esxA

ESAT-6 secretion system extracellular protein A

97 amino acids

Virulence factor that is important for the establishment of infection in the host. EsxA is required for EsxB synthesis as well as secretion and vice versa.

Belongs to the WXG100 family. sagEsxA-like subfamily.

11.036 kDa

MAMIKMSPEEIRAKSQSYGQGSDQIRQILSDLTRAQGEIAANWEGQAFSRFEEQFQQLSPKVEKFAQLLEEIKQQLNSTADAVQEQDQQLSNNFGLQ

esxA

ESAT-6 secretion system extracellular protein A

97 amino acids

Virulence factor that is important for the establishment of infection in the host.

Belongs to the WXG100 family. sagExaA-like subfamily.

11.036 kDa

MAMIKMSPEEIRAKSQSYGQGSDQIRQILSDLTRAQGEIAANWEGQAFSRFEEQFQQLSPKVEKFAQLLEEIKQQLNSTADAVQEQDQQLSNNFGLQ

esxA

ESAT-6 secretion system extracellular protein A

97 amino acids

Virulence factor that is important for the establishment of infection in the host.

Belongs to the WXG100 family. sagEsxA-like subfamily.

11.036 kDa

MAMIKMSPEEIRAKSQSYGQGSDQIRQILSDLTRAQGEIAANWEGQAFSRFEEQFQQLSPKVEKFAQLLEEIKQQLNSTADAVQEQDQQLSNNFGLQ

esxA

ESAT-6 secretion system extracellular protein A

97 amino acids

Virulence factor that is important for the establishment of infection in the host.

Belongs to the WXG100 family. sagEsxA-like subfamily.

11.036 kDa

MAMIKMSPEEIRAKSQSYGQGSDQIRQILSDLTRAQGEIAANWEGQAFSRFEEQFQQLSPKVEKFAQLLEEIKQQLNSTADAVQEQDQQLSNNFGLQ

esxA

ESAT-6 secretion system extracellular protein A

97 amino acids

Virulence factor that is important for the establishment of infection in the host.

Belongs to the WXG100 family. sagEsxA-like subfamily.

11.036 kDa

MAMIKMSPEEIRAKSQSYGQGSDQIRQILSDLTRAQGEIAANWEGQAFSRFEEQFQQLSPKVEKFAQLLEEIKQQLNSTADAVQEQDQQLSNNFGLQ

esxA

ESAT-6 secretion system extracellular protein A

97 amino acids

Virulence factor that is important for the establishment of infection in the host.

Belongs to the WXG100 family. sagEsxA-like subfamily.

11.036 kDa

MAMIKMSPEEIRAKSQSYGQGSDQIRQILSDLTRAQGEIAANWEGQAFSRFEEQFQQLSPKVEKFAQLLEEIKQQLNSTADAVQEQDQQLSNNFGLQ

esxA

ESAT-6-like protein EsxA

97 amino acids

May help regulate assembly and function of the type VII secretion system (T7SS) (PubMed:25865481). EsxA disassembles pre-formed EccC-EsxB multimers, possibly by making EccC-EsxA-EsxB trimers instead of EccC-EsxB-EsxB-EccC tetramers (PubMed:25865481).

Belongs to the WXG100 family. ESAT-6 subfamily.

10.83 kDa

MSDYTRANFGGLSEGEAQFSMTARALLDELTDLEGKLRAKLDRWDGDAQAAYWNYQKEWDAAAKDMQNVVAQLGVAIREAHDNYQAAERANTSIWAG

esxA

ESAT-6 secretion system extracellular protein A

97 amino acids

Virulence factor that is important for the establishment of infection in the host. EsxA is required for EsxB synthesis as well as secretion and vice versa.

Belongs to the WXG100 family. sagEsxA-like subfamily.

11.036 kDa

MAMIKMSPEEIRAKSQSYGQGSDQIRQILSDLTRAQGEIAANWEGQAFSRFEEQFQQLSPKVEKFAQLLEEIKQQLNSTADAVQEQDQQLSNNFGLQ

esxA

ESAT-6 secretion system extracellular protein A

97 amino acids

Virulence factor that is important for the establishment of infection in the host.

Belongs to the WXG100 family. sagExaA-like subfamily.

11.036 kDa

MAMIKMSPEEIRAKSQSYGQGSDQIRQILSDLTRAQGEIAANWEGQAFSRFEEQFQQLSPKVEKFAQLLEEIKQQLNSTADAVQEQDQQLSNNFGLQ

esxA

ESAT-6 secretion system extracellular protein A

97 amino acids

Virulence factor that is important for the establishment of infection in the host.

Belongs to the WXG100 family. sagEsxA-like subfamily.

11.036 kDa

MAMIKMSPEEIRAKSQSYGQGSDQIRQILSDLTRAQGEIAANWEGQAFSRFEEQFQQLSPKVEKFAQLLEEIKQQLNSTADAVQEQDQQLSNNFGLQ

esxA

ESAT-6 secretion system extracellular protein A

97 amino acids

Virulence factor that is important for the establishment of infection in the host.

Belongs to the WXG100 family. sagEsxA-like subfamily.

11.036 kDa

MAMIKMSPEEIRAKSQSYGQGSDQIRQILSDLTRAQGEIAANWEGQAFSRFEEQFQQLSPKVEKFAQLLEEIKQQLNSTADAVQEQDQQLSNNFGLQ

esxA

ESAT-6 secretion system extracellular protein A

97 amino acids

Virulence factor that is important for the establishment of infection in the host.

Belongs to the WXG100 family. sagEsxA-like subfamily.

11.036 kDa

MAMIKMSPEEIRAKSQSYGQGSDQIRQILSDLTRAQGEIAANWEGQAFSRFEEQFQQLSPKVEKFAQLLEEIKQQLNSTADAVQEQDQQLSNNFGLQ

esxA

ESAT-6 secretion system extracellular protein A

97 amino acids

Virulence factor that is important for the establishment of infection in the host.

Belongs to the WXG100 family. sagEsxA-like subfamily.

11.036 kDa

MAMIKMSPEEIRAKSQSYGQGSDQIRQILSDLTRAQGEIAANWEGQAFSRFEEQFQQLSPKVEKFAQLLEEIKQQLNSTADAVQEQDQQLSNNFGLQ

esxA

ESAT-6-like protein EsxA

97 amino acids

May help regulate assembly and function of the type VII secretion system (T7SS) (PubMed:25865481). EsxA disassembles pre-formed EccC-EsxB multimers, possibly by making EccC-EsxA-EsxB trimers instead of EccC-EsxB-EsxB-EccC tetramers (PubMed:25865481).

Belongs to the WXG100 family. ESAT-6 subfamily.

10.83 kDa

MSDYTRANFGGLSEGEAQFSMTARALLDELTDLEGKLRAKLDRWDGDAQAAYWNYQKEWDAAAKDMQNVVAQLGVAIREAHDNYQAAERANTSIWAG

esxA

ESAT-6 secretion system extracellular protein A

97 amino acids

Virulence factor that is important for the establishment of infection in the host.

Belongs to the WXG100 family. sagEsxA-like subfamily.

11.036 kDa

MAMIKMSPEEIRAKSQSYGQGSDQIRQILSDLTRAQGEIAANWEGQAFSRFEEQFQQLSPKVEKFAQLLEEIKQQLNSTADAVQEQDQQLSNNFGLQ

esxA

ESAT-6 secretion system extracellular protein A

97 amino acids

Virulence factor that is important for the establishment of infection in the host.

Belongs to the WXG100 family. sagExaA-like subfamily.

11.036 kDa

MAMIKMSPEEIRAKSQSYGQGSDQIRQILSDLTRAQGEIAANWEGQAFSRFEEQFQQLSPKVEKFAQLLEEIKQQLNSTADAVQEQDQQLSNNFGLQ

esxA

ESAT-6 secretion system extracellular protein A

97 amino acids

Virulence factor that is important for the establishment of infection in the host.

Belongs to the WXG100 family. sagEsxA-like subfamily.

11.036 kDa

MAMIKMSPEEIRAKSQSYGQGSDQIRQILSDLTRAQGEIAANWEGQAFSRFEEQFQQLSPKVEKFAQLLEEIKQQLNSTADAVQEQDQQLSNNFGLQ

esxA

ESAT-6-like protein EsxA

95 amino acids

Belongs to the WXG100 family. ESAT-6 subfamily.

10.407 kDa

MEKIKYGFGEIEAAASDIQSTSGRINSLLEDLKAHIRPMAAAWEGESAQAYNEAQQQWDSSAAELNTILSTISNTVRQGNDRMSEVNRMAAASWS

esxA

6 kDa early secretory antigenic target

95 amino acids

A secreted protein. Acts as a strong host T-cell antigen. Plays a number of roles in modulating the host's immune response to infection as well as being responsible for bacterial escape into the host cytoplasm.

Belongs to the WXG100 family. ESAT-6 subfamily.

9.904 kDa

MTEQQWNFAGIEAAASAIQGNVTSIHSLLDEGKQSLTKLAAAWGGSGSEAYQGVQQKWDATATELNNALQNLARTISEAGQAMASTEGNVTGMFA

esxA

6 kDa early secretory antigenic target homolog

95 amino acids

A secreted protein that might play a role in virulence.

Belongs to the WXG100 family. ESAT-6 subfamily.

10.465 kDa

MIQAWHFPALQGAVNELQGSQSRIDALLEQCQESLTKLQSSWHGSGNESYSSVQRRFNQNTEGINHALGDLVQAINHSAETMQQTEAGVMSMFTG

esxA

ESAT-6-like protein EsxA

95 amino acids

An exported protein. Unlike its M.tuberculosis counterpart has poor pore forming ability in artificial liposomes, does not undergo conformational change at acidic pH (PubMed:23150662). Mutation of 2 residues to those found in M.tuberculosis (25-TA-26 to IH) alters the properties of this protein so that it inserts into liposomes at acidic pH, forming pores, like its M.tuberculosis counterpart (PubMed:26801203).

Belongs to the WXG100 family. ESAT-6 subfamily.

9.738 kDa

MTEQVWNFAGIEGGASEIHGAVSTTAGLLDEGKASLTTLASAWGGTGSEAYQAVQARWDSTSNELNLALQNLAQTISEAGQTMAQTEAGVTGMFA

esxA

6 kDa early secretory antigenic target

95 amino acids

A secreted protein. Acts as a strong host T-cell antigen. Plays a number of roles in modulating the host's immune response to infection as well as being responsible for bacterial escape into the host cytoplasm.

Belongs to the WXG100 family. ESAT-6 subfamily.

9.904 kDa

MTEQQWNFAGIEAAASAIQGNVTSIHSLLDEGKQSLTKLAAAWGGSGSEAYQGVQQKWDATATELNNALQNLARTISEAGQAMASTEGNVTGMFA

esxA

6 kDa early secretory antigenic target

95 amino acids

May be critical in pro-bacteria versus pro-host interactions; ESX-1 mediates DNA mediated export (maybe via EsxA). The DNA interacts with host (human) cGAS, leading to cGAMP production and activation of the host STING-TBK-1-IRF-3 signaling pathway that leads to IFN-beta which is thought to be pro-bacteria. Mycobacterial dsDNA also interacts with AIM2-NLRP3-ASC to activate an inflammasome, leading to the pro-host IL-1-beta (PubMed:26048138, PubMed:26048136).

Belongs to the WXG100 family. ESAT-6 subfamily.

9.904 kDa

MTEQQWNFAGIEAAASAIQGNVTSIHSLLDEGKQSLTKLAAAWGGSGSEAYQGVQQKWDATATELNNALQNLARTISEAGQAMASTEGNVTGMFA