Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons (By similarity).

Belongs to the helicase family. Dicer subfamily.

1377 amino acids

MASLSDQDLEMGLFCPRNYQTEMFEASLQENIIVAMDTGSGKTHVALLRIMNELETRRPQKLIWFLAPTVALCFQQHDVITKNLPAVKSRTLTGQDKVELWTEQAIWDAILKDMQVVVSTHAVLADAMSNGFVRVSQLGLLIFDEAHHCMRRHPANRIMQDFYHPTLVKQGPDAVPGILGLTASPVVRTNSQELSMIESNMNAICKTPRAHRQELLTHTHRPHLQQIWYTPVNIDDPTSGTRTLRALIHAWETIDLEDDPYVKQLRRSTFDGKALQKALLTRKTYCNESLRRFVERSCHIFQELGGWAVDYFIHASIRRLREKIDDSALMLDWDNEEKEYLASFLSNIATIQSDPPRRPEDFIPSPKLEALISFLSSTDDSTFSGLIFAKQRATVTVLATLLSVHPLTKDRFRCAAFVGWSGGGNRKDLIGELLSMQMQRDTLSEFRSGQKNLIVATDVLEEGIDISACSVVICYDKPANVKSFVQRRGRARRKESTFAILFSTDDELCDLRKWQLLEEAMIEAYQDDERKRCEALALETMAEVVTERFEVESTGAVLTADTAVARLHHFCSILPQQPYVDNRPELSFEYDGTGRRRGTFKLPSCVHPDVRRTRGEKWWTTERAATKEAAFQTCKRLYEFGLLNDHLLPLTRKPELRLTDFGGLPSIIEVAEQYDPWTDWAYSWSSPDIHQSRIRVQLNGNPEYQLSMSLMGPTVLPALDAMTLFWDSQNIFTLAFDAAQRVPLVPGDVIEHMRAITALYLQAPSSRSIREERDYVALFGPDLPHTELGAWLLKNGGNDTALDVYSRQVASPTMGIVRDRTRYDEPLLFKKWVVTEDGDVAVVEMECHSLPKRRNLLQRQTLAQGEIVTTAVDTAPAKARIIPATACTIDRLPFTDTIFGLFISAILDRLEATLIATRLCETILQDVQFSSTRHVITAISAPTAQSPTDYQRYEFFGDSVLKFTVSCQLYMQHPNWPEGYLSEGRDEIVQNNRLARAALDVGLDAFILTRRFTPRKWTAPLISEKAVEVAGKRPLSSKVLADVVESLIGAAYMDGGQAKAHTCIRRLLPEIEICPITPPPVHESAPHVMNDSLKQHLGYTFVNEALLVEALTHPSCRSDASTQSYQRLEFLGDAVLDMVVVHAMAHHAVECPQGEMTMIKHALTNANLLAFFCMEFVVAQEHTDVDAVPAAGGFALRSEQKPIELWRFMRSEALDLNNARETVLHRHSQLRAEIVHALHHGAQYPWQALSQLNADKFFSDIVESILGAIFVDSRGDLDVCAMFVERIGLLPYLRRILADRVDVMHPRHTAQRLSKGEALFTAKRVVDGSGNASYRCVVKRNKEEIVVVEGCLSSEEAEVKAANATIGILRANAVNLV

155.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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