Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons (By similarity).

Belongs to the helicase family. Dicer subfamily.

1388 amino acids

MASTVSTCQDASPYQPRNYQLEMLEASMKENIIVAMDTGSGKTHIAVLRIKAELDICSPDKVVWFLAPTVALCIQQHEVIASNLPAVRTRTLTGLDKVELWTDQSIWDAVLNGYRVIVSTHAVLADALSHGFVKMSQLALLIFDEAHHCTRRHAANKIMQDFYHPTLTKSGPAAVPRIMGLTASPVVRSNHQELLMVESNLDAVCRTPRLHRQELLKFTHRPHLQQIWYTPTDPAGFRSASLTLGALYHAWENLDIGDDPYIQRLRKSPLDDRALKKALLTGKTYCREQLRRFVDRSRHIFEELGEWAAEYYIYASIKQLRDRVRDSYMSGDWDEAEKAYLVDFLSKIPTSDIHFALNDPDGFRISPKFESLLNFLDSSDQREFSGLIFVKQRVTVSAMTSLLSVHPYTRERFRCAAYVGWSNSSASKDILGDLLNMQLQRDTLDDFRSGRKNLIIATDVLEEGIDLSACSVVVCYDKPPNLKSFIQRRGRARRKQSTFAIMFPTDDTSADVSRWQDLEQAMIEAYQDDERQLQSVSALESLDEEVMERLTGDSTSAVLTADMAMAHLHHFCAVLPPQPYVDMRPVFSFETNEDGLLKGTVILPSCVHPKVRRTEGRRWWRTERAAMKETAFQAYKSLYEFGLVNDHLLPLTKKPELKTHDLGSMPSILETSEQYDPWIEWAYSWSSPDIHQSRIVVKMNEGRGDELCMRLIGPEYLPPLSPMTLFWNSSTTFTVTFKAAERVPLVPLSSVEDMRAITALYLKATSSRVCSAERDFMALFAPDLHHTELKGWLDTYEGSDPAMEVYSRGHNPLLMGVVRDHSRYGEPFLFRKWLVSHQNPSCSIVELECAPFPHRRNFLRRQTLANSQVDVDEAIPDSAAKNPIVAAEACTIDRLPFTMAIFGLFISAIVEQLEIELIATRLRDTILRDVSFKSTDHIITAISTPLAHRLTNYQRYEFLGDSILKFSVSCQLFFQHPNWHEGYLSEGRDMIVQNPRLAKAALDTGLDAYIVTKRLASRKWSAPLISEKLGRVPAKRQMSTKVLADVVEALIGAAYVDGGHSTAQACIRRFLPEINLHAVDTRTAARSVAPESARHMMNDRLKDHIGYTFEDESLLVEALTHPSCDYDSTTQSYQRLEYLGDAVLDMVIVSAIFNHRIQRPQGDMTKIKHAVVNANLLAFLCMEFAISEEKLDVAQTSKDSFAVTSSQESVELWRFMRYRGQGLKAARDASLARHRALRDEIASSLLQAPHYPWHALSRLNADKFFSDIIESVLGAIFVDSGGNLAPCEVFVEQIGLMAYLRRILDHGIDVRHPRSVVQQLAKTNIQFVLQRVPTEEGGASYQCSVQMEQAELFVVTGCLTAEEAEVTAAVEAIKFLTRDEGSTPLNKS

156.9 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.

Have you tried producing dcl2 in a cell-free protein expression systems? We have solved cell-free protein expression scale-up and purification challenges so that you can obtain up to low-milligram quantities of proteins in hours.

Order Here