ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).

Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.

721 amino acids

MPLDIEELLRKKKAADTAAAKPRFIPKAERERLAAEKAKKEEDDKKRKASEEEQKRKEEEQKWRSNGSSRPNESNGSGRVPTGPRSMNDGRDDRERDRDRDQGRGRVRGKDRKGDKQGVGADKQSAEDIEATLLRSRYLGPQVNQQSNFSAKKKRMRTTEKKFNFEWDADEDTSRDNDPLYDRQTAVSHNGSFAGIGGEFDDGAEERARKRAKMIAQRDPENGKERAEGIMEDFFRARDKARQRADRRGLGKHWSEKSLDDMRERDWRIFKEDFGIATKGGMIPNPMRSWQESNLPQRLLNIVDDVGYKDPSPIQRAAIPIALQARDLIGVAVTGSGKTAAFLLPLLVYISDLPPLDEINKHDGPYALIMAPTRELVQQIETEARKFAGPLGFRVVSIVGGHQIEEQAYNLRDGAEIVVATPGRLLDCIERRLLVLSQCCYVIMDEADRMIDLGFEESVNKILDALPVTNEKPDTDEAENAQIMQRYLGGRDRYRQTMMYTATMPPLVERIAKKYLRRPAIVTIGNAGEAVDTVEQRVEFVSGEDRRKKRLQEILSSGNFGPPIIVFVNIKRNCDAVARDIKQMGWSAVTLHGSKTQEQREAALGSVRAGHTQVLVATDLAGRGIDVPDVSLVVNFNMATNIESYTHRIGRTGRAGKSGVAITFLGPEDHETMYDLKQILSKSSISKVPEELRRHEAAQSKPVRGAKKDKDEGSGKGNWQH

81.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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