Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion (By similarity).

923 amino acids

MDGAHENAAESSSSVPRSEEPACSAGGPEVLPPEESEGCAGSLDAAPKKLCGYLSKFGGKGPIRGWKSRWFFYDERKCHLYYSRTAQDANPLDSIDLSSAVFDCKADAEEGTFEIKTPSRIITLKAATKQVMLYWLQQLQTKRWEFHSSPPAPPAAPDAAPAGNGPTLRLELEQEEEELEDFLSPVRTPPGLVGAAAALQPVPTKPLALQNISLKHLGTEIQNTMYNIRSNRQAQGTGHGPPGEDPPLSAEPQRAEWPLPSDPGTPGKDPADSPKPTPKSSLTANLIQKAKRPNNTFPLFAEGLTRTRTAQEKILALEQQVLMLTKELKSQKELVRILHKALEAAQQEKRASSAYLAAAEDKDRLELVRHKVRQIAELGKRVEALERERESLAQTAGLREQQVQELQRHVQQLLEKNQAKQQVICKLSEKVTWDFTHPPTQPPVPLGAADRDFLSQQEKMEHLKDDMEAYRTQNRFLNSEIHQVTKIWRRVAEKEKALLMKCAYLQAKNCQVESKYLAGLRRLQEAAGGEATESSELLRQLTQEALQWEAGEASADGVELSPISEYDEYGFLTVPNYEMEDLKLLAKIQALEVHSHHLLAHEAVERPLRERWAALGDLAPSVELKQLLRAGVPREHRPRVWKWLVQLRVRHLQSPGHYQELLSRGQVREHPAARQIELDLNRTFPNNKHFTCPTSTFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLVAIVETIMPADYYSKTLTSSQVDQRVLQDLLLEKLPRLMAHLGQYRVDLSFLTFNWFLVVFADSLISNILLRVWDAFLYEGTKYNEEEILRLQDSLEIYQYLRFFTKTICNSQKLMTIAFNDMNPFPMKQLRQLRRAHRERLEAELHELEQLKAEYLETQSSRGPAVPDGCTSEDEGEGEA

104.4 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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