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MUS81

Gene
mus81
Protein
Probable crossover junction endonuclease mus81
Organism
Dictyostelium discoideum
Length
920 amino acids
Function
Component of a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity).
Similarity
Belongs to the XPF family.
Mass
104.294 kDa
Sequence
MSTNKNHNNNTNNNDNNICINPHIVEFLNKQITNIKNRPGADIKTTSIYKKAIRSLNLYPLPVFSGKECEVLNGFGPSLTKKINDYLKTTSHPLYPKGPPTPLKSIYNRNNNNNDNNNNNNNNNNNNNNNNNNNNNNNNNNSPKKKIRKSKNNNTTSTISNTQSNLIGTESPSKNQNKQLERELKSKKKKQQSAILEQIVEEEDINFEIPTNENYYDYGSGSCFDNNDDNDDGYISSGINTTPDDLNKSFNFDFGSFDNGIPNYNNNNDNGGDNENNINSDIDSNKIKTTTSINDNHKEKYQKNNENYIHENEDNGDDVIVLISPIKTYKYGDMLNKSPSKFKSPSKLRSHNTTNTFNNSNFSNSDNDNNNNIRITTPLKNQNFNKFNDSIIFSPSISSPSPSKLSNYHKYLNNNNNNIKNTPISTSKKRKCNFSSPLLFSPFKYGVTSPFSPSKMKLKSPFKKRFKNDKSPSSSISKNKNSKSNDIVNNDFEDDDEVVNIQSESEINNNNNQFTSHNDNYNYSYNYNNNSNNINNNNNNDDDDDFDLTETEDEKDDYDKDDRTFSNLSVRLSFTEEDLAGVNIGESIINNSKLPKVIPSQIPPPTQSTQSTSTSTSTSKSKSKSTIKIKFKNIKCIIDNREVKSVTERDYICNKLNERGINAQVKKLELGDFVWVAIDEHDNEWLLNYIIERKRVDDLSSSIIDGRYKEQKFRLSKSGCDNIIYLIEGIVSNTINSSSQSQKKTWGTVNFSLSPDALATALVTTSICEGIIIKETKTIDNTIDYIVNITEYFKEKLLKNNNSGGGGGDEIIKFLFANKNTQCTLENFNQLNSKSKGLKLIEFFATQLIQIPGCSAEKAHSITQVYPTPMSLYLALKAIKDKESGESHFKDFTFGKNKRRFGQDVSEVIYNLYTNKKYLN

Gene
mus81
Protein
Crossover junction endonuclease mus81
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Length
677 amino acids
Function
Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity).
Similarity
Belongs to the XPF family.
Mass
76.241 kDa
Sequence
MKYVNHKTIVAFLPEIGKAGSHVTSRPNLEARVDRDSHGATKLFLSSICRVMAAKETQAERGLISSCFNLALGWQLSNAMSDDTCANPLLLGWIKEWLDQARERNTKGVTVYKKAYESMKACPLTFQHPSEAQQLNGLGPKLCERLTNKLKEYCKEHGLPMPEDPRTAKADKRKSTDGDTEGQPAKKARKPKPYAPALRSGPFALILALSSLDENSNQSMTKAELIEKAQPYCDSSFTVPSDPTKFFTAWNSMKILLTKELVYTRGHPLKKYSLTEEGWEVAKAIKKTAQKSIQNTLPFDVQSDVTADEPRTAQREDLASQRDFERQIRPGLQAHNSQRHTLDSLENTLDNSTITPIPISPDNFTVQLILDTREVRTSKDRDYISNELIRKGITPEVRALEVGDTMWVAKFHDPTFLRKYGEEGDEIMLDWIVERKRLDDLIGSIKDGRFHEQKFRLRRSGIKNVIYLIEEFAVTHHESNAAAAQKYHDMVASAIAQTQVVNGYFVKRTKNLDDTIRYLARMTFLLRNMYSAPSPPSSRTSARPSHTLALLPTRHLALSSSHISALNTLRAENPHVTYGVTFPTFCAIASKSDALTLRDIFLKMLMCTKGVSGDKALEIQRVWPTPQAFIRAFEELTDPKQKENMVADRMAHVMVGRKKIAKVLSRKIAEVWGGLPG

Gene
MUS81
Protein
Crossover junction endonuclease MUS81
Organism
Oryza sativa subsp. japonica
Length
660 amino acids
Function
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks, nicked Holliday junctions and also intact Holliday junctions with a reduced efficiency. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. Plays a role in DNA repair and in genotoxic stress-induced homologous recombination (HR) in somatic cells. Mediates a subset of meiotic recombination events that are insensitive to crossover interference (By similarity).
Similarity
Belongs to the XPF family.
Mass
73.042 kDa
Sequence
MAPEARQLKVHLRENEAVAQCVLEKWRSMEEKPGGLKENLAHTLYKSYRNVCAAKEPIRSLKDLYQIKGVGKWVIRQLKGSFPESSPDLSPPESNAAGEKGKKAGGSKRYVPQKNSAAYAILITLHRETINGKSHMKKQELIDATEASGLSRSAIGPDKSKAKPGAFASSQKDWYTGWSCMKTLTSKGLVAKSGNPAKYMITEEGKSTALECLSRSGLDDHAAPLVINSAPDTSNASHKLNNICMTSFVETSSGPSRAIGRPKTSIANPATKTSPEVTYLTSQESLNYNSDVRTAENCAEEIILSDSDSEELYTENYPLIGSEEFTERVAPPILNASNSGKTTTNYRFSDCSASISPRSSEGTFEMQSSSTMGIAEFNMLDNDTVCMDNSILAMPPRRSSKNFLEDYEVVLILDDRENFGGRSRKTVDNIHSQFRVPVEIKHLPVGDGIWIARDRKLHTEYVLDFIVERKNVADLCSSITDNRYKDQKLRLKKCGLRKLIYLVEGDPNPLDTSERIKTACFTTEILEGFDVQRTPGYAETVRTYGNLTHSITEYYSTHFSTGANTSQVCLTYDEFTKKCDDLKKITVSDVFALQLMQVPQVTEEAALAVIGLYPTLFSLAKAYSMLDGDTHAQEKMLKNKSTLINAGASRNIFKLVWAEG

Gene
MUS81
Protein
Crossover junction endonuclease MUS81
Organism
Arabidopsis thaliana
Length
659 amino acids
Function
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks, nicked Holliday junctions and also intact Holliday junctions with a reduced efficiency. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. Plays a role in DNA repair and in genotoxic stress-induced homologous recombination (HR) in somatic cells. Mediates a subset of meiotic recombination events that are insensitive to crossover interference.
Similarity
Belongs to the XPF family.
Mass
74.056 kDa
Sequence
MDDERRVLCPENRGLAAYVLQKKQEYAEKPKGLSENLERTFVKGYRSVCDAKDPINTLKDLSQIKGFGKWMVKLMKGYFDTAVESSEQEDLPDNRAGKKANGKKRYIPQRNSVGYALLITLHRRTTNGKEFMRKQELIDAADANGLSHAPVGPEKGKGKAGLGHSKREWYSGWSCMTTLIQKGLVVKSSNPAKYMLTVEGREVANECILRSGLPDSVDILSVDEMDPTPQAKKTPNQNPTCSFTMREELPYVDPRCRAQSAIPSDILEKFTPFGYSKEQVVAAFREVSDGSGDKDPSTLWLSVMCHLRQAEVYNSCPDSRNSKKDSSGPFKSQIRQVDLEGSRAKKFRSCNDGSTLNPCSSGSSHAVKACSSSLASDGTKGITNIPRLPPLQFGETFEEAYDVILILDDREKFATKGSRSRNIVENICSEFNIKIEVRRLPVGDCIWIARHKYLETEYVLDFIAERKNVDDMRSSIRDNRYRDQKLRLQRSGFKKLIYILEGDPNHSDAAESIKTACFTTEILEGFDVLRTHGLGETLRKYGYLTKSIYQYYKLRVNDNDQSKGAASCPSFDSFVKRCQDLDKMTISDVFAIQLMQVPQVTEEIAIAVLDMYPTLLSLASAYSHLEADVSAQEEMLRNRSNNVICASASKNIFKLVWGE

Gene
MUS81
Protein
Crossover junction endonuclease MUS81
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
651 amino acids
Function
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity).
Similarity
Belongs to the XPF family.
Mass
74.151 kDa
Sequence
MEGPPGDLKHLFIEWLQEAAINATKKGTKAAILYNKALGSVRNYPLPINDPKTLKSVQFVGDKTCIHLSKKLEEYCKLNNFELPVAFGGLINGGVGEKRKHEVSDTSNLPDAKPKKQRKQKQYIPRKRSGGYAILLALYFGDKKKTGLTKEEIIQRATPYSDKSFKSNPSANEFYSAWSSIKSLQTHDLVDSSGRSSKSYFLTEEGYELAKQLKDAEGFESSPITNHIADLSFDNQVRVTPDSSYSKISQQLDSSPLMKTKNNKDRYGLGPSRLSSTRERILDLSSSPRLISSPLKPKDFVLRESLSSHNSTRPLQDRESISKAEDGINTKTKARLVHDASKRIYDGTNYDIWVPGEFEIILIIDNREIRSQRDRDFFQTRLTSLKVECDVRPLSVGDVVWTAKHKKTGREVILNYICERKRLDDLVSSIKDGRFQEQKNRLKKSGMKQFYYLVEDVVTSDMNKFGDMSDAIQTAMSMTMTISNFYLKRFKSIEDTIAFLASLTQVIKDQFAKNKTNLLVLKARSIKNQAEYSSLIAKFKEKFENRSTSYECAHLFSTFQDSMGKTGMMTVKETFILMLMGIRGVSLERAVAIQNRFKTPKNLIEFFFVENNHLSELDKKQLMMDVFKNEIGNKKIGKVLSEKIYDVWGCV

Gene
MUS81
Protein
Crossover junction endonuclease MUS81
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
632 amino acids
Function
Interacts with MMS4 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks with regressed leading strands and nicked Holliday junctions. Cleavage probably occurs approximately half a helical turn upstream of the free 5'-end in these structures. May be required in mitosis for the processing of stalled replication fork intermediates arising spontaneously or subsequent to treatment with DNA damaging agents such as methylmethane sulfonate (MMS), camptothecin (CPT) or UV. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI). This involves consecutive cleavage of D-loops and nicked Holliday junctions leading to sister chromatid crossover. In contrast to MSH4-MSH5 dependent crossover, double Holliday junctions do not seem to be involved. Spore formation and viability are severely impaired in deletion strains.
Similarity
Belongs to the XPF family.
Mass
72.309 kDa
Sequence
MELSSNLKDLYIEWLQELVDGLTPKQEQLKIAYEKAKRNLQNAEGSFYYPTDLKKVKGIGNTIIKRLDTKLRNYCKIHHISPVEAPSLTQTSSTRPPKRTTTALRSIVNSCENDKNEAPEEKGTKKRKTRKYIPKKRSGGYAILLSLLELNAIPRGVSKEQIIEVAGKYSDHCMTPNFSTKEFYGAWSSIAALKKHSLVLEEGRPKRYSLTEEGVELTKSLKTADGISFPKENEEPNEYSVTRNESSEFTANLTDLRGEYGKEEEPCDINNTSFMLDITFQDLSTPQRLQNNVFKNDRLNSQTNISSHKLEEVSDDQTVPDSALKAKSTIKRRRYNGVSYELWCSGDFEVFPIIDHREIKSQSDREFFSRAFERKGMKSEIRQLALGDIIWVAKNKNTGLQCVLNTIVERKRLDDLALSIRDNRFMEQKNRLEKSGCEHKYYLIEETMSGNIGNMNEALKTALWVILVYYKFSMIRTCNSDETVEKIHALHTVISHHYSQKDLIVIFPSDLKSKDDYKKVLLQFRREFERKGGIECCHNLECFQELMGKGDLKTVGELTIHVLMLVKGISLEKAVAIQEIFPTLNKILMAYKTCSSEEEAKLLMFNVLGDAPGAKKITKSLSEKIYDAFGKL

Gene
MUS81
Protein
Crossover junction endonuclease MUS81
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
628 amino acids
Function
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity).
Similarity
Belongs to the XPF family.
Mass
72.027 kDa
Sequence
MLPDNLKDLYVQWLQELIDSLSEKQEQLINTYSKAKKNLIDHDGVFYYPKDLLKVKGIGATIAKRLEARLVKHCEEIGVDVPRKQLPIDNGTQGSKSLKRVRTQLRIDGINTNDTDINKPVRKKRKYIPKKRSGAYAILLALLELGAQNKGVIKPDIIEAAQKYTDHSMTPNYTTKEFYSAWSSIAQLKKHELVLIEGRPQQYTLTEEGLQLADTLRLADGIDIDGKSIASSMDTNNAYYSDEHTADFSALKHDLSGLTCAPIKDGTNSSGNYSILEKTFGSQDFNVRHHEIGMVQRSHTFGNGDSNNSIEPLPRDTSEFTTQPSLIQRRRFESVSYELWQPGTYEIYPVIDHREVRSHSDREFFFNAFKARDMKSEIRQLSLGDIIWVAKNKTTGQQCILNTIIERKRLDDLAMSIRDNRFMEQKNRLEKSGCKHKYYLIEETIGSSIGNMADALKTTLWIILVYYRFSMIRTVNAEDSVDKLHALHTVICESYKHKALVVLYPTDLKSQDHYRGILSIFQNEFERSGNLECCHTFDTFQDIMGKRELKTIKEITIHILMLVRGVSLEKAVFIQRHFPTLNHLLNAYRKCNSQMEAKLMMFQKFGNAPGAKKITKQLSEKLAETFAF

Gene
MUS81
Protein
Crossover junction endonuclease MUS81
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
614 amino acids
Function
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity).
Similarity
Belongs to the XPF family.
Mass
70.663 kDa
Sequence
MSVVNDDFKPLLIQWVEEEAINATKRGSKMVDLYNKILFQLRGYELPICDLKTLKSIKYVGDKTANQLRKKIAKHCKENELTLPRGFMDVAEKHRLDLEESNLTSSTSTIKTTNKRAKTSSKSKPKYVPKHRSGGFAILIALYLYDKDRNGMTKERIIAGATPYCDRSFSNNAASKEFYSAWSSAKTLENHNLISTTGRSPKIYFLTDEGVSLAQQLKTAIGLSSPPEGSKKNDRNMIMEQSFDNGIRLDTSFELSSPAGRAMLSSSPIRRISNPVHSNRAIQKMLEKELRNGETPPSSQHDAGNRIYDGIKYEVWRKEDYEVIVYMDNREIRSRADRDHFQTRLQTLGVKCEVKPLSSGDVLWVGRNTSTGTEAVLNYLCERKRLDDLCDSIKDGRFQEQKNRMKKTGIKHCYYLVEDMVSYQDKVYDLMDSIQSSLTQTMTTARLYLRRFKDIDETTAFIASNTKVIENLKSNLIVIKPQDIKNQQDYLNILLKFRNKFEKTQPHQDNPDYECVQLFSRFQDMLGKTNQMTVKEMFILMLMTIRGVSLEKAVVIQNRFPTPKSLLEYYHTEHATTDTNIKRDLMMNEFKDQIGNKKIGKALSEKIYNVWGKP

Gene
MUS81
Protein
Crossover junction endonuclease MUS81
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
614 amino acids
Function
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity).
Similarity
Belongs to the XPF family.
Mass
70.413 kDa
Sequence
MSIPSDAKQLYAEFLQQEVNQSTSAHQEKLVMVLNRALFALKNYPDPIYHPKDLLKVKGIGQTTMNKLSKRLKTYCEENGYSFPEESSSTDNTQSTQNDSNPSNTQKTRVRTLEPEENESQGTRKRRKKKYIPRNRSGGYGILLGLLELGCDKDGTACTRRQLIAVASKYCDQSYEKNPSTKEFYSAWSAIKSLKTNDLVIEQGRPSQFSLTEAGTILADSLKTANNIEFDVSSVYERRLNRGNTQNSFTNDEHDHTVNFSGLMNHANMSINESANSSRLFLDATANSSRIEQNEEPEVSAEISTPIPKQKVSKGRWKGVKYELWKPDSYDIILHIDHREVRSKEDRGFFARKLLQRGIETESSSLTVGDMIWLAKHKQSGQQCALDFIVERKRLDDLVISIRDNRFSEQKNRLQKTGCKHIFYLVEETTGYNVSDSADMMKTSIWTTVIYNDFHIKRTRNADTTVQWLTDMSLIIKELYSRKSLVVINHDHITNQSIYLTSLKMFRTEFERNKEIECCHNYESMQSAMVKTNLMTVKELYLRALMSVKGISLEKALMIQSRYPTFKTLLKAYRRCAAEADAKTLIQNELKDAPGNRKIGKSLSHTLWETFGKL

Gene
mus81
Protein
Crossover junction endonuclease MUS81
Organism
Xenopus tropicalis
Length
612 amino acids
Function
Interacts with eme1 and eme2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity).
Similarity
Belongs to the XPF family.
Mass
69.118 kDa
Sequence
MPGEITYGRKRPLPACPNPLFLKWLTEWRDSAAEKNLKTQFVYQKAISSLKKYPLPLNSGKEAKILQNFGDSICKMLDDRLEKHYAECGPNIPIHTVPSSSSTLRKAQRQPKAPSPLSIPHALEPPEQESQDLSPSKKKKTGGKKQREYVPQRRSGGYAVLLTLYRDTKSPSSRGYMTKAELQKEAQPLCDKSFTLTDPNSKYTAWTSVSTLIQKELVIKTHSPARYSLTEKGLELAQRLEEAEDQGRADGFPRQVQASSNEEEEQEEAESETNPYIHADPVQCPDQQLNLAYSHNAKNTSSDPPSVQYNHVPEFTLHPGDFNILLCVDFIETTGGAAHRKQELVTELRRNGVNFDVRKLHIGDFLWIAQEKVQPVPGQLRIPQARELVLDYVVERKRMDDLCGSIIDGRFREQKFRLKRCGLRRPIYLVEDHGSAQHLSIPETTLQQAIVNTQVVDGFFIKRTKDVRESAAYLTIMTRYLQGIYSRKSLLSCTKEEEWKCDRSLRPDASSCILVEFKDFNEGAMKNKAQTVKEVFARQLMQISGVSGEKAAAILEKYSTPASLMSAYESCSSAEEKEKLLSSVKCGKLQRNLGPVLSKTISQLYCTKEPLS

Gene
mus81
Protein
Crossover junction endonuclease mus81
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
608 amino acids
Function
Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
Similarity
Belongs to the XPF family.
Mass
69.044 kDa
Sequence
MDCGNPLFLQWIQEWMEESTRRFPKSYQTWRKAYDSMKSCPITFHRPSQALALKGIGPTICAKLEKKWNAYCLENNIPISTHNEQNDSHVNANKSSSETSSEKPRSVKKPTTRKRKVYVPSYRSGAYSILCALYMLNKHEFATKPQIVTMAQPYCDSSFGSATDRNMRYTAWSAMKTLITKNLVYQTGHPSKYCLTDDGEEVCIRLAKVDDSFQRKHTVSNFSVSKSDDHDSSLCQPPNFVTSINKAGSSSDHGGELHVTYCPVDHNEVSDGVETDIDVDQVDSLTGIHDHHIINNEQLIDLTEQEKKQPNESNLSNLKIETVLFSNCTVFLLIDTREIRSPLDRNLIIDKLTNDFGVNCQVRSLELGDALWVARDMESGQEVVLDFVVERKRYDDLVASIKDGRFHEQKARLKKSGIRSVTYILEESSYDESFTESIRTAVSNTQVDQLFHVRHTRSLEHSVSLLAEMTKQINLFYEKRKTLAVIPDLSIEAKTYESLREQLLKIDPSTPYHISYHAFSSVLSKSSTLTVGDIFIRMLMTIKGISASKAIEIQKKYPTFMHLFEAYEKSSSSQERNLLLNKTCQGYGFQTIGPALSAKVASVFFPES

Gene
MUS81
Protein
Crossover junction endonuclease MUS81
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
604 amino acids
Function
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity).
Similarity
Belongs to the XPF family.
Mass
68.728 kDa
Sequence
MSAKQLGDLKPLFIEWLKDEIDACGPRQEKMAMVYFRARESLKRFDQPITETAKVLKVKGIGNSIKNKLASKLAQYCQDNNIPLEDAAAPSHVVGISVTRVRTATQEKDDQSPKRKKRKYVPRKRSGAYAILLGALELGCPSRGLTKEEIIDAAAKYCDVSFVSNPLTREFYSAWTAIKVLIDHDLMLEQGRPRRYIVTEAGEQMAETLKHADSVIFPEDCPYQRRQQAPESTAEDHTELSASLSELVRQEHLPQNHSGMCFSFEPPSSAPSDYLDPGQKSANVASSPHRLRPPIGPSIDIVKARWNGTSYELWKPGSYDIELYIDHREVRAKSERDFFVNALLTRGVTVEGKALALGDMVWVARHRDSRSTCVLNFMLERKRLDDLAMSIRDNRFMEQKNRLKKTGCKHIFYLVEETSGTNVAGMEGAIKTSIWMTYVYSGFHVKRTRNADDTVEWLHDMTCTVQRYYCSKSLLVLRPREIANQEDYGSLLSAFRLQFERNNTSLECCHAFDCYQEVLGKTGLMTVKELYIRTLMLNRGVSLEKALAIQSKFPTLRSLMTAFRNCKSEEDGRRMLYLALLDQPASRRVGKALAATLWDTFGRR

Gene
mus81
Protein
Crossover junction endonuclease MUS81
Organism
Danio rerio
Length
604 amino acids
Function
Interacts with eme1 and eme2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity).
Similarity
Belongs to the XPF family.
Mass
68.017 kDa
Sequence
MPTDQVCLGRKRPLPSCPNPLFLQWLTELRDSAKEKGLKTHFVYQKAINSLKKYPLPLKNGKEAKILQNFGDGICKILDERLQKHYRENGSDAAVHLASSKQMEESQKEPSGNFSEHTKLTQKEVRKEKGAKKKREYVPQKRSGGYAVLLTLYRHMQMPGSKGFMFRNELQTEAQPLCEKSFTVPDLGSKYTAWSSVSTLIQKELVVKTHNPARYSLTDQGLSLAEKLDSEETGTRHEDVDSQDGQNVVDLTLEEEDEDEEKESWSSERPAVALPVNQARGLMSESDPMGKSQTSETGRTAMGWHLSPGSYDIVLCVDLCETTGGSSVRKQELVKELQRNSVTFDVRKLNVGDFLWVARERVTPVPGQLRPPVGKELVLDYIIERKRMDDLCGSIIDGRFREQKFRLKRCGLRKPIYLVEECGSAAAHLSIPESTLQQAIVNTQVVDGFFVKRVQDAKESAAYLTIMTRYLQKLYQNCTLLCRSRELEGDGEAESEKMVANLSCSLMAFTEFNYGAIKNKCQTVREVFARQLMQISGVSGDKAAAVLKHYSTVSSLLQAYDKCSSETEKEKLLSSVKYGKLKRNLGPALSRTIYQLYCTRGPLS

Gene
mus81
Protein
Crossover junction endonuclease mus81
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Length
596 amino acids
Function
Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity).
Similarity
Belongs to the XPF family.
Mass
67.215 kDa
Sequence
MSESCANPLLLEWIKEWLDQARERNSKGVTVYKKAYESMKACPLVFQHPSEAQQLNGLGPKLCERLTEKLKAYCEENGLPMPEHPQKAAASKRTSDEGVDDPPAKKPRKAKPYVPSLRSGPYALLLGLATLDENASQGLTKAQLIEKAQPYCDSSFTAPPDPSKFYTAWNSMKTLLQKELVYEHGRPLRRYALTEEGWEVAKRIKKTLPGGDLNTLAFRHQTGILSIEQGDSSTHVRSNTSTSAAPGPRDNDNNIVAQESLNGNNDEPIQIQDNDRGRDPIDEIGIEPIILPANSFTIQLVLDTREVRSSKDRDYIANELSKKGITPEVRALELGDAMWVARCNDPTFLSQYGEECNEVMLDWIVERKRMDDLLGSIKDGRFHEQKFRLRRSGIKNVIYLIEEFAITHDVGSASAMKYQEMMASAIASTQVVNGYFVKQTRNLDDTIRYLARMTYLLQKMYCFSPPTHTLSLIPSRQLSSAQSYLTTLERLRARDPSVTYSVTFSTFSALTSKSDILSLRDVFLKMLMCTRGVTGEKALAIQKRWSTPREFVEAFERLDEKGREDMVFERTKTLVGRKKMGKVLSKKIADIWGTGG

Gene
MUS81
Protein
Crossover junction endonuclease MUS81
Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084)
Length
581 amino acids
Function
Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity).
Similarity
Belongs to the XPF family.
Mass
65.501 kDa
Sequence
MADADSANPQFLEWVKEWLDLARERNSKGVTTYRTAYNSLKACPISFEHPAQLQQLKGFGPKLCERLEQQLKKHCEQNGLPMPPHPRSRKAAPVTSDENGEGSSKPAKKARKQKAYVPALRSGAFALVVGLSTLDEDTATGMTKAELIEVAQPYCDASFSAPSDPTKFYTAWNSMKTLLQKELVYERGRPLRRYALTDEGWEVAKRIKDTDHWQAEKDRTKDPTSAQPVIPNFQPGAISRQKSPSVEIAEPAQALSEYQNVVADGLTTSDDASLPNFTPILLPPGTFTVQLVLDVREVRAKTDRDYMQEELAKQGAKPIMRSMELGDAQWVAKCNDPNLLSSQGAEGDEVVLDWIVERKRLDDLIGSIKDGRFHEQKFRLQRSGVKKVIYIIEEIGMDPEVINRYAEAVRSAIASTQVVNGYFVKRTNKMDDTIRYLTRMTAMLKRTYESRSLHVIPTKVLTSQNYLPLLKHLRESISPDWYITYPAFSSLASKSESITLRDVFLKMLMTIKGVTGEKALEIQKCWKTPYDFVKAFEACGPGEQGLKRKRELVFSQTSHLVGRKKFTKPLSTKIAEVWGNT

Gene
MUS81
Protein
Crossover junction endonuclease MUS81
Organism
Homo sapiens
Length
551 amino acids
Function
Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.
Similarity
Belongs to the XPF family.
Mass
61.173 kDa
Sequence
MAAPVRLGRKRPLPACPNPLFVRWLTEWRDEATRSRRRTRFVFQKALRSLRRYPLPLRSGKEAKILQHFGDGLCRMLDERLQRHRTSGGDHAPDSPSGENSPAPQGRLAEVQDSSMPVPAQPKAGGSGSYWPARHSGARVILLVLYREHLNPNGHHFLTKEELLQRCAQKSPRVAPGSARPWPALRSLLHRNLVLRTHQPARYSLTPEGLELAQKLAESEGLSLLNVGIGPKEPPGEETAVPGAASAELASEAGVQQQPLELRPGEYRVLLCVDIGETRGGGHRPELLRELQRLHVTHTVRKLHVGDFVWVAQETNPRDPANPGELVLDHIVERKRLDDLCSSIIDGRFREQKFRLKRCGLERRVYLVEEHGSVHNLSLPESTLLQAVTNTQVIDGFFVKRTADIKESAAYLALLTRGLQRLYQGHTLRSRPWGTPGNPESGAMTSPNPLCSLLTFSDFNAGAIKNKAQSVREVFARQLMQVRGVSGEKAAALVDRYSTPASLLAAYDACATPKEQETLLSTIKCGRLQRNLGPALSRTLSQLYCSYGPLT

Gene
Mus81
Protein
Crossover junction endonuclease MUS81
Organism
Mus musculus
Length
551 amino acids
Function
Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.
Similarity
Belongs to the XPF family.
Mass
61.531 kDa
Sequence
MAEPVRLGRKRPLPVCPNPLFVRWLTEWRDEAASRGRHTRFVFQKALRSLQRYPLPLRSGKEAKILQHFGDRLCRMLDEKLKQHLASGGDHAPSSPSGKKGASKGPPEQVQDSSMPVPTQPQAGSTSVGYWPAQNSGAREILLQLYREHLNSDGHSFLTKEELLQKCAQKTPRVVPGSSKPWPALRSLLHRNLILGTHRPARYALTPEGLELAQKLAEAEGLSTRHAGFRPEEHHGEDSAVPEALSEPGTTEGAVQQRPLELRPSEYRVLLCVDIGETRGAGHRPEMLRELQRLRVPHTVRKLHVGDFVWVAQETRPRDPERPGELVLDHIVERKRLDDLCSSIIDGRFREQKFRLKRCGLGHRVYLVEEHGSVHNLSLPESTLLQAVTNTQVIDGFFVKRTMDIKESAGYLALLTKGLERLYQGHTLRSRPWGAPGAAESEAKPSTNPLCSLLTFSDFNAEAVKNKAQSVREVFARQLMQVRGLSGEKAAAVVDRYSTPASLLAAYDACATAKEQEMLLSTIKCGRLQRNLGPALSRTLYQLYCSHSPLS

Gene
Mus81
Protein
Crossover junction endonuclease MUS81
Organism
Rattus norvegicus
Length
551 amino acids
Function
Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity).
Similarity
Belongs to the XPF family.
Mass
61.903 kDa
Sequence
MAEPVRLGRKRPLPVCPNPLFVRWLTEWRDEAASRGRHTRFVFQKALRSLQRYPLPLRNGKEAKILQHFGDRLCRMLDERLKEHLASGGDHAPSSPSGKKRASKGPPAQVQGSSMPVPTQPQAGSTNAGYWPAQNSGAREILLQLYREHLNSDGHSFLTKEELLQKCAQKTPRVVPESSRPWPALRGLLHRNLVLRTHRPARYALTPEGLELAQKLAEAEGLSTLNTAFQPEEHHEESPVPEAILSEPGTTEVGVQQRPLELRPSEYRVLLCVDIGETRGAGHRPEMLRELQRLRVPHTVRKLHVGDFVWVAQETRPRDPERPGELVLDHIVERKRLDDLCSSIIDGRFREQKFRLKRCGLGHRIYLVEEHGSVQNLSLPESTLLQAVTNTQVIDGFFVKRTMDIKESAGYLALLTKGLERLYQGHTLHSRPWGTPGDAESEAKPSTNPLCSLLTFSDFNAEAVKNKAQSVREVFARQLMQVRGLSGEKAAALVDRYSTPASLLAAYDACATTKEQEMLLSTVKCGRLQRNLGPALSRTLYQLYCSHSPLT