Probable planar cell polarity effector involved in cilium biogenesis. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. May regulate protein and membrane transport to the cilium. May control the organization of the apical actin cytoskeleton, which is essential for the normal orientation of elongating ciliary microtubules.

Belongs to the fuzzy family.

418 amino acids

MEDSSVFLLCLAASSGVPLYSRSKGSSRQLTFSVIGSLNGVHMFASNQDVLLTSTCTENTRVAWRAFHDSITLIVMSSESGASKLSLNRLLENVFNAMVLVIGLDDLVNIKNVERLKKDLRACYRLIDSFLLETEKMGDLTQCVDCVIAYDVPILQECLDNFTQAAESNFGCLMAGGKVVVATEKWWRLSSQEVMLLCWLVASLAPHSSRDYPVYLPQGSPTVPHRLLTFQLVPGVDVCVLCGPKPSLQKVETELIERFWKPVHDPIKSCLRVQMRSFPASVPLHHGILGLLLINRDMNKSLYTVQAHPMEEMQKTDLKLTLEQRRSALRSFYTLAMSRYFPSERADGKNTLPSEESFQSGFSHSAHQCYTISSSCKCYGMKTELHLLFLLLKPEVPTFSMRSIANKTIAAFTKDFPF

46.8 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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