May be critical in pro-bacteria versus pro-host interactions; ESX-1 mediates DNA mediated export (maybe via EsxA). The DNA interacts with host (human) cGAS, leading to cGAMP production and activation of the host STING-TBK-1-IRF-3 signaling pathway that leads to IFN-beta which is thought to be pro-bacteria. Mycobacterial dsDNA also interacts with AIM2-NLRP3-ASC to activate an inflammasome, leading to the pro-host IL-1-beta (PubMed:26048138, PubMed:26048136).

Belongs to the WXG100 family. ESAT-6 subfamily.

95 amino acids

MTEQQWNFAGIEAAASAIQGNVTSIHSLLDEGKQSLTKLAAAWGGSGSEAYQGVQQKWDATATELNNALQNLARTISEAGQAMASTEGNVTGMFA

9.9 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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