Protein
Dicer-like protein 2
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)
Function
Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons (By similarity).
Similarity
Belongs to the helicase family. Dicer subfamily.
Sequence
MASSVTACQGASPYQPRNYQLEMLEASMKENIIVAMDTGSGKTHIAVLRIKAELDICPPDKLVWFLAPTVALCIQQHEVIASNLPAVRTRTLTGLDKVELWTEQSIWDAVLNGYRVIVSTHAVLADALSHGFVKMSRLALLIFDEAHHCTRRHAANKIMRDFYHPTLTKSGPGAVPRIMGLTASPVVRSNHQELLTVESNLDAVCRTPRVHRQELVKFTHRPHLQQIWYTPTDPAGFKSASQTLGALYHAWETLDIGDDPYIQRLRKSPLDDTALKKALLTGKTYCREQLRRFVDRSRHIFEELGEWAAEYYIYASIKQLGDRVRNSYMSGDWDEAEKAYLVDFLSKIPASEIQLALNDPGSFRISPKFESLLNFLDSLDEREFSGLIFVKQRATVSAMTSLLSVHPCTRERFRCAAYVGWSNGSASKDILGDLLNMQLQRDTLDDFRSGRKNLIIATDVLEEGIDISACSVVVCYDKPPNLKSFVQRRGRARRKQSTFAIMFPTDDASADVSKWQDLEQAMIEAYQDDERQLQSVSALESLDEEVMERLTVESTSAVLTADMAMAHLHHFCAVLPPQPYADMRPVFSFETNEDGLLKGTVILPSCVHPKVRRTEGRRWWRTERAAMKETAFQAYKALYEFGLVNDHLLPLTKRPELKSHDLGAMPSILETSEQYDPWIEWAYSWSSPDIHQSRIVVRMNEGRGDELCMRLMGPTYLPPLSPMTLFWNNSTTFTVTFEAAERVPLVPLSSVEDMRAITALYLKATNSRVCSSERDFTALFAPDLHHTELKGWLNAYEGCDPAMEVYSRGHNPLLMGVVRDHSRYGEPFLFRKWLVSDQNPSCSVVELECAPFPHRRNLLHRQRLANSQVDVDEETPESAAKNPIVAADACTIDRLPFTMAIFGLFISAIVERLETELIATRLRETILRDVGFKSTDHIITAISTPFAHALTNYQRYEFLGDSILKFSVSCQLFFQHPNWHEGYLSEGRAMIVQNPRLAKAALDTGLDAYIVTKRIASRKWSAPLISEKLERVPAKRQMSTKVLADVVEALIGAAYMDGGHATAQACIRRLLPEINLHAVDTRTATRSVAPESARHMMNERLKDHIGYTFEDESLLVEALTHPSCDYDSTTQSYQRLEYLGDAVLDMVIVSAIFNHPIQRPQGDMTKIKHAVVNANLLAFLCMESATSEEKLDVAQTSKDSFAVTTSQESVELWRFMRYRGQNLNAARDASLARHRALRDEIASSLLHAPHYPWHALSRLNADKFFSDIVESVLGAIFVDSGGDLAPCEVFVERIGLMAYLRRILDQEIDVRHPRSVAQQLAKTNIQFVLQRVPNEEGGASYQCSVRIEQAELFVVTGCLTAEEAEVTAAVEAIKFLTRDEGSTPLNTS