ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).

Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.

597 amino acids

MSKRPIPIDDLLKEDAIVPKYIPKSKRAKSSNGPGEDGANTTLKLQYPQSSVNHGSAVSRSTQFSAHQKSSTRPTTSLQPPSKLRHKKFQFDWDDIDDPHYNPQPLYSFELDQLGVENGDNYNDNKNNNDDDDNFDFQDPLLHDDRNSGHWSTKLLSEMTDRDWRIFNEDYGITTKGKKIPHATRSWDESGLDPKILASLKSFGFRQPTPVQRASIPISLELRDVVGVAETGSGKTLAFLLPLLHYLSRVDGNYLNYEKVRNEPLALVLAPTRELALQITQEAEKFGKQLGFNVLSIIGGRQYQETMDQIDNMIVGRGVHIVVGTPGRLLDSVERKILNFSKCYYLVMDEADRMIDMGFEKDLNKLINLLPKNEKLSTTIDGKLFHLTKRLTMMYTATISPPIEKITKSYLIDPAYIYIGGAGEALDNIDQHFDYLSTYAESARLSKLIKVVQGHKRRNRNALVIIFANFKHVCDVLSLELEQNNLLNVVIHGSKSQEAREEALEDFRTHQAPILVATDVAARGIDVPNVSLVINYQMSKKFDEYIHRIGRTGRAGNLGESYTFLDDADAETFMPLKKFLKSGRKKVPEWLYRYNIG

67.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.

Make PRP28 using our protein expression services starting at $99 + $.30/amino acid in as fast as two weeks (includes the cost of DNA synthesis)

Order Here