IFNAR2

Interferon alpha/beta receptor 2

536 amino acids

Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Mediates signal transduction via its association with the TYR kinase, JAK1.

Belongs to the type II cytokine receptor family.

60.261 kDa

MLLSQNVSAIGPLNLYPMVHISLVFGISYVVPDLSDESCTLKMRFRNFQSILSWELKNRSIVPTHYTLWYTIMSKPEDMKVVKDCINITRSFCDLTDVWVNRTDMYISQVVGYRENAVVVSCMGSFFLASDKPLDPPKFEIVDFTNNISVNVKFRLDSPRIPSEELQFYLAFIEEHAGNSVKRHQPQITGNITENFNYVIDKLIPNTNYCISVYFEPKDPRKINRSPLKCILFRPRRESESSEPATIGGILILFLLAAVCISTVMILKRIGYICLRNDFPEALNFYKLSVWVFPELPPLEKMATVEVIHITRKKKEWNYNYDDESDIENEVAPRVNSGGYTKHGLTGRLCPTSTTAASLEDCSLEDCSLEDCSDPSAEEPYLPEPKRDAETPAAPGPGPWQSEGTGGGYQTRGTLWQDPTSEEDSDSTEGSEGRIVFNVNLNSVCVRALEDDKDSEVTLMSPSPPEETAVLEEDLSETESSLLVASEEGTQLPFTDPSMECLRPQDALSDKSDTSESDVDIGDGYIVRQVNLKNFN

IFNAR2

Interferon alpha/beta receptor 2

530 amino acids

Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Mediates signal transduction via its association with the TYR kinase, JAK1.

Belongs to the type II cytokine receptor family.

59.584 kDa

MLLSQNVSAIGPLNLYPMVHISLVFGISYVAPVLSDEHCTLKMRFRNFQSVLSWELKNHSIVPTHYTLWYTIMSKREDMKVVKDCINVTRSFCDLTDVWVNTTDMYIPQVVGFRENAKLVICMGSFFLVPDKPLDPPEFEIVGFTNHISVNVKFQFDSPGILSEELQFYLAFIEEHAGNSVKRHQPQITGNITKNFNYVIDKLIPNTNYCISVYFEPKDPRKINRSPLKCTLFRPRRESESSESATIGGIITLFLITAVFISTVMILKRIGYICLRNDFPKVLNFYKLSVWVFAELPPLEKVATVEVIHVNRKKKVWNYNYDDENDIENEAAPHLISGGYTKHGLTGKLCPTSTTSPSLEDCSLEDCSEPSAEEPYLPEPKGDAETPMAPGPGLWQSEGTSGGYQTRGTLWQDPTSEEDSDSTEGSEGRIVFNVNLNSVCVRALEDDKDSEVTLMSPSCPEETVELEDLNETESSVLVASEEGTQLPFTNPSTECPRPQDAPSDKSDTSDPDVDMGDGYIVRQVNLKKFN

IFNAR2

Interferon alpha/beta receptor 2

515 amino acids

Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950).

Belongs to the type II cytokine receptor family.

57.759 kDa

MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHSIVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLFSCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKKHKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAESAKIGGIITVFLIALVLTSTIVTLKWIGYICLRNSLPKVLNFHNFLAWPFPNLPPLEAMDMVEVIYINRKKKVWDYNYDDESDSDTEAAPRTSGGGYTMHGLTVRPLGQASATSTESQLIDPESEEEPDLPEVDVELPTMPKDSPQQLELLSGPCERRKSPLQDPFPEEDYSSTEGSGGRITFNVDLNSVFLRVLDDEDSDDLEAPLMLSSHLEEMVDPEDPDNVQSNHLLASGEGTQPTFPSPSSEGLWSEDAPSDQSDTSESDVDLGDGYIMR

Ifnar2

Interferon alpha/beta receptor 2

513 amino acids

Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 2 and isoform 3 may be potent inhibitors of type I IFN receptor activity.

Belongs to the type II cytokine receptor family.

56.578 kDa

MRSRCTVSAVGLLSLCLVVSASLETITPSAFDGYPDEPCTINITIRNSRLILSWELENKSGPPANYTLWYTVMSKDENLTKVKNCSDTTKSSCDVTDKWLEGMESYVVAIVIVHRGDLTVCRCSDYIVPANAPLEPPEFEIVGFTDHINVTMEFPPVTSKIIQEKMKTTPFVIKEQIGDSVRKKHEPKVNNVTGNFTFVLRDLLPKTNYCVSLYFDDDPAIKSPLKCIVLQPGQESGLSESAIVGITTSCLVVMVFVSTIVMLKRIGYICLKDNLPNVLNFRHFLTWIIPERSPSEAIDRLEIIPTNKKKRLWNYDYEDGSDSDEEVPTASVTGYTMHGLTGKPLQQTSDTSASPEDPLHEEDSGAEESDEAGAGAGAEPELPTEAGAGPSEDPTGPYERRKSVLEDSFPREDNSSMDEPGDNIIFNVNLNSVFLRVLHDEDASETLSLEEDTILLDEGPQRTESDLRIAGGDRTQPPLPSLPSQDLWTEDGSSEKSDTSDSDADVGDGYIMR

ifnar2

Interferon alpha/beta receptor 2

268 amino acids

Involved in antiviral response. Associates with IFNAR1 to form the type I interferon receptor. In the presence of intracellular IFNAR2 (iIFNAR2) and IFNA1 (iIFN1b isoform), may mediate STAT1 and STAT2 phosphorylation and induction of EIF2AK2, MX1 and RSAD2.

Belongs to the type II cytokine receptor family.

29.459 kDa

MGPWTLLLLHLPLVVSMLPAPTNVSIVSFNLEHTLTWLPGPETPDNTHFTVQSLRKNSWQLVKGCARLKTRQSCDLTNTFKDPFYHYKARVQAITTTQKSNRSLSMLFYPLTDTLLGPPVVSVSGCGNCPLLQVTPPTSRGLQRSLSPTQLYYRQFTCKVRRTRDGSQFSMWVTSTEKTVIGYLEPGAEYCVTVTPSTSFNPHSVPSEPHCAFTSPTAANTVPVVLSVLCAFSLLVVLLCGIVVYSGRLLCMHKPLPKTLSSVPLCGG