Essential component of the TORC2 complex, which plays a critical role in akt1 'Ser-473' phosphorylation, and may modulate the phosphorylation of pkca and regulate actin cytoskeleton organization. May interact with a MAP kinase. May act on Ras-regulated pathways (By similarity).

Belongs to the SIN1 family.

520 amino acids

MAFLDNPLIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKLYQSSVSGENSTQMQSNGGETQGYVYSQSVDITSSWDFGIRRRSNTAQKLERLRKERQNQIKCKNVQWKDRNTSHSAEELSSLFERKNFKERALNQGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLSMQTSQDKLLPMTVVTIANAKVHDLIGLICWQYTTEGREPKLNDNVDAFCLHIAEDDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLAAKQSLFVRINAAHGFSLIQVDSTNVTMRDILEKALKRRKGSQRNSGPQYRLEKQSQPNVPVDLDSTLENQNSLEFCLVRENSSRGEEPPEEETQIDIATVQDMLSSHQYKSFKVSMIHRLRFTTDVQLGISGEKVEIDPVTNQKTSTKFWIKQKPISIDSDVLCACDLAEEKSPSHAMFKVTYLSNHDYKHLYFESDAATVNEIVLKVNYILESRASTARADYFAQKQRKLTRRTSFSFQKEKKPG

59.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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