Description
Catalyzes the conversion of aminoimidazole ribotide (AIR) to 5-hydroxybenzimidazole (5-HBI) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Is thus involved in the anaerobic biosynthesis of the benzimidazole lower axial ligand of the cobamide produced by G.sulfurreducens.
Family
Belongs to the ThiC family. 5-hydroxybenzimidazole synthase subfamily.
Species
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Sequence
MKTQIEQAREGIITPQMAAVAAEEHVSPEYVCRMVAEGKVVIPWNHVRAPKAVGIGKGLRTKVNASIGTSSDIVDYEAEVRKARAAQESGADTLMELSVGGDLDRVRREVIAAVDLPVGNVPLYQAFCEAARKYGDPNRLDPEMLFDLIERQCADGMAFMAVHCGINLYTIERLRRQGYRYGGLVSKGGVSMVGWMMANGRENPLYEQFDRVVGILKKYDTVLSLGNGLRAGAIHDSSDRAQIQELLINCELAEMGREMGCQMLVEGPGHVPLDEVEGNIQLQKRMSGGAPYYMLGPISTDVAPGFDHITAAIGAAQSSRFGADLICYITPAEHLALPNEEDVRQGVKAARVAAYIGDMNKYPEKGRERDREMSKARRDLDWQRQFELALYPEDARAIRASRTPEDEATCTMCGDFCASRGAGRLFAGDLRGDKV
Simulated SDS-PAGE

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)
Safety
Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.
Protein synthesis service