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prsW

Gene
prsW
Protein
Protease PrsW
Organism
Peptoclostridium difficile (strain 630)
Length
238 amino acids
Function
Involved in the degradation of specific anti-sigma factors, specifically RsiT. Involved in the regulation of extracytoplasmic function sigma factors expression. Seems to play a role in the resistance to antimicrobial peptides. Required for colonization or survival in the host cecum.
Similarity
Belongs to the protease PrsW family.
Mass
27.827 kDa
Sequence
MKLDLFLLAIIPILIGMFWIRSKDRYCREPLIHLIKFFLIGAFLSVIIILLENLLMKFNVFEGYSELIYVSFVVAGLVEEGVKALILIPALIKEKHFTEKLDGIIYSVFLALGFATIENMVYIFSESRNLALQVGINRAVISIPAHVMFAITMGYYISKYKFEGNKNKRREYLFMAVLIPILLHGVFDFILMIEYRWAIILLIVYVIILWKINLDKLEKYMNHSKKVFFGNLRKKKKK

Gene
prsW
Protein
Protease PrsW
Organism
Geobacillus kaustophilus (strain HTA426)
Length
225 amino acids
Function
Involved in the degradation of specific anti-sigma factors. Responsible for Site-1 cleavage of the RsiW anti-sigma factor. This results, after two other proteolytic steps catalyzed by the RasP and ClpXP proteases, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity).
Similarity
Belongs to the protease PrsW family.
Mass
25.541 kDa
Sequence
MFSLISAGVAPGVALLSYFYLKDEYEAEPLSFVLRMFLFGVLLVFPIMFIQYVLAAEGIVASPAAEAFLSAALLEEFVKWFVVYFFVYDHDEFDEPYDGIVYSASVSLGFATLENILYLLANGVETAIARALLPVSSHALFSVIMGFYFGKAKFAVKKRRYYLWASFLLPFFLHGVYDWLLLAKERWGYYMGLFMLALWWAALRKVKQAKGYARPQAVPPVKSQA

Gene
prsW
Protein
Protease PrsW
Organism
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Length
222 amino acids
Function
Involved in the degradation of specific anti-sigma factors. Responsible for Site-1 cleavage of the RsiW anti-sigma factor. This results, after two other proteolytic steps catalyzed by the RasP and ClpXP proteases, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity).
Similarity
Belongs to the protease PrsW family.
Mass
25.527 kDa
Sequence
MFGIISAGLAPGIALLMYFYLKEKYESEPIHMVIRLFILGVLLVFPTMFIQYVLEKEHISEGSFVVSFLTSGFLEEFLKWFLLMVSTFQHIDFDEHYDGIVYGTSLSLGFATLENILYLIGNGVEYAFMRALLPVSSHALFGVIMGFYIGKARFSDSKTKMKWLLCSLFIPALLHGLYDYILLALKNWIYFMLPFMAFLWWFGLRKAKKARSVKTGGQPLQQ

Gene
prsW
Protein
Protease PrsW
Organism
Bacillus subtilis (strain 168)
Length
218 amino acids
Function
Involved in the degradation of anti-sigma-W factor RsiW. Responsible for Site-1 cleavage of the RsiW anti-sigma factor. This results, after two other proteolytic steps catalyzed by the RasP and ClpXP proteases, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor. Seems to be responsible for sensing antimicrobial peptides that damage the cell membrane and other agents that cause cell envelope stress. Therefore it is a protease governing regulated intramembrane proteolysis and resistance to antimicrobial peptides in B.subtilis.
Similarity
Belongs to the protease PrsW family.
Mass
24.719 kDa
Sequence
MFAIISAGIAPGIALLSYFYLKDQYDNEPVHMVLRSFFLGVVLVFPIMFIQYVLEKENVGGGSFFVSFLSSGFLEESLKWFILMISVYPHAHFDEHYDGIVYGASVSLGFATLENILYLIGHGVEHAFVRALLPVSCHALIGVIMGFYLGKARFSADKARVKWLTLSLVVPSLLHGSYDFILTALSNWIYYMLPFMVFLWWFGLRKAKKARSVNMMQV

Gene
prsW
Protein
Protease PrsW
Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Length
215 amino acids
Function
Involved in the degradation of specific anti-sigma factors. Responsible for Site-1 cleavage of the RsiW anti-sigma factor. This results, after two other proteolytic steps catalyzed by the RasP and ClpXP proteases, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity).
Similarity
Belongs to the protease PrsW family.
Mass
24.818 kDa
Sequence
MFSLLTAAIAPAMALLCFFYLKNEYGSQTLGFVVRTFLIGALLMFPVMVLQHAFLAEGFFANPLLKAFILYGFFEEFFKWFMLYFFAYKHVEFNRRYDGIIFGVSLSLGFASMENGLYLIANGVETALGRALLPVSSHAIYGVIMGYYLGRAKMEEKHRKKWLVLSLFLPVLLHSLYDAILLLWSKHFLFVMVPFMLVLWWVAIQKVKLANQLDR

Gene
prsW
Protein
Protease PrsW
Organism
Bacillus clausii (strain KSM-K16)
Length
215 amino acids
Function
Involved in the degradation of specific anti-sigma factors. Responsible for Site-1 cleavage of the RsiW anti-sigma factor. This results, after two other proteolytic steps catalyzed by the RasP and ClpXP proteases, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity).
Similarity
Belongs to the protease PrsW family.
Mass
24.114 kDa
Sequence
MVSLVLAALAPAMALFSYVYLRDVYSKAKMFLVLRIFIIGALLVVPILVIQFAFTEENVFPHPAAKAFLLYGFLEEGLKWLMLFVFAYQHGQLQRPGDGILFGVSVSLGFATVENGLYMIAYGLEAAIPRTVLPTTAHAVYGIVMGYYIGQAKYKEDHKKMFLLLGAILPILLHGGYDFILSSFGHYVLYAMIPFMVILWLLAIWKLKKASRFTV

Gene
prsW
Protein
Protease PrsW
Organism
Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831)
Length
215 amino acids
Function
Involved in the degradation of specific anti-sigma factors. Responsible for Site-1 cleavage of the RsiW anti-sigma factor. This results, after two other proteolytic steps catalyzed by the RasP and ClpXP proteases, in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity).
Similarity
Belongs to the protease PrsW family.
Mass
24.855 kDa
Sequence
MLSILSAGIAPALALLSYIYLKDKITEPIWLIIRMFILGALLVLPIMFIQYAISSEFNYDSIFIEAFFQIALLEEFFKWFVFMFVIYQHEEFDNHYDGIVYASSLSLGFASIENILYLITNGIEYAFLRAVFPVSSHALFGIIMGYYLGKAKTHTNYKKKNLTLAFLLPFLLHGIYNFILKGFSSFTLILTPFMVLLWIIALYRLKRANENTIIN