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EXO1

Gene
exo1
Protein
Exonuclease 1
Organism
Dictyostelium discoideum
Length
1046 amino acids
Function
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment (By similarity).
Similarity
Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
Mass
116.366 kDa
Sequence
MGISGLLPALSPVTKAIHVKDYANKRVAIDGYSWLHKGAYSCSQEIVLGIPTRNYINYFISRIKMLISYKVIPVVIFDGGPLPNKKLKEQERLRHREEYKNKAKAYLLEGNKSQANICFQKAVDITPRMAFLLIKELRALKVEYLVAPYEADAQLTYLSITGQVDAIITEDSDLVAFGATHIIFKMDKYGYAQEIKTEDLGSCKKDGYDFIDFNQTMLRQMCILSGCDYLPSLSGMGLKTSFKLLKQHRDIEKVFKYLKREKSNFSQEYEQQFYKADFTFKHQRVFDPVSRILTTLLPLPTIIDSRFLNDNNNNTNDGDSNGDGSSGGSGSGGGFLDFIGPVIDDEIAEKIALGIIDPETHEQFDKTQPYPKNTFTPQPKKLLSPISFNTKEFKNQTNNNNNNNNNIKSNNGTNNKNGMILNEGKLVQKGRNLNDQFTFASNKITQYMTTTTTTTTTTTTTKNNNNNQKQQPMIEDDTGYDFQIDSFEIDDCLNDDDDDESIILSNNLNNQENVLESDCEFDDDDDQRGIDVDDSEKKDSFVLDSDYEDEKEEEEVKSSTFNSSSSISSGNSSKIKKTLVSSKFFVSSESSVLESDDDDGGDDDDDSFNHNQNFSSSGNNIQPNSNIFHNGELSSYGYQKNQKNFKNVNSNSSSNSSNSSNSSSGNSNSGNRIFNSGNSSNKNNTNGGIVKSTLLSSNDRVSLNFFDQFQFDGKKKQSILVSQSRKSFSSPTLSNNEDYDSSFVSSTIPSSIGDDYDQMNSCSNNNNFNYNNSSNFNNNNINNSNNNRNSGFSGFLKRKSSSQTAAPTTPTTPTTPKTSSSSSSTLTNSTITTEHSSYILKKPKYQATSNSPISTLDSSQNYNDQSFISKKAHSFSSLDSDLIFKEDDVDNLIFNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNDNNNKITTPSNKSFNSIVLTTTSATTSITQQDNEIYTTPKKKLPSTPISSSSNDIISKYFSSPSKVGPKSEGAPPTPVNLEGMSLRSVLSLRYQQTMASSPTK
Protein
Exonuclease 1: exo1

Gene
exo1
Protein
Exonuclease 1
Organism
Dictyostelium discoideum
Length
1046 amino acids
Function
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment (By similarity).
Similarity
Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
Mass
116.366 kDa
Sequence
MGISGLLPALSPVTKAIHVKDYANKRVAIDGYSWLHKGAYSCSQEIVLGIPTRNYINYFISRIKMLISYKVIPVVIFDGGPLPNKKLKEQERLRHREEYKNKAKAYLLEGNKSQANICFQKAVDITPRMAFLLIKELRALKVEYLVAPYEADAQLTYLSITGQVDAIITEDSDLVAFGATHIIFKMDKYGYAQEIKTEDLGSCKKDGYDFIDFNQTMLRQMCILSGCDYLPSLSGMGLKTSFKLLKQHRDIEKVFKYLKREKSNFSQEYEQQFYKADFTFKHQRVFDPVSRILTTLLPLPTIIDSRFLNDNNNNTNDGDSNGDGSSGGSGSGGGFLDFIGPVIDDEIAEKIALGIIDPETHEQFDKTQPYPKNTFTPQPKKLLSPISFNTKEFKNQTNNNNNNNNNIKSNNGTNNKNGMILNEGKLVQKGRNLNDQFTFASNKITQYMTTTTTTTTTTTTTKNNNNNQKQQPMIEDDTGYDFQIDSFEIDDCLNDDDDDESIILSNNLNNQENVLESDCEFDDDDDQRGIDVDDSEKKDSFVLDSDYEDEKEEEEVKSSTFNSSSSISSGNSSKIKKTLVSSKFFVSSESSVLESDDDDGGDDDDDSFNHNQNFSSSGNNIQPNSNIFHNGELSSYGYQKNQKNFKNVNSNSSSNSSNSSNSSSGNSNSGNRIFNSGNSSNKNNTNGGIVKSTLLSSNDRVSLNFFDQFQFDGKKKQSILVSQSRKSFSSPTLSNNEDYDSSFVSSTIPSSIGDDYDQMNSCSNNNNFNYNNSSNFNNNNINNSNNNRNSGFSGFLKRKSSSQTAAPTTPTTPTTPKTSSSSSSTLTNSTITTEHSSYILKKPKYQATSNSPISTLDSSQNYNDQSFISKKAHSFSSLDSDLIFKEDDVDNLIFNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNDNNNKITTPSNKSFNSIVLTTTSATTSITQQDNEIYTTPKKKLPSTPISSSSNDIISKYFSSPSKVGPKSEGAPPTPVNLEGMSLRSVLSLRYQQTMASSPTK
Protein
Exonuclease 1: exo1

Gene
EXO1
Protein
Exonuclease 1
Organism
Homo sapiens
Length
846 amino acids
Function
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.
Similarity
Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
Mass
94.103 kDa
Sequence
MGIQGLLQFIKEASEPIHVRKYKGQVVAVDTYCWLHKGAIACAEKLAKGEPTDRYVGFCMKFVNMLLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLLKGKQLLREGKVSEARECFTRSINITHAMAHKVIKAARSQGVDCLVAPYEADAQLAYLNKAGIVQAIITEDSDLLAFGCKKVILKMDQFGNGLEIDQARLGMCRQLGDVFTEEKFRYMCILSGCDYLSSLRGIGLAKACKVLRLANNPDIVKVIKKIGHYLKMNITVPEDYINGFIRANNTFLYQLVFDPIKRKLIPLNAYEDDVDPETLSYAGQYVDDSIALQIALGNKDINTFEQIDDYNPDTAMPAHSRSHSWDDKTCQKSANVSSIWHRNYSPRPESGTVSDAPQLKENPSTVGVERVISTKGLNLPRKSSIVKRPRSAELSEDDLLSQYSLSFTKKTKKNSSEGNKSLSFSEVFVPDLVNGPTNKKSVSTPPRTRNKFATFLQRKNEESGAVVVPGTRSRFFCSSDSTDCVSNKVSIQPLDETAVTDKENNLHESEYGDQEGKRLVDTDVARNSSDDIPNNHIPGDHIPDKATVFTDEESYSFESSKFTRTISPPTLGTLRSCFSWSGGLGDFSRTPSPSPSTALQQFRRKSDSPTSLPENNMSDVSQLKSEESSDDESHPLREEACSSQSQESGEFSLQSSNASKLSQCSSKDSDSEESDCNIKLLDSQSDQTSKLRLSHFSKKDTPLRNKVPGLYKSSSADSLSTTKIKPLGPARASGLSKKPASIQKRKHHNAENKPGLQIKLNELWKNFGFKKDSEKLPPCKKPLSPVRDNIQLTPEAEEDIFNKPECGRVQRAIFQ
Protein
Exonuclease 1: EXO1

Gene
EXO1
Protein
Exonuclease 1
Organism
Homo sapiens
Length
846 amino acids
Function
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.
Similarity
Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
Mass
94.103 kDa
Sequence
MGIQGLLQFIKEASEPIHVRKYKGQVVAVDTYCWLHKGAIACAEKLAKGEPTDRYVGFCMKFVNMLLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLLKGKQLLREGKVSEARECFTRSINITHAMAHKVIKAARSQGVDCLVAPYEADAQLAYLNKAGIVQAIITEDSDLLAFGCKKVILKMDQFGNGLEIDQARLGMCRQLGDVFTEEKFRYMCILSGCDYLSSLRGIGLAKACKVLRLANNPDIVKVIKKIGHYLKMNITVPEDYINGFIRANNTFLYQLVFDPIKRKLIPLNAYEDDVDPETLSYAGQYVDDSIALQIALGNKDINTFEQIDDYNPDTAMPAHSRSHSWDDKTCQKSANVSSIWHRNYSPRPESGTVSDAPQLKENPSTVGVERVISTKGLNLPRKSSIVKRPRSAELSEDDLLSQYSLSFTKKTKKNSSEGNKSLSFSEVFVPDLVNGPTNKKSVSTPPRTRNKFATFLQRKNEESGAVVVPGTRSRFFCSSDSTDCVSNKVSIQPLDETAVTDKENNLHESEYGDQEGKRLVDTDVARNSSDDIPNNHIPGDHIPDKATVFTDEESYSFESSKFTRTISPPTLGTLRSCFSWSGGLGDFSRTPSPSPSTALQQFRRKSDSPTSLPENNMSDVSQLKSEESSDDESHPLREEACSSQSQESGEFSLQSSNASKLSQCSSKDSDSEESDCNIKLLDSQSDQTSKLRLSHFSKKDTPLRNKVPGLYKSSSADSLSTTKIKPLGPARASGLSKKPASIQKRKHHNAENKPGLQIKLNELWKNFGFKKDSEKLPPCKKPLSPVRDNIQLTPEAEEDIFNKPECGRVQRAIFQ
Protein
Exonuclease 1: EXO1

Gene
Exo1
Protein
Exonuclease 1
Organism
Mus musculus
Length
837 amino acids
Function
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.
Similarity
Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
Mass
92.022 kDa
Sequence
MGIQGLLQFIQEASEPVNVKKYKGQAVAVDTYCWLHKGAIACAEKLAKGEPTDRYVGFCMKFVNMLLSYGVKPILIFDGCTLPSKKEVERSRRERRQSNLLKGKQLLREGKVSEARDCFARSINITHAMAHKVIKAARALGVDCLVAPYEADAQLAYLNKAGIVQAVITEDSDLLAFGCKKVILKMDQFGNGLEVDQARLGMCKQLGDVFTEEKFRYMCILSGCDYLASLRGIGLAKACKVLRLANNPDIVKVIKKIGHYLRMNITVPEDYITGFIRANNTFLYQLVFDPIQRKLVPLNAYGDDVNPETLTYAGQYVGDSVALQIALGNRDVNTFEQIDDYSPDTMPAHSRSHSWNEKAGQKPPGTNSIWHKNYCPRLEVNSVSHAPQLKEKPSTLGLKQVISTKGLNLPRKSCVLKRPRNEALAEDDLLSQYSSVSKKIKENGCGDGTSPNSSKMSKSCPDSGTAHKTDAHTPSKMRNKFATFLQRRNEESGAVVVPGTRSRFFCSSQDFDNFIPKKESGQPLNETVATGKATTSLLGALDCPDTEGHKPVDANGTHNLSSQIPGNAAVSPEDEAQSSETSKLLGAMSPPSLGTLRSCFSWSGTLREFSRTPSPSASTTLQQFRRKSDPPACLPEASAVVTDRCDSKSEMLGETSQPLHELGCSSRSQESMDSSCGLNTSSLSQPSSRDSGSEESDCNNKSLDNQGEQNSKQHLPHFSKKDGLRRNKVPGLCRSSSMDSFSTTKIKPLVPARVSGLSKKSGSMQTRKHHDVENKPGLQTKISELWKNFGFKKDSEKLPSCKKPLSPVKDNIQLTPETEDEIFNKPECVRAQRAIFH
Protein
Exonuclease 1: Exo1

Gene
Exo1
Protein
Exonuclease 1
Organism
Mus musculus
Length
837 amino acids
Function
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.
Similarity
Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
Mass
92.022 kDa
Sequence
MGIQGLLQFIQEASEPVNVKKYKGQAVAVDTYCWLHKGAIACAEKLAKGEPTDRYVGFCMKFVNMLLSYGVKPILIFDGCTLPSKKEVERSRRERRQSNLLKGKQLLREGKVSEARDCFARSINITHAMAHKVIKAARALGVDCLVAPYEADAQLAYLNKAGIVQAVITEDSDLLAFGCKKVILKMDQFGNGLEVDQARLGMCKQLGDVFTEEKFRYMCILSGCDYLASLRGIGLAKACKVLRLANNPDIVKVIKKIGHYLRMNITVPEDYITGFIRANNTFLYQLVFDPIQRKLVPLNAYGDDVNPETLTYAGQYVGDSVALQIALGNRDVNTFEQIDDYSPDTMPAHSRSHSWNEKAGQKPPGTNSIWHKNYCPRLEVNSVSHAPQLKEKPSTLGLKQVISTKGLNLPRKSCVLKRPRNEALAEDDLLSQYSSVSKKIKENGCGDGTSPNSSKMSKSCPDSGTAHKTDAHTPSKMRNKFATFLQRRNEESGAVVVPGTRSRFFCSSQDFDNFIPKKESGQPLNETVATGKATTSLLGALDCPDTEGHKPVDANGTHNLSSQIPGNAAVSPEDEAQSSETSKLLGAMSPPSLGTLRSCFSWSGTLREFSRTPSPSASTTLQQFRRKSDPPACLPEASAVVTDRCDSKSEMLGETSQPLHELGCSSRSQESMDSSCGLNTSSLSQPSSRDSGSEESDCNNKSLDNQGEQNSKQHLPHFSKKDGLRRNKVPGLCRSSSMDSFSTTKIKPLVPARVSGLSKKSGSMQTRKHHDVENKPGLQTKISELWKNFGFKKDSEKLPSCKKPLSPVKDNIQLTPETEDEIFNKPECVRAQRAIFH
Protein
Exonuclease 1: Exo1

Gene
EXO1
Protein
Exonuclease 1
Organism
Oryza sativa subsp. japonica
Length
836 amino acids
Function
Putative 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. May be involved in DNA mismatch repair (MMR) (By similarity).
Similarity
Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
Mass
92.248 kDa
Sequence
MGIQGLLPQLKSIMAPIGVEALKGQTVAVDTYSWLHKGALSCGDRLCKGLPTTRHIEYCMHRVNMLRHHGVKPILVFDGGHLPMKGDQETKRERSRKENLERAKEHESAGNSRAAFECYQKAVDITPRIAFELIQVLKQEKVDYIVAPYEADAQMTFLSVNKLVDAVITEDSDLIPFGCSRIIFKMDKFGQGVEFHITRLQRCRELDLNGFTMQMLLEMCILSGCDYLPSLPGMGVKRAHALIQKLKGHEKVIKHLRYSAVSVPPQYEENFRKAIWAFQFQRVYDPVTEDIVHLSGIPHGSSEDLDFLGPWLPQTVAKGIAQGNIDPITKEPFEGKTESSALAFDKVHLNRESSAPSNGKKKLDLPVQRNVLTNYFCLASLEAKRKFRAPKVTPKQQVLNGSLPSPRIEDSGTPDLIEDTSLPSNNIQVYQCSSEHFSSGTPLDDSINTASQCSSERVRCDIPRDDSASVSPQCSHDIGSDPAEDPDIEGNKVKVNFCNRSTIPTGSFLEGTLPGISDPFLDSHNTEPSRAAPRYAEKSNVVSANRNITVRSSYFKTVNKRVCTNQGEDECHDEDNCETGNYTLPGDQQRSSGGILKRRKFSDPQNFEDGMFQPTSPHESPPVADKGCDSDSHDGINTNSEGKFGCNVAHVNKYSGIAEKSMDKFAALISSFRYAGSRASGLRAPLKDVKNTLPVRSVLRPPEQRFGCTAKKTTRVPLQSRFSSDATNSTDVPDLSTFAYRPTTASAHSDQGKITSKATDAAAGPPDLRTFAYAPTRSTTSRFDQSENTRKAMCTADSPPDISTFEYKPMKSAVRRSDGSKFSGAALKAARRTSRS
Protein
Exonuclease 1: EXO1

Gene
EXO1
Protein
Exonuclease 1
Organism
Oryza sativa subsp. japonica
Length
836 amino acids
Function
Putative 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. May be involved in DNA mismatch repair (MMR) (By similarity).
Similarity
Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
Mass
92.248 kDa
Sequence
MGIQGLLPQLKSIMAPIGVEALKGQTVAVDTYSWLHKGALSCGDRLCKGLPTTRHIEYCMHRVNMLRHHGVKPILVFDGGHLPMKGDQETKRERSRKENLERAKEHESAGNSRAAFECYQKAVDITPRIAFELIQVLKQEKVDYIVAPYEADAQMTFLSVNKLVDAVITEDSDLIPFGCSRIIFKMDKFGQGVEFHITRLQRCRELDLNGFTMQMLLEMCILSGCDYLPSLPGMGVKRAHALIQKLKGHEKVIKHLRYSAVSVPPQYEENFRKAIWAFQFQRVYDPVTEDIVHLSGIPHGSSEDLDFLGPWLPQTVAKGIAQGNIDPITKEPFEGKTESSALAFDKVHLNRESSAPSNGKKKLDLPVQRNVLTNYFCLASLEAKRKFRAPKVTPKQQVLNGSLPSPRIEDSGTPDLIEDTSLPSNNIQVYQCSSEHFSSGTPLDDSINTASQCSSERVRCDIPRDDSASVSPQCSHDIGSDPAEDPDIEGNKVKVNFCNRSTIPTGSFLEGTLPGISDPFLDSHNTEPSRAAPRYAEKSNVVSANRNITVRSSYFKTVNKRVCTNQGEDECHDEDNCETGNYTLPGDQQRSSGGILKRRKFSDPQNFEDGMFQPTSPHESPPVADKGCDSDSHDGINTNSEGKFGCNVAHVNKYSGIAEKSMDKFAALISSFRYAGSRASGLRAPLKDVKNTLPVRSVLRPPEQRFGCTAKKTTRVPLQSRFSSDATNSTDVPDLSTFAYRPTTASAHSDQGKITSKATDAAAGPPDLRTFAYAPTRSTTSRFDQSENTRKAMCTADSPPDISTFEYKPMKSAVRRSDGSKFSGAALKAARRTSRS
Protein
Exonuclease 1: EXO1

Gene
exo1
Protein
Exonuclease 1
Organism
Danio rerio
Length
806 amino acids
Function
5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for DNA mismatch repair (MMR) (By similarity).
Similarity
Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
Mass
88.594 kDa
Sequence
MGIQGLLQFIKDASEPMHVKKYRGQTVAVDTYCWLHKGAFSCAEKLAKGEPTDQYVSYCMKFVDMLLSFGVKPILVFDGRNLPSKQEVEKSRRERRQANLQKGKQLLREGKITEARECFTRSVNITPSMAHDVIRAARTRGVDCVVAPYEADAQLAFLNKSDIAQAVITEDSDLLAFGCKKVILKMDKQGNGLEIEQCHLGRCKSLGNIFTEEKFRYMCILSGCDYLQSLYGIGLGKACKLLRMANNPDILKVIKKMGQYLKMDISVPEEYIEGFTKANNTFLYQLVFDPLRRKVVPLNPYPDHINPAALSYAGTNVGDEKGLQMALGNLDINTMQRIDDFNPDAPQTQPPKAPRSSSWNDRCDKTATTQASIWSQNYEPGCTKSQSPTSPKRPPPTRGKERIVSVQSLKLPQRESQVKRPREDTSLSVDDLLEQYTAGVKRHCPETQPTTKPLTNDNKVSKENHCGSTSGPFRPRNRFATLLQWRNRSEEGTEEQGTCSRFFCHDESNIAETQEDSKQDSSQSVESQEKHVSQSGGDTSSLCEEPEREQDKDEPSSPPASPSCSSRPASVGLGVFSWSGTTKELNKSVSHPARDSTERQRSSSTPSGLSTLQQFHRNKARISWAGPGLSLSSSPVEGSEDAGNSPGSPPSQDSAYFSQSSSISASVENSLVTEDNSDKEKERDSVVSNSPSSSPLDRLKPAVNRTKVSGLSRKGACGQGKGGKIETSAPARASGLRRKPSGKKNVNNENSPGLQATISGLWGAFSFKKDSPKLSATKKGEPMSPVGENVVMETTQADKEIFIIAE
Protein
Exonuclease 1: exo1

Gene
exo1
Protein
Exonuclease 1
Organism
Danio rerio
Length
806 amino acids
Function
5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for DNA mismatch repair (MMR) (By similarity).
Similarity
Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
Mass
88.594 kDa
Sequence
MGIQGLLQFIKDASEPMHVKKYRGQTVAVDTYCWLHKGAFSCAEKLAKGEPTDQYVSYCMKFVDMLLSFGVKPILVFDGRNLPSKQEVEKSRRERRQANLQKGKQLLREGKITEARECFTRSVNITPSMAHDVIRAARTRGVDCVVAPYEADAQLAFLNKSDIAQAVITEDSDLLAFGCKKVILKMDKQGNGLEIEQCHLGRCKSLGNIFTEEKFRYMCILSGCDYLQSLYGIGLGKACKLLRMANNPDILKVIKKMGQYLKMDISVPEEYIEGFTKANNTFLYQLVFDPLRRKVVPLNPYPDHINPAALSYAGTNVGDEKGLQMALGNLDINTMQRIDDFNPDAPQTQPPKAPRSSSWNDRCDKTATTQASIWSQNYEPGCTKSQSPTSPKRPPPTRGKERIVSVQSLKLPQRESQVKRPREDTSLSVDDLLEQYTAGVKRHCPETQPTTKPLTNDNKVSKENHCGSTSGPFRPRNRFATLLQWRNRSEEGTEEQGTCSRFFCHDESNIAETQEDSKQDSSQSVESQEKHVSQSGGDTSSLCEEPEREQDKDEPSSPPASPSCSSRPASVGLGVFSWSGTTKELNKSVSHPARDSTERQRSSSTPSGLSTLQQFHRNKARISWAGPGLSLSSSPVEGSEDAGNSPGSPPSQDSAYFSQSSSISASVENSLVTEDNSDKEKERDSVVSNSPSSSPLDRLKPAVNRTKVSGLSRKGACGQGKGGKIETSAPARASGLRRKPSGKKNVNNENSPGLQATISGLWGAFSFKKDSPKLSATKKGEPMSPVGENVVMETTQADKEIFIIAE
Protein
Exonuclease 1: exo1

Gene
EXO1
Protein
Exonuclease 1
Organism
Arabidopsis thaliana
Length
735 amino acids
Function
Putative 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. May be involved in DNA mismatch repair (MMR) (By similarity).
Similarity
Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
Mass
82.249 kDa
Sequence
MGIQGLLPLLKSIMVPIHIKELEGCIVAVDTYSWLHKGALSCSRELCKGLPTKRHIQYCMHRVNLLRHHGVKPIMVFDGGPLPMKLEQENKRARSRKENLARALEHEANGNSSAAYECYSKAVDISPSIAHELIQVLRQENVDYVVAPYEADAQMAFLAITKQVDAIITEDSDLIPFGCLRIIFKMDKFGHGVEFQASKLPKNKDLSLSGFSSQMLLEMCILSGCDYLQSLPGMGLKRAHALITKFKSYDRVIKHLKYSTVSVPPLYEESFKRALLTFKHQRVYDPNAEDIIHLCDISDNLGEDSDFVGPSMPQDIAKGIALGQLDPFTQLPFQAESVTPKLAVDDISRPKSFKPETVKKKLDLPVQKNLLTKYFCFASVEAKRKFKAPRISPMSLTPTDESPSIPDDNTPDLDALSSQTTNESPVYSLGENPCVSEVAEKRDSPDDDAVERNHKDLHHKYCEREVDRPKSDSLKVIVRSKYFKQKQEDKSLKQSIPCLNDCSVIGQRKAVKTVINMSSASKREESHRAIATSPCLHHDRIYNDHEDAKEASFSAMNEVAERTINTHKINHQINEEEQNPSVEIPSAFSTPENVIPLSSIAIDSCHGVATGKRKLDSDENLHKENLKSKHMRMDETDTALNAETPLETDDVEKFGSNISHIGHYSEIAEKSVERFVSAISSFKYSGTGSRASGLRAPLKDIRNTCPSKGLSLKPDISKFGYASSNRHMVTKSRRM
Protein
Exonuclease 1: EXO1

Gene
EXO1
Protein
Exonuclease 1
Organism
Arabidopsis thaliana
Length
735 amino acids
Function
Putative 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. May be involved in DNA mismatch repair (MMR) (By similarity).
Similarity
Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
Mass
82.249 kDa
Sequence
MGIQGLLPLLKSIMVPIHIKELEGCIVAVDTYSWLHKGALSCSRELCKGLPTKRHIQYCMHRVNLLRHHGVKPIMVFDGGPLPMKLEQENKRARSRKENLARALEHEANGNSSAAYECYSKAVDISPSIAHELIQVLRQENVDYVVAPYEADAQMAFLAITKQVDAIITEDSDLIPFGCLRIIFKMDKFGHGVEFQASKLPKNKDLSLSGFSSQMLLEMCILSGCDYLQSLPGMGLKRAHALITKFKSYDRVIKHLKYSTVSVPPLYEESFKRALLTFKHQRVYDPNAEDIIHLCDISDNLGEDSDFVGPSMPQDIAKGIALGQLDPFTQLPFQAESVTPKLAVDDISRPKSFKPETVKKKLDLPVQKNLLTKYFCFASVEAKRKFKAPRISPMSLTPTDESPSIPDDNTPDLDALSSQTTNESPVYSLGENPCVSEVAEKRDSPDDDAVERNHKDLHHKYCEREVDRPKSDSLKVIVRSKYFKQKQEDKSLKQSIPCLNDCSVIGQRKAVKTVINMSSASKREESHRAIATSPCLHHDRIYNDHEDAKEASFSAMNEVAERTINTHKINHQINEEEQNPSVEIPSAFSTPENVIPLSSIAIDSCHGVATGKRKLDSDENLHKENLKSKHMRMDETDTALNAETPLETDDVEKFGSNISHIGHYSEIAEKSVERFVSAISSFKYSGTGSRASGLRAPLKDIRNTCPSKGLSLKPDISKFGYASSNRHMVTKSRRM
Protein
Exonuclease 1: EXO1

Gene
exo1
Protein
Exonuclease 1
Organism
Xenopus laevis
Length
734 amino acids
Function
5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for DNA mismatch repair (MMR) (By similarity).
Similarity
Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
Mass
82.232 kDa
Sequence
MGIQGLLQFLKEASEPVHVKKYKGKTVAVDTYCWLHKGAFACAEKLAKGEPTDQYVQFCMKLVHMLLSFGVKPILVFDGCTLPSKKDVEKARREKRQTNLQKGKQLLREGKLAEARECFSRSVNITSSMAHEVIKAARSEGVDYIVAPYEADSQLAYLNKNDFAEAIITEDSDLLAFGCKKVLLKMDKFGNGLEIDQARFGMCRSLGDVFTEEKFRYMCILSGCDYLPSIHGIGLAKACKLLKVANNPDITKVIQKIGQYLKTNITVPEGYIEGFLRANNTFLYQLVFDPVERKLIPLNPYGNDVNPEELNYAGPNMGDSVALQIALGNMDINTRKQIDDYNPDIPQLSHHRSQSWDNKQLNRKTAHTDSIWYTKSEPCKTTKIEEIHSPRGLILPSKKHTVKRSYEDGVSDTDLISQYSFSKNKKARPDGDDPMQQVPASTMILQPLDDCANTKPKKPIHQPKTRNAFATFLQRQKQDCSSVSATGTRSRFFYKPADEKPHCTEKEQIVCNGSALDIAKETHELTEESSIKTEKEDSLSTISEVCKPNNQRISPLQNQRSCFTWSGSLDSESSPTPKQSPMLLSLQKFHRTTPYMQNEAENKPSWQSSCIKSDTVSQIDSNEKLLKKQDIEDTDSDEHASTPESPCQFTMKASPAHQSFFPEPKGSAPKSKVPGLLKSQSVVSGLRTKVKPRAPAKVSGLTNRSNTKATRNNENVPGLQATIGDLWKNFSYKK
Protein
Exonuclease 1: exo1

Gene
exo1
Protein
Exonuclease 1
Organism
Xenopus laevis
Length
734 amino acids
Function
5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for DNA mismatch repair (MMR) (By similarity).
Similarity
Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
Mass
82.232 kDa
Sequence
MGIQGLLQFLKEASEPVHVKKYKGKTVAVDTYCWLHKGAFACAEKLAKGEPTDQYVQFCMKLVHMLLSFGVKPILVFDGCTLPSKKDVEKARREKRQTNLQKGKQLLREGKLAEARECFSRSVNITSSMAHEVIKAARSEGVDYIVAPYEADSQLAYLNKNDFAEAIITEDSDLLAFGCKKVLLKMDKFGNGLEIDQARFGMCRSLGDVFTEEKFRYMCILSGCDYLPSIHGIGLAKACKLLKVANNPDITKVIQKIGQYLKTNITVPEGYIEGFLRANNTFLYQLVFDPVERKLIPLNPYGNDVNPEELNYAGPNMGDSVALQIALGNMDINTRKQIDDYNPDIPQLSHHRSQSWDNKQLNRKTAHTDSIWYTKSEPCKTTKIEEIHSPRGLILPSKKHTVKRSYEDGVSDTDLISQYSFSKNKKARPDGDDPMQQVPASTMILQPLDDCANTKPKKPIHQPKTRNAFATFLQRQKQDCSSVSATGTRSRFFYKPADEKPHCTEKEQIVCNGSALDIAKETHELTEESSIKTEKEDSLSTISEVCKPNNQRISPLQNQRSCFTWSGSLDSESSPTPKQSPMLLSLQKFHRTTPYMQNEAENKPSWQSSCIKSDTVSQIDSNEKLLKKQDIEDTDSDEHASTPESPCQFTMKASPAHQSFFPEPKGSAPKSKVPGLLKSQSVVSGLRTKVKPRAPAKVSGLTNRSNTKATRNNENVPGLQATIGDLWKNFSYKK
Protein
Exonuclease 1: exo1

Gene
EXO1
Protein
Exodeoxyribonuclease 1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
702 amino acids
Function
5'->3' double-stranded DNA exonuclease involved in mismatch repair and eventually also in mitotic recombination between direct repeats. Also has a minor role in the correction of large DNA mismatches that occur in the heteroduplex DNA during meiotic recombination at the HIS4 locus.
Similarity
Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
Mass
80.162 kDa
Sequence
MGIQGLLPQLKPIQNPVSLRRYEGEVLAIDGYAWLHRAACSCAYELAMGKPTDKYLQFFIKRFSLLKTFKVEPYLVFDGDAIPVKKSTESKRRDKRKENKAIAERLWACGEKKNAMDYFQKCVDITPEMAKCIICYCKLNGIRYIVAPFEADSQMVYLEQKNIVQGIISEDSDLLVFGCRRLITKLNDYGECLEICRDNFIKLPKKFPLGSLTNEEIITMVCLSGCDYTNGIPKVGLITAMKLVRRFNTIERIILSIQREGKLMIPDTYINEYEAAVLAFQFQRVFCPIRKKIVSLNEIPLYLKDTESKRKRLYACIGFVIHRETQKKQIVHFDDDIDHHLHLKIAQGDLNPYDFHQPLANREHKLQLASKSNIEFGKTNTTNSEAKVKPIESFFQKMTKLDHNPKVANNIHSLRQAEDKLTMAIKRRKLSNANVVQETLKDTRSKFFNKPSMTVVENFKEKGDSIQDFKEDTNSQSLEEPVSESQLSTQIPSSFITTNLEDDDNLSEEVSEVVSDIEEDRKNSEGKTIGNEIYNTDDDGDGDTSEDYSETAESRVPTSSTTSFPGSSQRSISGCTKVLQKFRYSSSFSGVNANRQPLFPRHVNQKSRGMVYVNQNRDDDCDDNDGKNQITQRPSLRKSLIGARSQRIVIDMKSVDERKSFNSSPILHEESKKRDIETTKSSQARPAVRSISLLSQFVYKGK
Protein
Exodeoxyribonuclease 1: EXO1

Gene
EXO1
Protein
Exodeoxyribonuclease 1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
702 amino acids
Function
5'->3' double-stranded DNA exonuclease involved in mismatch repair and eventually also in mitotic recombination between direct repeats. Also has a minor role in the correction of large DNA mismatches that occur in the heteroduplex DNA during meiotic recombination at the HIS4 locus.
Similarity
Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
Mass
80.162 kDa
Sequence
MGIQGLLPQLKPIQNPVSLRRYEGEVLAIDGYAWLHRAACSCAYELAMGKPTDKYLQFFIKRFSLLKTFKVEPYLVFDGDAIPVKKSTESKRRDKRKENKAIAERLWACGEKKNAMDYFQKCVDITPEMAKCIICYCKLNGIRYIVAPFEADSQMVYLEQKNIVQGIISEDSDLLVFGCRRLITKLNDYGECLEICRDNFIKLPKKFPLGSLTNEEIITMVCLSGCDYTNGIPKVGLITAMKLVRRFNTIERIILSIQREGKLMIPDTYINEYEAAVLAFQFQRVFCPIRKKIVSLNEIPLYLKDTESKRKRLYACIGFVIHRETQKKQIVHFDDDIDHHLHLKIAQGDLNPYDFHQPLANREHKLQLASKSNIEFGKTNTTNSEAKVKPIESFFQKMTKLDHNPKVANNIHSLRQAEDKLTMAIKRRKLSNANVVQETLKDTRSKFFNKPSMTVVENFKEKGDSIQDFKEDTNSQSLEEPVSESQLSTQIPSSFITTNLEDDDNLSEEVSEVVSDIEEDRKNSEGKTIGNEIYNTDDDGDGDTSEDYSETAESRVPTSSTTSFPGSSQRSISGCTKVLQKFRYSSSFSGVNANRQPLFPRHVNQKSRGMVYVNQNRDDDCDDNDGKNQITQRPSLRKSLIGARSQRIVIDMKSVDERKSFNSSPILHEESKKRDIETTKSSQARPAVRSISLLSQFVYKGK
Protein
Exodeoxyribonuclease 1: EXO1

Gene
exo1
Protein
Exodeoxyribonuclease 1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
571 amino acids
Function
5'->3' double-stranded DNA exonuclease that could act in a pathway that corrects mismatched base pairs.
Similarity
Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
Mass
63.867 kDa
Sequence
MGIKGLLGLLKPMQKSSHVEEFSGKTLGVDGYVWLHKAVFTCAHELAFNKETDKYLKYAIHQALMLQYYGVKPLIVFDGGPLPCKASTEQKRKERRQEAFELGKKLWDEGKKSQAIMQFSRCVDVTPEMAWKLIIALREHGIESIVAPYEADAQLVYLEKENIIDGIITEDSDMLVFGAQTVLFKMDGFGNCITIRRNDIANAQDLNLRLPIEKLRHMAIFSGCDYTDGVAGMGLKTALRYLQKYPEPRAAIRAMRLDKSLKVPVSFEKEFALADLAFRHQRVYCPKDKTLVHLSPPERELSVHEDAFIGSFFDNQLAIDIAEGRSNPITKCAFDIKDSSMQSFTKTTITISKRKGISKTDISNFFMKSIPPSKRPTKSTSLIDVTNVKVQRTHLANDISSEKQSIKSANEKAYVTPKSNSLKPGFGKSLSDISNSATKNENVPFLPPRTGVSKYFKLQKNTEKEIDEQVPSQSNNTTPTSAKSDSASPQNWFSSFSYQTPNSASPPFSSLSHTLPISALAKIGHDALNRKNHASLPSRRIVYKPPSSPSTPISMNPRPKGILSLQQYKFR
Protein
Exodeoxyribonuclease 1: exo1

Gene
exo1
Protein
Exodeoxyribonuclease 1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
571 amino acids
Function
5'->3' double-stranded DNA exonuclease that could act in a pathway that corrects mismatched base pairs.
Similarity
Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
Mass
63.867 kDa
Sequence
MGIKGLLGLLKPMQKSSHVEEFSGKTLGVDGYVWLHKAVFTCAHELAFNKETDKYLKYAIHQALMLQYYGVKPLIVFDGGPLPCKASTEQKRKERRQEAFELGKKLWDEGKKSQAIMQFSRCVDVTPEMAWKLIIALREHGIESIVAPYEADAQLVYLEKENIIDGIITEDSDMLVFGAQTVLFKMDGFGNCITIRRNDIANAQDLNLRLPIEKLRHMAIFSGCDYTDGVAGMGLKTALRYLQKYPEPRAAIRAMRLDKSLKVPVSFEKEFALADLAFRHQRVYCPKDKTLVHLSPPERELSVHEDAFIGSFFDNQLAIDIAEGRSNPITKCAFDIKDSSMQSFTKTTITISKRKGISKTDISNFFMKSIPPSKRPTKSTSLIDVTNVKVQRTHLANDISSEKQSIKSANEKAYVTPKSNSLKPGFGKSLSDISNSATKNENVPFLPPRTGVSKYFKLQKNTEKEIDEQVPSQSNNTTPTSAKSDSASPQNWFSSFSYQTPNSASPPFSSLSHTLPISALAKIGHDALNRKNHASLPSRRIVYKPPSSPSTPISMNPRPKGILSLQQYKFR
Protein
Exodeoxyribonuclease 1: exo1