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fuz

Gene
FUZ
Protein
Protein fuzzy homolog
Organism
Homo sapiens
Length
418 amino acids
Function
Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. May regulate the morphogenesis of hair follicles which depends on functional primary cilia (By similarity).
Similarity
Belongs to the fuzzy family.
Mass
45.679 kDa
Sequence
MGEEGTGGTVHLLCLAASSGVPLFCRSSRGGAPARQQLPFSVIGSLNGVHMFGQNLEVQLSSARTENTTVVWKSFHDSITLIVLSSEVGISELRLERLLQMVFGAMVLLVGLEELTNIRNVERLKKDLRASYCLIDSFLGDSELIGDLTQCVDCVIPPEGSLLQEALSGFAEAAGTTFVSLVVSGRVVAATEGWWRLGTPEAVLLPWLVGSLPPQTARDYPVYLPHGSPTVPHRLLTLTLLPSLELCLLCGPSPPLSQLYPQLLERWWQPLLDPLRACLPLGPRALPSGFPLHTDILGLLLLHLELKRCLFTVEPLGDKEPSPEQRRRLLRNFYTLVTSTHFPPEPGPPEKTEDEVYQAQLPRACYLVLGTEEPGTGVRLVALQLGLRRLLLLLSPQSPTHGLRSLATHTLHALTPLL

Gene
fuz
Protein
Protein fuzzy homolog
Organism
Xenopus tropicalis
Length
418 amino acids
Function
Probable planar cell polarity effector involved in cilium biogenesis. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. May regulate protein and membrane transport to the cilium. May control the organization of the apical actin cytoskeleton, which is essential for the normal orientation of elongating ciliary microtubules.
Similarity
Belongs to the fuzzy family.
Mass
46.842 kDa
Sequence
MEDSSVFLLCLAASSGVPLYSRSKGSSRQLTFSVIGSLNGVHMFASNQDVLLTSTCTENTRVAWRAFHDSITLIVMSSESGASKLSLNRLLENVFNAMVLVIGLDDLVNIKNVERLKKDLRACYRLIDSFLLETEKMGDLTQCVDCVIAYDVPILQECLDNFTQAAESNFGCLMAGGKVVVATEKWWRLSSQEVMLLCWLVASLAPHSSRDYPVYLPQGSPTVPHRLLTFQLVPGVDVCVLCGPKPSLQKVETELIERFWKPVHDPIKSCLRVQMRSFPASVPLHHGILGLLLINRDMNKSLYTVQAHPMEEMQKTDLKLTLEQRRSALRSFYTLAMSRYFPSERADGKNTLPSEESFQSGFSHSAHQCYTISSSCKCYGMKTELHLLFLLLKPEVPTFSMRSIANKTIAAFTKDFPF

Gene
fuz
Protein
Protein fuzzy
Organism
Drosophila melanogaster
Length
416 amino acids
Function
Plays a role in the organization of cell polarity via a planar cell polarity (PCP) cascade. Involved in the development of the hairs on the wings. Specify the correct orientation of the hair by limiting the site of prehair initiation to the distal vertex of the wing cells. Controls wing cell hair number by maintaining the integrity of the cytoskeletal components that direct hair development.
Similarity
Belongs to the fuzzy family.
Mass
46.261 kDa
Sequence
MSIYLLCLTTNGGLPVFTRKKGECENLPFSTVASLNGFHMFFKSLGIQLEATTTSKQQPIQNQAPADAEEWTYIWRDRESITLIVCGCGVGSEQLLQTLADLVFGAIGMFITRAAEMAHATLLDRLKKDAKKYVPIVDAILEAACAGTQLLGYTDCLLAAENAQLLQCLNEFSGHCGSLFCCLVVGHRIAVATEGWWDLDTRDRELLLFLLNSSSTMQHDVPVYLPVKSPHIAYRFVSIPVASNSALCVLCGAENASFRELHAHAMSAYRNEGNLLAAAERCVPRSLPEHLEIDGNVLAIILINRHTRKSLFTRNLNQSASVKRIIVGDLQRLDILKKFFDQTMDAVHQFETQSSSNKTTLVDQYSCSDYHKCYAHMDELGNVIFLLFVAAVPSHAMRFLAQRIHANILQEKSVCW

Gene
fuz
Protein
Protein fuzzy homolog
Organism
Drosophila pseudoobscura pseudoobscura
Length
416 amino acids
Function
Plays a role in the organization of cell polarity via a planar cell polarity (PCP) cascade. Involved in the development of the hairs on the wings. May specify the correct orientation of the hair by limiting the site of prehair initiation to the distal vertex of the wing cells. May control wing cell hair number by maintaining the integrity of the cytoskeletal components that direct hair development (By similarity).
Similarity
Belongs to the fuzzy family.
Mass
46.215 kDa
Sequence
MSIYLLCLTTNGGLPVFTRKKGECDNLPFSTVASLNGFHMFFKSLGIQLEATTTSKQPLQAQGSGLADPEEWTYIWRDRNAVTLIVCSSGVGSEQLLQSLADLVFGAIGMFITRASEMAHATLLERLKKDAKKYVPIVDAILEAACAGTQLLGYTDCVLTSDNGQLLQCLNEFSGHCGSLFCCLVVGHRIAVATEGWWDLDTIDRELLLFLLNSSSTLQHDVPVYLPVKSPNIAYRFVSIPVAPNSALCVLCGAENASFRELHMHAMNAYRNEGNVLAAAERCVPRSLPEHLDIDGNVLAIILINRQSRKSLFTRNLHQSASAKRIIVGDLQRLDMLKKFFDQTMETIQQFEANRETTTVLMDQYSCSDYHKCYAYADEQSNVIFLLFVAAVPTHAMRFLAQRVHASILQEKSVCW

Gene
Fuz
Protein
Protein fuzzy homolog
Organism
Mus musculus
Length
415 amino acids
Function
Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:19877275, PubMed:19767740, PubMed:27158779). May regulate the morphogenesis of hair follicles which depends on functional primary cilia (PubMed:20962855).
Similarity
Belongs to the fuzzy family.
Mass
45.588 kDa
Sequence
MGDEGPGSPVHLLCLAASSGVPLFCRSSSGGAPSRQQLPFSVIGSLNGVHMFGQNLDVQLNSARTEDTTVVWKNFHDSITLIVLSSEEGTSELRLERMLHMVFGAMVLIVGLEELTNIRNVERLKKELRASYCLIDSFLGNSELIGDLTQCVDCVIPPEGSAMQETLSGFAEATGTAFVSLLVSGRVVAATEGWWRLGMPEAVLLPWLVGSLPPQAARDYPVYLPHGSPTVPHRLLTLTLLRGLELCLLCGPRPPLGQLDPQLMERWWQPLLEPLRACLPLGPRALPEGFPLHSDILGLLLLHLELRRCLFTMEPSKDKEPSPEQRRRLLRNFYTLVATTHFPPEPGPAEKQEDTVYPAQMPRACYLVLGPGMGWQLVAVQLGLRLLLLLLSPHTPTHGLRSLATRTLQALTPLL

Gene
Fuz
Protein
Protein fuzzy homolog
Organism
Rattus norvegicus
Length
415 amino acids
Function
Probable planar cell polarity effector involved in cilium biogenesis. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. May regulate protein and membrane transport to the cilium. May regulate the morphogenesis of hair follicles which depends on functional primary cilia (By similarity).
Similarity
Belongs to the fuzzy family.
Mass
45.407 kDa
Sequence
MGDDGPGSTVHLLCLAASSGVPLFCRSSSGGAPSRQQLPFSVIGSLNGVHMFGQNLDVQLNSARTEDTTVVWKNFHDSITLIALSSEEGTSELKLERMLHMVFGAMVLIVGLEELTNIRNVERLKKELRASYCLIDSFLGNSELIGDLTQCVDCVIPPEGSVMQETLSGFAEATGTAFVSLLVSGRVVAATDGWWRLGMPEAVLLPWLVGSLPPQAARDYPVYLPHGSPTVPHRLLTLTLLRGLELCLLCGPRPPLGELDPQLLERWWQPLLEPLRACLPLGPRALPDGFPLHSDILGLLLLHLELRRCLFTVEPSKDKEPSPEQRRRLLRNFYTLVATTHFPPEPGPAEKQEDTVHPAQTPRACYLVLGPGMGWQLVAVQLGLRLLLLMLSPQTPTHGLRSLATHTLQALTPLL