Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.

Belongs to the SeqA family.

197 amino acids

MKIIEVDEELYQYIASQTRSIGESASDILRRLLSLPVHTSIVNDLIITSAETDQKPKQAINVKEVNIKTTKKQSITAINQIVEKVQTLLNSTEFQEESKAVVRFLAILRVLYRTNPESFAQATESLQGRTRVYFARDEATLLMAGNHTKPKQIPDTPYWVITNTNSGRKMLMLEGAMQSMELPETLIDEVRSYFTVN

22.4 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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