TBC1D2

TBC1 domain family member 2A

928 amino acids

Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion.

105.414 kDa

MEGAGENAPESSSSAPGSEESARDPQVPPPEEESGDCARSLEAVPKKLCGYLSKFGGKGPIRGWKSRWFFYDERKCQLYYSRTAQDANPLDSIDLSSAVFDCKADAEEGIFEIKTPSRVITLKAATKQAMLYWLQQLQMKRWEFHNSPPAPPATPDAALAGNGPVLHLELGQEEAELEEFLCPVKTPPGLVGVAAALQPFPALQNISLKHLGTEIQNTMHNIRGNKQAQGTGHEPPGEDSPQSGEPQREEQPLASDASTPGREPEDSPKPAPKPSLTISFAQKAKRQNNTFPFFSEGITRNRTAQEKVAALEQQVLMLTKELKSQKELVKILHKALEAAQQEKRASSAYLAAAEDKDRLELVRHKVRQIAELGRRVEALEQERESLAHTASLREQQVQELQQHVQLLMDKNHAKQQVICKLSEKVTQDFTHPPDQSPLRPDAANRDFLSQQGKIEHLKDDMEAYRTQNCFLNSEIHQVTKIWRKVAEKEKALLTKCAYLQARNCQVESKYLAGLRRLQEALGDEASECSELLRQLVQEALQWEAGEASSDSIELSPISKYDEYGFLTVPDYEVEDLKLLAKIQALESRSHHLLGLEAVDRPLRERWAALGDLVPSAELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHPAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEGTKVVFRYALAIFKYNEKEILRLQNGLEIYQYLRFFTKTISNSRKLMNIAFNDMNPFRMKQLRQLRMVHRERLEAELRELEQLKAEYLERRASRRRAVSEGCASEDEVEGEA

TBC1D2

TBC1 domain family member 2A

925 amino acids

May act as a GTPase-activating protein for Rab family protein(s). Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and further inhibition of cadherin degradation (By similarity).

105.045 kDa

MEGAQESPAESGSSVPWSEEPAGSAKVPEVSLSEESEGCTRPLEATPPKLCGYLSKFGGKGPIRGWKSRWFFFDERKCHLYYSRTAQDANPLDSIDLSSAVFDCKADAEEGTFEIKTPNRIITLKAATKQAMLYWLQQLQMKRWEFHNSLPALPAAHDAALAGNGPALRLELEQEEEEEEAFLCPVKTPTDLVGVAAAWQPVHARPLALQNISLKHLGTEIQNTMCNIRGNKQTQGANHRPPGEDSPLIEETQREEQPSPPGPGAPGKDPANSLKSSLTTSLIRKAKSQSNTFPLFSEGLMRNRTAQEKVLALEQQVLMLTKELKAQKELVKILHKALEAAQQEKRVSSAYLAAAQDKDRLELVRHKVRQIAELGRRVEALERERESLAQTASLQEQEIRELQQHVQLLLDKNQAKQQVICKLSEKVTQDFMKAPEEADRDFLSQQEKMEHLKDDMEAYRTQNRFLNSEIHQVTKIWRKVAEKEKALLMKCAYLQAQNCQVESKYLAGLRRLQEALGVEAGECSELLRQLIQEALQWEASEASADSVVLSPSTISEYDEYGFLTVPNYEVEDLRLLAKIQALEVHSHHLLAHEAVERPLRERWATLGELAPSAELKQLLRAGVPHEHRPRVWRWLIRLRVQHLQAPGCYQALLSRGQACKHSAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLDEEESAFWCLVAIVETIMPADYYSKTLLASQVDQRVLQDLLLEKLPRLMAHLGQRHVDLSFITFNWFLVVFADSLISNILLQVWDAFLYEGIKVVFRYALAIFKYNEEALLRLQDSLEIYQYLHFFTKTICDSRKLMHIAFNDMNPFPMKQLRQLRAAHRERLEAELNELEQLKAEYLETRAAQGPAVPEGSPSEDEGEAEP

Tbc1d2

TBC1 domain family member 2A

924 amino acids

Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion (By similarity).

104.975 kDa

MEDTPERTPSSESIQPPGLAREPEVTSPGDSEGCARPLDPAPKKLCGYLSKFGGKGPIKGWKCRWFFYDERKCHLYYSRTAQDANPLDSIDLSSATFDCKADAEEEGTFEIKTPSRVITLKAATRQVMLYWLQQLQMKRWEFHNSPPALPATPAAALTENGPTLHLKLEQEEAELEEFLCPVKTPPGLVGTAAALQPVPAMPSALQNISLKHLGTEIQNTMYNIRGNKQAQATAHGPPVEESSQSAEPQRGEQPLISDPSIPEKEPEDPPKSAPRSCVPSGPMQKPKRQSNTFPFFSDGLARSRTAQEKVVALEQQVLMLTKELKSQKELVIILHKALEAAQQEKRASSAYLAATEDRDRLELVRHKVRQIAELNQRVEALEQDRERLVHEAGLREQQVQALQQHVQLLMDKNQAKQQVICKLSQKLTEDLAQPQPADATNGDFLSQQERLEHLKDDMEAYRTQNRFLNSEIHQVTKIWRKVAEKEKALLTKCAYLQARNCQVESKYLAGLRRLQEAAGAEPGDFPELLQQLVQEALQWEAGEASDSVGLSPVSEYDDYGFLTVPDYEVEDLKLLAKIQALEVRSHHLLALEAVERPLRDRWATLTELMPSAELKQLLRAGVPREHRPRVWRWLVHRRVQHLHSSGCYQELLARGRACEHPAARQIELDLNRTFPTNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEDEESAFWCLVAIVETILPAEYYSKTLTASQVDQRVLQDLLSEKLPRLTAHLGQRHVDLSLITFNWFLVIFADSLISDILLRVWDAFLYEGTKVVFRYALAIFKYNEEAILRLQDSLEIYQYLRFFTKTICDSRKLTSIAFNDMNPFPMKQLRQLRAAHRERLEAELRELELLKAEYLERRASRGRAVPEGCVSEDEGEGDS

TBC1D2

TBC1 domain family member 2A

923 amino acids

Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion (By similarity).

104.425 kDa

MDGAHENAAESSSSVPRSEEPACSAGGPEVLPPEESEGCAGSLDAAPKKLCGYLSKFGGKGPIRGWKSRWFFYDERKCHLYYSRTAQDANPLDSIDLSSAVFDCKADAEEGTFEIKTPSRIITLKAATKQVMLYWLQQLQTKRWEFHSSPPAPPAAPDAAPAGNGPTLRLELEQEEEELEDFLSPVRTPPGLVGAAAALQPVPTKPLALQNISLKHLGTEIQNTMYNIRSNRQAQGTGHGPPGEDPPLSAEPQRAEWPLPSDPGTPGKDPADSPKPTPKSSLTANLIQKAKRPNNTFPLFAEGLTRTRTAQEKILALEQQVLMLTKELKSQKELVRILHKALEAAQQEKRASSAYLAAAEDKDRLELVRHKVRQIAELGKRVEALERERESLAQTAGLREQQVQELQRHVQQLLEKNQAKQQVICKLSEKVTWDFTHPPTQPPVPLGAADRDFLSQQEKMEHLKDDMEAYRTQNRFLNSEIHQVTKIWRRVAEKEKALLMKCAYLQAKNCQVESKYLAGLRRLQEAAGGEATESSELLRQLTQEALQWEAGEASADGVELSPISEYDEYGFLTVPNYEMEDLKLLAKIQALEVHSHHLLAHEAVERPLRERWAALGDLAPSVELKQLLRAGVPREHRPRVWKWLVQLRVRHLQSPGHYQELLSRGQVREHPAARQIELDLNRTFPNNKHFTCPTSTFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLVAIVETIMPADYYSKTLTSSQVDQRVLQDLLLEKLPRLMAHLGQYRVDLSFLTFNWFLVVFADSLISNILLRVWDAFLYEGTKYNEEEILRLQDSLEIYQYLRFFTKTICNSQKLMTIAFNDMNPFPMKQLRQLRRAHRERLEAELHELEQLKAEYLETQSSRGPAVPDGCTSEDEGEGEA

Tbc1d2

TBC1 domain family member 2A

922 amino acids

Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion (By similarity).

104.26 kDa

MEDAPERTPSSSESTQPPGLAREPEVVSPGDSEGCARPLDTVPKKLCGYLSKFGGKGPIKGWKCRWFFYDERKCHLYYSRTAQDANPLDSIDLSSAVFDCKADAEEEGTFEIKTPSRVITLKAATKQAMLYWLQQLQMKRWEFHNSPPALPATPAAALAENGPTLHLKLEQEEAELEEFLCPVKTPTGLVGAAAALQPVPAVPSALQNISLKHLGTEIQNTMHNIRGNKQAQAAAHGPLVEDSPQGGEPQSGEQPSISDPSLPEKEPEDPAKSAPRSSVPSGPTQKPKRQSNTFPFFSDGLARSRTAQEKVAALEQQVLMLTKELKSQKELVIILHKALEAAQQEKRASSAYLAATEDRDRLELVRHKVRQIAELNQRVEALEQGRERLAHEAGLREQQVQALQQHVQLLMDKNHAKQQVICKLTQKLTEDLAQPADATNGDFLSQQERMEHLKDDMEAYRTQNRFLNSEIHQVTKIWRKVAEKEKALLTKCAYLQARNCQVESKYLAGLRRLQEAAGAEAGDFPELLQQLIQEALQWEAGEADSVGLSPVSEYDDYGFLTVPDYEMEDLKLLAKIQALEVRSHHLLAHEAVERPLRDRWATLTELTPSAELKQLLRAGVPREHRPRVWRWLVHRRVRHLQAPGCYQELLARGRACEHPAARQIELDLNRTFPTNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEDEESAFWCLVAIVETILPAEYYSKTLTASQVDQRVLQDLLSEKLPRLTAHLGQHRVDLSLITFNWFLVVFADSLISDILLRVWDAFLYEGTKVVFRYALAIFKYNEEAILQLQDSLEIYQYLRFFTKTICDSRKLMSIAFNDMNPFPMKQLRQLRAAHRERLEAELRELELLKVEYLQRRASLGRAPPEGCVSEDEGEGDS