Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity).

Belongs to the XPF family.

677 amino acids

MKYVNHKTIVAFLPEIGKAGSHVTSRPNLEARVDRDSHGATKLFLSSICRVMAAKETQAERGLISSCFNLALGWQLSNAMSDDTCANPLLLGWIKEWLDQARERNTKGVTVYKKAYESMKACPLTFQHPSEAQQLNGLGPKLCERLTNKLKEYCKEHGLPMPEDPRTAKADKRKSTDGDTEGQPAKKARKPKPYAPALRSGPFALILALSSLDENSNQSMTKAELIEKAQPYCDSSFTVPSDPTKFFTAWNSMKILLTKELVYTRGHPLKKYSLTEEGWEVAKAIKKTAQKSIQNTLPFDVQSDVTADEPRTAQREDLASQRDFERQIRPGLQAHNSQRHTLDSLENTLDNSTITPIPISPDNFTVQLILDTREVRTSKDRDYISNELIRKGITPEVRALEVGDTMWVAKFHDPTFLRKYGEEGDEIMLDWIVERKRLDDLIGSIKDGRFHEQKFRLRRSGIKNVIYLIEEFAVTHHESNAAAAQKYHDMVASAIAQTQVVNGYFVKRTKNLDDTIRYLARMTFLLRNMYSAPSPPSSRTSARPSHTLALLPTRHLALSSSHISALNTLRAENPHVTYGVTFPTFCAIASKSDALTLRDIFLKMLMCTKGVSGDKALEIQRVWPTPQAFIRAFEELTDPKQKENMVADRMAHVMVGRKKIAKVLSRKIAEVWGGLPG

76.2 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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