Interacts with eme1 and eme2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity).

Belongs to the XPF family.

612 amino acids

MPGEITYGRKRPLPACPNPLFLKWLTEWRDSAAEKNLKTQFVYQKAISSLKKYPLPLNSGKEAKILQNFGDSICKMLDDRLEKHYAECGPNIPIHTVPSSSSTLRKAQRQPKAPSPLSIPHALEPPEQESQDLSPSKKKKTGGKKQREYVPQRRSGGYAVLLTLYRDTKSPSSRGYMTKAELQKEAQPLCDKSFTLTDPNSKYTAWTSVSTLIQKELVIKTHSPARYSLTEKGLELAQRLEEAEDQGRADGFPRQVQASSNEEEEQEEAESETNPYIHADPVQCPDQQLNLAYSHNAKNTSSDPPSVQYNHVPEFTLHPGDFNILLCVDFIETTGGAAHRKQELVTELRRNGVNFDVRKLHIGDFLWIAQEKVQPVPGQLRIPQARELVLDYVVERKRMDDLCGSIIDGRFREQKFRLKRCGLRRPIYLVEDHGSAQHLSIPETTLQQAIVNTQVVDGFFIKRTKDVRESAAYLTIMTRYLQGIYSRKSLLSCTKEEEWKCDRSLRPDASSCILVEFKDFNEGAMKNKAQTVKEVFARQLMQISGVSGEKAAAILEKYSTPASLMSAYESCSSAEEKEKLLSSVKCGKLQRNLGPVLSKTISQLYCTKEPLS

69.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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