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csoR

Gene
csoR
Protein
Copper-sensing transcriptional repressor CsoR
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Length
119 amino acids
Function
Copper-sensitive repressor that has a key role in copper homeostasis. It is part of the cso operon involved in the cellular response to increasing concentrations of copper inside the bacterium, which can be highly toxic. In the presence of copper, CsoR fully dissociates from the promoter in the cso operon, leading to the transcription of its genes. Binds to a GC-rich pseudopallindromic sequence, 5'-GTAGCCCACCCCCAGTGGGGTGGGA-3', in the cso promoter region (By similarity).
Similarity
Belongs to the CsoR family.
Mass
12.8 kDa
Sequence
MSKELTAKKRAALNRLKTVRGHLDGIVRMLESDAYCVDVMKQISAVQSSLERANRVMLHNHLETCFSTAVLDGHGQAAIEELIDAVKFTPALTGPHARLGGAAVGESATEEPMPDASNM

Gene
csoR
Protein
Copper-sensing transcriptional repressor CsoR
Organism
Mycobacterium bovis (strain BCG / Pasteur 1173P2)
Length
119 amino acids
Function
Copper-sensitive repressor that has a key role in copper homeostasis. It is part of the cso operon involved in the cellular response to increasing concentrations of copper inside the bacterium, which can be highly toxic. In the presence of copper, CsoR fully dissociates from the promoter in the cso operon, leading to the transcription of its genes. Binds to a GC-rich pseudopallindromic sequence, 5'-GTAGCCCACCCCCAGTGGGGTGGGA-3', in the cso promoter region (By similarity).
Similarity
Belongs to the CsoR family.
Mass
12.8 kDa
Sequence
MSKELTAKKRAALNRLKTVRGHLDGIVRMLESDAYCVDVMKQISAVQSSLERANRVMLHNHLETCFSTAVLDGHGQAAIEELIDAVKFTPALTGPHARLGGAAVGESATEEPMPDASNM

Gene
csoR
Protein
Copper-sensing transcriptional repressor CsoR
Organism
Mycobacterium tuberculosis (strain F11)
Length
119 amino acids
Function
Copper-sensitive repressor that has a key role in copper homeostasis. It is part of the cso operon involved in the cellular response to increasing concentrations of copper inside the bacterium, which can be highly toxic. In the presence of copper, CsoR fully dissociates from the promoter in the cso operon, leading to the transcription of its genes. Binds to a GC-rich pseudopallindromic sequence, 5'-GTAGCCCACCCCCAGTGGGGTGGGA-3', in the cso promoter region (By similarity).
Similarity
Belongs to the CsoR family.
Mass
12.8 kDa
Sequence
MSKELTAKKRAALNRLKTVRGHLDGIVRMLESDAYCVDVMKQISAVQSSLERANRVMLHNHLETCFSTAVLDGHGQAAIEELIDAVKFTPALTGPHARLGGAAVGESATEEPMPDASNM

Gene
csoR
Protein
Copper-sensing transcriptional repressor CsoR
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Length
119 amino acids
Function
Copper-sensitive repressor that has a key role in copper homeostasis. It is part of the cso operon involved in the cellular response to increasing concentrations of copper inside the bacterium, which can be highly toxic. In the presence of copper, CsoR fully dissociates from the promoter in the cso operon, leading to the transcription of its genes (By similarity).
Similarity
Belongs to the CsoR family.
Mass
12.8 kDa
Sequence
MSKELTAKKRAALNRLKTVRGHLDGIVRMLESDAYCVDVMKQISAVQSSLERANRVMLHNHLETCFSTAVLDGHGQAAIEELIDAVKFTPALTGPHARLGGAAVGESATEEPMPDASNM

Gene
csoR
Protein
Copper-sensing transcriptional repressor CsoR
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Length
119 amino acids
Function
Copper-sensitive repressor that has a key role in copper homeostasis. It is part of the cso operon involved in the cellular response to increasing concentrations of copper inside the bacterium, which can be highly toxic. In the presence of copper, CsoR fully dissociates from the promoter in the cso operon, leading to the transcription of its genes. Binds to a GC-rich pseudopallindromic sequence, 5'-GTAGCCCACCCCCAGTGGGGTGGGA-3', in the cso promoter region.
Similarity
Belongs to the CsoR family.
Mass
12.8 kDa
Sequence
MSKELTAKKRAALNRLKTVRGHLDGIVRMLESDAYCVDVMKQISAVQSSLERANRVMLHNHLETCFSTAVLDGHGQAAIEELIDAVKFTPALTGPHARLGGAAVGESATEEPMPDASNM

Gene
csoR
Protein
Copper-sensing transcriptional repressor CsoR
Organism
Mycobacterium ulcerans (strain Agy99)
Length
117 amino acids
Function
Copper-sensitive repressor that has a key role in copper homeostasis. It is part of the cso operon involved in the cellular response to increasing concentrations of copper inside the bacterium, which can be highly toxic. In the presence of copper, CsoR fully dissociates from the promoter in the cso operon, leading to the transcription of its genes. Binds to a GC-rich pseudopallindromic sequence, 5'-GTAGCCCACCCCCAGTGGGGTGGGA-3', in the cso promoter region (By similarity).
Similarity
Belongs to the CsoR family.
Mass
12.534 kDa
Sequence
MSHELTDKKRAALNRLKTARGHLDGIIRMLESDAYCVDVMKQLSAVQSSLERANRVMLHNHLETCFSAAVLDGRGQAAIDELIDAVKFTPALTGPQAQLGGAVVCKPPGDQPAQSPA

Gene
csoR
Protein
Copper-sensing transcriptional repressor CsoR
Organism
Bacillus subtilis (strain 168)
Length
101 amino acids
Function
Copper-sensitive repressor that has a key role in copper homeostasis. Negatively regulates expression of the copZA operon and of ycnJ. In the absence of copper ions, binds with high affinity to the copZA promoter and represses the transcription. In the presence of copper ions, CsoR binds Cu(1+), which significantly decreases its DNA binding affinity and leads to the transcription of the genes.
Similarity
Belongs to the CsoR family.
Mass
11.475 kDa
Sequence
MEKHNEHKTLNHKSSKEKDQITNRLKRIEGQVRGIQNMVENDRYCVDILVQISAVQAAMKNVALHLLEDHAHHCVADAIKSGDGEQAISELLDVFKKFTKS