TOM1

E3 ubiquitin-protein ligase TOM1

3268 amino acids

Probable ubiquitin ligase protein involved in many cellular processes, such as transcription regulation, maintenance of nuclear structure, cell cycle, mRNA export and rRNA maturation. E3 ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. Involved in transcription regulation by interacting, and probably mediating, ubiquitination of some subunit of the SAGA complex. Required for SPT7 ubiquitination. Participates in mRNA export from the nucleus by regulating the transport of hnRNP proteins. Required for the shuttling of hnRNP protein NAB2, probably by mediating ubiquitination of a protein associated with NAB2. Also required for full induction of the general stress and heat-shock responses. Involved in 18S rRNA maturation by affecting several early steps in the rRNA processing pathway.

Belongs to the UPL family. TOM1/PTR1 subfamily.

374.185 kDa

MVLFTRCEKARKEKLAAGYKPLVDYLIDCDTPTFLERIEAIQEWDRSRDDLYVWIPILDRMDGLLLKVAEKYKYKQDPKKECEVKLVEMEAHDVDYCLKMLKFTRRLLLNTENRFVYSSGDVLMYLLNCPNFTIKLAVMRILAILGERFVIAREKIVAHNIFGDHNLRKKTLKLALSLSSSVMDEDGEHFSLVDLYFDKKKVPQKWRKLRFTHYTSNDFKKSSQQKNNINETQTSIKKVTMTTQELCEHSLQQIFDKGMALLPAESWFDFSIKASVAKAFSDDSGENIDLRNIIIETKLNAIAFVNTIFSPPQVSSKLFELDPYAFNSLTDLISLSETKIPKELRTDALFTLECISLKHVWCSDIIRNLGGNISHGLLFQILRYIAKTLREATDEIDEEYNVRFFYLISNLADVKPLHESLFAAGLIPTLLEIVSIRNCPYKRTLASATHLLETFIDNSETTTEFIENDGFTMLITSVANEIDFTLAHPETWQPPKYSVVYYSISFRELAYIRSLLKLVLKLLSTDSGDRIRNLIDSPILVSLKKILENKLVFGLTLITYTLDVVQKVINSEPTIYPVLVEAGLIPYVIDNFPKLIGPSAELLSLLPDVVSAICLNPEGLKQVKEKGLINNLFDFLLDADHARILTGGDRSTEYGTDIDELARHYPDLKANIVEALCNVIRKMPSTFRNEREFLFTSPKDQKYFFHRKNEEILTDKEEHEPAYWELLDKGTMLDTFTSVLFGMSLGNGSFSQVPQHLEARDFLAIIFMENPPYEYFTSVAISNVTEVLQYLDEKYEDYAFMDVMKVLNDQLENLNDFLNSPNDRSFFLERDGENSVRSCHSKLCRLAAILNIVTNVYIDLTTLSCKRIMQIYSYFDKRGFSLIKNLKLLFQKCALEEMYIRQHMPDSVITETMPLPIVDVSGDGPPLQIYIDDPKKGDQKGKITSVKTRNTLQMRTILYTLQSNTAILFRCFLRLSHSRNMDLEHKDLTTEVHIFENVVENVIEMLKATELEGHLPYILVLLNFNTFVFTIPKASPNSTEILQTIPAYIFYQKGGYLLYLHIIRDLFTRMTKIKDLSSLDNINYIDESNGILTLSCLINALTFYNKSMQTETMENVQSIGKYYVSIDDDYNIMKALTVPIKVMALAMILDLDKSDSLFKTQSRNVPYSVFKQLLSMLKNIFTNVNIYTKELYELHWDLIFPPIKKISLFEQVGIPGDVAANYLTDTGDDLPADNSIGLFSPEQWEKYKKLIGEDKSIYYPQPMQAQYYKGCSSKELDELRDTFFNDGLPSRIFTVLPFYPKLVNAFAKTLLQIFTKYDEPTEVFAGRILDRILETDLDDPATLSSLIHLFGIFLNEKYIYQKASHLMQRFIEYLEKSLKPEHVNTPWFSKALYVYEIILAKSELPHLEELSKDVLLRYPLLSMAKVFRIPDPMKQKLFDILIRVSDISNFYSALATSRILIFYSRDELYANNIARSGILSRLLKVIGSFQKLDKINFLESSFLLLTRRCFETTENVDALIRAEINRSFTARPLGGGDDAVRELTTILEEKAHVVMRSPSQFIDVLCETARFHEFDDQGALVDYSLKRFLGEKDKNTQASSTEKSDIYERTGIMHLLLSQLMAASEKDWLSEPANSSDLPENKKAQLDPSRNPVCAYMIFLLKLLVELVSSYNQCKFEFLTFSRRNTYAERPRPRTTAINFFLYRLLDKPVGTDHDKHEAKRREVIGMLARSVIIGFLATVQDDRTTKTDVKLADPHMNFIRKFAIEAIIKAIRNATSSSKLLESNHLKLDMWFRIITSMVYVQAPYLRQLLDSNKVEADQYQLCKLVIDLGLPSVITEAMASIDLNYPFSKKIFNVAVEALNTISSTRNNFSEHFKIEDHDEVEDEVDESDKEEIPDMFKNSALGMYDVEDIEEDDDDDTSLIGDDDAMAFVDSDNGFEVVFSDEDDDMGEEDADDARSDSEENELSSEMQSSTADGTDVDYEVDDADGLIINIDQPSGDDEEMADYDANISHSSHSENEDDASMDVIEVYDDELSSGYDVDLSDYDVDESDWDSGLSSLSISDEDSESSEDEPINSTRMGDSRRRWLIAEGVELTDDSQGESEEDDRGVFRGIEHIFSNENEPLFRVHDEMRHRNHHRSINRTHFHSAMSAPSLSLLNRGRRNQSNLINPLGPTGLEQVENDISDQVTVAGSGSRPRSHHLHFSEVLVSGSFFDEPVLDGIILKSTVSRWKDIFDMFYDSKTYANCIIPTVINRLYKVSLALQKDLENKREQEKLKNKNLLFNEAKVESHNSSDAISVEQDDIQESNVTHDDHEPVYVTIQGSEVDIGGTDIDPEFMNALPDDIRADVFAQHVRERRAEARLNSDHNVHSREIDSDFLEAIPEDIREGILDTEAEEQRMFGRIGSSADVIRADDDVSNNDEEVENGLDHGNSNDRNNADPEKKKPARIYFAPLIDRAGIASLMKSVFISKPYIQREIYHELFYRLCSSKQNRNDLMNTFLFILSEGIIDQHSLEKVYNIISSRAMGHAKTTTVRQLPSDCTPLTVANQTIEILQSLIDADSRLKYFLIAEHDNLIVNKANNKSRKEALPDKKLRWPLWHLFSLLDRKLITDESVLMDLLTRILQVCTKTLAVLSTSSNGKENLSKKFHLPSFDEDDLMKILSIIMLDSCTTRVFQQTLNIIYNLSKLQGCMSIFTKHLVSLAISIMSKLKSALDGLSREVGTITTGMEINSELLQKFTLPSSDQAKLLKILTTVDFLYTHKRKEEERNVKDLQSLYDKMNGGPVWSSLSECLSQFEKSQAINTSATILLPLIESLMVVCRRSDLSQNRNTAVKYEDAKLLDFSKTRVENLFFPFTDAHKKLLNQMIRSNPKLMSGPFALLVKNPKVLDFDNKRYFFNAKLKSDNQERPKLPITVRREQVFLDSYRALFFKTNDEIKNSKLEITFKGESGVDAGGVTREWYQVLSRQMFNPDYALFLPVPSDKTTFHPNRTSGINPEHLSFFKFIGMIIGKAIRDQCFLDCHFSREVYKNILGRPVSLKDMESLDPDYYKSLVWILENDITDIIEETFSVETDDYGEHKVINLIEGGKDIIVTEANKQDYVKKVVEYKLQTSVKEQMDNFLVGFYALISKDLITIFDEQELELLISGLPDIDVDDWKNNTTYVNYTATCKEVSYFWRAVRSFDAEERAKLLQFVTGTSKVPLNGFKELSGVNGVCKFSIHRDFGSSERLPSSHTCFNQLNLPPYESYETLRGSLLLAINEGHEGFGLA

TOM1

Probable E3 ubiquitin-protein ligase TOM1

3258 amino acids

Probable ubiquitin ligase protein, which may be involved in mRNA export. E3 ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. Participates in mRNA export from the nucleus by regulating the transport of hnRNP proteins.

Belongs to the UPL family. TOM1/PTR1 subfamily.

372.401 kDa

MVVTLTKLERLQKAEKSRTFKPLIDELINCEDAVFVGKLEAIREWDRPKDDLFLWIPVLDRMDDMLGKVVAKYKYHTTDCKRHPVKLIEMAKPDEDWVATLLFFTCRLLNNTSNRSLYSSLDMMSDLLNCPNFRVKLGAMKVIATIGERHVVARHRIENSSVLASQHLKKRSLSLALALPSSTTDDNSDHFSLVDLFFDKRKYPSKWSQLQYTYYITKKQAGQQSTQKPSQVSSMKRFVLNNEELRFLSLQQIFDRAMNDLPSEFWFDFSLQASIAKAFSDDSFENIQLRSLIIQTKFAAIAFANAIYIPPQVSSKLFEMDPYAFNNLTDFISLSETKIPKDLRTDALFALECISLKHVWCSDIVRNLGGNMSHGLLFQILRYIAKVLREGDEDAVDEEYNVRFFYLISNLADVKALQESLISAGLISSLLEIVSTQNSKYKRTLASAAHLLEDVISDADATAEFINNNGFNILIQTVTYEVNFAVQNPSSAEPPKYSVVYYSISFRQLGFIRSLLKLVLKLLKTDSGDRIRNLIDSPILLAFNKILENRPVFGYTLVSHALDVVQTIINTEPTIYQVLVESGTIPYILQNFDQFLGPTSDLLCMLPEVISAICLNTDGLKQVKEKNLLKYLFQVIKTPEFAKILSWEDQAVNYGVALDELARHYPELKPLIEDYFAATVKELPSLTSYTHSYLYESTAGNGEFYLSENETIIDNEDGADELAFWEVQESSPIIDCFSGVFYSMASENISWANLTEKIAFQDFLSVAIPEKPTFDYINSQTLLNFTDVLKMFDDERRSYALPELLTILDSKFADLEDFLSYDFTKSYVLNEPKDRVVATLNKLNVLNVILYIMTDIYINITTLFPVRVIQMMEFFEKNGFNLITNLRKMFQRCVLEEMYIRSRLPPAVAEETISPGISFVPPILIHKDVPLKTEAKQEKTSAKFKNTLETRHLFQKVQSWTSMLFRCFLRLTHARKMNVERYDRALEIRIFDKVVNEIVEMLNLDYLDSHLSYFLVVLDFNTHIFTCPKASLTISDGIVQTVPTFLFYQAGGFAIYHELIKKLSTRLLGFDGIEAIEKVEYVKDQDDILTVGVLMNSIAFMNRCIQLETMENIRSIAEYYPYDDIYYNLTRALIVPVKILSLGAISEIFSQGEVFDTDRRRIPYSVFKQILSLLKNIYNSTFELEEGTDVYELRWDLMPISHRKVEMLKSCGISHDVAVGYLEEEKDELPIHVKPDVFSDSEWQRYQEERSSGSWRTNIELLPPQYNGSSTRETLSKMRTEFYQNGFESGILKILQHYPKLINAISHMFFEMYGELGFSHTTMLEDLQDMMNTIPIENTNKLAPVIHLFGIFLNDKNIYDQAKKEIFKFVSYLSMNLHPENVNYSWFSKALYVYEIIFAKSETPEASPLPENVTVSFSSIPIIYRISQKDKDIIFNLLIRANEVTDFYSALAISRILILYTREERYAQEVTQSGILSKLLKVIGANQKFDKINYLESSYLLLVRRCFETKEIVTSLIDYELTRAFTTRAIGDHKEKPRDLPALVNEKASIVMRDPEVFVNRISETARFEDFNSSKELASLSVRRHMDEKDEEMTSKPLSSEGSNSPITGIVHLLLSQLMAAHKRDWVSETPLTPEEENQKNKKKKDEVKVSKNPVCAYMIFLLKVLTELVSSYKQSKFEFLTYNKKNVYNETPKPRATALNFFLYQLLDTNFQDMDKHEGKRRAMISGLARDTIIGFVSSVQDSETKKVDPKIVDSDMTYIRKFTIEAISKAIKEAGVSAKTIDANAGKLFGWFHLISSLLVVDKGYIFSVLDSNKSSNDKYQLCKLLIEMNTPGTITDCMASLDLNYPLTKKLFNSAVEPLNALNEVRNNFADLFKLENNEDEDVEDVESDKDDVPDMFKNSALGMYDIEDVEDDHDDDENESLIGDDEDIAFVHDEDGLEVVFSEDEDANEDTTDASNSIGSDSEGNSDFGGSGPNVTLEVYTDSEDAIEDVNTAAIRITSGNSAEHSYYSEGEDSAEIEIYEEEYDSEIDIDMDDDSELGSSNWESGLSDLSDSEAYSDEERTNNTGDGFVRWYSDDGVEFEDDTDEEGRGLFTGIQHVFPTEEQLFRVHASGAARSTGRHHHRHGAAPFTTSTITLGASQRRPHSILSNPLGPSGLEEVENDIVSHYLGNVETSDRIGLSSIPRLPRVLLFDGELFDDKSSSGILLKSTTARWNDIYEMFYDSKVYSNNVVTTIISRIFEPSAELYLKEQEENAVKESSRINEPTRRQDERKRKLHEIDSDEEHIEEEEEHDEVVEPIEAPGINSPQARAPQEPVYVTIDGEAVNIAGTDMDAEFLNALPDDIRAEVFAQHIREYRTQFQGSEGSSRELDAGFLNTIPETLRQEILAQEVPLERNARPSILGLRNREGEEFSEVEDESPRFNEQRTESSKTKTDRVHFAPLLDRSGIAAIMKAVFIPQPYLSREIYHELFYRLCSSKQNRSDIMNMLLLILMDGINDQHSLERVYNLLSNRAASSNSGTSKTPQRQLPPDCTPLIVTNQCIEILQSMVDADSKLKYFFITEHENLLINKSPLKNKKDIFSKNMKWPINCILALLEKKVITDEAVLMDLLTRILQVCSKPISSIVKSSKDGKKKKFEVPDIEKKYLASIVSIIKLDSCNTKVFQQTLNLMTNLFAIKDAHETFTTELCNLAKETIEVLVTDLDALAKEVPAVDSGTEVSSEIIQKFTVPSSDQSKLLKVLTAIDYIYVNRKKEEEQVVDQLLPLYNKMELGHIWVSLSNCLTRFEEKPRMSTSATILLPLIESLMVVCKHSKVRETKDALLKYEAKKCDFARTPVENLFFAFTDLHKKLLNEMIRSNPKLMSGPFSLLVKNPKILDFDNKRYYFTAQLRAITHDRPKLSISVRREHVFLDSYRSLFFKSNEDIKISKLEISFKGEAGVDAGGITREWYQVLSRQMFNPDYALFIPVASDKTTFRPNRTSGINPEHLSFFKFIGMIIGKAISDQCFLDCHFSREVYKNILGKPVALKDMESLDLDYYKSLIWILENDITDIIEETFSVETDDYGEHKVIELIENGAHVAVTEQNKHDYVKKIVEYKLQTSVKDQMENFLQGFYAIIPKDLISIFDEQELELLVSGLPDIDVDDWKNNTIYVNYTPTCKQINYFWRAVRSFDKEERAKLLQFVTGTSKVPLNGFKELSGVNGISKFSIHRDYGSIDRLPSSHTCFNQLDLPAYDSYETLRGSLLLAINEGHEGFGIA

tom1

Target of Myb protein 1

663 amino acids

May contribute to the sorting of ubiquitinated proteins and transfer them for further sorting/trafficking processes to the endosomal multivesicular bodies (MVBs) pathway. Binds to phospholipids, such as phosphatidylinositol PtdIns(3)P and PtdIns(3,5)P2. These phospholipids are involved in the recruitment of the ESCRT machinery to endosomal membranes (By similarity).

75.375 kDa

MVTELVDKATNELLIQTDWTTVLQISDILNRDPIHARGVVRQVTKKLKDRSRVILLALELADSLLQNCHCTHVYFAERTFQTELCRLIMNKKTKLNVKEKTLEIVESWGNAFQARHDVPGFYETYSFIKRSGYKFPPKPSDAPILNFNNSPAKRTVSTTILTNNSHSTTPPQANVPSFNNVSSVGSNNAGGGGSSSQPIKNQEISSIKGSTSVFNEMISFLNVEDEDPQENDLIKELFETCKQSQIRVKEMIESGSTNERDLNVLLKLNDEINNALNDHEACIKRRRAFVENGYKPVPPPQQQQQQQQQQQQQQQQQQQQQSHSNNHNGTTTTTTTNNNNKNPSYLTKHKELEEIDFFKAPDGISPYSVQQQLQPFQQQQFNSTYNPFAQPQPQQFQQQPQQQLQQQPQQQQGFNQRIQQPQQQADAFDLFVANRQQSNNNNNNNNINNTTSSFGANNPFANNSSNNNNTNGAIQPYIPNTAKSLPPVSQQLQQPMQNQFSPQPQKFVGSSITPSAPPPFKPNTTQSNPFNTSPPLNNMNNHNNNMMQQQQPQQQQQQQPQQQFNPMYNNNAMAPSYPNYNAIGADNQHNTNPYGMMNHQQQQQQQQQQQPMMNQMNNFSAPTYSQFTNYAQPNQQPYNNNYGGMNQSNMYPNNNMSGKSSLI

TOM1

Target of Myb protein 1

515 amino acids

May be involved in intracellular trafficking. Probable association with membranes.

Belongs to the TOM1 family.

57.024 kDa

MDFLLGNPFSSPVGQRIERATDGSLRGEDWSLNMEICDIINETEEGPKDAFRAIKKRIVGNKNFHEVMLALTVLETCVKNCGHRFHILVASQDFVESVLVRTILPKNNPPAIVHDKVLTLIQSWADAFRSSPDLTGVVAVYEDLRRKGLEFPMTDLDMLSPIHTPRRSVYSSNSQSGQNSPAVNSPQQMESILHPVTLPSGRDTSSNVPITPTQEQIKKLRSELEVVNGNVKVMSEMLTELVPSQAETSDLELLQELNRTCRAMQQRVLELIPRVQHEQLTEELLLINDNLNNVFLRHERFERVRTGQPVKAPSEAENNLIDLRPSTPPAVRQPEVTNNLSSQLAGMTLGSRSVSAGLHSLDTSGKLEEEFDMFAVTRGSSLAEQRREVKYEDPQATKGLAGALDARQQNTGAEESSASSDGAQLTNWMMRQGMVPVPQANFMEDIEKWLSTDVGESEDGKGVTSEEFDKFLEERAKVADRLPTLSSSSAGTPVSPAAASRHQKQAKEDDAMFAL

TOM1

Target of Myb protein 1

492 amino acids

May be involved in intracellular trafficking. Probable association with membranes.

Belongs to the TOM1 family.

53.818 kDa

MDFLLGNPFSSPVGQRIEKATDGSLQSEDWALNMEICDIINETEEGPKDALRAVKKRIVGNKNFHEVMLALTVLETCVKNCGHRFHVLVASQDFVESVLVRTILPKNNPPTIVHDKVLNLIQSWADAFRSSPDLTGVVTIYEDLRRKGLEFPMTDLDMLSPIHTPQRTVFNSETQSGQDSVGTDSSQQEDSGQHAAPLPAPPILSGDTPIAPTPEQIGKLRSELEMVSGNVRVMSEMLTELVPTQAEPADLELLQELNRTCRAMQQRVLELIPQIANEQLTEELLIVNDNLNNVFLRHERFERFRTGQTTKAPSEAEPAADLIDMGPDPAATGNLSSQLAGMNLGSSSVRAGLQSLEASGRLEDEFDMFALTRGSSLADQRKEVKYEAPQATDGLAGALDARQQSTGAIPVTQACLMEDIEQWLSTDVGNDAEEPKGVTSEEFDKFLEERAKAADRLPNLSSPSAEGPPGPPSGPAPRKKTQEKDDDMLFAL

Tom1

Target of Myb protein 1

492 amino acids

May be involved in intracellular trafficking. Probable association with membranes.

Belongs to the TOM1 family.

54.325 kDa

MDFLLGNPFSSPVGQRIEKATDGSLQSEDWALNMEICDIINETEEGPKDAFRAVKKRIMGNKNFHEVMLALTVLETCVKNCGHRFHVLVANQDFVENVLVRTILPKNNPPTIVHDKVLNLIQSWADAFRSSPDLTGVVAVYEDLRRKGLEFPMTDLDMLSPIHTPQRTVFNSETPSRQNSVSSNTSQRGDLSQHATPLPTPAVLPGDSPITPTPEQIGKLRSELEMVSGNVRVMSEMLTELVPTQVEPADLELLQELNRTCRAMQQRILELIPRISNEQLTEELLMINDNLNNVFLRHERFERFRTGQTAKASSEAELATDLIDMGPDPAATNNLSSQLAGMNLGSRSVRAGLQSLETSGHLEDDFDMFALTRGSSLADQRKGVKYEAPQTTDGLAGALDARQQSTGAIPATQARIMEDIEQWLSTDVGNSAEEPSGVTSEEFDKFLEERAKAADRLPNLASPSAEGPPRPSPGTAPRRKTQEKDDDMLFAL

TOM1

Tobamovirus multiplication protein 1

291 amino acids

Necessary for the efficient intracellular multiplication of tobamoviruses, probably being a membrane anchor promoting the formation of the replication complex.

Belongs to the plant tobamovirus multiplication TOM1 protein family.

33.009 kDa

MTDSGLMMPAEIAGILTTAITSWWDDVNESTQWQDGIFFALCGAYALVSAVALVQLIRIQMRVPEYGWTTQKVFHLMNFVVNGVRAVLFGFHMQVFLVHPKALCWVLLDLPGLLFFSAYTLLVLFWAEIYHQARSLPTDKLRITYISVNVAVYLAQIGIWAYIWVHDNSTVELVGKIFIAVVSFIAALGFLLYGGRLFFMLRRFPIESKGRRKKLHEVGSVTAICFTCFLIRCVVVAVSAFDKDLTLDVLDHPVLNLIYYMVVEVLPSALVLFILRKLPPKRVSAQYHPIQ

TOM1

Tobamovirus multiplication protein 1

288 amino acids

Necessary for the efficient intracellular multiplication of tobamoviruses, probably being a membrane anchor promoting the formation of the replication complex.

Belongs to the plant tobamovirus multiplication TOM1 protein family.

32.748 kDa

MTRLPLGSSSIDIAGPTTNWWDQINESVQWQDGIFYSLCASYALVSAVALIQLIRIELRVPEYGWTTQKVFHLMNFVVNGVRAIVFGFHKQVFLFHPKVLSLAILDLPGLLFFSTFTLLVLFWAEIYHQARSLPTDKLRISYISINGAIYFIQACIWVYLWSNDNSTVEFIGKIFIAVVSFIAALGFLLYGGRLFLMLRRFPIESKGRRKKLHEVGSVTAICFTCFLISCFVVVLSAFDPDASLDVLDHPVLNLIYYLLVEILPSALVLYILRKLPPKRVSAQYHPIS