rad50

DNA repair protein RAD50

1351 amino acids

Essential component of the MRN complex, a complex that possesses single-stranded DNA endonuclease and 3' to 5' exonuclease activities, and plays a central role in double-strand break (DSB) repair, chromosome morphogenesis, DNA repair and meiosis. In the complex, it mediates the ATP-binding and is probably required to bind DNA ends and hold them in close proximity (By similarity).

Belongs to the SMC family. RAD50 subfamily.

156.207 kDa

MTSIEKLLVQGIRSFDPREASVIDFYSPLTLIVGQNGAGKTTIIECLKYTCTGEMPPNCSSGQAFIHDTKIAGESEVKAQIKLRFKNPIGKPIVASRSLSLIQKSNKKQEYKQIDASLQSYTSDGQKVSKSFRCSDMDKEIPDLMGVAKPILKHVIFCHQEDSNWPLSESAKLKLKFDEIFSAVKYTKALKSLKDKRKELTTLIKELKLRLETISANIEHCNRIRKELIKAEEIYSNGNKSLEDIKIAIIEKQKTLSTIKIAESKLQELKNEVTVLNARKLEMERVKNQLFNSLTEVYQNETDEELVFMQSEFNRECETMATAEKELLENSEVLLSQKEVINNLIKENSSQKGRLQSLISQQDSILSDRDKQMKELVTRYKMSDFIQIQLPYQKEIVIKFINEITQKFDTLTSGISNYSKTNKQKLNAIQMKINQKRVDSNQFTSSSNEKMSTITLNSKKIQSLDQEIQQHTNSIGEIDTLEKQIQFSQSELSILKSDANLQEIQQSLDNLTTEKLEIEKEIQSLQSSLKLLNLQASSRTRLNIKRKEIQQNQQNINSQLNSQIINSINLILPNEFNNDNNNDDDDDQFRFNIIQRIEPIVPLINKKRLIFTNQLNELKQQFQILQNKKNQIDAQLTSSIEPQLKKKQIELESYEKLINDSKLKQSNLFENVNSNNNNNNNNNNGITVLLFENKINEMKLSLEKLEKSFIVLESEDILYKEYIEKANQDKECSLCKNEMNGNELTSFVHTLETHCNDIPNQLKQLKIEISNSKIQLEKFNKLLPIIVKREELIEKSIPELKESQKNLLEQQLKSNEMVLEKQNQIESLESQSVLYQQVTLVFQYIDQTKQSIQSIESEIQKEEKEIMKQSSDLRTIEEVDKDLEIQQEQLKTIEKEISNFTNKQKNDQIGIFEKERQLISIKNQLTTIKSASGIIDHLRDTKKELQSNNQQLQLEIENLQQSIDQSNNDAKQLENEFQQLEIEFEKKIDAYSKEKNTFSVRLDSINSLQSKILDPSELCKQLNEIQEKNQELESNLSTLSQDYLIGQQHISTIQQNLSSKDITKRAISDNISFRQHKNNVEQIIRQISRKNELIKEMMQSQLEIDSNKLEQEINSLKSKFDQITGQTAVLQSQINSNRQELSKPTYKNIDDVNKDLLIKLQTTETVGKDLDKYYKALDKSLMKYHTLKMDEINRSIKEIWQTTYKGSDIDTIEIRSEESGTANKTINYRVVMIKGDVELDMRGRCSAGQKVLACLVIRLALAENFCSNCGILALDEPTSHLDRANIESFANSLLNIIESRKSQKGFQLIIITHDEEFVQYLSRGNYCDYYWRVTKNANQHSHLERKEIAEL

rad50

DNA repair protein RAD50

1318 amino acids

Essential component of the MRN complex, a complex that possesses single-stranded DNA endonuclease and 3' to 5' exonuclease activities, and plays a central role in double-strand break (DSB) repair. The complex participates in processes such as DNA recombination, DNA repair, genome stability, telomere integrity and meiosis. The MRN complex may protect telomeres by facilitating recruitment of HOAP and HP1 at chromosome ends. In the complex, it mediates the ATP-binding and is probably required to bind DNA ends and hold them in close proximity.

Belongs to the SMC family. RAD50 subfamily.

152.16 kDa

MSSIESLSIQGIRSFGTYADDLQSIKFSSPVTLILGENGCGKTTVVECLKYALTGECPPGSDRGKSFVHDPKIFGLNEVLAQIKMQVRDRRGAQVSICRTMKVSKKRNKMSFETMDSTINFLTGAGQSKREKQDSLSGRSVDIDVAISDFMGVSKAIINNVLFCHQEDSSWPLDESKKLKEKFDAIFGITEYNKALDKIIKLRKEAMEELKIKEANIKHVAYLKQEMEVKTLNLQKAQRKCDAIKAQCSECEEEMKPIEARLVEIRNVEFEIGKYQAQKVEMDTKHKNCKDQISTLTLKIKKPFRGTLDELDQEISNFDQRMLEMRQKRTEVEGDLSQIKRSSVAEQEKLGTQDRKHCLAKQRHQSELACRAQLLKRVKEFCRELHIPIDCDLVEQPEKMGEVLRDIEAMIITKHCEITEIVEQNEKADRSRQVKIDELRIELTKSEQSVTAQEKQRESSKRESETLGVEIKKIETSMQDLKKLEKEINEVNELYESATKNIDQQAIKDAIARKKASIAENQIQFKKLDEQLTFLGSMAKLVAECSLKQKELDKKNQEVHRVRSRHSDHFGKLFKEPITCNYRRSMQVVYEKLRREIQELNEKANTQKLKEQSYEIKRKNLISDISRMEKELKDSEELIYQKCRSTPYDDLLERSKTTISKLQFDHGALKSSEALYKKYIQKMDEEPSCPLCHHNMTSDEACDLTSELTDEIQKLPDNITRAEKALKAEQIKYENLLQLKPTILKVKELKDSLPQKKEELKKVEELLGDSVSEYETLIALIGEPTHNMELANSMMGDMSLLDEALKDSARLTKDLDLQKGQLPASYDSSVSMDDLQAEKSKVSKELETERKELESAQNAVQQQMDALNRLREKKNSLKDRQIHLREGLQSLPQLKERLEKLNSFLTTVASEISELKAKIQPLKLNLRAAIEEKERLKKSESEKLAQLNSKYNSYKSTDHDIQRLNKEAEDYAKLDLRNEIKKLDEIIMASKDKLRKLEAEISLKTDELETIKTECSNQQTVERDLKDNRELKQLEDKEAKLRESCQVLDKQLGNLDFHSVSKEKVNLTKQRDKATVRKGELLGQLGEIHSQVNKLQREIDEPRFKESLKNFRKANYEIEVTRLCIEDLGQYRLALEWALIQFHSEKMEMINRLIREYWRKIYRGNDIDYIQVKTDEVSSDASADRRKTYNYRVVQSKNYSEIEMRGRCSAGQRVLASLIIRLALAETFSSNCGVLALDEPTTNLDRANINSLCEALNCIVEERQSQSNFMLIIITHDENFVSSLGKITSYHRVFRNEECKSVIRRVEAGPSKKALIDQ

RAD50

DNA repair protein RAD50

1316 amino acids

Implicated in double-strand breaks (DSBs) repair by non-homologous end joining (NHEJ). Involved in telomere maintenance. Involved in telomerase action on chromosome ends. Required during meiosis for both male and female gametophytic development, for pairing and synapsis of homologous chromosomes during the early stages of meiotic recombination, especially during the pachytene stage of the first division.

Belongs to the SMC family. RAD50 subfamily.

152.815 kDa

MSTVDKMLIKGIRSFDPENKNVVTFFRPLTLIVGANGAGKTTIIECLKVSCTGELPPNARSGHSFIHDPKVAGETETKAQIKLRFKTAAGKDVVCIRSFQLTQKASKMEYKAIESVLQTINPHTGEKVCLSYRCADMDREIPALMGVSKAILENVIFVHQDESNWPLQDPSTLKKKFDDIFSATRYTKALEVIKKLHKDQAQEIKTFKLKLENLQTLKDAAYKLRESIAQDQERTESSKVQMLELETSVQKVDAEVHNKEMMLKDLRKLQDQVSIKTAERSTLFKEQQRQYAALPEENEDTIEELKEWKSKFEERLALLGTKIRKMEREMVDTETTISSLHNAKTNYMLEISKLQTEAEAHMLLKNERDSTIQNIFFHYNLGNVPSTPFSTEVVLNLTNRIKSRLGELEMDLLDKKKSNETALSTAWDCYMDANDRWKSIEAQKRAKDEIKMGISKRIEEKEIERDSFEFEISTVDVKQTDEREKQVQVELERKTKQNSERGFESKIEQKQHEIYSLEHKIKTLNRERDVMAGDAEDRVKLSLKKTEQENLKKKHKKIIDECKDRIRGVLKGRLPPEKDMKREIVQALRSIEREYDDLSLKSREAEKEVNMLQMKIQEVNNSLFKHNKDTESRKRYIESKLQALKQESVTIDAYPKLLESAKDKRDDRKREYNMANGMRQMFEPFEKRARQEHSCPCCERSFTADEEASFIKKQRVKASSTGEHLKALAVESSNADSVFQQLDKLRAVFEEYSKLTTEIIPLAEKTLQEHTEELGQKSEALDDVLGISAQIKADKDSIEALVQPLENADRIFQEIVSYQKQIEDLEYKLDFRGLGVKTMEEIQSELSSLQSSKDKLHGELEKLRDDQIYMERDISCLQARWHAVREEKAKAANLLRDVTKAEEDLERLAEEKSQLDLDVKYLTEALGPLSKEKEQLLSDYNDMKIRRNQEYEELAEKKRNYQQEVEALLKASYKINEYHDLKKGERLDDIQEKQRLSDSQLQSCEARKNELAGELNRNKDLMRNQDQLRRNIEDNLNYRTTKAKVEELTREIESLEEQILNIGGIAAVEAEIVKILRERERLLSELNRCRGTVSVYESSISKNRVELKQAQYKDIDKRHFDQLIQLKTTEMANKDLDRYYNALDKALMRFHTMKMEEINKIIRELWQQTYRGQDMDYIRIHSDSEGAGTRSYSYKVLMQTGDTELEMRGRCSAGQKVLASLIIRLALAETFCLNCGILALDEPTTNLDGPNSESLAGALLRIMEDRKGQENFQLIVITHDERFAQMIGQRQHAEKYYRVAKDDMQHSIIEAQEIFD

Rad50

DNA repair protein RAD50

1312 amino acids

Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation (By similarity).

Belongs to the SMC family. RAD50 subfamily.

153.488 kDa

MSRIEKMSILGVRSFGIEDKDKQIISFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVAQETDVRAQIRLQFRDVNGEMVAVHRSMLCSQKNKKTEFKTLEGVITRMKHGEKVSLSSKCAEIDREMISCLGVSKSVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALDTLRQVRQTQGQKVKECQTELKYLKQNKEKACEIRDQITSKEAQLASSQEIVRSYEDELEPLKNRLKEIEHNLSKIMKLDNEIKALESRKKQMEKDNSELEQKMEKVFQGTDEQLNDLYHNHQRTVREKERRLVDCQRELEKLNKEARLLNQEKAELLVEQGRLQLQADRHQEHIRARDSLIQSLATHLELDGFERGPFSERQIKNFHELVKERQEREAKTASQLLSDLTDKEALKQRQLDELRDRKSGLGRTIELKTEILTKKQSELRHVRSELQQLEGSSDRILELDQELTKAERELSKAEKNSSIETLKAEVMSLQNEKADLDRSLRKLDQEMEQLNHHTTTRTQMEMLTKDKTDKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASAEQNKNHINNELKKKEEQLSSYEDKLFDVCGSQDLESDLGRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKERRRDEMLGLVPVRQSIIDLKEKEIPELRNRLQSVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGVDLDRTVQQVNQEKQEKQHRLDTVTSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIATNLQRRQQMEEQSVELSTEVQSLNREIKDAKEQISPLETALEKLQQEKEELIHRKHTSNKMAQDKINDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNGVAVQLNECEKHREKINKDMGTMRQDIDTQKIQERWLQDNLTLRKRRDELKEVEEEPKQHLKEMGQMQVLQMKNEHQKLEENIDTIKRNHSLALGRQKGYEDEILHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGRCSAGQKVLASLIIRLALAETFCLNCGILALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGRSEYVEKFYRVKKNMDQCSEIVKCSISSLGSYVH

Rad50

DNA repair protein RAD50

1312 amino acids

Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation (By similarity).

Belongs to the SMC family. RAD50 subfamily.

153.784 kDa

MSRIEKMSTLGVRSFGIEDKDKQIISFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVAQETDVRAQIRLQFRDVNGEMVLVQRSMLCSQKSKKTEFKTLEGVITRIKHGEKVSLSSKCAEIDREMISCLGVSKSVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALDTLRQVRQTQGQKVKECQTELKYLRQNKEKACEIRDQITSKEAQLASSREIVKAYENELEPLKNRLKEIEHNLSKIMRLDNEIKALDSRKKQMEKDNSELEQKMEKVFQGTDEQLNDLYHNHQRTVREKERRLVDCQRELEKLSKEARLLNQERAELLVEQGRLQLQADRHQEHIRARDSLIQSLAAHLELDGFERGPFSERQIKNFHELVRERQEREAKTASQLLSDLTDKEALKQRQMDEMRDKKSGLGRMIELKTEILTKKQTELRNVRNELQQLEGSSDRILELDQELTKAERELSKAEKNSSIETLKAEILNLQSEKADLDRNLRKLDQEMEQLNHHTTTRTQMEMLTKDKTDKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASAEQNKNHINNELKKKEEQLSSYEDKLFDVCGSQDFESDLDRLKEDIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPGCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKERRRDEMLGLVPMRQSIIDLKEKEIPELRNRLQSVNRDIQRLKNDIEEQETLLGTVMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGVDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIATNLQRRQQMEEQTVELSTEVQSLNREIKDAKEQINPLEIALEKLQQEKEELIHRKNTSNKMAQDKINDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNEVVIQLNECDKHKEKINKEMGTMRQDIDTKKIQERWLQDNLTLRKRREELKEVEEERKQHLKEMGQMQVLQMKNEHQKLEENIDTIKRNHSLALGRQKGYEEEILHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDHAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGRCSAGQKVLASLIIRLALAETFCLNCGILALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGRSEYVEKFYRVKKNIDQCSEIVKSSINSLGSYVH

RAD50

DNA repair protein RAD50

1312 amino acids

Involved in DNA double-strand break repair (DSBR). The rad50/mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific exonuclease activity. Rad50 provides ATP-dependent control of mre11 by unwinding and/or repositioning DNA ends into the mre11 active site.

Belongs to the SMC family. RAD50 subfamily.

152.569 kDa

MSAIYKLSIQGIRSFDSNDRETIEFGKPLTLIVGMNGSGKTTIIECLKYATTGDLPPNSKGGVFIHDPKITGEKDIRAQVKLAFTSANGLNMIVTRNIQLLMKKTTTTFKTLEGQLVAINNSGDRSTLSTRSLELDAQVPLYLGVPKAILEYVIFCHQEDSLWPLSEPSNLKKKFDEIFQAMKFTKALDNLKSIKKDMSVDIKLLKQSVEHLKLDKDRSKAMKLNIHQLQTKIDQYNEEVSEIESQLNEITEKSDKLFKSNQDFQKILSKVENLKNTKLSISDQVKRLSNSIDILDLSKPDLQNLLANFSKVLMDKNNQLRDLETDISSLKDRQSSLQSLSNSLIRRQGELEAGKETYEKNRNHLSSLKEAFQHKFQGLSNIENSDMAQVNHEMSQFKAFISQDLTDTIDQFAKDIQLKETNLSDLIKSITVDSQNLEYNKKDRSKLIHDSEELAEKLKSFKSLSTQDSLNHELENLKTYKEKLQSWESENIIPKLNQKIEEKNNEMIILENQIEKFQDRIMKTNQQADLYAKLGLIKKSINTKLDELQKITEKLQNDSRIRQVFPLTQEFQRADLEMDFQKLFINMQKNIAINNKKMHELDRRYTNALYNLNTIEKDLQDNQKSKEKVIQLLSENLPEDCTIDEYNDVLEETELSYKTALENLKMHQTTLEFNRKALEIAERDSCCYLCSRKFENESFKSKLLQELKTKTDANFEKTLKDTVQNEKEYLHSLRLLEKHIITLNSINEKIDNSQKCLEKAKEETKTSKSKLDELEVDSTKLKDEKELAESEIRPLIEKFTYLEKELKDLENSSKTISEELSIYNTSEDGIQTVDELRDQQRKMNDSLRELRKTISDLQMEKDEKVRENSRMINLIKEKELTVSEIESSLTQKQNIDDSIRSKRENINDIDSRVKELEARIISLKNKKDEAQSVLDKVKNERDIQVRNKQKTVADINRLIDRFQTIYNEVVDFEAKGFDELQTTIKELELNKAQMLELKEQLDLKSNEVNEEKRKLADSNNEEKNLKQNLELIELKSQLQHIESEISRLDVQNAEAERDKYQEESLRLRTRFEKLSSENAGKLGEMKQLQNQIDSLTHQLRTDYKDIEKNYHKEWVELQTRSFVTDDIDVYSKALDSAIMKYHGLKMQDINRIIDELWKRTYSGTDIDTIKIRSDEVSSTVKGKSYNYRVVMYKQDVELDMRGRCSAGQKVLASIIIRLALSETFGANCGVIALDEPTTNLDEENIESLAKSLHNIINMRRHQKNFQLIVITHDEKFLGHMNAAAFTDHFFKVKRDDRQKSQIEWVDINRVTY

RAD50

DNA repair protein RAD50

1312 amino acids

Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:11741547, PubMed:9590181, PubMed:9705271, PubMed:9651580). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888).

Belongs to the SMC family. RAD50 subfamily.

153.892 kDa

MSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKVAQETDVRAQIRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVITRTKHGEKVSLSSKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGRCSAGQKVLASLIIRLALAETFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGRSEYVEKFYRIKKNIDQCSEIVKCSVSSLGFNVH

rad50

DNA repair protein rad50

1285 amino acids

Involved in DNA double-strand break (DSB) repair. Involved in mating type switching and has a role in choosing the sister chromatid for recombinational repair. Also has a role in telomere length maintenance.

Belongs to the SMC family. RAD50 subfamily.

149.029 kDa

MSCIDRMSIMGIRSFDNRSRESIQFFSPLTLIVGQNGSGKTTIIECLKYATTGILPPNTKGGAFIHDPKICGEKEVLAQVKLAFRNTNQVKMICTRSLQLSVKKTTRQQKTLDGQLLILKDNERTTISNRCAELDSQVPLSLGVSKALLDYVIFCHQEESFWPLSEPANLKKRFDEIFESLRYAKALDQIKGLKRDQETQVKVDQATLTHYRSDKERAEKIELRVHESLKRISCIRSKVEELDQEITETARLQDELFKSTEEYEQQMITIRHLESQSDIINTTINDLKSQMTITDESSEDLEKLHSNFAEKVKEEQELYKSLEKKRSDLESLLKSRRELLEKLTGDLGKIQGEIESLEKLKVKKSTMINEIVHRYNINEINEEGIMTEVSKYASLVNKNYEISSGKLKERQVAVRARIEGIKAHEMFLNNRVSEINSSLEKQLTTQKELRSRFEILFPVKLQREDFTKDVEKSDLWIKSLRQEYESKNLLELLDKHQTALSSVENRLDEISEIVDSYHKYSGVRTKLQVFEENKTNKSAILANQLMTLKSSFSEVMSYELKDDDNYNEELDKLVEDVRKKLQEKEEAESSLRSVRERLEIRISLSVQSINDLTENKKIKTKTLKSYSGTFASMISEIKALESEIEENRKTLHSLQFGSTFYEKAIEICVDQHACQLCQRSLDKEEEKLFVEHCHSMIDVIPSKSAEVYSHLETLTKTFKNLSEAKPIFDEIELLDKRLSETKTELSDLQGDLQGLDIRKDEIQSELDTLYLRRANLEKLQLLVKDISNLEEEIRTIDRETEVLRIELPSSIAHHNLDEIYAEREKLLEKRGYLRKQIERTKLEETSFKKKIDDAVLANNEQKLKLTKLNFQVNELEQLEKDINKSSEDCDLQKKKLLEVSSKQGSQAPFLNELESEYEKLEADIQEMAQKSRTEILEANEYLHQLNEWNSELRIDVSTKFKCIKEKKSNIGEEVRIIASKIESTDDNLRKLQERLADLRTRERNASDNLRLRALMRQLEEAVTQKNYLLSQQSHDDRESFRERMQILKSKYGALNAERAGLLGECKQLENSITKDKEELNMEFKDADERFRRQLIKTKTTGKANEDLGKYAKALDVAIMQLHSMKMNEINRIVDELWKQTYCGTDIDTILIRSDSEGKGNRTYNYRVCMVKGDAELDMRGRCSAGQKVLACIIIRLALAECLGVNCGILALDEPTTNLDEENICSLAKNLSRIVEFRRKQANFQLIVITHDEQFIRLVNSDAYCSYYYRVKRDTNQKSMIVKEPL

RAD50

DNA repair protein RAD50

1247 amino acids

Involved in DNA double-strand break repair (DSBR). The RAD50/MRE11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific exonuclease activity. RAD50 provides ATP-dependent control of MRE11 by unwinding and/or repositioning DNA ends into the MRE11 active site (By similarity).

Belongs to the SMC family. RAD50 subfamily.

144.547 kDa

MASIKKLMIRGVRSFSHKESNTLEFYSPLTLIVGANGTGKTTIIESLKYATTGSLPPNSRGGAFIHDPSVAGLAEVQGQVKLLFTNVHGETMICSRTIQLAQRRDRREQKTLESVIWAERDGEGVSGRSGDVDAEMPQHFGVSGSILESIIFCHQEESTWPLGEPVVVKKKLDDIFASAKYGKALDSLKSSRKECSSDVKMKMQELEFLRKMKERKESLELRIRSGCMSIEKNEIRVEACDNEIGRCERVIEEIDLELKGNEEAEKRAHLLRGEHRELMEFIDGFREKKLPLEDATDIMSGKSLQEAEEEYERMKMDAEESEMRFKDLSEERSRYIRSKAELDGVFSEISVKSSFLDEARRQKMEALKSLESELKVKKDFRETALEVFGKVEDDIKQRKECIHRLEEEALRLKKEDRDRTVALSEKKRIVDEYSGLESDGSIDVSVSYEDEVGRLRAEISRDREMEALEERLGDYQRRLNDAYSIAERNFAMNQMRGRKREIEGMLNGVNVSELKSKLERQKAKLREKESRAKEIEREMSLRKARAIERSKENDRIRRELRTKSMELGSMGQRSRMAIFEELGIPMLRNGSRCSVERAKEVVRSNEGFFARDDMGFGVEMLDLESLYDGEEVLQRSGASDGIWRERIYREMLEDGCRSHECPVCNKPLSKEEEVEFKRKLEAGIERALDGKENALGSWNDRERIAGEIEALNKEIAGRNKIREEMAELILRYEEVEDVSGEEALDEMELDMLDEAEGIKKTEFLIGLVEELFLIDGKLRGSEEGESVQELRSMVDGIRKIYEEKKEEVRRKKERIEYLCRKQEVIRAEREIREKINFREEAKEAMQRIERSSARIRASDVEEEIRRKKSKLDRILERFARKRVELEMSMEAFYQKEREEACLAKEIEELNSKVRKLLQAEFLDEAKDEVKFDDARSDLLERKNKVLEIGQKIRRMYEMRSLAEESMKYYNRERRVREIERELSETDFEYLAALKEKRRLLEEKKAKLSSQKSLLLGECKQIALGVKSYKQELLKDHGRTVENYNKCFIEVKALELSCMDLDKCIQALDKAIVDFHTSKLEEVNATLKDLWTNTYRGDDVDWIKIKTESSGQRTYNYKVVFVKGGVELDMRGRSSAGQKMIASILIRLALADSFASSCSVLALDEPTTNLDRDNIESLAFTLSRVISRHRRDADFQLIVITHDEDFVQLLSRGGPEYFYRLSRSESGDSMIVRHSIYGTREMGPNKVY

rad50

DNA double-strand break repair Rad50 ATPase

1074 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.

Belongs to the SMC family. RAD50 subfamily.

121.649 kDa

MKLKNLYIENIRSYRKLDFTFEDGVTVISGVNGSGKSSLLEACFMGLFGSKILSKDFVLADMIFKGAETAKINLGFEHLGKEYLIEQAFRYSSKSENASSSKCVLYADGENIIDQATRTYEEVRTLLNMDEEAYRNCAYIRQGEIDVLINAKPKDRQRMIDDLLQLGKLEEYRERTGYAKTAVRRLERDTKNSLVGVKAEIEGIESTEPVKALNGLKQKAKETDGSLKELNEKKDYAAARKGELDLRIAEYRERLQEIEVLKEAIRKTQEDKAGCFKEKEAFSGEVQGQRRILLELGEENTGLRDDCGFGDLEIEALLLHQEKEESSAREKVNAVSKDLALLLKEGETGSQALCELEKEKTQAERTLLECRTSIGAANKEIEGYRENIRKLEEESKGLREKAGFKAASGAADEIALLIKEFEEKESLLRDRKNEASTKLGLSLKEKETCDLNLVELEKELQNAGAAVRKGSTEIEALEKELRENSKAVLDIQEQKSEVLAELKGLGFAADQLENLEDFSELLLENKSRLHGKEKELEATLRELENNIRKNRELFAAGKCPTCGQELKGSEIACTAEECEDKKEKLASELADIKVQHAELEKKITRLKDAKKLEKRISDYDIEIEKLQEKAKASGKLIETHRARIEEDALKLESLDKRKQELETSGRQLLSDIKTLQVQEAEARKAHIEGEKTLIEVKTLDRKLAENTAEIESLNGKIRTSLALIENYGERLGELNDKLKALAEKENLSKEKLKALELALEAAQKKENEAKKAHSESEKLLGQAKKLQANLLSMENIKHKISELEAAIRNLAEKVGFLDREILERSERIRQLGEKLEGNRLSELQQKRAQFEQAQAKITENIREKTEEKDSLLKEIGMLENSLKRLRELRKELKALENRQLYLEAVYSNAEELENTYIRVRADMRARNIGALSVLLNEMFAFMYTNNAYSHIELDPEYNLTVYRKDGTPLEPKLLSGGERAIFNLVLRCAIYRLLALGFGGDKADGLPPMILDEPTVFLDRGHIRQLLKLIDMMRSIGVGQIIVVSHDDSLIDSADHVFQVEKDPLTNMSSITRL

rad50

DNA double-strand break repair Rad50 ATPase

1070 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.

Belongs to the SMC family. RAD50 subfamily.

121.981 kDa

MKLKNLYIENIRSYKKLDFTFEDGVTVISGVNGSGKSSLLEACFMGLFGSKILSKDFVLADMIFKGAESAKIHLGFEHLGREYLIEQAFRYSLKSENASNSRCVLFADGENIVDQATRTYEEVCALLNMDEEAYRNCAYIRQGEIDVLINAKPRDRQRMIDDLLQLGKLEEYRERAGYAKTAVRRLERDAKNSFLGVKAEIEGIESTEPVAAVNRLRQKVKETDAILEELNKKKEFAAARKGELDLRIAEYRERLQEIEVLKQAIRKSQEDKAACFKEKETFSEEVQVQRRVLLELGEENSGMREECGFGDLEIEALLLQQEKSESSAREKVNSGSKELALLLKEEETGVQALRELEKDKVETERVLVECRTSIGAANKEIEGYRANIKQLEEENKRLREKAGFGAAGEIASVIKELEEKESLLRDRKNEVSTKLGFALKEKESGDASLRELDSEMQSCRVAVSKGKSEIEALEKEIRDNSKAVLDFQEQKSEVFAGLKALGFTEEQLENLEDFNELLLENKNRLHGKEKELEVTLREIENTLRKNRELLAEGKCPTCGQELKGSGIACTAEECEEKKEKLSLELADIKLQRAELEKKLNRLKEAKKLEKQAYDYDIEIEKLLEKAKASEKLIDTHRTRIEEDSLKLESSGKRKQELEAAGSKLLLDIKALREQEKAAQKVHLESEKALREAKVFERKLAENASEIESLNGKIRTSLALIENYGQRLGELNEKLKAFAEKETQSKEKLEALELTLETARKNEEEAKKAHIESARLLGEAKKLQANLLRMQNIKHKISEFEAGIGNLAEKIGFFDREIVERSDRIRQLEGKLEGNRLEELQQKLARFEEAQVNITEKIREITAEKDTLLKEIGMIENSLKRLKELKEELKALENKRLYLEAVYNNADELENTYMRVRADMRARNIGALSILLNEMFSFMYTNNAYSHIELDPEYNLTVYRKDGTPLEPKLLSGGERAIFNLVLRCAIYRLLALGFGGDRPDGLPPMILDEPTVFLDRGHVRQLLKLIDMMRSIGVGQIIVVSHDESLIDSADHVFQVEKDPLTNMSSITKI

rad50

DNA double-strand break repair Rad50 ATPase

1005 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.

Belongs to the SMC family. RAD50 subfamily.

119.388 kDa

MSMILKEIRMNNFKSHVNSRIKFEKGIVAIIGENGSGKSSIFEAVFFALFGAGSNFNYDTIITKGKKSVYVELDFEVNGNNYKIIREYDSGRGGAKLYKNGKPYATTISAVNKAVNEILGVDRNMFLNSIYIKQGEIAKFLSLKPSEKLETVAKLLGIDEFEKCYQKMGEIVKEYEKRLERIEGELNYKENYEKELKNKMSQLEEKNKKLMEINDKLNKIKKEFEDIEKLFNEWENKKLLYEKFINKLEERKRALELKNQELKILEYDLNTVVEARETLNRHKDEYEKYKSLVDEIRKIESRLRELKSHYEDYLKLTKQLEIIKGDIEKLKEFINKSKYRDDIDNLDTLLNKIKDEIERVETIKDLLEELKNLNEEIEKIEKYKRICEECKEYYEKYLELEEKAVEYNKLTLEYITLLQEKKSIEKNINDLETRINKLLEETKNIDIESIENSLKEIEEKKKVLENLQKEKIELNKKLGEINSEIKRLKKILDELKEVEGKCPLCKTPIDENKKMELINQHKTQLNNKYTELEEINKKIREIEKDIEKLKKEIDKEENLKTLKTLYLEKQSQIEELELKLKNYKEQLDEINKKISNYVINGKPVDEILEDIKSQLNKFKNFYNQYLSAVSYLNSVDEEGIRNRIKEIENIVSGWNKEKCREELNKLREDEREINRLKDKLNELKNKEKELIEIENRRSLKFDKYKEYLGLTEKLEELKNIKDGLEEIYNICNSKILAIDNIKRKYNKEDIEIYLNNKILEVNKEINDIEERISYINQKLDEINYNEEEHKKIKELYENKRQELDNVREQKTEIETGIEYLKKDVESLKARLKEMSNLEKEKEKLTKFVEYLDKVRRIFGRNGFQAYLREKYVPLIQKYLNEAFSEFDLPYSFVELTKDFEVRVHAPNGVLTIDNLSGGEQIAVALSLRLAIANALIGNRVECIILDEPTVYLDENRRAKLAEIFRKVKSIPQMIIITHHRELEDVADVIINVKKDGNVSKVKING

rad50

DNA double-strand break repair Rad50 ATPase

993 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.

Belongs to the SMC family. RAD50 subfamily.

116.892 kDa

MIIKNIKMENFRSHRNTSINFSKGITSIIGQNGSGKSSIFQAMNFALFAPRGNNFRIENLMQQGAASFSVELEFEMMGNTYLVKRKRFQHKTDDKLYVNGKLNAESASEINKKIEEILEIDNSVFSNAIYIKQGEIANLIQMTPRDRKEVIGKLLGIEKYEKASEKMNIVKKSYEETLLKLEGELTQEPEILENLEKLKNEVSESEILKEEILKKYENLEKLKLEKNSEILQMEEKFAENNQLKENLKDIISEIKNINLEIQNFKNSLNLVAEESKNISENEENYKKYLELELKIKELNNKLIGHKSNYESYNKLKTIEESLLKELGVLKESLKDNKKNPDELKENLKENDEKILILDKIKEKIKELEFIEKQIYEIKIHKKTVETLFDSVKIYDDSIKTFEELKTKKNSYENLLKEKFDLEKKLQNETDEKTKLISELTDFEKIEEKINLENELKEKYEDLSEKIDKLNEIVLKKESKISEYKNSKAELEKTKDSCHVCQSKITEEKKQELLEKYNSEIQNEQLSTESLKKQLEIILNKKEKMKVKLNEIDSFKLKYGELKEKKNYSLKVEESIIETTEKLNELTGKINEYSSLNDEISLIENKLKNLENDYKNCNYSSQFLTKNDESEFLTKKLELSKIIGDYDSSKIENEKKSLENLKDELKNTIYNLEREINLKKELKNIQNDISSKIGIVECYVKWETEKSDFENKLSECKENYEKYMESLAVLKNYSKTYSVEINNLNEFLNQKIAEKQQFCEKLLETRTEIEKNIQTVNYNPELHENAKRLYENILNEFNDILRTLERISSELKLKNENISYLNEKIQNLSNKKEEKKKIEEFKEYLDKIKREIFSKDGFQKYLREKYIPLIQRHTNQIFQEFELPYSHIQLKDDYSLIVDGLPVETLSGGEQIAVSLALRLGISKAVCNNIECIILDEPTAYLDEDRRKNLLNIFKNIKTINQMAIITHHQELEQIADNIVKVRKIGENSKVSLE

rad50

Probable DNA double-strand break repair Rad50 ATPase

978 amino acids

Involved in DNA double-strand break repair (DSBR). The Rad50/Mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of Mre11 by unwinding and/or repositioning DNA ends into the Mre11 active site (By similarity).

Belongs to the SMC family. RAD50 subfamily.

115.898 kDa

MRPLKLEVKGFTVYKKPQVIDFTPLKFFVIQGKTGAGKTSIIDAITYALYGKVPRYGASVATKYVLSRGEKELKVALDFSLRGRNYRVERYYREFPEDSQVRVYEEGRRLNIKANEVEKWLFKISGLDYKTFTKVILLPQGEFDRFLKESSERKKILINLLGLEELEKVRQLASETFKNLEGKREALKKEYELLKDYTPTKKEVLEKTLKNLEEELKELKETEEKLRQELKKAEEKDSLERELSQVVTKLKELENLEKEVEKLREKLEFSRKVAPYVPIAKRIEEIDKKLTELKVRKNKLTKELAVLKDELSFAQEELNRIEAEKEKFKEEKEREKELEHRLKKLQEIKEILKELSQLSSSLKEKEREYEQAKQEFEDLSERVEKGKKLVAETEEKLEKIKELFSEEEYTSLKMKERLLVELQRKLKELKEKEGQLENLTQKYKEKKKVHEKVLNELKELERELKERELHYHAHMVASYLSPGDTCPVCGGIYRGKALENVDAEGISELKHAKELKEKEEREIDTTLKLYAQKINSLKEEMEKLRNEVEELRKEIPENLKERIKKLEELRIEKEKLEHKLNKYRKALEDRQKQKEEAQAKLHKAQTELELLKEKIREKSRLVKEFKELYRVERLEDYEESLKEEINYINSKLQEIEEKEKKLRKHFEELSSRKSKLEGELSALNESINSLEEERKEKLKELANIYEVAKSPREVVELYLGDKEAELERKIKEFEESFQSLKLKKSEIEEKLKEYEGIRELSDIKGEYESVKTQLEEKHKKLGEVKRELEHLGERLKRKEELQKEISELEKKLEVYRVISNDFRGDRFQKYVSEIMLQKVVDRASEYFYKFTGNYFFELERATKGRDKDIVVVESSTSQRRPVSSLSGGETFLASLSFAFAVSDLLSGSANLESLFIDEGFGSLDQDMRERVSEILEAIKTNVNKMIGIVSHIPDFAERFTERIVVEKKGDYSEVRVIY

rad50

DNA double-strand break repair Rad50 ATPase

919 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.

Belongs to the SMC family. RAD50 subfamily.

104.139 kDa

MYVLKRLELRNIMSHFNTSIDFREGFTAIVGRNGAGKSTILEAILFSITPHQAPRRSSMISENSSRGEIYLALQSSEGRLLELRNKLIRRGGGTNTEAAIITLEGRRIASKPTGYKEEIHKILGLRGLPNPASYIEKAIIISQGGLQTLAEILSEPKELRDLLDAALGYALLKQAISNIGDVVLGVSPDGSPVKLGSKSITRLQSGYMTLRNEVLGVDREIREASKRLEELEREREELERRARDLESEAKALQSEIGKLETMEEMLVNVTSMIRSERSKLDTINTRLRYAESKISSIDDLEKRRAELRAKASLAHEVAELARLQSRLDKLGRDLEMIRDAVEKLEVSRRLKEIESARREAENRLLEARSSIKEEQRRYTLLDYRVTRGRSIVTNIRRVLSECRSKDLCGSEKPESVLERLDAVINDLESKARALDQEASALEAEARRLVQALSMLEESGGSARCPVCGAELPPGRAEAIARHYRHEAERLRKAAKEKAAEAEKARAEASRLQDKRRRIELLLSRLNQLEEGLRELGFQTPEDLAKAEQKLRMLRERLEELRKLENSLEEKVRNLSREEVALREAKTRALEVLQRLGIKEEEAREKLKTLSSESKKLERMLVSKAEDLATRLGITAYRSLDDLLEKAREALEGVDKELSAIERRLEEARRLKEEAAKLKWEAEQVMKRLEELEAEEKKLRKEVSRKSEIEARLKEVQNTLAELDDRISRIDREMGELQTRIREMKSRKASGEEALKLYLPAAASRRIMEEIGEIAYRRLLAVLEDEMNDILSRFNLDVAGVEIREKAAREIEVKAIGGNGAYRPLEAVSGGERTVLALSFVLALNKAVGGKLGFLALDEPTANLDEDRRRSLVEVLRGISVEGLVRQLVVVTHHEDVRDYADTICLVTRTQQGSRVECTY

rad50

DNA double-strand break repair Rad50 ATPase

896 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.

Belongs to the SMC family. RAD50 subfamily.

103.436 kDa

MIIDRIRLINFLSHEDSEIFFDTGVNIIVGHNGAGKSSIIDAIRFALFGDKRTKKIEDMIRKGAKSLEVEMEFRHGGHTYIIRRSITRRSKNPESNAMIMVDGSALSQSVKDANDYIEKNIITKSKDVFLNSVFSKQGEMDDLISGDPARRKKLLDEILEIEKLEETYDVLKDVIDSLQAGISNLDYLISENERDRDDLRRYQDDVAELSKQIDQEEAIESDLLRKKEEASAEYNAVSKELIMLDATLKNMMSLSDEANRYEEEIRKIDGKLQEISGSTERYNEITSSKVYASRERIRGYWTDKGQIIDYRKMLKNIDGQVQSYEDNMKKAAELQADHDQYEIMQRRMDEIKHELDDLRTYESKYVSLINEIEQKKKKREEYRKKQKDLGDEISRTLGRAFANASELVAIYEEIRRDIDEINTDLGNLQVKIGALRQKEEEIRRNMNMLEGHNKCPVCGTDLGDEGSRRIREHYSEDLNRLNEEIDHLEREASAIDEKKRQLISMESYLAKGKIREYETYDRQMKDLEAQITDDENSLSTIAYKHTKYEQLDEEYRSMHLEDLRQKYTDWNNAMAVISNIGDIEALRKQKDEVSKKLKDAEDRTHEIESEFPDINSYTPSYIGKIEDEVRLLEPQIKLAEDLKRQRETLREKVKDLRSRSAGMDEIQKRKNELSVKASESETRLKYVEGQIQATLSSLSGKRSKVETLRSHVSEIEQRISDRERDIERMKKIEKAINDVKRIREAFGKNGVPAMIRQSVSDYLTAKTRDYLSSFDLDFDDISVDQDFNVTVYRGGVPEGIDSLSGGEKTAVAFAIRVAVAQFLNADLSLLILDEPTAFLDEERRNSLSDIIEYTLKDSSVIPQVIIISHHRELLASANVAIEVKKIGGRSVVSNAD

rad50

DNA double-strand break repair Rad50 ATPase

895 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.

Belongs to the SMC family. RAD50 subfamily.

103.224 kDa

MIIERIRLRNFLSHSDSDIYFDTGINMIIGQNGAGKSSIVDAIRFALFSDKRTRRTEDMIKKGERYMEVELYFRSEGHSYRIRRTIERRGKSISTDAEIERDGSIITRGASDVSNYVEKNVLNINKDVFLTSIFVRQGEMDALVSKDPAERKKILDEILNIDRLEAGYLLLKEVIDDLTANVSDYDYLKNELQSKINEIDNNNKQIEELESKLRLIEPEIKALEEEINIKENKKDHLNEELHRLNAQLETIKKYEMELAESQSRKASIEMEVVKLPSIEEELKRLENNAAVVKRNEIIEYINLKKDLGSLSEIIEGLKSDLSKYDEAHRKLEDLQSFRSEFLEKKKRKEDLDKLRSSLKEDEDNYQSAVRNIENIKKWIENEEKEIERMSAFISEILKIQEITPEIINSRRAEINSSLMQIEGKIASLNASIDAMRSHKMEVEENAAMLSGRGVCPVCGTHLGTEKSEDLVKHYGEEASRLEEDINKTENEIKKLDEERKHQKKLLDRINGKDVERLIASYNLLSSKRAELKKFMDDEARLKEAHLKAEAAISQYNSIDLGDLEAKNEEWLKANAVISSIDIENIRSRFEEKNKQLNDIIKRMNEIEVNIPDVESYNENSLKRIDEELNSLRNKKNELYAKKAAMDEIQKTIEHFKEEISKKKGIEDSQAEVNAQLLQINDDLKQLSSRLDKINVDQYEWKSLHKVLLQDNEKLNIAVADIRKRLEKKETIIKAIADLKRVREAFSKDGVPAIIRKSASEFITNQTRQYIQRFELDIDDVDVDQDFNITVFRGGIAEGIDSLSGGERMAVAFALRVAIAQFLNKDVSLLVMDEPTAFLDEDRRSDLANIIEYSLKDSSGIPQVIMISHHRELLSASDLALEVKKRNGSSIVDVIR

rad50

DNA double-strand break repair Rad50 ATPase

893 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex (By similarity). In polyploid organisms, the Rad50/Mre11 complex appears to restrain the repair of double-strand breaks by homologous recombination, allowing another pathway to act as the primary mode of repair (PubMed:19593371).

Belongs to the SMC family. RAD50 subfamily.

100.087 kDa

MRFTRIAIRNFKPYEDAELDLRDGVTVIHGVNGSGKSSLLEACFFALYGSKALAGTLEDVVTTGADDAEITLEFVHDGGEYRIDRRVRVSGDRATTAKCVLDGPEGTVEGARDVRRHVASLLRMDAEAFVNCAYVQQGEVNKLINATPSQRQDMIDDLLQLGKLETYRERAGNARLGVEDVLTKKRSVLEDVESQIEAKEDADLHATLNALESELDSLDEEISNYESQRDKAKSALDAAEATLDEHAEKRERLDEIESAIEDLTAKISADETKRDDLSERVRELDAAADELESDIDDALARADLDDASDEAIADAREALSARESELRDDLSEARTRAQAFETQAERLRERADDLESRAEEKREAAEVDAETAAEAERELESFRETRAELRSALDDAEARFEDAPVELGEAADLLEERREARSEARESLAETETELKNARERLAEAERLRDAGKCPECGQPVEGSPHVDAISEREAAVESLEADRESLESAVESRSAAVEAAEALVEVETRASSRRDRLDLVDERIADREETVESRREAAEEKREAAAELDSEAEEKREAATTQAERAEEVAETVDSLESDLDTLDDRRDRLDRVESLVDTRAEKIDARDRLREKRETLAEVNRERREHLRERRERRDELRETVDEEAVEGAKQRKKNAAAYLERVEDEVLPELREKRDDLQSRVGGVEAELEQLDDLRERRDHLAERVDALESVHDEVSTLESTYGDLRAELRQRNVEVLERMLNETFDLVYANDAYSRIRLDGEYGLTVFQKDGTALEPEQLSGGERALFNLSLRCAIYRLLAEGIDGAAPLPPLILDEPTVFLDGGHVSRLVDLVEDMQSRGVKQILIVSHDEDLVGAADDLVRVEKNPTTNRSTVERTDAPIVEGALADD

rad50

DNA double-strand break repair Rad50 ATPase

886 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.

Belongs to the SMC family. RAD50 subfamily.

103.858 kDa

MIIREIRLQNFLSHEDTTVKFEGSINVIIGNNGAGKSSIIDGILFGLFKRTNRDIGKNEELIKKGKKSGQVSIKFEINGDTYLIDRNVGETSRDTISLLKEGKIITLARQSTTVNNKIKEILGFDHKILMSTTIIGQGSVESVFSDFPEVMKELLKINKLEMLRESNGPIHSLIKVLTDRIRSLQSIKDILKREEAEIDRLKKEIEEIKVKLENIEREAKEKEDELNQYNTEFNRIKEIKVQYDILSGELSVVNKKIEEIALRLKDFEEKEKRYNKIETEVKELDENREKINTISSFKSILVQIDSLKSQINVVENDLKRKKEKLKRKKELEEKEKQYEEIEKRKKELEEKEKQYEEIEKRLTYVLKNIERQKNEIEKLNYVDTQDLENKIKDVSDRINQIDNELKGLLDRRGDLNGRKEQTLKIYNNLNSIEDDRCPICGRPLDSEHKAKIREEIKVQLLELNKQITALQARINSLIKEREELEATRNKLQLELQKRSKEKGIYEAKLKELQRLEEEKNKLQNEILSLLSYHQEFENIAEKEKELIDYHEEYLKNSDILEEDIQEQEQRLNELNSKLSELEKSYNDYKAKYQFLPADLKSLVSLEERIRRRISELEKLKIEYERLKEEITRMKGLKEEYEKLKEEEDALLNRISELGYSEKRYKQLEEIIDKLSKILSGIEADKGKIKGSLEEKIKNIEEKERNIEELRNKMNEESKLNLGISKLQKLREVLDNKHLQSHIMNIVRNQIENNVNEVIAKFDLSFSAVEIDFVGKSELYVYTASGQKIHINALSGGERISIALALRLAIAKALMNQFSTLILDEPTVNLDEYRRKELIDVIRSAIEIVPQIILVTHDQELIQAGDYIIRVEKKGDTSKVEVSSYDR

rad50

DNA double-strand break repair Rad50 ATPase

886 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.

Belongs to the SMC family. RAD50 subfamily.

103.635 kDa

MILLKELQIKNFRSHSDSKIEFDTGINLIAGRNGAGKSSILEAILVAFYGLKPATLRKNDLVRVNSSGYSLSLTFSLNGDDYTISRKSNGESILTGKEIVEGDSNITEWVERHLCPAHVFTGAIYVRQGEIDSIIRDDESRERIIRQITRIEDYENAWKNLGAVIRMLEREKERLKEFLSQEEQIKRQKEEKKAEIERISEEIKSIESLREKLSEEVRNLESRLKELEEHKSRLESLRKQESSVLQEVRGLEEKLRELEKQLKEVVERIEDLEKKAKEVKELKPKAERYSILEKLLSEINQALRDVEKREGDLTREAAGIQAQLKKAEEDNSKLEEITKRIEELERELERFEKSHRLLETLKPKMDRMQGIKAKLEEKNLTPDKVEKMYDLLSKAKEEEKEITEKLKKLIAKKSSLKTRGAQLKKAVEELKSAERTCPVCGRELDEEHRKNIMAEYTREMKRIAEELAKADEIEKKLKERLEKVEKALEKQETVLKYRQMVDELKALENELSSHDAEKLSAESEEYRKVKERLDGLRGQQKILLSSASRIKELKSSLREIEEALKNVESERGELHRKIREEGFESLEELEREVQSLRPFYNKWLELKDAESRLESELKRREKLEDEISEAIAKLEEANGKAEEIRGQIDELLRIYSEEEHRRLSDEHLRKSKELAGLKSRLETLRESLQSAEKDLKFLEEQLAKMDEYRKKVEVFEKIAIPELTRIREKFRKYRNLVAENSMREVERYASQIFEELTEGKYSGVRLKKTTERGKEKLKVFVVYQGEEREIGFLSGGEIIALGLAFRLALSMFMIRGKIPLLILDEPTPFLDEERRRKLVDITTNYLRKIPQVIIVSHDEELKDAADKVIFVESQGGVSRVRYVEAQ

rad50

DNA double-strand break repair Rad50 ATPase

883 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.

Belongs to the SMC family. RAD50 subfamily.

102.727 kDa

MKIEKLIIKDFRSHALTKVNFSSGINLIIGQNGSGKSSILDALLVGLYWPSKPKDLKKDDFERINGSGTEITVFFEKGNVKYQIHRNIGRGLAFVKYHDGSSWKTLETGQKPVRDWMEKLVPYDVFLNAIYIRQGEIDAILESDESREKVVRQVLGLDRYENSYKNLLDVRKEIDARIKAIEDYLKSTENIDELIGNLEKELTSVLREINEISPKLPELRGELGGLEKELKELEKTAEELAKARVELKSEEGNLRELEAKKSGIQSMIRETEKRVEELKEKVKELESLEEKAKEYERLSRFYRNFTEGINRIEKLLATYSQQAENLRERIDELSKKEARVKELLKEKEGLQKELGALEEDLKAYQRAKELMANLERLKKRLTLSEEEIEKLEAEIQKARERKEEIMKELEEIGSRRGELKSIAGERNKALMELKKAKGRCPVCGRELTEEHRKELLEKYTAELKEISAEMKELEKREKKLRAELVEVEKTLKKERELFALKEVLEQIRETEEKLKEYDLEKLEEANEKAEELKKKLAGLEGEIKSLEDEIKKGELLKKKLALVEKKLRELEEERASLLGELKKLGFGDVKELEERLKELEPAYKRYIELRPARDELKREEDLLKSLKLDLTAILKEIEKTSKRVEELRKRVEELEKSYDKDRHEELKGKTRELSNELAGLEARLKSLEERRDEVKASLEKLREEKETRKEKAKELEKLKKARERVQRLREKVKAYKNLLKEGALAKVGEMASEIFEELTEEKYSGVTVKAEENKVRLGVVYNGKEYGLGFLSGGERIALGLAFRLALSLYLAGEISLLILDEPTPYLDEERRRRLVDIMQRYLRKIPQVIVVSHDEELKDAADRVIRVSLENGVSVVREAEVG

rad50

DNA double-strand break repair Rad50 ATPase

883 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.

Belongs to the SMC family. RAD50 subfamily.

96.97 kDa

MRFTRLSLSNFKCYADAAVSLDPGVTVIHGLNGSGKSSLLDACFFALYGTTALDTTLADAVTIGAETAEIDLHFEHAGGDYHVHRRIRASGGRAQTAACVLETPTDRIDGVTDVEAHISGLLRMDAEAFVNCAYVRQGEVNKLINAAPSTRQDMIDALLQLGKLEEYRQRAGDARLGVEDVKSNVEGQLDRLADQIADKEAADPHDRLASHNTALAEVTADIEHFEAEREQARQTRDDAADVLERYEESRTALADVEETIADVREAVAEAERERETLADRVSDHRERASDLDDEAAALAADLGLDDPDAEDASAERDAVADQREAVAERVREVAPAVSRLTEQADSAADDAATLDERAETLREEAAALDAEADDAAAKRDDAAARIEALDADIEAAMAAFDDAPVAFGAAEAFLDDATAERDELRERVATLRADRQSAADRVAEAEALLDEGKCPECGQPVEGAPHVERVTDDRERVAELDAELADVEDELDAVAQRVDRGESLVAAEDRVDDLEQQRERAVERRDEQADIADAKRDQAAEKRDRAADLDAEAEDARADAAAKRDAADEKRETLAALNADQTALKERLDALADLVDRLEAAADAREAAQRLAEKRAALAAQNEQRRDRLSELRERKRTLDSEFDADRIETARADKDRAEDYLEQVEPKLQALREDRDDLQAKIGAAENAIAELESLREEHERVQSRHQDLQAVHDEVTALETMYGELRAELRQQNVSKLERLLNETFELVYQNDSYARIELSGEYELTVYQKDGEPLEPAQLSGGERALFNLSLRTAVYRLLAEGIEGDAPLPPLILDEPTVFLDSGHVSQLVELVESMRRLGVEQIVVVSHDDELVAAADDVVRVAKDATSNRSRVSTPEHI

rad50

DNA double-strand break repair Rad50 ATPase

882 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair (PubMed:11029422, PubMed:18957200). The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA (PubMed:18957200). Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex (PubMed:24493214). The ATP-bound conformation promotes DNA end binding and end tethering, and alters Mre11 nuclease activity (PubMed:24493214). ATP hydrolysis promotes both Mre11 activity as well as HerA/NurA activity (PubMed:24493214). Has also reversible adenylate kinase activity (PubMed:17349953).

Belongs to the SMC family. RAD50 subfamily.

103.84 kDa

MKLERVTVKNFRSHSDTVVEFKEGINLIIGQNGSGKSSLLDAILVGLYWPLRIKDIKKDEFTKVGARDTYIDLIFEKDGTKYRITRRFLKGYSSGEIHAMKRLVGNEWKHVTEPSSKAISAFMEKLIPYNIFLNAIYIRQGQIDAILESDEAREKVVREVLNLDKFETAYKKLSELKKTINNRIKEYRDILARTENIEELIKENEQELIQVLQEISKIEEVLPSKRSKVDMLRKEVLRLEETKVEIENSERLLEKRRGDKRTLEERIKNTEEYLEKLKEKEKELEEQVKEITSIKKDVDAYLALKEFKNEYLDKKYKIEKELTRVEELINEIQKRIEELNEKESEKEKLENEKKEILNKLAILEKDHQLYEEIKAKKENLRQLKEKLGDKSPEDIKKLLEELETKKTTIEEERNEITQRIGELKNKIGDLKTAIEELKKAKGKCPVCGRELTDEHREELLSKYHLDLNNSKNTLAKLIDRKSELERELRRIDMEIKRLTPLLTVAEQIRSIEEELNVVNLEKIEKNATEYEKLLEELRTLEGRIRGLAEDLKKLAPLEKKLAALIHKKQELEKELKELNTKLESFGFKSVEDLDSKLRELEEIYKRYLTLLNSKKELEITQREIAKAKETLEMSFEELAEVEADIERIEKKLSQLKQKYNEEEYKKKREEKEELEKELARLEAQKKELEKRRDTIKSTLEKLKAEKENRERVKKEIKDLEKAKDFTEELIEKVKKYKALAREAALSKIGELASEIFAEFTEGKYSEVVVRAEENKVRLFVVWEGKERPLTFLSGGERIALGLAFRLAMSLYLAGEISLLILDEPTPYLDEERRRKLITIMERYLKKIPQVILVSHDEELKDAADHVIRISLENGSSKVEVVS

rad50

DNA double-strand break repair Rad50 ATPase

880 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.

Belongs to the SMC family. RAD50 subfamily.

103.971 kDa

MKIEEVKVYNFRSHEETVVRFRKGINLIIGQNGSGKSSLLDAILVGLYWSKKLRLRGLKKDEFRRIGGKGGTRIEIKFENDDSKYVLFRDFSRNVAYLKVQENGKWRHASEPSMESVSSYIERILPYNVFLNAIYIRQGQIDAILESDETRDKVVREILNLDKLESAYENLKRIKTNINLLIESKKSFIARTENIEELIKANEDELTKKLSEINEISSKLPPIRGELEKVRENVKELESIKGKISELKIQVEKLKGRKKGLEEKIVQIERSIEEKKAKISELEEIVKDIPKLQEKEKEYRKLKGFRDEYESKLRRLEKELSKWESELKAIEEVIKEGEKKKERAEEIREKLSEIEKRLEELKPYVEELEDAKQVQKQIERLKARLKGLSPGEVIEKLESLEKERTEIEEAIKEITTRIGQMEQEKNERMKAIEELRKAKGKCPVCGRELTEEHKKELMERYTLEIKKIEEELKRTTEEERKLRVNLRKLEIKLREFSVMRDIAEQIKELESKLKGFNLEELEQKEREFEGLNEEFNKLKGELLGLERDLKRIKALEGRRKLIEEKVRKAKEELENLHRQLRELGFESVEELNLRIQELEEFHDKYVEAKKSESELRELKNKLEKEKTELDQAFEMLADVENEIEEKEAKLKDLESKFNEEEYEEKRERLVKLEREVSSLTARLEELKKSVEQIKATLRKLKEEKEEREKAKLEIKKLEKALSKVEDLRKKIKDYKTLAKEQALNRISEIASEIFSEFTDGKYSNVIVRAEENKTKLFVVYEGKEVPLTFLSGGERIALGLAFRLALSMYLVGRIDLLILDEPTPFLDEERRRKLLDIMERHLRRISQVIMVSHDEELKDAADYVIRLRLEGGKSKVEVVS

rad50

DNA double-strand break repair Rad50 ATPase

879 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.

Belongs to the SMC family. RAD50 subfamily.

103.674 kDa

MKIERVIVQNFRSHKNSEIEFKPGINLIIGQNGAGKSSLLDAILVGLYWSKRMRLRGLKKDEFTRTGTRGAIIEITFEEDGTKYKVLRDFARNVSYLKRLDGREWRHVTETSMESVSSFIDRIIPYNVFLNAIYVRQGQIDAILESDETRDKIVKEILNLDKLEKAYDNLGKIRKYIKYSIEEKEKFIMKTENIEDLIRTQEKSFTEVLNEIRNISSNLPRLRRELEGIKEEVKTLEATFNSITELKLRLGELNGKKGRLEERIRQLESGIEEKRKKSKELEEVVKELPELEKKETEYRRLIEFKDEYLVKKNELEKRLGILSNRLQEVKRKIKDAESKVARIRWIEERLKEIQEKIMKLEPRVREFEDAMRLKAQMESLKSKLGGLEPEKINEKLLYLENRKKELEEEIDKITRKIGELNQRSKDRRLAIIELKKARGKCPVCGRELTEEHKADLLRKYSLELSSIEKEIQEAKALERQLRAEFRKVENELSRLSSLKTIADQIIEIRERLSKINLEDLKRDKEEYELLKSESNKLKGEVESLKKEVNELNDYKNESTKLEIEIDKAKKELSEIEDRLLRLGFKTIDELSGRIRELEKFHNKYIEAKNAEKELRDILESLKDEREELDKAFEELAKIETDIEKVTSQLNELQRKFDQKKYEEKREKMMKLSMEIKGLETKLEELERRRDEIKSTIEKLKEERKERESAKMELEKLNIAIKRIEELRGKIKEYKALIKEEALNKIGEIASEIFSEFTDGKYSGIAIRAEDNKVKLFVIYDGVERPLTFLSGGERIALGLAFRLAMSMYLIGKVDLLILDEPTPFLDEERRRKLIEIMERHLRKISQVIIVSHDEELKDAADHVIRIRLEGGASKVEVVS

rad50

DNA double-strand break repair Rad50 ATPase

879 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.

Belongs to the SMC family. RAD50 subfamily.

103.488 kDa

MIIRRIDIENFLSHDRSLIEFKGTVNVIIGHNGAGKSSIIDAISFSLFRKSLRDAKKQEDLIKRGAGRATVTLYLENKGKIYVIKRNAPNQYTSEDTISELTNDTRRTIARGATTVSQKIKELLNLDEEVLKSTIIVGQGKIESVFENLPDVTKKILKIDKIEKLRDSNGPIKEVMDKINNKIIELQSLEKYKNESENQKIQKEKELENIKRELEDLNIKEEKERKKYEDIVKLNEEEEKKEKRYVELISLLNKLKDDISELREEVKDENRLREEKEKLEKDILEKDKLIEEKEKIIEAQNKIKLAQEKEKSLKTIKINLTDLEEKLKRKRELEEDYKKYIEIKGELEELEEKERKFNSLSDRLKSLKIKLSEIESKISNRKISINIEELDKELQKLNEDLNNKNQEREKLASQLGEIKGRIEELNKLLGNLNQVKGNVCPVCGRELSDDHKRKIQNEIIEKLKELDELNKKFKLEINKINGLISELNQIINKKSKEKDIAIRNLADYNNLLTQQQELRKEIEEIENEIERLSIYHEKYIRLKEEEKNLKPKYEEYLKYYDVTEEKIRELERQKIELEKEIEEIMNKVREYYNTDLTQKIRDIEKRIQEIKGKENKLRELDTLLAKIETAKQKIKQNEEEIKKLTDELQLLNFDPNRFQQIKREKEVLEKILGEINSKKGELLGKKEVLENDIKRLEEQIKDYEEKLKNKQKLITAYDKLKKLREHLAEDKLQAYLMNTVKSLVEDSLNSILSRFELSFTRVEVDFNDKNGIYAYTTSGQRLPVNLLSGGERVSIALALRLAIAKSLMNEVGFLILDEPTVNLDEYRKKELIDIIRSTVEVVPQIIVVTHDEELLQAGDYIIRLEKRGDSSKVEVINND

rad50

DNA double-strand break repair Rad50 ATPase

876 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.

Belongs to the SMC family. RAD50 subfamily.

103.706 kDa

MIERVKIENLRSHSSTEIEFREGINVLVGPNGAGKTTVLEAITLALFPRTFRSYDHMIREGERRAVVEVVFWGADGHKYKVRREFYRGGGQRNPRLYREEGDGWKVVASGRAEDVDREVMNALGGVDRDVFREAVYIRQGEIAKLVEATREERKRIVDRTLGLAEFKKAREQAHELLRVAEAKLETFRERVRDLKGSKKELKRVERELEELKREVKELEPEVEELKERLNELREAKREFERLEGELRLLENKIESLKGRRDDLRKLVEEGKEAERELQRLGDVPSKVRELENEEAELRRRIEELRNLLDDLRSLRNRLESAEEELEGVKRELEELKDEAGVDPERLVEFKDKIVEASERLRDLRREEELKRKLEKVSDELSELGDREETLQSEYEELQERLDEIQGELKEIRVKEKELLERIESLREAEGECPVCLRKLPRERAEKLLRDAEKELERLQGREEDLRKERRELKDRLESVRRELEGTKERMWRLRERREELERELEEIEELKEELADLSRELGVEEDRLPELRDLAVRAESLLRDLERRRGDVLRLEKELERTLDRCEKVIGRTPSGVEDVEEELRRLEEERDHVGQKLREAEGELERYHNLEEKVKRAREARKELKRIERDLEDAKGRLEQVERNLEGLRERYGSEDRLEEELESVEKKYERVRDKLSEVKGRLNGMEKRREELKKQVRKYREAKERKERLERVVEVLSLCKEVFRYSRDVAREKVLPAVEREASKILQDLSDRYGSLRIEDDGAVIRVSVPGGHFIEADRMSGGEKIIIGLALRLALAMVGSSFAPFIMLDEPTVHLDAEHRERLAQALRELDLGKGRVRQAIVVTHDEELEDAADELWRIENRAGESRVERYSG

rad50

DNA double-strand break repair Rad50 ATPase

864 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.

Belongs to the SMC family. RAD50 subfamily.

101.602 kDa

MRIDKITLTNFLSHEHSEIQFMGEINVIVGQNGAGKSSIIDGIVFSLFRTHSRGNNDNLIRKGSNRGSVTLYLSNEKDKIEIIRDIRSTTEDRLIRNQFPIARSATVVSNEIEKILGIDKDIALSTIIVRQGELDKILENFQEIMGKILKLELIEKLIDSRGPIVEFRKNLENKLRELDRIEQDYNNFKKTVEEKRARVLELKKDKEKLEDEIKNLEKRIKDIKDQFDEYEKKRNQYLKLTTTLKIKEGELNELNRSIEELRKQTENMDQLEKEINELENLRNIKLKFEKYEVLAKSHTEMSANVINLEKEIEEYEKAIRRKEELEPKYLKYKELERKLEELQPKYQQYLKLKSDLDSKLNLKERLEKDASELSNDIDKVNSLEQKVEETRKKQLNLRAQLAKVESLISEKNEIINNISQVEGETCPVCGRPLDEEHKQKIIKEAKSYILQLELNKNELEEELKKITNELNKIEREYRRLSNNKASYDNVMRQLKKLNEEIENLHSEIESLKNIDEEIKKINEEVKELKLYYEEFMRLSKYTKEELDKKRVKLDEMKKKKEEIEKEMRGLESELKGLDRKALESKILDLENKRVKLDEMKKKKGILEDYIRQVKLLQEEVKNLREEVNIIQFDENRYNELKTSLDAYNLSLKEKENRKSRIEGELESLEKDIEEISNRIANYELQLKDREKIINAINKLEKIRSALGERKLQSYIIMTTKQLIENNLNDIISKFDLSIKNVEMEIMPKTGRGRSSSGDILVYTNSGDTLPIVSLSGGERIALSIALRLAIAKALMSNTNFFILDEPTIHLDDQRKAYLIEIIRAAKESVPQIIVVTHDEEVVQAADYVIRVEKRGNKSFVREET

rad50

Probable DNA double-strand break repair Rad50 ATPase

852 amino acids

Involved in DNA double-strand break repair (DSBR). The Rad50/Mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of Mre11 by unwinding and/or repositioning DNA ends into the Mre11 active site (By similarity).

Belongs to the SMC family. RAD50 subfamily.

100.002 kDa

MRPERLTVRNFLGLKNVDIEFQSGITVVEGPNGAGKSSLFEAISFALFGNGIRYPNSYDYVNRNAVDGTARLVFQFERGGKRYEIIREINALQRKHNAKLSEILENGKKAAIAAKPTSVKQEVEKILGIEHRTFIRTVFLPQGEIDKLLISPPSEITEIISDVFQSKETLEKLEKLLKEKMKKLENEISSLQALYTAIWKYLEENDLEVLKSELKTVSEKKKELLKKREELQKEEEQLKRLLEKYRELVKKKERLRVLSLRRNELQKEVIYEQKVKKAKELEPLFREIYLRQREFERFSQELNSREKRYKELESEKEAISKEIPVHRERLSKLEEIGEKIKEELDLLEKVLKASRPLLEQRIRLKENLTRLEEEFRRLVGEKEKREKELLSIEKTENETKNELEKLLDELSILKKDHMKWLAYQIASSLNEGDTCPVCGGVFHGKVEAVEFNIDEFEKLDQKRSELENTLNVLKERKKSLSSLIEDLLMKIEEGKKNLKSIRNQIEKIEEELHRLGYSEDLEEKLDEKRKKLRKIEEERHSISQKITAADVQISQIENQLKEIKGEIEAKRETLKEQREEMDQLKSDFFDRLRKIGIGFEEFRILVKEEVKDAEKELGVVETEIRLLEESLKELESENVRDVSEDYEKVRNQLEALSQEISDLERKEGRLNHLIEETLRRERELKSLEKKLKEMSDEYNNLDLLRKYLFDKSNFSRYFTGRVLEAVLKRTKAYLDILTNGRFDIDFDDEKGGFIIKDWGIERPARGLSGGERALISISLAMSLAEVASGRLDAFFIDEGFSSLDTENKEKIASVLKELERLNKVIVFITHDREFSEAFDRKLRITGGVVVNE

rad50

DNA double-strand break repair Rad50 ATPase

837 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.

Belongs to the SMC family. RAD50 subfamily.

97.637 kDa

MIIRSLELKNIRSYESGRVEFDDGVTLFEGDIGSGKTTLLLAVEFALFGLGDQRGDSLLRATSNSGSVKLTFTVDGEEYTVYRELKRGSSGVQQGELYIRKQGVVKKLSAKELKAEVLEILGYREPLNPRARSRIYRYAVFTPQEQMKSIIEAPKNDRLERLRKAFDLEKYSRAADNANLVSRRIRRESESLEDRSYDLEDKKRELEGLLGEKEKLESEKKQLDSDIEGIEAEIAKLKSEMEVLQREKNRIESAEREIESLQNEIETLRSSSERLMERNRSIEEEYRRSLDELQKCSDIREKLQEELNSLGERISALELKRESLMDDSRRFREASIQYRNLVSELENLIKTGRDLEDEISGLEDYTDRIKSKIESMESIEDPGYTEDEVEAGIRKLEVEVSDLQQELGGIHGKIEDYESIGRRGVCPTCDQEVNPDYINDKLSSARERKGSVESRIADLRNEIMNKNELMKRIAEYKRSREELRLLREDLEKRIKECHRRRESLDNIRERIRQIEEGKAESEKLIEELKDAESDFNKVEHELKSLREMESGYSSKLAAASGRMDQLRTRITELNPETSREYRDNLKKIDENESNIAEKRAKIRENEEALKNRDEVESSIHDLTQSICEMENLRDEKRDRRAAVEGKIEEKQRQIGNLESEIAKKRELRKRARELGNYVTWLNEYFIPAMDDIETHVMAQINHEFNERFQKWFRVLVDDPGKSVRIDEDFTPIVEQDGYEQNLEYLSGGERTSIALAYRLALNMVVQRLTDVRSDILILDEPTDGFSKEQLYKLRDIFDELESRQIILVSHEEELENLADHIYRVEKSDGTSIIEKTG

rad50

DNA double-strand break repair Rad50 ATPase

786 amino acids

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.

Belongs to the SMC family. RAD50 subfamily.

93.236 kDa

MVIVKKVILNNVKTHSKREFDFEKGINLILGPNGSGKTTLVESIFLALFGGDFARVIDYFKKGEKTMAITLILEDKGKTYRIRRKWVLENNAKLVESSLELIDTIPKKLASDHNKLLQQIKHLFGLDKKIIPLIYYKQNEITKIIEMDPRKRKEWFDEILGIKDLEEFSEKLKMAIKLIKTGKISRIEDRIKLLKAELNKKSLLENKLKNYKEKLVLLSNELENLEKEYKILENQYKEYLELKAKLKSIEGQINNINVKEIESKINNIREELNNIEELTDYEKDILSKKHEIIRCNEIKNRLKELEKEIKDYDKIKKEFLEIESKYKQYEEKRLEYEKAKMLEKEKEKAKREYSYLLKEKESLEKEIAELQNKINQIKELEKMEQELLEIQERIGVIKAKLKLLENIKDRCPLCGAKLSSDTIEHLQKEREKLQKEYYYLKEKYNQLLIKIRALEKYKGLEKVLEAKTKHLETIENRLKEIKPIIELEIPKIELDESIPYKYKQLLNKVSYLEAKIKEYERYKNIECPYDIAIEELKRIEDKYNKYIKKPALERELNLLLKELERYNSLLKEKEEILSKLNPEIETKYKELTKKKENLLSEISKVKGIIKEIESQIKEIEKHESTIKQLEEKKRKWEKLVEKLNRIVKALGRDGIPKALREGAINYINDMANIYLREFTDKYKLKVNNDLSIYAIPIDNPHYEIEAKNLSGGEKVVFSLSIALAIISWLSLQNMFMVLDEPTANLDNERTLALRKTFDKLEKMVEQAIIVTHNELLDTGENHVVRL