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prp28

Gene
PRP28
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28
Organism
Coccidioides immitis (strain RS)
Length
820 amino acids
Function
ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
Similarity
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
Mass
90.447 kDa
Sequence
MDGMLTEGTSAIPPPQPPLEPIERPPTPPPLPPDESALPPPPTDPAPPPPPPDSLAPPPPPEDVPRSTYTVPVVVKKKKVGWGSSKSTTPLSVEELLRKKKEADEAASRPKFLTKSQREKLALEKRAKEIEHERRIRAASTNGSMMSDSNGGGGNSNGRASPTTRYDNVNGSSRTSIPTAPRALRGEIPTAPAAMRSSQAKNNDPRPGNKVPSDSAATGEKRTAPEDAQALLTRQRYMGADQTSSFSAKKKRRRTTERKFNFEWNADEDTSPDYNPLYQNRSEMNFFGRGRLAGFSDDVVDSAAKRYAKALEDRDLEAGSARAREILEMERRRREEGGRNGLDLHWSQKRLDQMRERDWRIFKEDFNISTKGGSIPNPMRSWGESGLPKRLLEIIDKVGYKDPSPIQRAAIPIALQNRDLIGVAVTGSGKTAAFLLPLLVYIAELPRLDEFEWRKSDGPYAIILAPTRELAQQIENEARKFCNPLGFNVVSIVGGHSLEEQSFSLRNGAEIIIATPGRLVDCIERRILVLSQCCYVIMDEADRMIDLGFEEPVNKILDALPVSNEKPDTEEAEDARAMSQHLGGKDRYRQTMMYTATMPSAVERIARKYLRRPAIVTIGNIGEAVDTVEQRVEFISGEDKRKKRLADILASGEFRPPIIVFVNIKRNCDAVARDIKQMGYSSVTLHGSKTQEQREAALASVRNGNTDVLVATDLAGRGIDVPDVSLVVNFNMATNIESYTHRIGRTGRAGKSGVAITFLGNEDADVMYDLKQMLMKSSISRVPEELRKHEAAQSKPTKAGGGQKRLDEGGMSAPKTGSGW
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28: PRP28

Gene
prp28
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase prp28
Organism
Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)
Length
816 amino acids
Function
ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5' splice site duplex to permit an effective competition for the 5' splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5' splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
Similarity
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
Mass
89.525 kDa
Sequence
MASNGYLNSIDAVPPPLIDSDGRPPSPPPPPPDSFVPPPPPSSLAPPPPPSSDLPPPPPSELQPPPPEPKKKKGWGAPKPGPLSIEDILKKKKEADEAAAKPKFLSKAAREKLALEKRAKEVEEQRRKRESEQDNRIPVGTVNGNGYGAANGRDGYERSHQQDNARRDSSFVPTGPRAMRNGQQNRPSSDKPNDMEPPPKSAKPATTAAGSSKASVAGEKRPANAEDLQAALIRTRYMGAETNQSTFSAKKKRRRTTEKKFNFEWNAEEDTSPDYNPIYQNRAEAGLYGRGRLAGFAEDEAATLKYAKALEERDIEAGSARAREIVEMERRRKEDAGRNSLDKHWSEKKLEHMRERDWRIFKEDFNISTKGGAIPNPMRSWSESKLPKRLLDVINQVGYDEPSAVQRAAIPIALQARDLIGVAVTGSGKTAAFLLPLLVYISELPPLNEFTKNDGPYAIILAPTRELAQQIEVEAKKFATPLGFTCVSIVGGHSLEEQSYNLRNGAEIIIATPGRLVDCIERRVLVLGQCCYIIMDEADRMIDLGFEESVNKILDALPVSNEKPDTDDAEDAQAMSRHLGGKDRYRQTMMYTATMPPAVEKIAKKYLRRPAIVTIGNIGEAVETVEQRVEFVAGEDKRKKRLNEILASGEFQPPIIVFVNIKRNCDAVARDIKHMGFTSVTLHGSKTQEQREAALASVRSGATNVLVATDLAGRGIDVPDVSLVVNFNMATNIESYTHRIGRTGRAGKSGVAITFLGNEDADTMYDLKQMLMKSSISRVPEELRKHEAAQQKSQRGQGLKKIEEGGFGGKGGAGGC
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase prp28: prp28

Gene
prp28
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase prp28
Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Length
810 amino acids
Function
ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
Similarity
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
Mass
89.81 kDa
Sequence
MDGIMTNGSSEAHPPMPPPEPIERPPTPPPPPPEDSALPPPPPDTSAPPPPPEDLPPAPPPETEPKKKKVGWGTKRPAPTPLSVEELVRKKREADAAAAKPKFLSKKEREKLALEKRAQEVAATRRLKSEHASNGVDRSATHSPSVSSEGPNGDARSIPTGPRAMRNSDAAPTAPAAMRHSQSHNKNYDLAPPPPPKSMSFGLTSGKGDSRFVDEDEAAAQAALVKQRYMGADQTSNFSAKKKRKRTTDRKFNFEWNAEEDTSGDYNPLYQHRHETNFFGRGRLAGFGDDVAESVAHKYARALEDRDREAGSIRAREILEMERRRREESTRNQLDKHWSEKKLEHMRERDWRIFKEDFNISTKGGSVPNPMRSWDESNLPKRLMELINRVGYKEPTPIQRAAIPIAMQNRDLIGVAVTGSGKTAAFLLPLLCYIAELPRIDEFEWRKADGPYAIVLAPTRELAQQIEIEAKKFTGPLGFNVVSIVGGHSLEEQAYSLRDGAEIIIATPGRLVDCIERRILVLSQCCYVIMDEADRMIDLGFEEPVNKILDALPVSNEKPDSEDAENPLAMSRHINHDQHRYRQTMMYTATMPTAVERIARKYLRRPAIVTIGSAGEAVDTVEQRVEMIAGEDKRKKRLGDILSSGEFRAPIIVFVNIKRNCDAIAREIKQWGFSSVTLHGSKTQDQREAALASVRNGTTDVLVATDLAGRGIDVPDVSLVVNFNMATSIESYTHRIGRTGRAGKSGVAITFLGNEDADVMYDLKQMLMKSPISRVPEELRKHEAAQSKPTRGFSSKKNNEEGGGGGKVGW
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase prp28: prp28

Gene
prp28
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase prp28
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40)
Length
803 amino acids
Function
ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
Similarity
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
Mass
89.34 kDa
Sequence
MDDIVMNGSPEVPPPQPPPEPVERPPTPPPPPPEESVAPPPPPEVVAPPPPPEDLPPAPPPPEPKKKKVGWGAKKPAATPLSVEELVRKKREADAAAARPKFLSRAERERIALEKRAKEVEAERRLKASNGVDRSATQSPSVSSEVNHSDGRTIPTGPRAMRSSDTPTAPAAMRNSHSHNKNRDLSPPPPPKSMSFGLASSKGDKRPVDDDEVAAQVALVKQRYMGADQTSTFSAKKKRKRTTDRKFNFEWNAEEDTSGDYNPLYQHRHEANFFGRGRLAGFGDDVADNVAKKYARALEDRDHEAGGIRAREILEMERRRREESTRNQLDKHWSEKKLEHMRERDWRIFKEDFNISTKGGSVPNPMRSWDESGLPKRLMELVNKVGYKEPTPIQRAAIPIAMQSRDLIGVAVTGSGKTASFLLPLLVYIAELPRIDEFEWRKNDGPYAIVLAPTRELAQQIEIEAKKFTEPLGFNVVSIVGGHSFEEQAYSLRNGAEIIIATPGRLVDCIERRMLVLSQCCYVIMDEADRMIDLGFEEPVNKILDALPVSNEKPDSEEAENSMAMSQHIGTKDRYRQTMMYTATMPTAVERIARKYLRRPAIVTIGSAGEAVDTVEQRVEFIAGEDKRKKRLGDILSSGEFRPPIIVFVNIKRNCDAIAREIKQWGFSSVTLHGSKTQEQREAALASVRNGQTDVLVATDLAGRGIDVPDVSLVINFNMATTIESYTHRIGRTGRAGKSGVAITFLGNEDTDVMYDLKQMIMKSSISRLPEELRKHEAAQSKPTRGFAKKNDDNSAFGSKGGW
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase prp28: prp28

Gene
prp28
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase prp28
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Length
798 amino acids
Function
ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
Similarity
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
Mass
88.854 kDa
Sequence
MDGFISNGPAEAPATMPPPEPFERPPTPPPPPPEDSAAPPPPPDTSAPPPPPEDAIPAPPLEKKKKAGWGAKRAAATPLSVEELVRKKREADAAAAKPKFLSRAERERLALEKRAKEVDADRRLKTERTANGADSSSAQSTPVYPERPNSDKRVIPTGPRAMRNTEAPARSGPAATRNKNYDMTPPAPPKPMSFSLTDSKGDSKRQAEEDETVAQVALIKQRYMGEEKTSNFSAKKKRKRTTDRKFNFEWNAEEDTSGDYNPLYQHRHEANFYGRGRLAGFGDDVADSLAKKYARALEDRDQEAGSIRAREMLEMEKRRREESTRNQLDKHWSEKKLEHMRERDWRIFKEDFNISTKGGSVPNPMRSWEESGLPKRLLELVDRVGYKEPTPIQRAAIPIALQSRDLIGVAVTGSGKTASFLLPLLVYIAELPRIDEFEWRKNDGPYAIVLAPTRELAQQIEIEAKKFTQPLGFNVVSIVGGHSLEEQAYSLRNGAEIIIATPGRLVDCIERRILVLSQCCYIIMDEADRMIDLGFEEPVNKILDALPVTNEKPDSDEAENSAAMRSHRYRQTMMYTATMPSAVERIARKYLRRPAIVTIGSAGEAVDTVEQRVELIAGEDKRKKRLADILSSGEFRPPIIVFVNIKRNCDAIAREIKHMGFSSVTLHGSKTQDQREAALASVRNGSTDVLVATDLAGRGIDVPDVSLVVNFNMATSIESYTHRIGRTGRAGKSGVAITFLGNEDADVMYDLKQMLMKSPISRVPEELRKHEAAQSKPTRGYAKKSDESSGFRDKGAWQ
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase prp28: prp28

Gene
prp28
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase prp28
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Length
796 amino acids
Function
ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
Similarity
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
Mass
88.337 kDa
Sequence
MDGIISNGSPGAPVTQPPPEPLERPPTPPPPPPEDSAAPPPPPDTSVPPPPPEDAPPAPPPEKKKKVGWGAKRPAATPLSVEELVRKKREADAAAAKPKFLSKAERERIALEKRAKEVEAGRRLKLDPFTDGTDRSGTQSPSVYPETPNGDERSIPTGPRAMRNSEVPTGPAAMRNKTYDMSPPPPPKAMSFSLTDGKGDSKRQAEEDEAAAQAALIKQKYMGTEKTSSFSAKKKRKRTTDRKFNFEWNAEEDTSGDYNPLYQQRHEANFYGRGRLAGFGDDVADTLAQKYARALEDRDREAGSIRAREILEMERRRREESTRNQLDKHWSEKKLEHMRERDWRIFKEDFNISTKGGSVPNPMRSWEESGLPKRLLELVDQVGYKEPTPIQRAAIPIALQSRDLIGVAVTGSGKTASFLLPLLVYISELPRIDEFEWRKNDGPYAIVLAPTRELAQQIEIEARKFTQPLGFNVVSIVGGHSFEEQAYSLRNGAEIIIATPGRLVDCIERRLLVLSQCCYVIMDEADRMIDLGFEEPVNKILDALPVTNEKPDTEEAENSAAMRSHRYRQTMMYTATMPSAVERIARKYLRRPAIVTIGSAGEAVDTVEQRVEMIAGEDKRKKRLADILSSGEFRPPIIVFVNIKRNCDAIAREIKQMGFSSVTLHGSKTQEQREAALASVRNGSTDVLVATDLAGRGIDVPDVSLVVNFNMANSIESYTHRIGRTGRAGKSGVAITFLGNEDADVMYDLKQMLMKSPISRVPEELRKHEAAQSKPNRGLAKKSDDSSGFGTKSGWQ
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase prp28: prp28

Gene
prp28
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase prp28
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)
Length
796 amino acids
Function
ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
Similarity
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
Mass
88.38 kDa
Sequence
MDGIISNGSPGASVTRPLPEPLEKPPTPPPPPPEDSAAPPPPPDTSVPPPPPEDAPPAPPPEKKKKVGWGAKRPAATPLSVEELVRKKREADAAAAKPKFLSKAERERIALEKRAKEVEAGRRFKSEPSTNGTDRSGTQSPSVYSETPNGDERSIPTGPRAMRNSEVPTGPAAMRNKNYDMSPPPPPKPMSFSLTDGKGDSKRQAEEDEAAAQAALIKQKYMGTEKTSSFSAKKKRKRTTDRKFNFEWNAEEDTSGDYNPLYQQRHEANFYGRGRLAGFGDDVADTLAQKYARALEDRDREAGSIRAREILEMERRRREESTRNQLDKHWSEKKLEHMRERDWRIFKEDFNISTKGGSVPNPMRSWEESGLPKRLLELVDQVGYKEPTPIQRAAIPIALQSRDLIGVAVTGSGKTASFLLPLLVYISELPRIDEFEWRKNDGPYAIVLAPTRELAQQIEIEARKFTQPLGFNVVSIVGGHSFEEQAYSLRNGAEIIIATPGRLVDCIERRLLVLSQCCYVIMDEADRMIDLGFEEPVNKILDALPVTNEKPDTEEAENSAAMRSHRYRQTMMYTATMPSAVERIARKYLRRPAIVTIGSAGEAVDTVEQRVEMIAGEDKRKKRLADILSSGEFRPPIIVFVNIKRNCDAIAREIKQMGFSSVTLHGSKTQEQREAALASVRNGSTDVLVATDLAGRGIDVPDVSLVVNFNMANSIESYTHRIGRTGRAGKSGVAITFLGNEDADVMYDLKQMLMKSPISRVPEELRKHEAAQSKPNRGFAKKSDDSSGFGNKSGWQ
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase prp28: prp28

Gene
prp28
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase prp28
Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Length
783 amino acids
Function
ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
Similarity
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
Mass
86.214 kDa
Sequence
MPGPPATAPPPEPIERPPTPPPPPPEDSAAPPPPPDMSAPPPPPQDELPPAPEPKKKKLGWGSKRPAAAPLSVEELVRKKREADAAAAKPKFLSKKEREKIALEKRAKEVEQSRRKTSTNGASDTASVRSESATPNGVDRTASIPTGPRAMRTSEAPPPPRPRHDSSSNGNGNSNSNSNSNGTVDEDEAAAQAALVKQRYMGAEMTSSFSAKKKRKRTTDRKFNFEWNAEEDTSRDYNPLYAQRHEANFFGRGRLAGFGDDVADGVARKYAAALEDRDREAGSVRAREILEMERRRREESTRNQLDKHWSEKKLEHMRERDWRIFKEDFNIATKGGSVPNPMRSWAESGLPSRLLDLVHRVGYKDPTPIQRAAIPIAMQSRDLIGVAVTGSGKTAAFLLPLLVYIAELPRIDEFEWRKNDGPYAIVLAPTRELAQQIEIEAKKFTIPLGFTVVSIVGGHSLEEQAYSLRNGAEIIIATPGRLVDCIERRLLVLSQCCYVIMDEADRMIDLGFEEPVNKILDALPVSNEKPDSDAAENAAAMSQLHHAGGGRDTRYRQTMMYTATMPTAVERIARKYLRRPAIVTIGSAGEAVDTVEQRVELIAGEDKRKKRLGDILSSGEFRPPIIVFVNIKRNCDAIAREIKQWGFSSVTLHGSKTQEQREAALASVRNGSTDVLVATDLAGRGIDVPDVSLVVNFNMATSIESYTHRIGRTGRAGKSGVAITFLGNEDADVMYDLKQMLIKSPISRVPDELRKHEAAQQKPTRGFSKKNDESSAFGGKGGW
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase prp28: prp28

Gene
prp28
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase prp28
Organism
Botryotinia fuckeliana (strain B05.10)
Length
783 amino acids
Function
ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5' splice site duplex to permit an effective competition for the 5' splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5' splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
Similarity
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
Mass
85.754 kDa
Sequence
MASNGYSNSADAVPPPPSDNDGRPPSPPPPPPDSFVPPPPPSSLAPPPPPSSDLPPPPPSELLPPPPEPKKKKGWGAPKPGPLSIEDILKKKKEADEAAAKAKFLSKAAREKLALETRAKEVEEQKRKREAEQDNRISIGSVNGNGNGYGSAANGPDGYERSYQQENGRRESSFVPTGPRAMRNSQQSRSSSDKPNDMEPPPKPAKSAAAGTGKASVAGEKRPANAEDLQAALIKTRYMGAETNQSTFSAKKKRRRTTEKKFNFEWNAEEDTSPDYNPIYQNRAEAGLYGRGRLGGFAEDEGATLKYAKALEERDAEAGGARAREIVEMERRRKEDAGRNSLDKHWSEKKLEHMRERDWRIFKEDFNISTKGGAIPNPMRNWSESKLPKRLLDVIHQVGYDEPSAVQRAAIPIALQARDLIGVAVTGSGKTAAFLLPLLVYISELPPLNEFTKNDGPYAIILAPTRELAQQIEVEAKKFATPLGFTCVSIVGGHSLEEQSYNLRNGAEIIIATPGRLVDCIERRVLVLGQCCYIIMDEADRMIDLGFEESVNKILDALPVSNEKPDTDDAEDAQAMSRHLGGKDRYRQTMMYTATMPPAVEKIAKKYLRRPAIVTIGNIGEAVETVEQRVEFVAGEDKRKKRLNEILASGEFAPPIIVFVNIKRNCDAVARDIKHMGFTSVTLHGSKTQEQREAALASVRSGATNVLVATDLAGRGIDVPDVSLVVNFNMATNIESYTHRIGRTGRAGKSGVAITFLGNEDSDTMYDLKQMLTKSSISRCRKS
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase prp28: prp28

Gene
prp28
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase prp28
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Length
782 amino acids
Function
ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
Similarity
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
Mass
86.908 kDa
Sequence
MESQSILPPPPPPEDASAPPPPPEESAAPPPPPDVSAPPPPPEDLPPPPPEPEVKKKKVGWGTKRPATTPLSVEELVRKKREADAAAARPKFMSKAERERLALEKRAKEVDAQRRRTNGTPNGVDGMDLDTPSRGFRTPNGDSRSIPTGPRAMRNGDGPTPTGPAAMRSRNDSGTTKSDKKVDKRFNEEDEAAAQAALIKQRYMGADQTSNFSAKKKRKRTTDRKFNFEWNAEEDTSGDYNPLYQHRHEANFFGRGRLAGFGDDVADSVAKKYAKALEDRDREAGSIRAREILEMERRRREESTRNQLDKHWSEKKLEHMRERDWRIFKEDFNIATKGGSVPNPMRSWDESGLPKRLLELVDRVGYKEPTPIQRAAIPIAMQSRDLIGVAVTGSGKTAAFLLPLLCYIAELPRIDEFEWRKNDGPYAIVLAPTRELAQQIEIEAKKFTEPLGFNVVSIVGGHSFEEQAYSLRNGAEIIIATPGRLVDCIERRMLVLSQCCYVIMDEADRMIDLGFEEPVNKILDALPVTNEKPDTEEAEDSSAMSRHLGSKDRYRQTMMYTATMPTAVERIARKYLRRPAIVTIGSAGEAVDTVEQRVEMIAGEDKRKKRLGEILSSGDFRPPIIVFVNIKRNCDAIAREIKQWGFSSVTLHGSKTQEQREAALASVRNGSTDVLVATDLAGRGIDVPDVSLVINFNMATSIESYTHRIGRTGRAGKSGVAITFLGNEDADVMYDLKQMLIKSPISRVPEELRKHEAAQSKPTRGAGKKIEEASGFAGKGGW
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase prp28: prp28

Gene
PRP28
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28
Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)
Length
746 amino acids
Function
ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
Similarity
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
Mass
83.308 kDa
Sequence
MTDTTLPPPPPPPPPPADKMPPPPPTDVPPPPPPQEEELGPVLVPSKKAKKGWASQRKQPPSIDDILKAKREQEAAAAKPKFLSKAERERIALEKRRKEVEEAQRRREGSNSSTNGASHKGHYDASSSIPTGPRAMRPEAPSGPPSRQQRSNGDMAPPPLPDKKTGKRPPPEDAEAAMIRQRYMGAEQNQSTFSAKKKRKRTTEKKFNFEWNEEEDTSYDYNPIYQQKAEAGFFGRGRLGGFTEDVTEQGTQKFIEAMIERDPVSGRERAERILDMERRRKEEGGRAQLDKHWSEKKLEHMRERDWRIFKEDFNIATKGGAIPNPMRNWQESGLPDKVLRLVEHVGYAEPSAVQRAAIPIALQCRDLIGVAVTGSGKTASFVLPLLVYISQLPPLGPSNRADGPYAIVLAPTRELAQQIEVETRKFAAPLGFNTAVIVGGHSIEEQAFQMRDGAEIVIATPGRLVDCIERRMLVLSQCTYVIMDEADRMIDMGFEEPVNKILDALPVTNEKPDSDAAEDPNAMKRGMYRQTMMYTATMPTAVERIARKYLRRPAIVTIGNVGEAVETVEQRVEHIQGEEKRKKRLQEILNSGEFTPPIIVFVNIKRNCDAIARDIKNMGFSSVTLHGSKTQEQREAALAQLREHRVDVLVATDLAGRGIDITDVSLVVNFNMATSIESYTHRIGRTGRAGKSGVAITFWGNEDADVLYDLKQMLTKSQISKVPEDLRKHEAAQQKGGRNKEKKALT
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28: PRP28

Gene
PRP28
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28
Organism
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
Length
738 amino acids
Function
ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
Similarity
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
Mass
82.157 kDa
Sequence
MAGPLSVEDMLAKQKAEKEAAAKPKFLSKAERQKIALEKRQSEVREQQEREDAERRQREEFDRAAEEERRRHEQERYGYNAGPSGRNDRDGYGRDGYGRDNRRGFGDRRDGSGPAIPSGPRGAALPVGPRSMQSRNGGGLPYDGFAQGSPSQLSSTPVAGSASPGPASTTASGDAVPPSQAELEALRARYLGKRTDGKKPRLRKAQDKKIIFDWNEQDDTSAADQSSWTREVRELVPGGTMFGGRLAGMDGAKKNETRSDNHADPLERRRAVKGKDDDRHWSDKPLDEMKERDWRIFREDFSIAARGGGIPHPLRNWRESAIPSQILDIIEEIGYKEPSPIQRQAIPIGMQNRDLIGVAKTGSGKTAAFVIPMLDYIGHLPPLNDDNRHLGPYALIMAPTRELAQQIETETRRFALPLGYKCVSIVGGRSVEEQQFALRDGAEIIIATPGRLKDMVDKSILVMSQCRYVVMDEADRMVDLGFEVDLNFILDSMPATFVKPDDSVALQPTKEGEWQGWRVTTLFSATMPPAVERLARKYLIKPATVVIGNAGEAVDTVEQRVEFVHGDEKKKARLIEILRTIGLPPPIIVFVNQKKTADMVVKYVQQAGMSGVTLHSGKSQEQREAALQALRDGEISVLVATDLAGRGIDVPDVSLVINWQMSDTIEKYVHRIGRTGRAGKTGVAITFLTNDDDEVMYDLRIEVEKSKMSKMNPELARHEAARTRVTREMKRKRGDEEE
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28: PRP28

Gene
PRP28
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28
Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)
Length
738 amino acids
Function
ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
Similarity
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
Mass
82.157 kDa
Sequence
MAGPLSVEDMLAKQKAEKEAAAKPKFLSKAERQKIALEKRQSEVREQQEREDAERRQREEFDRAAEEERRRHEQERYGYNAGPSGRNDRDGYGRDGYGRDNRRGFGDRRDGSGPAIPSGPRGAALPVGPRSMQSRNGGGLPYDGFAQGSPSQLSSTPVAGSASPGPASTTASGDAVPPSQAELEALRARYLGKRTDGKKPRLRKAQDKKIIFDWNEQDDTSAADQSSWTREVRELVPGGTMFGGRLAGMDGAKKNETRSDNHADPLERRRAVKGKDDDRHWSDKPLDEMKERDWRIFREDFSIAARGGGIPHPLRNWRESAIPSQILDIIEEIGYKEPSPIQRQAIPIGMQNRDLIGVAKTGSGKTAAFVIPMLDYIGHLPPLNDDNRHLGPYALIMAPTRELAQQIETETRRFALPLGYKCVSIVGGRSVEEQQFALRDGAEIIIATPGRLKDMVDKSILVMSQCRYVVMDEADRMVDLGFEVDLNFILDSMPATFVKPDDSVALQPTKEGEWQGWRVTTLFSATMPPAVERLARKYLIKPATVVIGNAGEAVDTVEQRVEFVHGDEKKKARLIEILRTIGLPPPIIVFVNQKKTADMVVKYVQQAGMSGVTLHSGKSQEQREAALQALRDGEISVLVATDLAGRGIDVPDVSLVINWQMSDTIEKYVHRIGRTGRAGKTGVAITFLTNDDDEVMYDLRIEVEKSKMSKMNPELARHEAARTRVTREMKRKRGDEEE
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28: PRP28

Gene
PRP28
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28
Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084)
Length
721 amino acids
Function
ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
Similarity
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
Mass
81.083 kDa
Sequence
MPLDIEELLRKKKAADTAAAKPRFIPKAERERLAAEKAKKEEDDKKRKASEEEQKRKEEEQKWRSNGSSRPNESNGSGRVPTGPRSMNDGRDDRERDRDRDQGRGRVRGKDRKGDKQGVGADKQSAEDIEATLLRSRYLGPQVNQQSNFSAKKKRMRTTEKKFNFEWDADEDTSRDNDPLYDRQTAVSHNGSFAGIGGEFDDGAEERARKRAKMIAQRDPENGKERAEGIMEDFFRARDKARQRADRRGLGKHWSEKSLDDMRERDWRIFKEDFGIATKGGMIPNPMRSWQESNLPQRLLNIVDDVGYKDPSPIQRAAIPIALQARDLIGVAVTGSGKTAAFLLPLLVYISDLPPLDEINKHDGPYALIMAPTRELVQQIETEARKFAGPLGFRVVSIVGGHQIEEQAYNLRDGAEIVVATPGRLLDCIERRLLVLSQCCYVIMDEADRMIDLGFEESVNKILDALPVTNEKPDTDEAENAQIMQRYLGGRDRYRQTMMYTATMPPLVERIAKKYLRRPAIVTIGNAGEAVDTVEQRVEFVSGEDRRKKRLQEILSSGNFGPPIIVFVNIKRNCDAVARDIKQMGWSAVTLHGSKTQEQREAALGSVRAGHTQVLVATDLAGRGIDVPDVSLVVNFNMATNIESYTHRIGRTGRAGKSGVAITFLGPEDHETMYDLKQILSKSSISKVPEELRRHEAAQSKPVRGAKKDKDEGSGKGNWQH
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28: PRP28

Gene
PRP28
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28
Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)
Length
705 amino acids
Function
ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
Similarity
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
Mass
78.791 kDa
Sequence
MDRRRLPPDLPALLRQREAERAAAAKPRFIPKKERERMAAEKAAKEEEERKRREEALIAQRHSSANGTNGSNGYSSGKSTTNSIPTGPKAMRHPGDSGEPEHGGKRRRLNDNDEKRAEMERKDAAELRAKYMGPEVNQSTFSAKKKRKRTAANKFNFDWDPEDDTSRPFDPVYAERPESLVRLAGYENTDELVLRKAEAIRRGDPETGEERARKLLEQHERVKQAAERKNFGKHWSEKKLEDMKERDWRIFKENFGIATKGGAIPNPMRSWAESNLPRRLLEIVENVGYDEPTPIQRAAIPIAQQARDLIGVAVTGSGKTAAFLLPLLVYISELPPLTEFNKNDGPYALILAPTRELVQQIETEARKFAGPLGFTVVSIVGGHSLEEQAFALRNGAEIIVATPGRLVDCLERRLLVFSQCCYIIMDEADRMIDQGFEEPLTKILDALPVANEKPDTEDAENSQLMSRYLGGKDRYRQTMMYTATMPPLVEKIAKKYLRRPAIVTIGNAGEAVDTVEQRVEFVSGEDKRKRRLQEILNSGQFKPPVIVFVNIKRNCEMVAKDIKSWGYSTVTLHGSKTQEQREASLASVRNGQANILVATDLAGRGIDVADVSLVVNFNMPSSIEAYTHRIGRTGRAGKSGVAITFLGNEDSDVMYDLKQIISKSSISKVPEELRRHEAAQSKPTRGGGKKLDDSGGFAGKGGSWQ
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28: PRP28

Gene
PRP28
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28
Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
Length
674 amino acids
Function
ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
Similarity
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
Mass
76.093 kDa
Sequence
MAPLDLEEILKKHKAAKAEAAKPRFIPRGQRKKMEEEKKLKVEEEQKRQQEELQKTRSELQKAREELAGLQRVRRQEQSRSRESDHSVPTGPRAMRSYDDDSFNGNGNGSNSNRNNNNNQRDRQDASTKTNGSRTAEEVQEEKKYLERYTGPPAKVSTFSANKKRRRTTDQKFNFDWDPKDDTSQPWRYEETGAHERSANGATEQVRRKKATRDYNDPRLVPWQDKELSQMTTRDWRLFKVNLEIVTKGNNIPNPMRFWEESNLPHVLKDTIKQVGYTEPTPVQRAAIPIALQCRDLIGISKTGSGKTAAFVLPMLSYIEPLPPLNEVTKTEGPYALILAPTRELATQIQAEVIKFATRMGFTVVCLIGNKRTIEEDAFALRNGAEIIVATPGRLVDCLERHLLVLSQCSYVVLDEADRMVDGGFEDSIHKILAALPPSNGKPDDRDAEDPNIMSKFLTPNLRYRQTVMYSATMPPSVERIAKNYLKHPAMVTIGTIGEAVDTVEQQAMWVVSEDERRNKLRAMLNTYGTGKLVIVFVNTKSNCDAVAKDLKSSSFSAVTLHGNKTQDQREAALQSFRDGRTNVLVATDVAARGLDIPDVSLVINFNMAGTIEVYTHRIGRTGRAGKEGMAITFCGPEDHGVLYHLKQIMSKSQMSKVPPWLKDHPEAQSKPTF
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28: PRP28

Gene
prp28
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase prp28
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
662 amino acids
Function
ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
Similarity
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
Mass
74.224 kDa
Sequence
MTAQDSIPSLEQLVQQKRVKEEKAARPKFLSKAERARLALERRQKEVEEAKAKQNDKLLDLRKRTFTNHLENNELADDEKKSQVSSVSSNNSGTESSATDEAFSMTIRQRYMGIKPPVVKKRRRNADKKFVFDWDATDDTMKDAETSASPEATIAVFGRGKLGGFDDQSIRKAKSNSGLIQRLLQGTEQDKARAHELIQLQEKRAKKIDWDDVPWREKPLEAMKPRDWRILKEDYNISIKGDDLPNPLRNWEEAGLPSEMLKVLKKVNYKEPSSIQRAAIPVLLQRKDLIGIAETGSGKTAAFIIPLIIAISKLPPLTESNMHLGPYAVVLAPTRELAQQIQVEGNKFAEPLGFRCVSVVGGHAFEEQSFQMSQGAHIVVATPGRLLDCLERRLFVLSQCTYVVMDEADRMLDMGFEDDVNKILSSLPSSNASEKDGSILATANSSSSRRQTIMFSATLPPRVANLAKSYLIEPVMLTIGNIGQAVDRVEQRVEMISDDSKKWRRVEEILESNRFSPPIIIFVNLKRNIEAIAKQLNAIGWHAVTLHGSKSQEQRERAIEQLRNKTADILVATDIAGRGIDIPNVSLVLNYNMAKSIEDYTHRIGRTGRAGKSGTAITFLGPEDTDVYYDLRVLLSRSAKAHIPDELRNHEAAFVRHAAITQ
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase prp28: prp28

Gene
PRP28
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28
Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)
Length
597 amino acids
Function
ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
Similarity
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
Mass
67.685 kDa
Sequence
MSKRPIPIDDLLKEDAIVPKYIPKSKRAKSSNGPGEDGANTTLKLQYPQSSVNHGSAVSRSTQFSAHQKSSTRPTTSLQPPSKLRHKKFQFDWDDIDDPHYNPQPLYSFELDQLGVENGDNYNDNKNNNDDDDNFDFQDPLLHDDRNSGHWSTKLLSEMTDRDWRIFNEDYGITTKGKKIPHATRSWDESGLDPKILASLKSFGFRQPTPVQRASIPISLELRDVVGVAETGSGKTLAFLLPLLHYLSRVDGNYLNYEKVRNEPLALVLAPTRELALQITQEAEKFGKQLGFNVLSIIGGRQYQETMDQIDNMIVGRGVHIVVGTPGRLLDSVERKILNFSKCYYLVMDEADRMIDMGFEKDLNKLINLLPKNEKLSTTIDGKLFHLTKRLTMMYTATISPPIEKITKSYLIDPAYIYIGGAGEALDNIDQHFDYLSTYAESARLSKLIKVVQGHKRRNRNALVIIFANFKHVCDVLSLELEQNNLLNVVIHGSKSQEAREEALEDFRTHQAPILVATDVAARGIDVPNVSLVINYQMSKKFDEYIHRIGRTGRAGNLGESYTFLDDADAETFMPLKKFLKSGRKKVPEWLYRYNIG
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28: PRP28

Gene
PRP28
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
588 amino acids
Function
ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing.
Similarity
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
Mass
66.641 kDa
Sequence
MARPIDVSQLIAGINKKKGLDENTSGKISKPRFLNKQERSKQERLKENEESLTPTQSDSAKVEIKKVNSRDDSFFNETNDKKRNPSKQNGSKFHFSWNESEDTLSGYDPIVSTRAIDLLWKGKTPKNAAESSYMGKHWTEKSLHEMNERDWRILKEDYAIVTKGGTVENPLRNWEELNIIPRDLLRVIIQELRFPSPTPIQRITIPNVCNMKQYRDFLGVASTGSGKTLAFVIPILIKMSRSPPRPPSLKIIDGPKALILAPTRELVQQIQKETQKVTKIWSKESNYDCKVISIVGGHSLEEISFSLSEGCDILVATPGRLIDSLENHLLVMKQVETLVLDEADKMIDLGFEDQVTNILTKVDINADSAVNRQTLMFTATMTPVIEKIAAGYMQKPVYATIGVETGSEPLIQQVVEYADNDEDKFKKLKPIVAKYDPPIIIFINYKQTADWLAEKFQKETNMKVTILHGSKSQEQREHSLQLFRTNKVQIMIATNVAARGLDIPNVSLVVNFQISKKMDDYIHRIGRTGRAANEGTAVSFVSAAEDESLIRELYKYVRKHDPLNSNIFSEAVKNKYNVGKQLSNEIIY
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28: PRP28

Gene
PRP28
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
582 amino acids
Function
ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
Similarity
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
Mass
65.53 kDa
Sequence
MLVLRKFRWRKWTAETLESTKMTRPIDVHQLLKSRSAGPKYMSVEERERVVIEHSNDEVDLGVEYAKKRNVDEVAEDSARESKKKSKRLDFDWDPADNTLEGYQPIVNPVILERIRQQEDQGDDLEAQYLGKSWREKLLVEMDERDWRIMREEFNITSKGKGAVKHPLRNWSETNVIPTDLVRALTEGMGFDEPTAIQRITIPNAISSNKSVPRDILGIASTGSGKTLAFSIPILARLDALPARPVNLKTLDGPLALVLVPTRELAQQISQEINRLLSAWENKKNLNAVSIVGGHSMSDISHTLRNGCDILIATPGRLLDVLDNHLVVLNKIQSLVLDEADRMIDLGFEDQMKSILSHLMADELAARQTMLFTATLSSSVESIAKGYLKNPLHVSVGSRWDSDKPLITQVVRHTGDDDKKLSFLKDDLIKNGLPAIIFINYKETADWLTLRLSDRFNIVTLHGSKSQSQRESAIQKLKSGTANVLIATNVAARGLDIPDVALVVNFQMSKKFDDYIHRIGRTGRAGKTGIAVTYLTGEEDPQLIKQLAKYVKDVDPNKENDFPEECAKHFGIVSETRNRIIY
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28: PRP28

Gene
PRP28
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
581 amino acids
Function
ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
Similarity
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
Mass
65.641 kDa
Sequence
MSSNIFKRFKSAEESLDEDESVTPVYIPKAKRAKLEALKAKKSQIASRLSTHKQQSAPTTTTNTSTTASTTTTATTNNTNNSKPSIQTKKPTGKKFQFDWDVEEEDTASGFVPLIEMDEEIDDPLFSGQESTHWTNKNLEEMTDRDWRIFKEDYNITTKGKNIPNPLRYWNEGSINDKLVSIISQLGYEEPTSVQRASIPLALKKRDVVGVAETGSGKTLAFLIPVLNYILSIDENYLKYEKISNEPVGLILAPTRELALQITKEAEKFCKKLGYQVLPIIGGHHYQDTINKIDQTGVHLIVATPGRLVDSIERKIVDLSKCYCLVMDEADRMIDMGFEKDLNKVLDKLPTEKQLSSTIDGRIFHLEKRSTMMFTATISPTVEKLTKKYLIDPGYLYIGGAGEALDNISQSFEFLSSATTEATKFNKLIKIIRSHWRVTENPLIIIFANFKHVCDSLSQELSSNDINNVVIHGSKSQDMREQAITNFRNHESEVLIATDVAARGIDIPNVTLVINYQMVKKFDEYIHRIGRTGRAGNLGESFTFISDQDTEIFTPLKKFLKKGGKRLPDWLYKHQSQTVQE
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28: PRP28

Gene
PRP28
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
580 amino acids
Function
ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
Similarity
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
Mass
66.188 kDa
Sequence
MSKRPISVEELIGKSQSAEVISKPKFLSKSERQKLSLQRNQEIQDKKRQQSTVNNGAKKRYNNSIEDNPEPKKINKKLKKGRNFNFDWDEEEDTSNNYQPLVRYDNRTNPPDLGLSDMHWSEKQIDDMTTRDWRIFKEDYNITSKGGDIENPLRCWAESKLPAKLLNILIKNLGYDSPTPIQRASIPLALNGRDIVGIAETGSGKTLAFLLPLFSYILSVDSNYLLYEHQQESNFNKPLGLILAPTRELALQITKEAKLFGDKLNLNVVTIIGGHQYEETVHSVRNGVHIVVATPGRLIDSLERGIINLSNCYFFTMDEADKMIDMGFEKSLQSILNYLPASEKLETTIDGKIFNIKKRITLMFTATISPPIEKITKNYLMKPGYLFIGNVGEAVDNINQQFEYFGARQSSDEILDPKKLDKLFSILRFHKDENRNYSIIIFANFKKACEELAYELSRKGFSDNTVIHGSKSQEARERAIDSFREGKDKILIATDVAARGIDIPNVSLVVNYQMTKKFDEYIHRIGRTGRAGNKGTSCTFIDDGDSEVFLDLKKFLNKGKKKCPEWLLKHSSTQSQILRD
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28: PRP28

Gene
PRP28
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28
Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)
Length
575 amino acids
Function
ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
Similarity
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
Mass
64.693 kDa
Sequence
MRPLNAAELLKSRSQDHKLAKPQFLSKKKRLELQRAKEDEEREKTELKRKTNTLKRSSPSEPETILDQKDTSTANKKRKKRFNFEWDDEEDTSSQLEPMMAYPTSNNDFLPAEEHWSDKKLEDMTSRDWRIFKEDFSITCKGNNIPNPLRSWKESGIPTTLLNTIDQLGYKEPTPIQRAAIPTALGHRDVVGIAETGSGKTLAFLIPLLSYLSAIDKDYMEVEHKQESNLNKVLGLVLAPTRELALQISKEAKKFASVLGYNVVTIIGGHQYEETVKSVQDGAHIVVATPGRLIDSAEKGLIDLSQCYHLTMDEADRMIDMGFEKALQSILSFLPSTSSSGFGLDSTIFKVKSRITLMFTATISPPIEKITKDYLQTPAYLYIGDAGEIVDNINQKFEYLGDNVDSQEELNAPRTNKMISALRQHIRETEQPLIIIFANFKRTCELLSVELSNQNVGSNIVIHGSKSQEARESAIASFREHKVNVLIATDVAARGIDIPNVSLVVNYHMPKRFDEYIHRIGRTGRAGKSGASLSFVDDGDSEILVNLKSFLSKGTKRLPDWLLRHPAVQSLTLKD
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28: PRP28

Gene
PRP28
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
575 amino acids
Function
ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
Similarity
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
Mass
63.75 kDa
Sequence
MPVSIEELKALQVQKKEASKPKFISKAKRAEMAAKAKQIQKNTTSEETTLKDIRSTTDLKRSVVQETVETTKPLPSKPKPKSTSGKFSFDWSAADDTSKAYQPSYSIDSGDGQVPKRQKRDLEDAHWSDKPVESMTSRDWRIFKEDYSIVTKGGGNIPNPLRSWNECKEIPGIVRDTISRMGYKEPTPIQRAAIPIALGIRDVIGVAETGSGKTASFLIPLISYICELPKLDERSKVNGPYGLILAPTRELAMQIKDEAVKFCAPLGFKVVSVVGGYSAQEQALAVQEGAELIVATPGRLLDVIDRRLLVLNQCCYVVMDEADRMVDMGFEEQVQKVLASLPSSNAKPDSDEAENLAAVSTRRYRQTMMYTATMPVAIEKLAKKYLRRPGIVTIGSAGQAGSTVTQLVEFLNTDEKRKRRLLDIISKRQYRPPIVVFLNYKRDCEAVSDALVAAGWRTAIIHGGKQQEQREQAVQHLKRGAVDVLVATDVAGRGLDIPNVSLVVNFQMANNIESYTHRIGRTGRAGKRGTAVTFLGQEDDDVLFELKQMISRSEASPNNQELSRHPAARMKKLQQ
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28: PRP28

Gene
PRP28
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
539 amino acids
Function
ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
Similarity
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
Mass
61.249 kDa
Sequence
MLRPVSIDDLISDTVPAKKPRFLIKKRTFPQPEEEEASKALSHTVIKRKDNYRNLDEDELYEEQVSNEPDDLLFLARKSADLLKKRQNEDESIVDNYLGKHWSEKKYEEMSTRDWRILSEDFNISSKGGTVEKPLRNWHELKLIPEDLLNIITNDLHYNEPTSIQRSTIPNVINNRDFIGVASTGSGKTLAFLLPILIKLHGIPPLNSITKHDGPLALVLAPTRELAQQIQHEGQSITKLWKRPCNIVSIVGGHSLEEISANLRDGCDILVATPGRLLDCLDSHLLFLKQVNTLVLDEADKMIDFGFEDQLTTILAKTETISNRQTMMFTATFSPTIEKVANGYLKKPSYVTVGGEESKPKIKQIVRYVPDEEEKLKILVKDFLPNYKAPIIIFINYKRTADWLFDKLREARFRATTLHGSKSQEQREHSLSLLRNGKVDILIATDVAGRGIDIPNVSLVVNLQFPKSFDSFVHRVGRTGRAGKTGTALTFLTEEEDHSAMAKLFDYVKKNDFTGENYISKEAMSKYNVDKSSYKPIII
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28: PRP28

Gene
PRP28
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28
Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)
Length
482 amino acids
Function
ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
Similarity
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
Mass
54.612 kDa
Sequence
MMALEPVSTTRDNIDFVETTHWSEKSLDQMTARDWRIFREDYGITSKGGDIDNPLRTWNEASIPSKLLSIIVDKLEYLEPTPIQRAAIPLALNQRDVVGIAETGSGKTLAFLIPLLSYILNTDKNYLEYEHQQEQNYNKPLGLILAPTRELAQQITKEAQKFGDRLGLNVVSIIGGHQYEETVHSIRTGVHVVVATPGRLVDSLERNIIGLDKCYYLIMDEADRMIDMGFEKALQSILSYVPSTDRLNSTIDSMIFHIKKRITLMFTATISPPIEKITKNFLIKPGYLYIGGAGEALDHIVQNFEYLGSATGGSEDFDSKRFDKLVRIIQQHSRESRQFSIIIFANYKRVCDLLSLELEKNGFRDNVVIHGSKTQELREKAISSFRSHESRILIATDVAARGIDVPNVSLVVNFQMSRKFDEYVHRIGRTGRAGNRGESYTFIDDSDSDVFIDLKKFLVNGGKKCPDWLIKHASTQSQVLRD
Protein
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28: PRP28