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recB

Gene
recB
Protein
RecBCD enzyme subunit RecB
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Length
1211 amino acids
Function
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.
Similarity
Belongs to the helicase family. UvrD subfamily.
Mass
139.858 kDa
Sequence
MAETIPLNPITLPLNQISLIEASAGTGKTYTIGSLYLRLLLKAGENNFSRPLNVEEILVVTFTEMATEELKKKIRERITDAINKLTAFAKTQDKSAFKNDEFLTALCDNLNIFEAIHRLKLAEQNMDLAAIYTIHGFCRRMLMQYAFHSGIHFNLELIKDQSDLLVRFANEFWREHFYPLDFESANFIATELVSPANVLSLLKADLGKDLQVEIENKQALSVPIQIFLPQYLGGYQKALNELKAFWLESADEISAIITNELVKDYPKDQLKSLNRKKYQVKRLGDWINKINQWSNNPRDYQINTTLKDYFLQSSIEKNCEESTDKNKDKKPATPFYSPIFADLEKRVNALMTPDLLSKLTLYHYRQGLQQKLLDYKLNHQEKSFDDLLRLLCEALQDAQGDELAEMIRFQYPFAMIDEFQDTDSQQYAIFSKIYRDNPEKNTGFIMIGDPKQAIYRFRGADIFTYLKASDEAQSRFELTKNYRSEKHLVDGVNALFDFPQSPFIYQNIKFTAVDSRDDHLRFYLNGKVEPAYRFYLTESDKVNKTEMAKICAISIQHWLKSAAENQAVFQNEDTYKTLQAANIAVLVRDKNEAALVKNELQKLGIASVYLSDQNSVFDSNVAKELAWVLKACLNVAERPILNAIATALFGLNAADIHQIQQNEADWQRWADSFAQYQQTWQRQGILAMLHQILLEQGISERLLSQATGERDLTDFLHLAEILQQAATLHESEAALLSWFEKQIQGEARQEAQIRLESERQLVKIVTIHKSKGLEYDLVWLPFLAAPSKDPSKKYINIYYSKERDETLWDIENRNLNALCEETFAEELRLLYVALTRAKYQMAFALPAQFDKKWNALHYVLSQGEIGKEINLSDSKDTETLLQTFKEKMQDNVEICTKPNLEALPTLSINTKNDDFKASEFTGNIEQDWRITSFTSIEQAHRRQNYFTESAGKKHAVFDDAKDYDSQNAIEISTALLNENESNILDLPRGKQVGTALHRHFENCYFSDLANTEEIDKLRQSLQLDETFTESLQNWLQQISHTPLSNEIGIALADLANKDCIKEMPFYLAIREHFDVEAFNHTLKAHHHLPSESLQFEQIQGMVRGSIDLVFRHNGKYYLVDYKSNFLGSTLADYNQEALKKEMLHSHYDWQYLIYTLALHRYLQSVVPHYDYARDFGGVFYLFLRGMNGEPQSGVFYDRPSVELITELDGVF

Gene
recB
Protein
RecBCD enzyme subunit RecB
Organism
Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
Length
1180 amino acids
Function
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.
Similarity
Belongs to the helicase family. UvrD subfamily.
Mass
139.436 kDa
Sequence
MITTIPKSINVTTIPLSGKILIEASAGTGKTFSLTILYIRLLLGITNHVKYKKGLLIKEILVVTFTEHTRAELEIRIKTYIKIFKTACIKKYSNNYVLSKLLSKITDFPKTIDILSKAENSIHELSIYTIHGFCYKILKLNKFNSELMLQNKILKHTYPLYLKISIKFWKYYFAFLSLDITSILLEYFNNPKTLLKEILPLLNKTQLISKLTKTKRKNIVQEYYILIKKIKLFKQKWANYSHLIHSEIIKTNVNKRIYTKSNLKRWINNITAWATQKQTKNFFIPSELKYFRYSFIIKKTTSEKILDDKFFKFIDTFLDSKFSLKEIFIIDASLEIKAMFMQEKIKNRYFEYDDLITFCWNMVNKNNFNISQTILKKYPVALIDEFQDTNNKQYNIFKKIYKKENLLILISDPKQAIYSFSGADITSYLQAKSNIKNQYFLDTNWRSSPKIINSINLLFSRLKNPFLTKNITFYPVKSSRINKTTKFEVNGKNQPALRFLLNKNKNISINEYKEWISITTAKYISYWISSGIKGNATITISNKVRTVNFSDIAIIVRNNLEAKTIQLELTKLNIQSLYLTSKNNIFQSKEILEILWILQAILNPNIERLLKRAMSTNIMSKNTKEIISIPNNHSYWIKLSQEFNQYLIFWNNYGILYVIQQLIINYNISNNNNLLHNFSPNIKNILYIGELLEEKSITIKNKFLLINWLKKNITQDFYLTKPKYIKPNYEKNNYIKIVSIHKSKGLEYPITIIPFATITFNKTVSTVEKICFNLNNTKIKKQKTLKIEKHKFSEDIRLLYVALTRSIIHCSIGISLAQTITQKKKIQKEKSKFKINVLRYIIQSGKNHISTKKLYTELSILKKNKNIEIISEIPNIIKKNFQIPTLNTNSQSLMHYQVSRKFNYNYNFTSYSQLKKNIKPSTMYSTLNTKKLFELNVKKKHCFENKILTPHTFPSGKIYGTLLHKILKNISFHKSINSNWLLKKLSEYNLDKRWCLILKNWMYSILYKNLDKNYNLRLSKLDSKNYIKELKFLLPIKKKLTALKLNNIFQTHQCSSLENKLCFHPIQGILSGSIDLVFLWKTKYFLVDYKSNWIGNSNQSYSQQNIKKIIKKHHYNFQLQLYSLVLHRYLKQHIKNYSFYNHFGGTYILFIRSINEIPSQNGIFYSIPNIEIIKKLEQIF

Gene
recB
Protein
RecBCD enzyme subunit RecB
Organism
Escherichia coli (strain K12)
Length
1180 amino acids
Function
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a rapid (>1 kb/second) and highly processive (>30 kb) ATP-dependent bidirectional helicase. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator, 5'-GCTGGTGG-3') sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to Chi site, by nicking one strand or switching the strand degraded (depending on the reaction conditions). The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang which facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination (PubMed:4562392, PubMed:4552016, PubMed:123277). In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA. The RecBC complex requires the RecD subunit for nuclease activity, but can translocate along ssDNA in both directions.
Similarity
Belongs to the helicase family. UvrD subfamily.
Mass
133.959 kDa
Sequence
MSDVAETLDPLRLPLQGERLIEASAGTGKTFTIAALYLRLLLGLGGSAAFPRPLTVEELLVVTFTEAATAELRGRIRSNIHELRIACLRETTDNPLYERLLEEIDDKAQAAQWLLLAERQMDEAAVFTIHGFCQRMLNLNAFESGMLFEQQLIEDESLLRYQACADFWRRHCYPLPREIAQVVFETWKGPQALLRDINRYLQGEAPVIKAPPPDDETLASRHAQIVARIDTVKQQWRDAVGELDALIESSGIDRRKFNRSNQAKWIDKISAWAEEETNSYQLPESLEKFSQRFLEDRTKAGGETPRHPLFEAIDQLLAEPLSIRDLVITRALAEIRETVAREKRRRGELGFDDMLSRLDSALRSESGEVLAAAIRTRFPVAMIDEFQDTDPQQYRIFRRIWHHQPETALLLIGDPKQAIYAFRGADIFTYMKARSEVHAHYTLDTNWRSAPGMVNSVNKLFSQTDDAFMFREIPFIPVKSAGKNQALRFVFKGETQPAMKMWLMEGESCGVGDYQSTMAQVCAAQIRDWLQAGQRGEALLMNGDDARPVRASDISVLVRSRQEAAQVRDALTLLEIPSVYLSNRDSVFETLEAQEMLWLLQAVMTPERENTLRSALATSMMGLNALDIETLNNDEHAWDVVVEEFDGYRQIWRKRGVMPMLRALMSARNIAENLLATAGGERRLTDILHISELLQEAGTQLESEHALVRWLSQHILEPDSNASSQQMRLESDKHLVQIVTIHKSKGLEYPLVWLPFITNFRVQEQAFYHDRHSFEAVLDLNAAPESVDLAEAERLAEDLRLLYVALTRSVWHCSLGVAPLVRRRGDKKGDTDVHQSALGRLLQKGEPQDAAGLRTCIEALCDDDIAWQTAQTGDNQPWQVNDVSTAELNAKTLQRLPGDNWRVTSYSGLQQRGHGIAQDLMPRLDVDAAGVASVVEEPTLTPHQFPRGASPGTFLHSLFEDLDFTQPVDPNWVREKLELGGFESQWEPVLTEWITAVLQAPLNETGVSLSQLSARNKQVEMEFYLPISEPLIASQLDTLIRQFDPLSAGCPPLEFMQVRGMLKGFIDLVFRHEGRYYLLDYKSNWLGEDSSAYTQQAMAAAMQAHRYDLQYQLYTLALHRYLRHRIADYDYEHHFGGVIYLFLRGVDKEHPQQGIYTTRPNAGLIALMDEMFAGMTLEEA

Gene
recB
Protein
RecBCD enzyme subunit RecB
Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Length
1179 amino acids
Function
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.
Similarity
Belongs to the helicase family. UvrD subfamily.
Mass
141.041 kDa
Sequence
MVYSDTKTSKKIKKYKINIMKKKLNIFQIPLKGIHLIEASAGTGKTSTIAFLYLRLLLGLEKNKENIRKLSVKEILVVTFTNAAKEELYIRIKKSIKELHLSCIKKKSKDPIFQSFLTKIKNFDEAIHILEDAKININNAAIYTIHGFCQDVLENNTLISNREIIENESFLYLQATQDFWRYFFYNLPKKIIKIIYEEYRSPEDLLREIKPILKVNSSINFKKKFDKKETLITFHEKIINKINIFKQKWLNYNLIILKIINQLKVNKKIYSNFNILKWKKKITEWAESETKNYKMPICLKYFSETSIEKNIKNYNFKKHIFFEEIDKILKKNFSLKNIILFYAIKNIPKFVKREKEKKLLLGFNDLLKILLKNIKKEESLREIIIKQYPVALIDEFQDTNIQQYQIFNTLYKNKKTALFLVGDPKQSIYSFRGADIFSYLHAKFKIKNYYYLDTNWRSSKNICKAINYLFSKNKNPFYFKNIPFEPILSSSKNLNMKFKIKEKNQTAISFFFQKKEEVNIEEYRDWIAKQCANEISYWLTCSKKGEAIISDGSQERILTEKDIVILVRNRTEAQIIKESLKKVNILSKYSSPYESVFKTFDALELLSILKSILDPTDINLLKKSILTHILNKIAFQKIKENSKTKISHFLIQKLYEYNDKWKTIGIFYTIKTMILEYQKYANNFEMYKNQQRNINFLHIAELLQEKSQNCYKENSLMRWFEKKILEKNNISENEYIKNFAESKIIRIITIHKSKGLEYPIVWIPFIVDFNVSKSYFYHEKKTLKIFFDNNKSSETLKKSDEERLAEDLRFLYVALTRSIYHCSIGISYLVKKRKKNKKSSDIHKSSLGYIIQNGKCMNYKELLYELKILNKKLYIEVKYQAMNCKSLTIKKDDLYILSQPQFLLKEIKLYSQITSFTKIKQENKHFNNIQYNNIESYFFKEKDKKKTIHNFPHGNKAGIFIHYILKTIKFNNTFNIDWFYTILKKYEFSEKWAKTLMFWINNILNFKINNLNITLSSLKKTQYIKELEFFLPIKNTLYCEDLNQIIQSIDLISSISQKIFFNPVIGILKGFIDLVFIFNKKYYILDYKCNYLGNNDNCYSSKNIKKEIIKNRYDIQYQLYTLALHQYLKKKVKQYHYKTHFGGVFYLFLRGINVKDSIFYILPDYLLIKKLTKLILQKK

Gene
recB
Protein
RecBCD enzyme subunit RecB
Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)
Length
1174 amino acids
Function
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.
Similarity
Belongs to the helicase family. UvrD subfamily.
Mass
139.038 kDa
Sequence
MKIDSLKEKLNIFKIPLNGIKLIEASAGTGKTFTIVLLYLRLLLGIGEKKIYKKKLLVHEILVVTFTNKAKEELYIRIKDGIQNMYLTCINKTTSDSSFQFFFKEIHDIKEAIYVLKRAQNDMNSSSIYTIHSFCQHILQLHTFHFNDIFEEKIIENEDNLYLQATQDFWRRFFYTLPEDIIKIIYQDYKSPDHLLKTIKPFFYIKSINFPTKILNNKKLIMYHEENIKKIIFFKEMWLIYHKIIQKTINDLEINKKIYSKFNLIKWINKITEWAKSETKDYTIPSILKYFTKKNIEKNTINNTCSKYIIFEESEKILKKKFSLKNVIIIYAVKKIHQFLLKEKKKKSLIGFNDLLSILLKTIKKEKFLKDLIIKKYPAAFIDEFQDTDIQQYKIFNLLYKKNKTTVLFLIGDPKQAIYSFRGADIFSYLYAKSKIKKYYYLDTNWRSSINICKSINFLFSQNINPFIFKNIPYIPVVPSSKNLKMNFTINDVAQTPISFFLQEEKEVSIDDYQVWISKQCANEISFWLTCAKTGKAKITTKNGEKILTANDIAILVRNRKEADLIQDELEKLNIISIYSSNKNSVFQTLDAQELLWILESILEPENEILLQQSMASHILKKLSLVVENKTISNKNSYFIIEKLYEYHDIWEKIGVFQMIKIMILEYQKNSFCTEINENHIKNLNFLHIGELLQEQFQFFHKKISLIRWFQKKISTKTQPEYNESIKCFDESPSIKIITIHKSKGLEYPIVWIPFSIDFKKSTLAIYHDQKSLKTFFDENYSNKFLKIADEERLAEDIRFLYVALTRSILHCSIGLACLIKKIIKNRNNSDIHQSGLGFTIQGGKTMNYEGLLEKLKKLSINNFIEVKNNTDNFSFSRKPQTISLICKNKFLNKKNIRNTWSITSFSQLNKINKLSKHHQKEVALKELCIKNQEKKNQSLLTIHNFPKGKKTGLMIHYILKNLHVLKNKNSNWFSCILEKYNIHIKWTSVLIYWIKNIINTPLNDEKIILSRIDEKSSIRELEFFFPIKNMLYSTELNKIIQSINPTSITSPQLSFNPVKGMLTGFVDLVFIWKKKYYILDYKSNWLGKNNNFYSSIHINKEIVKKRYHLQYQIYTIAIHKYLQKKLKNYNYKDDFGGVFYFFLRAIDCPKKNNGIFYTMPNYSLIKKTMTLIS

Gene
recB
Protein
RecBCD enzyme subunit RecB
Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Length
1169 amino acids
Function
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.
Similarity
Belongs to the helicase family. UvrD subfamily.
Mass
137.829 kDa
Sequence
MNKILEKIQNNTTILIEASAGTGKTHILENVVINLIKTKLYSINEILVLTFTKKATEEMHTRILKVIENAYSNSKTNEILKEAYEQSKKLFISTINKFALHALNNFQIETENYSKYKPKEKFSKEIDEIVYDFLRKSDSLIQALDIKDYELKVFKSDAKKTEEIVLKIKKAYERDTTQELGDWLKTQTAFENILLKKEELIKDYNKIIEDLDKMTKDEILSFYNKHIQTGKLEIEYSKENDIFKIAETLLKNKFFSTLIEKETKKNSKLSPKELKIKNDLICLGINIKHEKYKSEDNRNKNRNNLKQYVILKVEYKILKYIEKELKKTIKSTNTIDQNYIISNLKNYLKSEDKKLLNAIKNRYKIILIDEAQDLSLIQIEIFKILKTAGIKLIFIADPKQIIYSFRKADISFYNKEIKNKINTDARIVLKINHRSSKKLIGPLNKIFNNIYNNAIADEIEKIDFTNSLPNQKNDNNKIVINGQEIEGINIITTNTESEEDIYQKTALTIKYLLAYGKIAENNKIRNIKMQDIKVLCRGKNEINLIDKALKKEQIQTNKTQEKFLKTKEFSEIFYIIKCLDRKQSFKTLNYILSSKILNVPWNLQRILIKQDKICLIEEFIENIIVLLEKNEITLINAINKITFEKNLWIKIANITKDQKIIEWAKNKINYKGLLIKEGKLENLKTYETTLEIISKIYHKEQNIQSLISTLESLIINEEPEEIEEKINNINNDNESIELMTIHKSKGLGMNIVFLLNTTPIENSNFFSKKNQFYKFYQDGKIEYDFFKLEENKKYARLKILSEEKNIFYVGATRAKFALFIIKINSITSKLLEIAKIFTIDDIKHDFNIHEFIGQKRFNKKKYNTNVNTKLIPPKPIIKNMFKKEYTSSFSSLTAQAHHKEFYENYDFKNINYEKETELDYEPGLEETLPKGKDIGNILHAAMEEIIFSTAKDTFDNFKKNNIEIIEKQIQKINSNLNTIEIQNSLAKMIYNILTYNIRAINTRLCDIEELQKEMEFLIKINPEFQKQKYLFDKHFEDLHIKLSDGYLKGIVDLIFKANNKIYILDYKTNYLGKNKEDYNITNLENTIKKEYYDLQYKIYALGIKKILFKNKKEYNQKFGGIIYLFTRAFEDNIECLKSKFENGIYFNLPKFNDVDLDKIILELGIKRHL

Gene
recB
Protein
RecBCD enzyme subunit RecB
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Length
1094 amino acids
Function
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.
Similarity
Belongs to the helicase family. UvrD subfamily.
Mass
118.722 kDa
Sequence
MDRFELLGPLPREGTTTVLEASAGTGKTFALAGLVTRYLAETAATLDEMLLITFNRAASRELRERVRGQIVEAVGALQGDAPPSGELVEHLLRGSDAERAQKRSRLRDALANFDAATIATTHEFCGSVLKSLGVAGDNAADVELKESLTDLVTEIVDDRYLANFGRQETDPELTYAEALALALAVVDDPCAQLRPPDPEPGSKAAVRLRFAAEVLEELERRKGRLRAQGFNDLLIRLATALEAADSPARDRMRERWRIVLVDEFQDTDPMQWRVLERAFSRHSALILIGDPKQAIYGFRGGDIHTYLKAAGTADARYTLGVNWRSDRALVESLQTVLRDATLGHADIVVRGTDAHHAGHRLASAPRPAPFRLRVVKRHTLGYDGTAHVPIEALRRHIPDDLAADVAALLASGATFAGRPVVAADIAVIVEHHKDARACRNALAEAGIPAIYTGDTDVFASQAAKDWLCLLEAFDAPQRSGLVRAAACTMFFGETAESLAAEGDALTDRVAGTLREWADHARHRGVAAVFQAAQLAGMGRRVLSQRGGERDLTDLAHIAQLLHEAAHRERLGLPGLRDWLRRQAKAGAGPPEHNRRLDSDAAAVQIMTVFVAKGLQFPIVYLPFAFNRNVRSDDILLYHDDGTRCLYIGGKDGGAQRRTVEGLNRVEAAHDNLRLTYVALTRAQSQVVAWWAPTFDEVNGGLSRLLRGRRPGQSQVPDRCTPRVTDEQAWAVFAQWEAAGGPSVEESVIGARSSLEKPVPVPGFEVRHFHRRIDTTWRRTSYSDLVRGSEAVTVTSEPAAGGRADEVEIAVVAAPGSGADLTSPLAALPSGASFGSLVHAVLETADPAAPDLAAELEAQVRRHAPWWTVDVDHAQLAPELARALLPMHDTPLGPAAAALTLRQIGVRDRLRELDFEMPLAGGDLRGRSPDVSLADVGELLASHLPGDDPLSPYADRLGSAGLGDQPLRGYLAGSIDVVLRLPGQRYLVVDYKTNHLGDTAADYGFERLTEAMLHSDYPLQALLYVVVLHRFLRWRQRDYAPARHLGGVLYLFVRGMCGAATPVTAGHPAGVFTWNPPTALVVALSDLLDRGRLQS

Gene
recB
Protein
RecBCD enzyme subunit RecB
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
1094 amino acids
Function
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.
Similarity
Belongs to the helicase family. UvrD subfamily.
Mass
118.722 kDa
Sequence
MDRFELLGPLPREGTTTVLEASAGTGKTFALAGLVTRYLAETAATLDEMLLITFNRAASRELRERVRGQIVEAVGALQGDAPPSGELVEHLLRGSDAERAQKRSRLRDALANFDAATIATTHEFCGSVLKSLGVAGDNAADVELKESLTDLVTEIVDDRYLANFGRQETDPELTYAEALALALAVVDDPCAQLRPPDPEPGSKAAVRLRFAAEVLEELERRKGRLRAQGFNDLLIRLATALEAADSPARDRMRERWRIVLVDEFQDTDPMQWRVLERAFSRHSALILIGDPKQAIYGFRGGDIHTYLKAAGTADARYTLGVNWRSDRALVESLQTVLRDATLGHADIVVRGTDAHHAGHRLASAPRPAPFRLRVVKRHTLGYDGTAHVPIEALRRHIPDDLAADVAALLASGATFAGRPVVAADIAVIVEHHKDARACRNALAEAGIPAIYTGDTDVFASQAAKDWLCLLEAFDAPQRSGLVRAAACTMFFGETAESLAAEGDALTDRVAGTLREWADHARHRGVAAVFQAAQLAGMGRRVLSQRGGERDLTDLAHIAQLLHEAAHRERLGLPGLRDWLRRQAKAGAGPPEHNRRLDSDAAAVQIMTVFVAKGLQFPIVYLPFAFNRNVRSDDILLYHDDGTRCLYIGGKDGGAQRRTVEGLNRVEAAHDNLRLTYVALTRAQSQVVAWWAPTFDEVNGGLSRLLRGRRPGQSQVPDRCTPRVTDEQAWAVFAQWEAAGGPSVEESVIGARSSLEKPVPVPGFEVRHFHRRIDTTWRRTSYSDLVRGSEAVTVTSEPAAGGRADEVEIAVVAAPGSGADLTSPLAALPSGASFGSLVHAVLETADPAAPDLAAELEAQVRRHAPWWTVDVDHAQLAPELARALLPMHDTPLGPAAAALTLRQIGVRDRLRELDFEMPLAGGDLRGRSPDVSLADVGELLASHLPGDDPLSPYADRLGSAGLGDQPLRGYLAGSIDVVLRLPGQRYLVVDYKTNHLGDTAADYGFERLTEAMLHSDYPLQALLYVVVLHRFLRWRQRDYAPARHLGGVLYLFVRGMCGAATPVTAGHPAGVFTWNPPTALVVALSDLLDRGRLQS

Gene
recB
Protein
RecBCD enzyme subunit RecB
Organism
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Length
1083 amino acids
Function
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes DNA-dependent ATPase activity, exonuclease activity and 3'-5' helicase activity (By similarity). Unlike the case in E.coli, suppresses RecA-dependent homologous recombination, is instead required for single-strand annealing pathway repair of DSB.
Similarity
Belongs to the helicase family. UvrD subfamily.
Mass
117.443 kDa
Sequence
MKVFDLLGPLPAPNTTTVLEASAGTGKTFALAGLVTRFVAEGVATLDQMLLITFGRAASQELRERVRAQIVAALVALDDPSRACNDLEEYLVKTDQQARRRRLRDALAGFDAATIATTHQFCQIVLKSLGVAGDSDAGVTLVESLDDLVSEIVDDLYLAHFGGQKDDPELSYPEALKLARVVVGNPATQLRPRDPDPDSPAAVRLKFARDVLAELEIRKRRRGVLGYDDLLTRLADALEPEDSPARVRMQQRWPIVMVDEFQDTDPVQWQVIERAFSGRSTLVLIGDPKQAIYAFRGGDIATYLRAAATAGDKQTLGTNWRSDRALVDRLQAVLRGAQLGGPDIVVHDVQARHQGHRLVGAPRNDPFRLRVVSRKPGNTRVIPIDQLRRHIGRDLAADISALLNSGATWCDQPVQAKDIAVITETHKDARACHAALLAAGIPAVYTGDSDVFTSEAAEDWLYLLEAFDQPHRPGLVRAAAATMFFGETAESLAAGGDALTDRVADTLREWAGHARERGVAAIFEAAQLAGMGKRVLSWQGGERLMTDLAHMTQLLQDTAHREGFGLAALRDWLRTQRSERGGESERNRRLDSDAAAVQIMTVWVSKGLQFPVVYLPFAFNRYVPEPDLVLFHDDGQRCLHVGGADPAVARAGRAEAAGDDSRLTYVALTRAQSQVVAWWAPSYDEPNGGLSRLMRGRAPGEAIVPDKCSPPKISDEDALERLRAWEAAGGPVIEESVIGAVSPVPPEPAPEDLAARKFFRAIDMAWKRTSYSGLLRAAETAGVGVSSEPEVTERDDEFDDIPVVAPAEGADVPSPMAHLPTGAAFGSLVHAVLETADPFAEDLTAELATHIDAHSQHWPVEVETAELAAALVPMHDTPLGPLAPGLTLRQIGLRDRLCELDFEFPMAGGDLRGGRFARLSDVGELLREYLPADDPLAVYAERLSTGILGVQPLRGYLSGSVDAVLRVGEKFVIVDYKTNWLGTGDGTLTAADYGRRRMVEAMLHSDYPLQALLYAVVLHRYLGWRLSGYDPATHLGGVLYLFVRGMCGAGTPVVDGHPAGVFSWEPPADLVVALSKLLDAEAP

Gene
recB
Protein
RecBCD enzyme subunit RecB
Organism
Chlamydia pneumoniae
Length
1050 amino acids
Function
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.
Similarity
Belongs to the helicase family. UvrD subfamily.
Mass
121.056 kDa
Sequence
MKPFNIFDSNSSIQGKFFLEASAGTGKTFTIEQIVLRALIEGSLTHVEHALAITFTNASTNELKVRIKDNLAQTLRELKAVLNSQPASLPTYLDINCNVKQIYMQVRNALATLDQMSLFTIHGFCNFVLEQYFPKTRLIHKNPALTHSQLVLHHITNYLKQDLWKNVLFQEQFHLLAVRYNVTSKHTSSLVDKLLASYTQPISSYFSSRVERLEQISLWHQQIYNSLLEIPKQVFLDQLTAHISGFKKQPFSILDDLHHFVDLLYTSETHSSLFSFFKIAETFNFKHRLARYKPCAAFTVLENMSWVERTLEFCNLDRIFNTLLVDLQEYLKQNYTPWLSPDESVFALEKLLSSSEAQPVVQALREQYQLVLIDEFQDTDKQQWSIFSNLFISPKFTGSLFLIGDPKQSIYEWRSADLPTYLTAKSSFSEDKQLQLVNNYRSTPKLMEAINQIFGKISPFLEIPGYLPIEYHALNPQSSETFENPPHAPIHFFFYETIKDQALWIFSEALRLQKEQKIPLGNMVVLVSDSNQAFELISYATIPVSFSKNKSIFHLTETHILTTALLEAILHPENYEKISKILFSSLFGLSLDEVTTKKEDFTIYFQSLHSYISHHGLLATFYRVMTTQGNVLFSSPRGDLIFQEMEKLCGYLDTISSYPYHQLLHLKNFSETGRWEEELAISSYSEDLETLKITTIHSSKGLEYDIVFCPGIEKSKKNKSSSELLREMYVACTRAKKQLYLPISTQPPSLQRSSALTNYVKLEGTQSSAYDLAIHLHQEHPDLFSYSLPKDHGHATTVLNLPLLETFALKVTPPKTIFSFSSTKFLLDTHKDSQSIPYSKLPISKQQLPLGEKTGILIHKILESIQFSLLQDTEYLMSTIMRFIKHTHLEGFEETILKLLSKTFFSPLTFSSQTFSLSQVLPNKIFRETSFLFLENQELWQGVIDLFFEHEGKYYIIDWKTSFLGETNSDYSKSNLSIYIKQEKLDYQGRIYVKAVRKFLNQFEIDDDVELGVIFIRGIDTQGNGFFALNSSEDIPNFNPKAIQKCQAYH

Gene
recB
Protein
RecBCD enzyme subunit RecB
Organism
Chlamydia muridarum (strain MoPn / Nigg)
Length
1026 amino acids
Function
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.
Similarity
Belongs to the helicase family. UvrD subfamily.
Mass
117.832 kDa
Sequence
MSSFDIFSPTTSVSGKFFLEASAGTGKTFTIEQVILRSLLEGNVEQTKNILVVTFTNAATNELKLRIQESLKQALTLFSQALSHPETPLPPYVSSQETKVKQLYXKXRNSLATLDEMNIFTIHGLCRFTLEQHFPWVQPIHPSSMFSEPQTIQQYILDYLRQNSWENVLSPKQYAFLSYHHRATTQQTRHLADRLLQDYASTPNLALPPLSITLQKVKNWSSQYKHLSPLSLEELQDFSLRFKQSDLPIDRELPDFVKQFETDPNSLDILFFPGMVQKFQEENRNKKKLGPPFSPLDPFLKDWLLIAQPFCQKEPIFHTLLKSVQQHLKTYCAQSYSHDESIATLESLLAQNDHVVSQLRKQFQLVLIDEFQDTDKRQWKIFSKLFASPDYSGSLFLIGDPKQSIYEWRNADLPTYLQAKNSFPKESQLILDTNYRSTPQLMQALNHLFSLPSPFLETPQTILYHPLQSKGSASTSYSEFRPIHFFTTQDSQEEALWISKTASYLRSTFAIPFGNMAVLVQDYPQALKLITHSTIPMAYCKEKRIFDRTESPYLLILLLEALLYPENQQKIQAILLSRFFHLSATDIHQHLKIFSSLFFMLNTYLHQYSLLATFYKLMGETVFSQTIGETLLQTPLGDIIFQELEELCLYLDKTTENPHHKLFHLINILDTGKYDEELSFSSQSNDDNVLKITTVHSSKGLEYDVVFCSSLNKVKEKSPSVHMREMYVACTRAKKFLFIPFSSIEKRLQSNKKVSALANYANITQHDNIPHLVETLTASHPEFFSSGTQPPESNISIFSEPLPEQEFFSLPILSSQPIYSFSSTTESQYFTEPFQEISSSSLFPGGSLTGTLIHKLLESLSGNFNASLEEITHKAQTLLKNTILEGFESIISEKIYTAFSTKLPFVSGSFALKDVHPYNIRVEETFLLQENGELWQGIVDLFFEHNNRFFIIDWKTSFLGDEPSLYSPDKLLLYIQRQGLDKQGVLYKRAAKKFLHQFNSSLQIEMAFVFIRGIDDKGNGFLQPSP

Gene
recB
Protein
RecBCD enzyme subunit RecB
Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Length
1026 amino acids
Function
A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.
Similarity
Belongs to the helicase family. UvrD subfamily.
Mass
117.829 kDa
Sequence
MSSFDIFSPTASVSGKFFLEASAGTGKTFTIEQVVLRSLLEGSIEQTKNILVVTFTNAATNELKLRIQASLKQALSLFSQALSHPGTPLPPYISSSETKVKQLYMKIRNSLATLDEMNIFTIHGFCRFTLEQHFPWIQPIQPSSIFSEPQTIQQHILDYLRKNLWDTVLSPKQYAFLSYHHRATTQQTRHLIERLLQDYTSTPNLALSPLSITLQKLKAWVSRYQHLAPLSLEEMQAFSLRFKQSDLSIERELPAFVQQFETNPYSLDMLFFPGMVQKFQEENRNKKKLSAPASPLDPFFQDWIQLAHPFCQKEPIFHTLLKSVQQHLKTHCAQSYSHDESIATLESLLAHNDTVVSQLRKQFQLVLIDEFQDTDKRQWQIFSKLFASPDYSGSLFLIGDPKQSIYEWRNADLPTYLQAKHSFPKEAQLILDTNYRSTPELMQALNHLFSLPTPFLETPQNILYHPLHSKGSAEISYSEFSPIHFFSSEDIQEETLWISKTASYLRSAYSIPFGNMAVLVQDYPQALKLITHSTIPMAYCKEKRIFDRTESPYLLILLLEALLYPENQQKIQAILMSRLFQLSSTEIHQHLKTFSSLFFTLNRHLYHYSLLATFYKLMGENVLSQTIGETLLQTPLGDIIFQELEALCLYLDKTTENPHHKLLHLINILITGKYDEELSFSSQSNDENMIKITTVHSSKGLEYDVVFCSCLNKAKEKTPSVHMREMYVACTRAKKFLFIPFSPIEKRSLSTKKLSALANYANVTKHHSVPHLVETLTSSSPELFSSSFQPPESSLTPDRERLPQQTYFSLPHLPSRTIHSFSSTVENLHFSEPIQELSPSLLFPGGSLTGTLIHKLLESLAGNFAACFEEIFNKAQTLLKNTPLEGYESIIAEKICTVFSTTLPFSSGSFALRNVHPHNIRAEETFLLQEEGELWQGIVDLFFEHKDRFFIIDWKTSFLGDETSCYSPDQLHLYIQRQGLDRQERLYRKAAKRFLHQFNSLLQVEMAFVFIRGLDDKGNGFLQPGR