About Products Protein Database Contact

mapkap1

Gene
MAPKAP1
Protein
Target of rapamycin complex 2 subunit MAPKAP1
Organism
Bos taurus
Length
522 amino acids
Function
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex (By similarity).
Similarity
Belongs to the SIN1 family.
Mass
59.125 kDa
Sequence
MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGETQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQELKSLFEKKSLKEKPPNSGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRKGSQKISGPQYRLEKQSEPNVAVDLESTLESQSAWEFCLVRENSSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTSQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVLKVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ
Protein
Target of rapamycin complex 2 subunit MAPKAP1: MAPKAP1

Gene
MAPKAP1
Protein
Target of rapamycin complex 2 subunit MAPKAP1
Organism
Gallus gallus
Length
522 amino acids
Function
Essential component of the TORC2 complex, which plays a critical role in AKT1 'Ser-473' phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization. May interact with a MAP kinase. May act on Ras-regulated pathways (By similarity).
Similarity
Belongs to the SIN1 family.
Mass
59.221 kDa
Sequence
MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKFNPSSTYGDSASETQGSNGETQGYVYSQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNVQWKDRNTSYSAEELSSLFEKKNFRVRSPCSGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHANQDKLQPMTVVTIANAKVHDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLAAKQSLFVRINAAHGFSLIQVDSMKVTMKDILQKALKRRKGSQRGSGPQYRLEKQSEPNVPVDLDCTLESQSTLEFCLVRENSSRGEEISEEDPQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKASTKFWIKQKPISIDSELLCACDLVEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVLKVNYILESRASTARAEYFAQKQRKLNRRTSFSFQKEKKSGQQ
Protein
Target of rapamycin complex 2 subunit MAPKAP1: MAPKAP1

Gene
MAPKAP1
Protein
Target of rapamycin complex 2 subunit MAPKAP1
Organism
Homo sapiens
Length
522 amino acids
Function
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex.
Similarity
Belongs to the SIN1 family.
Mass
59.123 kDa
Sequence
MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGETQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQELKSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRKGSQKVSGPQYRLEKQSEPNVAVDLDSTLESQSAWEFCLVRENSSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVLKVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ
Protein
Target of rapamycin complex 2 subunit MAPKAP1: MAPKAP1

Gene
Mapkap1
Protein
Target of rapamycin complex 2 subunit MAPKAP1
Organism
Mus musculus
Length
522 amino acids
Function
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Isoform 1 is involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex.
Similarity
Belongs to the SIN1 family.
Mass
59.009 kDa
Sequence
MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKTHPPSVPGDSGSEVQGSSGETQGYIYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQELKSLFEKKSLKEKPPSSGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRKGSQKISGPQYRLEKQSEPNIAVDLESTLESQNAWEFCLVRENSSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKASTKFWIKQKPISIDCDLLCACDLAEEKSPSHAVFKLTYLSSHDYKHLYFESDAATVSEIVLKVNYILESRASTARADYLAQKQRKLNRRTSFSFQKEKKSGQQ
Protein
Target of rapamycin complex 2 subunit MAPKAP1: Mapkap1

Gene
MAPKAP1
Protein
Target of rapamycin complex 2 subunit MAPKAP1
Organism
Pongo abelii
Length
522 amino acids
Function
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex (By similarity).
Similarity
Belongs to the SIN1 family.
Mass
59.138 kDa
Sequence
MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGETQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQELKSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRKGSQKVSGPQYRLEKQSEPNVAVDLDSTLESQSAWEFCQVRENSSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVLKVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ
Protein
Target of rapamycin complex 2 subunit MAPKAP1: MAPKAP1

Gene
Mapkap1
Protein
Target of rapamycin complex 2 subunit MAPKAP1
Organism
Rattus norvegicus
Length
522 amino acids
Function
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-421'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex (By similarity).
Similarity
Belongs to the SIN1 family.
Mass
59.043 kDa
Sequence
MAFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKTHPPSVPGDSGSEVQGSSGETQGYIYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQELKSLFEKKSLKEKPPSSGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKALKRRKGSQKISGPQYRLEKQSEPNIGVDLESTLESQNAWEFCLVRENSSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKASTKFWIKQKPISIDCDLLCACDLAEEKSPSHAVFKLTYLSSHDYKHLYFESDAATVSEIVLKVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ
Protein
Target of rapamycin complex 2 subunit MAPKAP1: Mapkap1

Gene
MAPKAP1
Protein
Target of rapamycin complex 2 subunit MAPKAP1
Organism
Ovis aries
Length
522 amino acids
Function
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex (By similarity).
Similarity
Belongs to the SIN1 family.
Mass
59.175 kDa
Sequence
MGFLDNPTIILAHIRQSHVTSDDTGMCEVVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGETQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQELKSLFEKKSLKEKPPNSGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRKGSQKISGPQYRLEKQRQPNVAVDLESTLESQSAWEFCLVRENSSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTELQLGISGDKVEIDPVTSQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVLKVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ
Protein
Target of rapamycin complex 2 subunit MAPKAP1: MAPKAP1

Gene
mapkap1
Protein
Target of rapamycin complex 2 subunit MAPKAP1
Organism
Xenopus laevis
Length
520 amino acids
Function
Essential component of the TORC2 complex, which plays a critical role in akt1 'Ser-473' phosphorylation, and may modulate the phosphorylation of pkca and regulate actin cytoskeleton organization. May interact with a MAP kinase. May act on Ras-regulated pathways (By similarity).
Similarity
Belongs to the SIN1 family.
Mass
59.223 kDa
Sequence
MAFLDNPLIILAHIRQSHVTSDDTGMCEMVLIDHDIDLEKLYQSSVPGENSTQMQSNGGETQGYVYSQSVDITSSWDFGIRRRSNTAQKLERLRKERQNQIKCKNVQWKDRNTSHSAEELGSLFERKNFKERDLNHGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLSMQTSQDKLLPMTVVTIANAKVHDLIGLICWQYTTESREPKLNDNVDAFCLHIAEDDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLAAKQSLFVRINAAHGFSLIQVDSTNVTMQEILEKALKRRKGSQRNSGPQYRLEKQSQPNVPVDLDSTLESQNSLEFCLVRENSSRGEEHPEEETQIDIATVQDMLSSHQYKSFKVSMIHRLRFTTDVQLGISGEKVEIDPVTNQKTSTKFWIKQKPISIDSDLLCACDLAEEKSPSHAMFKVTYLSNHDYKHLYFESDAATVNEIVLKVNYILESRASTARADYFAQKQRKLTRRTSFSFQKEKKTG
Protein
Target of rapamycin complex 2 subunit MAPKAP1: mapkap1

Gene
mapkap1
Protein
Target of rapamycin complex 2 subunit MAPKAP1
Organism
Xenopus tropicalis
Length
520 amino acids
Function
Essential component of the TORC2 complex, which plays a critical role in akt1 'Ser-473' phosphorylation, and may modulate the phosphorylation of pkca and regulate actin cytoskeleton organization. May interact with a MAP kinase. May act on Ras-regulated pathways (By similarity).
Similarity
Belongs to the SIN1 family.
Mass
59.129 kDa
Sequence
MAFLDNPLIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKLYQSSVSGENSTQMQSNGGETQGYVYSQSVDITSSWDFGIRRRSNTAQKLERLRKERQNQIKCKNVQWKDRNTSHSAEELSSLFERKNFKERALNQGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLSMQTSQDKLLPMTVVTIANAKVHDLIGLICWQYTTEGREPKLNDNVDAFCLHIAEDDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLAAKQSLFVRINAAHGFSLIQVDSTNVTMRDILEKALKRRKGSQRNSGPQYRLEKQSQPNVPVDLDSTLENQNSLEFCLVRENSSRGEEPPEEETQIDIATVQDMLSSHQYKSFKVSMIHRLRFTTDVQLGISGEKVEIDPVTNQKTSTKFWIKQKPISIDSDVLCACDLAEEKSPSHAMFKVTYLSNHDYKHLYFESDAATVNEIVLKVNYILESRASTARADYFAQKQRKLTRRTSFSFQKEKKPG
Protein
Target of rapamycin complex 2 subunit MAPKAP1: mapkap1