQMQWLVDEIKRNPDSRRLVISAWNVGELPQMALMPCHSLFQFYVVNGKLSCQLYQRSGDIFLGVPFNIASYALLTHMVAQATGLGVGDFVHTLGDAHLYSNHFEQAREQLTRTPRALPSLRLNPEVTDLFAFRFEDIAIEGYDPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Xanthomonas campestris pv. vesicatoria (strain 85-10)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.076 kDa
Sequence
MKPYLELLQHVLEHGAEKSDRTGTGTRSVFGWQMRFDLNDGFPLVTTKKLHLRSIIHELLWFLKGDTNIGYLSDNQVRIWDEWADDNGDLGPVYGKQWRRWTGPDGVEIDQMQWLVDEIKRNPDSRRLVISAWNVGELPQMALMPCHSLFQFYVVNGKLSCQLYQRSGDIFLGVPFNIASYALLTHMVAQATGLGVGDFVHTLGDAHLYSNHFEQAREQLTRTPRALPTLRLNPEVTDLFGFRFEDIAIEGYAPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Xanthomonas campestris pv. campestris (strain 8004)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.126 kDa
Sequence
MKPYLELLQHVLEYGAEKSDRTGTGTRSVFGWQMRFDLNAGFPLVTTKKLHLRSIIHELLWFLQGDTNIAYLKDNQVRIWDEWADANGDLGPVYGKQWRRWTGPDGVEIDQMQWLVDEIKRNPDSRRLVISAWNVGELPQMALMPCHSLFQFYVVDGKLSCQLYQRSGDIFLGVPFNIASYALLTHMVAQATGLGVGDFVHTLGDAHLYSNHFEQAREQLTRTPRPLPTLRLNPDVTDLFAFRFEDIAIDGYDPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.126 kDa
Sequence
MKPYLELLQHVLEYGAEKSDRTGTGTRSVFGWQMRFDLNAGFPLVTTKKLHLRSIIHELLWFLQGDTNIAYLKDNQVRIWDEWADANGDLGPVYGKQWRRWTGPDGVEIDQMQWLVDEIKRNPDSRRLVISAWNVGELPQMALMPCHSLFQFYVVDGKLSCQLYQRSGDIFLGVPFNIASYALLTHMVAQATGLGVGDFVHTLGDAHLYSNHFEQAREQLTRTPRPLPTLRLNPDVTDLFAFRFEDIAIDGYDPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.105 kDa
Sequence
MKPYLDLLQHVLEHGAEKSDRTGTGTRSVFGWQMRFDLNDGFPLVTTKKLHLRSIIHELLWFLQGDTNIGYLSDNQVRIWDEWADDNGDLGPVYGKQWRRWTGPDGVEIDQMQWLVDEIKRNPDSRRLVISAWNVGELPQMALMPCHSLFQFYVVNGKLSCQLYQRSGDIFLGVPFNIASYALLTHMVAQATGLGVGDFVHTLGDAHLYSNHFDQARKQLTRTPRALPTLRLNPEVTDLFAFRFEDIAIEGYDPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.105 kDa
Sequence
MKPYLDLLQHVLEHGAEKSDRTGTGTRSVFGWQMRFDLNDGFPLVTTKKLHLRSIIHELLWFLQGDTNIGYLSDNQVRIWDEWADDNGDLGPVYGKQWRRWTGPDGVEIDQMQWLVDEIKRNPDSRRLVISAWNVGELPQMALMPCHSLFQFYVVNGKLSCQLYQRSGDIFLGVPFNIASYALLTHMVAQATGLGVGDFVHTLGDAHLYSNHFDQARKQLTRTPRALPTLRLNPEVTDLFAFRFEDIAIEGYDPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.352 kDa
Sequence
MKQYLDLMKKVLEEGTAKDDRTGTGTRSIFGHQMRFNLQEGFPLVTTKRCHLRSIIHELLWFLNGDTNIKYLHDNGVSIWDEWADENGDLGPVYGKQWRAWGSADGRHIDQLTQVLEQLKGDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCNLDVGDFVWTGGDTHLYNNHLEQTHLQLSREPRALPKLVIKRKPDSLFDYRFEDFEIVDYDPYPGIKAPVAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Xylella fastidiosa (strain 9a5c)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.086 kDa
Sequence
MKQYLELLNDVLVHGIQKPDRTGTGTRSVFGWQMRFDLSQGFPLVTTKKLHLRSIIHELLWFLRGETNIAYLKKHQVHIWDEWADATGELGPVYGKQWRRWAGADGHEIDQIRWLLEEIKRNPDSRRLVISAWNVADLPQMALVPCHALFQFYVANGKLSCQLYQRSADIFLGVPFNIASYALLTHMLAQVTGLAVGDFVHTLGDAHLYANHVEQASVQLERVPRPQPVLMLNPAVTDLFDFTYDDIVIEGYDPYPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Xylella fastidiosa (strain Temecula1 / ATCC 700964)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.084 kDa
Sequence
MKQYLELLNDVLVHGIKKPDRTGTGTRSVFGWQMRFDLSQGFPLVTTKKLHLRSIIHELLWFLRGETNIAYLKKHQVHIWDEWADATGELGPVYGKQWRRWAGADGHEIDQIRWLVEEIKRNPDSRRLVISAWNVADLPQMALVPCHALFQFYVANGKLSCQLYQRSADIFLGVPFNIASYALLTHMLAQVTGLVVGDFVHTLGDAHLYANHVEQASVQLGRVPRPQPVLRLNQAVTDLFDFTYDDIVIEGYDPYPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.122 kDa
Sequence
MKQYLDLMKKVLEEGTTKDDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLNGDTNIGYLKENNVSIWDEWADENGDLGPVYGKQWRAWGAADGRQIDQLSKVVQQLKQDPNSRRIIVSAWNVGELDQMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLAVGDFVWTGGDTHLYSNHIEQTHLQLSREPRALPKLIIKSKPASLFDYRFEDFEIEGYDPHPGIKAPIAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.113 kDa
Sequence
MKQYLDLMKKVLEEGTPKADRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLNGDTNIAYLKENNVSIWDEWADENGDLGPIYGKQWRAWGAADGRKIDQLSNVVNQLKQDPDSRRIIVSAWNVGELDQMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLAVGDFVWTGGDTHLYSNHIDQTHLQLSREPRALPKLVIKRKPDSLFDYHFDDFDIEGYDPHPGIKAPIAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Yersinia pestis bv. Antiqua (strain Antiqua)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.111 kDa
Sequence
MKQYLDLMKKVLEEGTPKADRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLNGDTNIAYLKENNVSIWDEWADENGDLGPIYGKQWRAWGAADGRKIDQLSNVVNQLKQDPDSRRIIVSAWNVGELDQMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLAVGDFVWTGGDTHLYSNHIDQAHLQLSREPRVLPKLVIKRKPDSLFDYHFDDFDIEGYDPHPGIKAPIAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Yersinia pestis
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.111 kDa
Sequence
MKQYLDLMKKVLEEGTPKADRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLNGDTNIAYLKENNVSIWDEWADENGDLGPIYGKQWRAWGAADGRKIDQLSNVVNQLKQDPDSRRIIVSAWNVGELDQMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLAVGDFVWTGGDTHLYSNHIDQAHLQLSREPRVLPKLVIKRKPDSLFDYHFDDFDIEGYDPHPGIKAPIAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Yersinia pestis bv. Antiqua (strain Nepal516)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.111 kDa
Sequence
MKQYLDLMKKVLEEGTPKADRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLNGDTNIAYLKENNVSIWDEWADENGDLGPIYGKQWRAWGAADGRKIDQLSNVVNQLKQDPDSRRIIVSAWNVGELDQMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLAVGDFVWTGGDTHLYSNHIDQAHLQLSREPRVLPKLVIKRKPDSLFDYHFDDFDIEGYDPHPGIKAPIAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Yersinia pestis (strain Pestoides F)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.111 kDa
Sequence
MKQYLDLMKKVLEEGTPKADRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLNGDTNIAYLKENNVSIWDEWADENGDLGPIYGKQWRAWGAADGRKIDQLSNVVNQLKQDPDSRRIIVSAWNVGELDQMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLAVGDFVWTGGDTHLYSNHIDQAHLQLSREPRVLPKLVIKRKPDSLFDYHFDDFDIEGYDPHPGIKAPIAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Yersinia pseudotuberculosis serotype I (strain IP32953)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.113 kDa
Sequence
MKQYLDLMKKVLEEGTPKADRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLNGDTNIAYLKENNVSIWDEWADENGDLGPIYGKQWRAWGAADGRKIDQLSNVVNQLKQDPDSRRIIVSAWNVGELDQMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLAVGDFVWTGGDTHLYSNHIDQTHLQLSREPRALPKLVIKRKPDSLFDYHFDDFDIEGYDPHPGIKAPIAI
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.835 kDa
Sequence
MKQYLDLLRRILDEGVRKEDRTGTGTISVFGHQMCFDLEEGFPLLTTKRLHLKSIIYELLWFLRGDTNVHYLQEHGVRIWNEWADENGDLGPIYGYQWRSWPDYRGGHIDQMQEVLRQLREEPDSRRIIVCSWNVGQLADMHLPPCHCFMQFYVADGRLSLQLYQRSADSFLGIPFNIASYALLLQMIAHVTGLKPGRFVHTLGDAHIYLNHLEQVQLQLSREPRALPRMVLNPEVSDLFDFRYEDFRLEGYDPHPHIAGVVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Pseudomonas aeruginosa (strain PA7)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.1 kDa
Sequence
MKQYLDLMRHVREHGTFKSDRTGTGTYSVFGYQMRFDLAAGFPLVTTKKCHLKSIVHELLWFLQGSTNIAYLKEHGVSIWDEWADENGDLGPVYGYQWRSWPAPDGRHIDQIANLMTMLKKNPDSRRLIVSAWNPALIDEMALPPCHALFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTLMVAQVAGLRPGEFIWTGGDCHLYANHLEQADLQLTREPLPLPSMKLNPEVKDLFDFRFEDFELVGYQAHPHIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Pseudomonas aeruginosa (strain LESB58)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.016 kDa
Sequence
MKQYLDLMRHVREHGTFKSDRTGTGTYSVFGHQMRFDLAAGFPLVTTKKCHLKSIVHELLWFLKGSTNIAYLKEHGVSIWDEWADENGDLGPVYGYQWRSWPAPDGRHIDQIANLMAMLKKNPDSRRLIVSAWNPALIDEMALPPCHALFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTLMVAQVAGLQPGEFIWTGGDCHLYANHLEQADLQLTREPLPLPSMKLNPEVKDLFDFRFEDFELVGYEAHPHIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Pseudomonas aeruginosa (strain UCBPP-PA14)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.016 kDa
Sequence
MKQYLDLMRHVREHGTFKSDRTGTGTYSVFGHQMRFDLAAGFPLVTTKKCHLKSIVHELLWFLKGSTNIAYLKEHGVSIWDEWADENGDLGPVYGYQWRSWPAPDGRHIDQIANLMAMLKKNPDSRRLIVSAWNPALIDEMALPPCHALFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTLMVAQVAGLQPGEFIWTGGDCHLYANHLEQADLQLTREPLPLPSMKLNPEVKDLFDFRFEDFELVGYEAHPHIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.016 kDa
Sequence
MKQYLDLMRHVREHGTFKSDRTGTGTYSVFGHQMRFDLAAGFPLVTTKKCHLKSIVHELLWFLKGSTNIAYLKEHGVSIWDEWADENGDLGPVYGYQWRSWPAPDGRHIDQIANLMAMLKKNPDSRRLIVSAWNPALIDEMALPPCHALFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTLMVAQVAGLQPGEFIWTGGDCHLYANHLEQADLQLTREPLPLPSMKLNPEVKDLFDFRFEDFELVGYEAHPHIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Pseudomonas mendocina (strain ymp)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.247 kDa
Sequence
MKQYLDLMRHVREHGTFKEDRTGTGTYSVFGYQMRFDLADGFPIVTTKKCHLRSIIHELLWFLQGDTNIKYLKDNGVSIWDEWADENGDLGPVYGYQWRSWPAPNGESIDQIAKLIEMIRKNPDSRRLIVSAWNPALVEQMALPPCHALFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTLMVAQVCDLQPGEFIWTGGDCHLYANHIEQADLQLTRQPLPLPTMKLNPEVKDLLAFRFEDFELVGYEAHPHIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Pseudomonas stutzeri (strain A1501)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.21 kDa
Sequence
MKQYLDLMRHVREHGTFKSDRTGTGTYSVFGYQMRFDLAEGFPLVTTKKCHLKSIIHELLWFLQGDTNIKYLKENGVRIWDEWADENGELGPVYGYQWRSWPAPNGESIDQIANLLAMIKKNPDSRRLIVSAWNPALVEQMALPPCHALFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTLMVAQVCDLEPGEFIWSGGDCHLYANHLEQADLQLTREPLPLPTMKLNPEVKDLFAFRFEDFELVGYEAHPHIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Ralstonia solanacearum (strain GMI1000)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.381 kDa
Sequence
MQPYLDLMRHVHEHGTDKADRTGTGTRSVFGHQMRFDLQQGFPLVTTKKVHIKSIVYELLWFLQGATNVRWLRENGVTIWDEWADAEGELGPIYGYQWRSWPTPSGEHIDQIAELIAQIKRNPDSRRLIVSAWNVADIPRMKLPPCHAFFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTHMIAQQTGLDVGDFVWTGGDCHLYNNHFEQVETQLARTPLPLPKLHIKRKPDSIFDYRYEDFEIVGYESHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Rhizobium etli (strain CFN 42 / ATCC 51251)
Length
264 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
29.782 kDa
Sequence
MQQYLDLLAHVMEKGSDRGDRTGTGTRSVFGYQMRFDLGEGFPVLTTKKLHLRSIVHELLWFLKGETNIRYLKENGVSIWDEWADENGDLGPVYGAQWRSWPAPDGGHIDQIANLVKGIVNNPNSRRHIVSAWNPAEVDQMALPPCHCLFQFYVADGKLSCQLYQRSADVFLGVPFNIASYALLTMMVAQVTGLKGGDFVHTLGDAHLYHNHFDQAKLQLTRRPKPLPFMRINPEVKDIFGFTFDDFELIGYEADASIKAPIAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Length
263 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
29.853 kDa
Sequence
MTPYEDLLRFVLETGTPKSDRTGTGTRSLFGQQMRYDLSAGFPLLTTKKVHFKSVAYELLWFLRGDSNIGWLHEHGVTIWDEWASDTGELGPIYGVQWRSWPAPSGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIERMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLSVGEFIWTGGDCHIYDNHVEQVRLQLSREPRPYPKLLLADRDSIFEYTYEDIVVKNYDPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Mycobacterium bovis (strain BCG / Pasteur 1173P2)
Length
263 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
29.853 kDa
Sequence
MTPYEDLLRFVLETGTPKSDRTGTGTRSLFGQQMRYDLSAGFPLLTTKKVHFKSVAYELLWFLRGDSNIGWLHEHGVTIWDEWASDTGELGPIYGVQWRSWPAPSGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIERMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLSVGEFIWTGGDCHIYDNHVEQVRLQLSREPRPYPKLLLADRDSIFEYTYEDIVVKNYDPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019)
Length
263 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
29.853 kDa
Sequence
MTPYEDLLRFVLETGTPKSDRTGTGTRSLFGQQMRYDLSAGFPLLTTKKVHFKSVAYELLWFLRGDSNIGWLHEHGVTIWDEWASDTGELGPIYGVQWRSWPAPSGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIERMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLSVGEFIWTGGDCHIYDNHVEQVRLQLSREPRPYPKLLLADRDSIFEYTYEDIVVKNYDPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Length
263 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.769 kDa
Sequence
MSKADEKYLDIIENILENGYYDNNRTGIETYKLPHQIMQFDLSKEFPILTTKFVAFKTSVKELLWIYKDQSNDVRKLQNENVTIWDEWMLEDGTIGKAYGYQVAKFKQIDNLIDTLKTDPQSRRMLISLWNIADLKDMSLTPCCYETLWDVQNGKLNCMLVQRSGDMPLGVPFNMCQYAVLVHLIAQVTGLKPGLFTHVINNAHIYKNQIEGMKIQLKRRDKAYEAPKLWINPNIKNFYDFTADDIKLIDYKHHDKIKMEVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052)
Length
263 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
30.645 kDa
Sequence
MSLYDDKYLAIANDILENGYFDNNRTGVKTYKLPHQIMQFNLEKEFPILTTKFVAFKTAVKELLWIFKDQSNSVKELQSQNVKIWDEWMMEDGTIGTSYGWIVKKFDQIDKLIDALKNNPQDRRMMINLWQIPYLDSAPLYPCCFLTMWDVTDGKLNCMLVQRSGDWGLGVPFNTSQYAVLVHLLAQVTGLKPGLFTHVINNAHIYENQVDGLKLQLTRKNDAYNAPKLWINPEITNFYDFTPDDIKLEDYKHHESIKMDVSV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Length
263 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
29.853 kDa
Sequence
MTPYEDLLRFVLETGTPKSDRTGTGTRSLFGQQMRYDLSAGFPLLTTKKVHFKSVAYELLWFLRGDSNIGWLHEHGVTIWDEWASDTGELGPIYGVQWRSWPAPSGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIERMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLSVGEFIWTGGDCHIYDNHVEQVRLQLSREPRPYPKLLLADRDSIFEYTYEDIVVKNYDPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Length
263 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
29.853 kDa
Sequence
MTPYEDLLRFVLETGTPKSDRTGTGTRSLFGQQMRYDLSAGFPLLTTKKVHFKSVAYELLWFLRGDSNIGWLHEHGVTIWDEWASDTGELGPIYGVQWRSWPAPSGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIERMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLSVGEFIWTGGDCHIYDNHVEQVRLQLSREPRPYPKLLLADRDSIFEYTYEDIVVKNYDPHPAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase ThyA
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
263 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
29.853 kDa
Sequence
MTPYEDLLRFVLETGTPKSDRTGTGTRSLFGQQMRYDLSAGFPLLTTKKVHFKSVAYELLWFLRGDSNIGWLHEHGVTIWDEWASDTGELGPIYGVQWRSWPAPSGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIERMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLSVGEFIWTGGDCHIYDNHVEQVRLQLSREPRPYPKLLLADRDSIFEYTYEDIVVKNYDPHPAIKAPVAV
Protein
Thymidylate synthase ThyA: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Length
260 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
29.53 kDa
Sequence
MRPYLDLLRDILDHGCPKGDRTGTGTLSVFGRMMRFDLSRGLPLVTTKKLHLPSIIHELLWFVSGSTNVRDLQRHGVTIWDEWADDNGELGPVYGRQWRNWNGAIDQLAGLVEQLRRNPGSRRLLVSAWNPSDLDAMALPPCHYAFQCHVADGRLSLMFQMRSADVFLGLPFNIAGYALLTHMLAQQTGYEPGELIWCGGDVHLYLNHLEQARLQLTREPYPPPTLKLARKPGSLFDYRYEDFVVEDYQAHPHIKAAVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Dichelobacter nodosus (strain VCS1703A)
Length
258 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
29.569 kDa
Sequence
MQTYLTLLETLLTTGVDKSDRTGVGTRSLFGYQMRFDLAAGFPLLTTKKMHFKSIVYELLWFLSGNTNIAYLNQNGVSIWDEWADKNGDLGPIYGKQWRNWAGRDQIHQVLTSLKTNPDSRRMLVSSWNVAQLEEMALPPCHVLFQFYVANGRLSCQLYQRSADVFLGVPFNIASYALLTMMMAQQADLELGDFVWTGGDVHLYRNHFAQAQEQLKRQPYPLPKMHIKRAKSIDDYVFEDFLLVDYRCHAAIKAPVAV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Bacillus atrophaeus
Length
227 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
26.901 kDa
Fragment
single
Sequence
SEVPILTTKKLAWKTAIKELLWIWQLKSNDVNDLNKMSVHIWDQWKQEDGTIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTPCVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNIGDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFEVRV
Protein
Thymidylate synthase: thyA

Gene
thyA
Protein
Putative thymidylate synthase
Organism
Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg)
Length
223 amino acids
Function
May catalyze the biosynthesis of dTMP using an unknown cosubstrate. In vitro, also catalyzes the dehalogenation of 5-bromo-deoxyuridine monophosphate (Br-dUMP) and the tritium exchange of [5-3H]deoxyuridine monophosphate ([5-3H]dUMP).
Similarity
Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
Mass
25.589 kDa
Sequence
MAYEISVDEIAEGWLKLVEKIMSDGREIRDERGSLTREVMNTVVTIKNPLGRSGDFYHLPARSLINIRVPEGYFWSGEKLEKYSEQFLSDDRKGFVYTYGNRLRAHFGVDQVDRAIERLKNCKESRRATMVTWDPKIDTESDEVPCMILVDFKVREGRLFTTALWRSHDIYGAWFPNAVGLAYLADHVASEVGVEVGHITIHSISAHIYEVNFKEAKEVIKNG
Protein
Putative thymidylate synthase: thyA

Gene
thyA
Protein
Putative thymidylate synthase
Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)
Length
222 amino acids
Function
May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
Similarity
Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
Mass
25.556 kDa
Sequence
MAYSIEVNEIADGWKKLVEKIMHDGREIRDERGSLTREVMNTVVTIKKPLGKSDDFYHIRRGSLLNIKVPEGYFWSGEKLEKYSEQFLSGDRKGFVYTYGNRLRAHFGVDQLDEAIRRLKNCTESRRATMVTWDPPEDTASDEVPCMILVDFKIRDGRLFTTALWRSHDIYGAWFPNAVGLAYLADHVAAEVGVEVGHITIHSISAHIYEVNFKEAEEVIKW
Protein
Putative thymidylate synthase: thyA

Gene
thyA
Protein
Putative thymidylate synthase
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Length
222 amino acids
Function
May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
Similarity
Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
Mass
25.933 kDa
Sequence
MLCIKKPSVASAFNELIPKILKDGEVVETEFEERTKEIRNTIIEITNPKLKKVPEKYPLGEKAVEEYTKNLLYGSKNVFSYDYHQRLFEYPYADEKINQIDYIIEKLNQQKNSRRAVAITWNPKIDIEVSRDERGSVPCLQLVQFLIRNGKLYQTVIFRSNDALLAFVSNAIGLITLGEYIAKKVGVGYGTYTHHAISMHIYVDRDFDYIKKYFPECLKYLW
Protein
Putative thymidylate synthase: thyA

Gene
thyA
Protein
Putative thymidylate synthase
Organism
Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
Length
217 amino acids
Function
May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
Similarity
Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
Mass
25.159 kDa
Sequence
MEDKFEIGRIIRAKNISDAWYRGLNIIWNHGQVITDERGSQIREFMDLMVVIENPYTDRIPEDTAWNEERLEEYAKQLISGENAQDFEYTYGQRLRNWNEEVDQIEYVIEKLQESPTSRRATAVTWIPPVDTKVNEVPCMILDDFKIRDGKVHLTTLFRSHDFGGAYPANLYGLSKLLEYVAGRVGVEPGMITTVSISAHVYDHDWDMVENIVKGIN
Protein
Putative thymidylate synthase: thyA

Gene
thyA
Protein
Putative thymidylate synthase
Organism
Methanosarcina barkeri (strain Fusaro / DSM 804)
Length
217 amino acids
Function
May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
Similarity
Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
Mass
25.233 kDa
Sequence
MEDRFEIGRIVRAKTISDAWYRGLNIIRNHGQVITDERGSQIREFMDLMIIIEDPYTDRIPHETAWNEERLEEYAKQLISGENTQDFEYTYGQRLRNWHGKVDQIDYVIEKLQQNPTSRRAIAVTWIPPVDTKVNEVPCMMLDDFKIRDGKIHLTTLFRSHDFGGAYPANLYGLSKLLEYVADKVGTKPGTITTISISAHIYDHDWDMVENIVKGVN
Protein
Putative thymidylate synthase: thyA

Gene
thyA
Protein
Putative thymidylate synthase
Organism
Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)
Length
217 amino acids
Function
May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
Similarity
Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
Mass
24.953 kDa
Sequence
MTHDAAIGRLIKARTISDAWYRGLNVIWNHGSLITDERGSQIREFMNLMVVIEDPYSNEIPEDSAWNHERLEEYAKQLITGENAQDFEYTYGQRLRNWDGKVDQIEYVIEKLTNNKTTRRATAVTWVPTIDTKVDEVPCMIIDDFKIRDDTVHLTTLFRSHDFAGAYPANLYGLSKLLEYVADKVGLAPGTITTMSVSAHIYDHDWDKIEKIIKGVQ
Protein
Putative thymidylate synthase: thyA

Gene
thyA
Protein
Putative thymidylate synthase
Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)
Length
217 amino acids
Function
May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
Similarity
Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
Mass
25.154 kDa
Sequence
MENKFEIGRIIRAKNISDAWYRGLNIIWNHGRVITDERGSQIKEFMDLMVVIENPYTDRIPADTAWNEERLEEYAKQLISGENIQDFEYTYGQRLRNWNGEVDQIEYVIEKLKESPTSRRATAVTWIPPVDTKVNEVPCMILDDFKIRDEKVHLTTLFRSHDFGGAYPANLYGLSKLLEYVAEKVGVEPGVITTVSISAHVYDHDWDMVENIVKGIN
Protein
Putative thymidylate synthase: thyA

Gene
thyA
Protein
Putative thymidylate synthase
Organism
Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Length
209 amino acids
Function
May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
Similarity
Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
Mass
23.781 kDa
Sequence
MLGKGRPLVVRGRTVEQVWRQAVTGIKVHGEKVERERGPVKEVRGLIAHLEPSGPESFDIPDDYPLDEHSVRAYEDQLLDPELRGFEYTYGHRLRRYFGLDQVTKIVERLSESNNTRRAIAVTWDPRRDLDEEEVPCLTALQLQSDGGSGLELHAFYRSWDVGKALVANMIALRRLQEHVAERAGLEPTTLTVYAANAHVYEEDLPDLP
Protein
Putative thymidylate synthase: thyA

Gene
thyA
Protein
Thymidylate synthase
Organism
Staphylococcus epidermidis
Length
97 amino acids
Function
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Similarity
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
Mass
10.843 kDa
Fragment
single
Sequence
SADIFLGVPFNIASYALLTHLVAKECGLEVGEFIHTFGDAHIYSNHMDAIHTQLSRDSYLPPQLKINTDKSIFDINYEDLELINYESHPAIKAPIAV
Protein
Thymidylate synthase: thyA