bzaF

5-hydroxybenzimidazole synthase

439 amino acids

Catalyzes the conversion of aminoimidazole ribotide (AIR) to 5-hydroxybenzimidazole (5-HBI) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Is thus involved in the anaerobic biosynthesis of the benzimidazole lower axial ligand of the cobamide produced by D.autotrophicum.

Belongs to the ThiC family. 5-hydroxybenzimidazole synthase subfamily.

48.307 kDa

MKTQIELARDGIISRQMEQVAADENFNPEIIRTRVAAGEIVIPCNPNRTNQKVVGIGTGLRTKINASIGTSSDICSIENEVQKAIAIEEEGADTLMELSAGGNLDKVRQEVLKAVNLPVGNVPLYQAFKETGRKYNDPSKLDPEFLFDLIERQLSDGLSFMAIHCGINQYTIERLRKQGFRYGGLASKGGTFMVAWMDATGKENPLYEQFDRVCTLMKKYDAVLSLGNGIRAGAIHDSHDRAQMAEMIINCELAELGREQGCQMMVEGPGHVPLDEIQANIILEKRMSGNAPYYVLGPIPADTGAGYDHITSAIGAASSTWHGADLICYITPAEHLALPTEADVREGVRATKLAVRIGDIAKYPDRRENERLASMARRDMRWDDLEQHLLFPDIARKTRASRAPEDGGTCTMCGDFCAMKKGNEIFKDDIKNDKIAPGA

bzaF

5-hydroxybenzimidazole synthase

435 amino acids

Catalyzes the complex conversion of aminoimidazole ribotide (AIR) to 5-hydroxybenzimidazole (5-HBI) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Is thus involved in the anaerobic biosynthesis of dimethylbenzimidazole (DMB), the lower axial ligand of vitamin B12 (cobalamin).

Belongs to the ThiC family. 5-hydroxybenzimidazole synthase subfamily.

48.157 kDa

MKTQVEHAVDGIITEQMATVAHDEDLSPEYIRTMVAEGKIVIPNNSNSTPKPVGIGKGLRTKVNASIGTSSDIVNYQAEVRKARIAEQAGADTLMELSVGGNLDRVRREVLAAVNLPVGNVPLYQAFCDATRKYGSADKLDPEELFDLIEQQCEDGLAFMAIHCGINRYTIERLRKQHYRYGGLVSKGGTSMVSWMEHNNRENPLYEQFDRVVAILKKYDVCLSLGNGLRAGAIHDSHDRAQMQELIINCELAQLGREMGCQMLVEGPGHMPLDEVEANILIQKRMSNEAPYYMLGPISTDVVPGFDHISSAIGAAQSARYGADLICYITPAEHLALPNEDDVRSGVEAARVATYIGDMNKYPDKGRQRDKAMSKARRDLQWDKQFELALMPEQARQVRDSRLPEEEHSCTMCGNFCAANGSKTLFDGDLQGDKC

bzaF

5-hydroxybenzimidazole synthase

435 amino acids

Catalyzes the conversion of aminoimidazole ribotide (AIR) to 5-hydroxybenzimidazole (5-HBI) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Is thus involved in the anaerobic biosynthesis of the benzimidazole lower axial ligand of the cobamide produced by G.metallireducens.

Belongs to the ThiC family. 5-hydroxybenzimidazole synthase subfamily.

47.67 kDa

MKTQIEIAREGTISSQMMAVAAEEHVSPDYVRQMVAEGKIVIPGNHSRKPRAVGIGKGLRTKVNASIGTSSDIIDYGAEVRKALAAQEAGADTLMELSVGGDLDRVRREVIAAVDLPVGNVPLYQAFCEAARKYGDPNKLDPEMLFDLIEKQCEDGMAFMAVHCGINLYTIERLKRQGYRYGGLVSKGGVSMVAWMMANRRENPLYEQFDRVTSILRKYDTVLSLGNGLRAGAIHDSSDRAQIQELLINCELAELGREMGCQMLVEGPGHVPLDEVEGNIQLQKRMSGGAPYYMLGPISTDVAPGFDHITAAIGAAQSSRYGADLICYITPAEHLALPNEEDVRQGVKAAKIAAYIGDMNKYPERGRERDKEMSKARRDLDWKKQFELALFPEDAKAIRASRTPEDEATCTMCGDFCASRGAGKLFAADLRGDKI

bzaF

5-hydroxybenzimidazole synthase

435 amino acids

Catalyzes the conversion of aminoimidazole ribotide (AIR) to 5-hydroxybenzimidazole (5-HBI) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Is thus involved in the anaerobic biosynthesis of the benzimidazole lower axial ligand of the cobamide produced by G.sulfurreducens.

Belongs to the ThiC family. 5-hydroxybenzimidazole synthase subfamily.

47.75 kDa

MKTQIEQAREGIITPQMAAVAAEEHVSPEYVCRMVAEGKVVIPWNHVRAPKAVGIGKGLRTKVNASIGTSSDIVDYEAEVRKARAAQESGADTLMELSVGGDLDRVRREVIAAVDLPVGNVPLYQAFCEAARKYGDPNRLDPEMLFDLIERQCADGMAFMAVHCGINLYTIERLRRQGYRYGGLVSKGGVSMVGWMMANGRENPLYEQFDRVVGILKKYDTVLSLGNGLRAGAIHDSSDRAQIQELLINCELAEMGREMGCQMLVEGPGHVPLDEVEGNIQLQKRMSGGAPYYMLGPISTDVAPGFDHITAAIGAAQSSRFGADLICYITPAEHLALPNEEDVRQGVKAARVAAYIGDMNKYPEKGRERDREMSKARRDLDWQRQFELALYPEDARAIRASRTPEDEATCTMCGDFCASRGAGRLFAGDLRGDKV