Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Mediates signal transduction via its association with the TYR kinase, JAK1.

Belongs to the type II cytokine receptor family.

536 amino acids

MLLSQNVSAIGPLNLYPMVHISLVFGISYVVPDLSDESCTLKMRFRNFQSILSWELKNRSIVPTHYTLWYTIMSKPEDMKVVKDCINITRSFCDLTDVWVNRTDMYISQVVGYRENAVVVSCMGSFFLASDKPLDPPKFEIVDFTNNISVNVKFRLDSPRIPSEELQFYLAFIEEHAGNSVKRHQPQITGNITENFNYVIDKLIPNTNYCISVYFEPKDPRKINRSPLKCILFRPRRESESSEPATIGGILILFLLAAVCISTVMILKRIGYICLRNDFPEALNFYKLSVWVFPELPPLEKMATVEVIHITRKKKEWNYNYDDESDIENEVAPRVNSGGYTKHGLTGRLCPTSTTAASLEDCSLEDCSLEDCSDPSAEEPYLPEPKRDAETPAAPGPGPWQSEGTGGGYQTRGTLWQDPTSEEDSDSTEGSEGRIVFNVNLNSVCVRALEDDKDSEVTLMSPSPPEETAVLEEDLSETESSLLVASEEGTQLPFTDPSMECLRPQDALSDKSDTSESDVDIGDGYIVRQVNLKNFN

60.3 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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