About Products Protein Database Contact

seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
Length
253 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
27.382 kDa
Sequence
MKYIEVDEELYRFIASKTERIGESASDILRRLLTLPVDTVTPFEPNAIDEPSLDVAHHQASNFAASNQEQQTGHGHAGEPSAVQTPESNDYAKAQPHSSGYQPGQLEGHKSEPQTLAQLNSQPLAVGQSSQSATSQVDFNALVNEHLLSQQKGAVGRFMWLLEGLAALAPSQFNKVLLVQGKGRLYFARSKDELLASSASANPKEIGTTGYWVTTNNNTAKKQAILVEVLTKLHCDETLASAIADRICDKVAG
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Mannheimia succiniciproducens (strain MBEL55E)
Length
215 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
24.428 kDa
Sequence
MKIIEVDEELYQYIASQTKSIGESASDILRRLLNLPVSGVNLTAVDLTQSTMNSTNEEKGTQLPAEKNVVAETPKPSSEQEIRTPARKQSTQSIQHIVTKVKNLLQSEAFQEESKMVVRFLNILSVLYRTNPESFAQATEQETSQGRTRTYYARDEATLLAAGNHTKPRQIPDTPYWVITNTNSGRKMLMLERTMQFMELPEELIDEVRPYFAVV
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Haemophilus parainfluenzae (strain T3T1)
Length
213 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
23.946 kDa
Sequence
MKIIEVDEELYQYIAAQTQSIGESASDILRRLLNLPTHATSSVDFFESVASAETPKSAVHAEPVLTEKTTEVSQPKVEPVEPPKAVKKQSDEAINHIVDKVRALLNSAEFKEEPKAVVRFLSILRTLYRTNPESFAQATESLQGRTRVYFARDEGTLLVAGNHTKPKQIPDTPYWVITNTNSGRKMLMLEGAMQSMHLPEYLIDEVRPYFVSN
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Actinobacillus succinogenes (strain ATCC 55618 / DSM 22257 / 130Z)
Length
212 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
23.654 kDa
Sequence
MKIIEVDEELYQFIASHTQSIGESASDILRRLLNLPTSSVSSVALETVAVESAEAANPETPSAVKNDFVLEPVAEKSSLEKTVKKQPEQVICHIVNKVRQVIESEAFQHETKAVVRFLAILTALYRTNPEGFSLAIESEQVQGRTRVYFARDEATLLAAGTHTKPKQIPDTPYWVITNNNSGRKMIMLEGVMHGMQLPDELIEDIRGYFIVN
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Shewanella frigidimarina (strain NCIMB 400)
Length
208 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
23.017 kDa
Sequence
MKYIEIDEELYRFIASKTERIGESASDILRRLLNLSVENVDVSLPTDISHPSLESQSPVNRHPVFDQAKAAVEKVIADQNSANEHYPVDEDIASSTSIDFDAMVSQHLLSQQKGAVGRFMYLLSSLESTAGSDFDKVLNVQGKGRLYFARSKQALLNSSKSSNPKEIASSGFWVTTNNNTAKKQTILTEVLEHLGCDSERAKSIAEHI
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Psychromonas ingrahamii (strain 37)
Length
207 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
23.299 kDa
Sequence
MKNIEIEDDLYKYILANIEAFGETPSQILRRLLSLPNASPDNATPITSSVTPSAPRQEAVNDESSVFEAVTPKVLDRANISLPEPLAHGVNALFDSEVFKTEAVVTNKFMMLLATMYYENKNAFEDAADKTKGRTRDYLGQNLNALLAADSEEEQNFFKASKPRNIPHTPFWVITNANTGRKRIIITQMMASMGYPHYLIERIKEEI
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Colwellia psychrerythraea (strain 34H / ATCC BAA-681)
Length
200 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
22.379 kDa
Sequence
MKNIEIDEELYQYIATNTQFIGESASAILRRLLNLGVEAKLETVTVNEPSDVVEVNILPESEEKAVKIETAEVKEPKSKAVVKVTAESHETVFNFINKEELAMQRGAVGRFLLILAALYRAHPDQFGVVTDISGRDRLYFANSENKLAESGSSTKPRQIPESPFWVITNSNTTRKKMMLTKASISLGYSDSDVEKIRELL
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Length
197 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
22.381 kDa
Sequence
MKIIEVDEELYQYIASQTRSIGESASDILRRLLSLPVHTSIVNDLIITSAETDQKPKQAINVKEVNIKTTKKQSITAINQIVEKVQTLLNSTEFQEESKAVVRFLAILRVLYRTNPESFAQATESLQGRTRVYFARDEATLLMAGNHTKPKQIPDTPYWVITNTNSGRKMLMLEGAMQSMELPETLIDEVRSYFTVN
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Pseudoalteromonas haloplanktis (strain TAC 125)
Length
197 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
22.157 kDa
Sequence
MKQIDIDDELYQYIASNTQSIGESASTILRRLLNLSGEKIQTANVELNQNNQTTTTLPKVPPVAEQTPALAAKPSAVAEKSVQQKNANVFNVLNKEELAMQKGVVGRFLFILSAFYRTHKTDFRAVLDIKGRDRVYFATSKEDLVNSGSSMNPKNITDSEYWVMTNSNTTRKKMMLHEVALCLGYSTEQAEKIRDYL
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)
Length
191 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
20.887 kDa
Sequence
MKYIEVDEELYRYIAGKTERIGESASDILRRLLGLSVAEVSEVAPVDISEPGMEHEPVQVREAEPEPVPEVEVAAQTEIDFSDLLSEAGLAAQKGAVGRFLYALECLHQAAPSRFEQVLQIQGRDRLYFATSKEALLKASQSANPKEIGSSGFWVTTNNNTAKKRTILEEALVQLGCDPVRAKSLGELALA
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Shewanella halifaxensis (strain HAW-EB4)
Length
186 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
20.624 kDa
Sequence
MKYIEVDEELYRHIASKTEHIGESASDILRRILGLQVESVVQDAPEEISHPSLERVSPKPVKVAKVITKMTSTAVSDFTSLIDADVLAAQKGAVGRFLFILDTVHRASPVQFEQVLQIQGRDRLYFATSKDALLKASKSANPKEIGQSGFWVTTNNNTAKKRTILSEVLLQFGTDEAQVTDIIEKI
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Haemophilus ducreyi (strain 35000HP / ATCC 700724)
Length
186 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
20.914 kDa
Sequence
MKTIEVDDELYHYIASRTQAIGESASDILRRLLRLPSSPQPFVLVQPNIAEELNASTKSTNQAKKQTNIEKTVQKFERVLKSDTFVNETKNVRRFLMLLSALHISDQQGFANATAVVTGTERTYFATNEDMLLRCGNGVKAKKIPDSPFWVVTNNSTARKGLILTAVMQSMQMPSHLIDRVRVLFA
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Haemophilus parasuis serovar 5 (strain SH0165)
Length
186 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
21.179 kDa
Sequence
MKTIEVDDELYHYIASRTQAIGESASDILRRLLRLPASPQPFVLVQENMINELKDLAKLPKQKKQLHQQDKVIKQVEFVLASSLFNNETKGVNRFLYLLSALYKADPESFSHATENVQGSERIYFARDEQTILATGSSVKAKQIPESPFWVITNNNTERKGIILCALMNAMELPEELVARIKAQFN
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Shewanella oneidensis (strain MR-1)
Length
183 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
20.503 kDa
Sequence
MKYIEVDEELYRHIASKTERIGESASDILRRLLGLSVDTVEQAQPQAISQPSLEAATPEPQFVPQVETFVAAADFHQLVDEHKLEQQKGAVGRFLFLLESLYQLNKTQFAQILQIQGRDRLYFARSREELLKASATANPKEIGQTGFWVTTNNNTAKKRAILAEALVQFGCDAEIANGIAERV
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Pantoea ananatis (strain AJ13355)
Length
183 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
20.422 kDa
Sequence
MKTIEVDEELYRYIASHTQHIGESASDILRRMLKFTAGQPAAVNDTQPVSAPAPSKAAPSAGNESRPQDRVRAVRELMLSDEYAEQKRAVNRFMLILSTLYRLDTAAFAEATTSLQGRTRIYFAGDEHTLLQSGTHTKPKHVPGTPYWVITNTNTGRKRSMVEHIMLSMQFPSELAEKVCGTI
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Proteus mirabilis (strain HI4320)
Length
183 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
20.761 kDa
Sequence
MKKIEIDDELYRYIASETRHIGESASDILRRLLKLDAKQPVQPVVVTESVQAPVVKQDADLKPVAPAKNPVREMRELLLSDSYAEKTKSVDRFLQILSTLYSLDSATFTQSAETVHGRTRIYFAGDEKTLLDSGRHTKPRHIPGTPFWVITNSNTERKRTMVQSIMQDMQFPANEIDKVCGTI
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Shigella dysenteriae serotype 1 (strain Sd197)
Length
181 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
20.29 kDa
Sequence
MKTIEVDDELYSYIASHTKHIGESASDILRRMLKFSAASQPAAPVTKEVRVASPAIVEAKPVKTIKDKVRAMRELLLSDEYAEQKRAVNRFMLLLSTLYSLDAQAFAEATESLHGRTRVYFAADEQTLLKNGNQTKPKHVSGTPYWVITNTNTGRKCSMIEHIMLSMQFPAELIEKVCGTI
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Shigella flexneri
Length
181 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
20.315 kDa
Sequence
MKTIEVDDELYSYIASHTKHIGESASDILRRMLKFSAASQPAAPVTKEVRVASPAIVEAKPVKTIKDKVRAMRELLLSDEYAEQKRAVNRFMLLLSTLYSLDAQAFAEATESLHGRTRVYFAADEQTLLKNGNQTKPKHVPGTPYWVITNTNTGRKCSMIEHIMQSMQFPAELIEKVCGTI
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Length
181 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
20.315 kDa
Sequence
MKTIEVDDELYSYIASHTKHIGESASDILRRMLKFSAASQPAAPVTKEVRVASPAIVEAKPVKTIKDKVRAMRELLLSDEYAEQKRAVNRFMLLLSTLYSLDAQAFAEATESLHGRTRVYFAADEQTLLKNGNQTKPKHVPGTPYWVITNTNTGRKCSMIEHIMQSMQFPAELIEKVCGTI
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Escherichia coli (strain K12)
Length
181 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. Can also bind to hemimethylated GATC sequences outside of oriC region. Binds, with less affinity, to fully methylated GATC sites and affects timing of replication. May play a role in chromosome organization and gene regulation.
Similarity
Belongs to the SeqA family.
Mass
20.315 kDa
Sequence
MKTIEVDDELYSYIASHTKHIGESASDILRRMLKFSAASQPAAPVTKEVRVASPAIVEAKPVKTIKDKVRAMRELLLSDEYAEQKRAVNRFMLLLSTLYSLDAQAFAEATESLHGRTRVYFAADEQTLLKNGNQTKPKHVPGTPYWVITNTNTGRKCSMIEHIMQSMQFPAELIEKVCGTI
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Aliivibrio fischeri (strain ATCC 700601 / ES114)
Length
180 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
20.208 kDa
Sequence
MKTIEVDEELYRFIASQTQHIGESASDILRRLLMQSSPSDLAVSAPVEVQKKGIVVSKDAGKEASVDRVKAVRTLLISDEFSALDKAIDRFLTVLSELYKIDSKAFSEATEVKGRTRVYFADNQETLIASGKTTKPREIVGTPFWVITNTNTNRKRHMVELLMERMGFQHDLTEKVCAAI
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Enterobacter sp. (strain 638)
Length
180 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
20.171 kDa
Sequence
MKTIEVDDELYAYIASHTRHIGESASDILRRMLKFSAASQPATPVSKEVRASNVVAEAKTVAPVKDKVRAVRELLLSDEYAEQKKAVNRFLLVLTTLYSLDNKAFAEATESLHGRTRVYFAADEQTLIQNGNQTKPKQVPGTPYWVITNTNTGRKRSMVEHIMQSMQFPAELIEKVCGTI
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Ferrimonas balearica (strain DSM 9799 / CCM 4581 / PAT)
Length
180 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
19.911 kDa
Sequence
MKYIEIDDELYRYIASNTQQIGESASDILRRLLGLEVTAEAESIPERISEPSMEGVEEAAPVRSAVAEAGVFEELVDDEQLPRQKGAVGRFLYLLDCLYRQHPSAFDGVLAIRGRDRLYFSQSKEALLKASPSANPKQIGASPFWVSANNNTAKKRAILEEVLEILGCQKALAARIAEQV
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Length
180 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
20.149 kDa
Sequence
MKTIEVDDELYSYIASHTKHIGESASDILRRMLKFSATTQPTASAVKGTPAAQPVAEAKPVNPVKDKVRAMRELLLSDEYAEQKKAVNRFMLILTTLYSLDHHAFAEATESLHGRTRVYFAADEQTLLKNGNQTKPKHVPGTPYWVITNTNTGRKCSMIEHIMQSMQFPAELIEKVCGTI
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Shewanella woodyi (strain ATCC 51908 / MS32)
Length
179 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
20.073 kDa
Sequence
MKYIEVDEELYRLIASKTERIGESASEILRRLLGLEVEASATQEKDEPEVISQPGLEETADVEDKPRFIDLHSSINKEELAAAKGAVGRFLFILEAVYLASPEQFAQVLKIKGRDRLYFATSKQSLLKASKSANPKEIGQSGYWVTTNNNTAKKRTILTEVLHQYGTVEAQIESITRNI
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Vibrio tasmaniensis (strain LGP32)
Length
179 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
20.235 kDa
Sequence
MKTIEVDEDLYRFIAGQTERIGESASDILRRLLLVDNQGTVPIEEIVEPKGIVVSKEVGFTPEKFDGVKEMRSLLISDEFASLKKAIDRFMLVLSTLHKIDPLSFSEATQVKGRKRVYFADNEATLLANGNTTKPKAIPQSPFWVITNNNTSRKRQMVEQLMSRMNFQAELIEKVTGSI
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Photobacterium profundum (strain SS9)
Length
178 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
20.178 kDa
Sequence
MKSIEVDEELYRYIASQTQHIGESASDILRRLLMVPAEQQLEVVVPVRPKGIIVSKDAGNEHKLDRVKEMRTLLISDEFAVQGKAIGRFMMILSSLYRIDSDGFIEAAAIKGRTRVYFADNEEALLASGKTTKPKAIPETPYWVITNTNTDRKRQMVDQLMVKMNYNTDIIEKVCGVI
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Length
177 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
19.694 kDa
Sequence
MKTIEVDEDLYRYIASQTLHIGESASDILRRLLNVDGELATAAPAAEPKGIVVSKDAAFDTKIDGVKAMRSLLISDEFAGLKNAIDRFMLILSTLHRIDSASFSEATMFKGRKRVYFADNEQTLLASGQTTKPKAIPNTPFWVITNNNTSRKQQMVEQVMVRMGFPSDIIEKVTHSI
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)
Length
176 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
20.3 kDa
Sequence
MKLIEVDEELYRYIAAHTQYIGESASEILRRMFSLTQKKQTEIKIKKTPKIHQSSVKATLFSRIQILNDILSSETYASKNKVIARFMLILSTLYDLDSKAFSVAAESLQGRKRAYFSGSKNFLLKNGTHTKPKQIPKTPYWVITNTNSERKRTMLKNMMIAMKFPNEIAKKVSQTI
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087)
Length
174 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
19.392 kDa
Sequence
MKNIEIEDDLYAYIASQTQHIGETASDILRRLVMPENTVVKTVVAAKPSATTKKPVGDVFSQITTDELSEYPKMVERFLKILSVLESMHGAQFDEVLTLSGRNRVYFAKDKETLLQASSVTNPKQIGESTFWVMTNNNTAKKASLIKEVAEVLGYNANDGQRLAALFAPELYED
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Tolumonas auensis (strain DSM 9187 / TA4)
Length
170 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
19.074 kDa
Sequence
MKTIEVDDQIYRYIASRTLHIGESASDILRRLLALPLDTEPTVALGHEANAEQTDEVSTDVLTMLLDNAQLAKEESAIARFMLILSALYRSQPDAFRHAADIKGRKRIYFAEDPQALLDNGKTTKPKPVPETPYWVITNTNTGRKRLIIEQLMQAMGYSADLIAEVCNKV
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / JCM 1027 / KCTC 2358 / NCIMB 9240)
Length
169 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
18.78 kDa
Sequence
MKTIELDDDLYFYIASQTRHIGESASDILRRLLEQPANQAAPVTEPVTTAQPHTVADAMGLEALLDSGELQKEEKSINRFMQVLSTLYRDDPVGFTQATEIKGRKRVYFSRDPDALRASGSTTKPKPVPETPFWVITNTNTSRKQNMVAQLMTSMGYGDEVIARVCGAI
Protein
Negative modulator of initiation of replication: seqA

Gene
seqA
Protein
Negative modulator of initiation of replication
Organism
Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)
Length
160 amino acids
Function
Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
Similarity
Belongs to the SeqA family.
Mass
18.397 kDa
Sequence
MKRIDIDDDLYTYIASHTRQIGESASDILRRLLDVNSSEPEADSKSEPTESVFNRLNEQDVRIQKSVVARFLYILSMLYRCHPSEFSQVLDIRGRDRQYFARSEEALLTSGNSTNPKQIPDSPFWVITNTNTTKKKAMLTQVAEKLGYQSADAEKIRDFL
Protein
Negative modulator of initiation of replication: seqA