May contribute to the sorting of ubiquitinated proteins and transfer them for further sorting/trafficking processes to the endosomal multivesicular bodies (MVBs) pathway. Binds to phospholipids, such as phosphatidylinositol PtdIns(3)P and PtdIns(3,5)P2. These phospholipids are involved in the recruitment of the ESCRT machinery to endosomal membranes (By similarity).

663 amino acids

MVTELVDKATNELLIQTDWTTVLQISDILNRDPIHARGVVRQVTKKLKDRSRVILLALELADSLLQNCHCTHVYFAERTFQTELCRLIMNKKTKLNVKEKTLEIVESWGNAFQARHDVPGFYETYSFIKRSGYKFPPKPSDAPILNFNNSPAKRTVSTTILTNNSHSTTPPQANVPSFNNVSSVGSNNAGGGGSSSQPIKNQEISSIKGSTSVFNEMISFLNVEDEDPQENDLIKELFETCKQSQIRVKEMIESGSTNERDLNVLLKLNDEINNALNDHEACIKRRRAFVENGYKPVPPPQQQQQQQQQQQQQQQQQQQQQSHSNNHNGTTTTTTTNNNNKNPSYLTKHKELEEIDFFKAPDGISPYSVQQQLQPFQQQQFNSTYNPFAQPQPQQFQQQPQQQLQQQPQQQQGFNQRIQQPQQQADAFDLFVANRQQSNNNNNNNNINNTTSSFGANNPFANNSSNNNNTNGAIQPYIPNTAKSLPPVSQQLQQPMQNQFSPQPQKFVGSSITPSAPPPFKPNTTQSNPFNTSPPLNNMNNHNNNMMQQQQPQQQQQQQPQQQFNPMYNNNAMAPSYPNYNAIGADNQHNTNPYGMMNHQQQQQQQQQQQPMMNQMNNFSAPTYSQFTNYAQPNQQPYNNNYGGMNQSNMYPNNNMSGKSSLI

75.4 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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