Involved in DNA double-strand break repair (DSBR). The Rad50/Mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of Mre11 by unwinding and/or repositioning DNA ends into the Mre11 active site (By similarity).

Belongs to the SMC family. RAD50 subfamily.

978 amino acids

MRPLKLEVKGFTVYKKPQVIDFTPLKFFVIQGKTGAGKTSIIDAITYALYGKVPRYGASVATKYVLSRGEKELKVALDFSLRGRNYRVERYYREFPEDSQVRVYEEGRRLNIKANEVEKWLFKISGLDYKTFTKVILLPQGEFDRFLKESSERKKILINLLGLEELEKVRQLASETFKNLEGKREALKKEYELLKDYTPTKKEVLEKTLKNLEEELKELKETEEKLRQELKKAEEKDSLERELSQVVTKLKELENLEKEVEKLREKLEFSRKVAPYVPIAKRIEEIDKKLTELKVRKNKLTKELAVLKDELSFAQEELNRIEAEKEKFKEEKEREKELEHRLKKLQEIKEILKELSQLSSSLKEKEREYEQAKQEFEDLSERVEKGKKLVAETEEKLEKIKELFSEEEYTSLKMKERLLVELQRKLKELKEKEGQLENLTQKYKEKKKVHEKVLNELKELERELKERELHYHAHMVASYLSPGDTCPVCGGIYRGKALENVDAEGISELKHAKELKEKEEREIDTTLKLYAQKINSLKEEMEKLRNEVEELRKEIPENLKERIKKLEELRIEKEKLEHKLNKYRKALEDRQKQKEEAQAKLHKAQTELELLKEKIREKSRLVKEFKELYRVERLEDYEESLKEEINYINSKLQEIEEKEKKLRKHFEELSSRKSKLEGELSALNESINSLEEERKEKLKELANIYEVAKSPREVVELYLGDKEAELERKIKEFEESFQSLKLKKSEIEEKLKEYEGIRELSDIKGEYESVKTQLEEKHKKLGEVKRELEHLGERLKRKEELQKEISELEKKLEVYRVISNDFRGDRFQKYVSEIMLQKVVDRASEYFYKFTGNYFFELERATKGRDKDIVVVESSTSQRRPVSSLSGGETFLASLSFAFAVSDLLSGSANLESLFIDEGFGSLDQDMRERVSEILEAIKTNVNKMIGIVSHIPDFAERFTERIVVEKKGDYSEVRVIY

115.9 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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