A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes DNA-dependent ATPase activity, exonuclease activity and 3'-5' helicase activity (By similarity). Unlike the case in E.coli, suppresses RecA-dependent homologous recombination, is instead required for single-strand annealing pathway repair of DSB.

Belongs to the helicase family. UvrD subfamily.

1083 amino acids

MKVFDLLGPLPAPNTTTVLEASAGTGKTFALAGLVTRFVAEGVATLDQMLLITFGRAASQELRERVRAQIVAALVALDDPSRACNDLEEYLVKTDQQARRRRLRDALAGFDAATIATTHQFCQIVLKSLGVAGDSDAGVTLVESLDDLVSEIVDDLYLAHFGGQKDDPELSYPEALKLARVVVGNPATQLRPRDPDPDSPAAVRLKFARDVLAELEIRKRRRGVLGYDDLLTRLADALEPEDSPARVRMQQRWPIVMVDEFQDTDPVQWQVIERAFSGRSTLVLIGDPKQAIYAFRGGDIATYLRAAATAGDKQTLGTNWRSDRALVDRLQAVLRGAQLGGPDIVVHDVQARHQGHRLVGAPRNDPFRLRVVSRKPGNTRVIPIDQLRRHIGRDLAADISALLNSGATWCDQPVQAKDIAVITETHKDARACHAALLAAGIPAVYTGDSDVFTSEAAEDWLYLLEAFDQPHRPGLVRAAAATMFFGETAESLAAGGDALTDRVADTLREWAGHARERGVAAIFEAAQLAGMGKRVLSWQGGERLMTDLAHMTQLLQDTAHREGFGLAALRDWLRTQRSERGGESERNRRLDSDAAAVQIMTVWVSKGLQFPVVYLPFAFNRYVPEPDLVLFHDDGQRCLHVGGADPAVARAGRAEAAGDDSRLTYVALTRAQSQVVAWWAPSYDEPNGGLSRLMRGRAPGEAIVPDKCSPPKISDEDALERLRAWEAAGGPVIEESVIGAVSPVPPEPAPEDLAARKFFRAIDMAWKRTSYSGLLRAAETAGVGVSSEPEVTERDDEFDDIPVVAPAEGADVPSPMAHLPTGAAFGSLVHAVLETADPFAEDLTAELATHIDAHSQHWPVEVETAELAAALVPMHDTPLGPLAPGLTLRQIGLRDRLCELDFEFPMAGGDLRGGRFARLSDVGELLREYLPADDPLAVYAERLSTGILGVQPLRGYLSGSVDAVLRVGEKFVIVDYKTNWLGTGDGTLTAADYGRRRMVEAMLHSDYPLQALLYAVVLHRYLGWRLSGYDPATHLGGVLYLFVRGMCGAGTPVVDGHPAGVFSWEPPADLVVALSKLLDAEAP

117.4 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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