5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for DNA mismatch repair (MMR) (By similarity).

Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.

734 amino acids

MGIQGLLQFLKEASEPVHVKKYKGKTVAVDTYCWLHKGAFACAEKLAKGEPTDQYVQFCMKLVHMLLSFGVKPILVFDGCTLPSKKDVEKARREKRQTNLQKGKQLLREGKLAEARECFSRSVNITSSMAHEVIKAARSEGVDYIVAPYEADSQLAYLNKNDFAEAIITEDSDLLAFGCKKVLLKMDKFGNGLEIDQARFGMCRSLGDVFTEEKFRYMCILSGCDYLPSIHGIGLAKACKLLKVANNPDITKVIQKIGQYLKTNITVPEGYIEGFLRANNTFLYQLVFDPVERKLIPLNPYGNDVNPEELNYAGPNMGDSVALQIALGNMDINTRKQIDDYNPDIPQLSHHRSQSWDNKQLNRKTAHTDSIWYTKSEPCKTTKIEEIHSPRGLILPSKKHTVKRSYEDGVSDTDLISQYSFSKNKKARPDGDDPMQQVPASTMILQPLDDCANTKPKKPIHQPKTRNAFATFLQRQKQDCSSVSATGTRSRFFYKPADEKPHCTEKEQIVCNGSALDIAKETHELTEESSIKTEKEDSLSTISEVCKPNNQRISPLQNQRSCFTWSGSLDSESSPTPKQSPMLLSLQKFHRTTPYMQNEAENKPSWQSSCIKSDTVSQIDSNEKLLKKQDIEDTDSDEHASTPESPCQFTMKASPAHQSFFPEPKGSAPKSKVPGLLKSQSVVSGLRTKVKPRAPAKVSGLTNRSNTKATRNNENVPGLQATIGDLWKNFSYKK

82.2 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.

Make exo1 using our protein expression services starting at $99 + $.30/amino acid in as fast as two weeks (includes the cost of DNA synthesis)

Order Here