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SRY

Gene
Sry
Protein
Sex-determining region Y protein
Organism
Mus musculus
Length
395 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Promotes DNA bending. Also involved in pre-mRNA splicing (By similarity). Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.
Similarity
Belongs to the SRY family.
Mass
49.494 kDa
Sequence
MEGHVKRPMNAFMVWSRGERHKLAQQNPSMQNTEISKQLGCRWKSLTEAEKRPFFQEAQRLKILHREKYPNYKYQPHRRAKVSQRSGILQPAVASTKLYNLLQWDRNPHAITYRQDWSRAAHLYSKNQQSFYWQPVDIPTGHLQQQQQQQQQQQFHNHHQQQQQFYDHHQQQQQQQQQQQQFHDHHQQKQQFHDHHQQQQQFHDHHHHHQEQQFHDHHQQQQQFHDHQQQQQQQQQQQFHDHHQQKQQFHDHHHHQQQQQFHDHQQQQQQFHDHQQQQHQFHDHPQQKQQFHDHPQQQQQFHDHHHQQQQKQQFHDHHQQKQQFHDHHQQKQQFHDHHQQQQQFHDHHQQQQQQQQQQQQQFHDQQLTYLLTADITGEHTPYQEHLSTALWLAVS
Protein
Sex-determining region Y protein: Sry

Gene
Sry
Protein
Sex-determining region Y protein
Organism
Mus spretus
Length
355 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is responsible for initiating male sex determination. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Promotes DNA bending (By similarity).
Similarity
Belongs to the SRY family.
Mass
44.26 kDa
Sequence
MEGHVKRPMNAFMVWSRGERHKLAQQNPSMQNTEISKQLGCRWKSLTEAEKRPFFQEAQRLKTLHREKYPNYKYQPHRRAKVSQRSGILQPRVASTKLYNLLQWDRNPHAITYRQDWSRAAHLYSKNQQSFYLQPVDIPTGHPQQQQQQFHNHHQQKQQFHDHHQQKQQFHDHHQQQQQFHDHQQQQQQFHDHQQQKQQFHDHQQQQQQFHDHHHQQQQQQFHDHHHHQQQQQQFHDHHQQKQQFHDHHQQQQQQQFHDHPQQQQQFHDHPQQKQQFHDHHHHQQQKQQFHDHHQQKQQFHDHHQQQQQFHDHQQQQQQQQFHDQQLTYLLTADITGEHTPYQEHLSKALWLAVS
Protein
Sex-determining region Y protein: Sry

Gene
Sry
Protein
Sex-determining region Y protein
Organism
Mus spicilegus
Length
311 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is responsible for initiating male sex determination. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Promotes DNA bending (By similarity).
Similarity
Belongs to the SRY family.
Mass
38.469 kDa
Sequence
MEGHVKRPMNAFMVWSRGERHKLAQQNPSMQNTEISKQLGCRWKSLTEAEKRPFFQEAQRLKTLHREKYPNYKYQPHRRAKVSQRSGILQPRVASTKLYNLLQWDRNPHAITYRQDWSRAAHLYSKNQQSFYLQPVDIPTGHPQQQQQQQFHNHHQQKQQFHDHHQQQQQQQFHDHHQQKQQFHDHQQQQQQFHDHHHHQQQQQFHDHQQQQQQLHNHHHQQQQQFHDYPQQQQQFHDHPQQKQQFHDRPQQQQQFHDHHQQQQQFHDHHHQQQQQQFHDQQLTYLLTADITGEHTPYQEHLSKALWLAVS
Protein
Sex-determining region Y protein: Sry

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Ovis aries
Length
240 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
27.882 kDa
Sequence
MNRTVQSYASAMFRVLKDDVYSPAVVQQQNTFAFGKTSSLCTDNHSANDQRERGENVRESSQNHVKRPMNAFIVWSRERRRKVALENPKLQNSEISKQLGYEWKRLTDAEKRPFFEEAQRLLAIHRDKYPGYKYRPRRKAKRPQKSLAADSSILCNQMDAETLHPFTYRDDCAKTTHSQMESQLSRSQSVIITNSLLQKEHHSSWTNLGHDRVTLASRISADFPFYQSLEPGLSCAYVQY
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Capra hircus
Length
240 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
27.945 kDa
Sequence
MNRTVQSYASAMFRVLKDDVYSPAVVQQQNTFAFGKTSSLCTDNHSANDQCERGENVTESSQDHVKRPMNAFIVWSRERRRKVALENPKLQNSEISKQLGYEWKRLTDAEKRPFFEEAQRLLAIHRDKYPGYKYRPRRKAKRPQKSLDADSPILCNQMDVETLHPFTYRDDCAKTTHSQMESQLCRSQSLILTNSLLQKEHHSSWTNLGHDRVTLDTRISADFPFYQSLEPGLSCAYVQY
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Sus scrofa
Length
236 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is responsible for initiating male sex determination. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Promotes DNA bending (By similarity).
Similarity
Belongs to the SRY family.
Mass
27.019 kDa
Sequence
MVQSYASAMFRVLKADDYSPAAQQQNILALGKGSSLFPTDNHSSNDGRETRGSGRESGQDRVKRPMNAFIVWSRDQRRKVALENPQMQNSEISKWLGCKWKMLTEAEKRPFFEEAQRLQAVHRDKYPGYKYRPRRKGERAQNLLPAEAAVLCSQVRVEERMYPFTYTVAKAKCSGTESQLSHSQPMNITSSLLQQEDRCNWTGLCHSRVTSTGQIRADLPFHRGLQPGLSHIYFPY
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Felis catus
Length
234 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
26.811 kDa
Sequence
MLRVLSSDEHREAVQQQNILAVEGTSCELCTESPTSNYRCETRGKGRDRGQDRVKRPMNAFMVWSRDQRRKVALENPQTQNSEISKQLGYQWKMLTQAEKWPFFEEAQRLQALHREKYPGYRYRPRRKARPEKSDKLPPADASSTLCSQLHAGERLYAFPYKDGCTKAAHSGMKDQLYSSSEPMSITSSLLEPGPHRTSTTLQDSPEDLAMQLSADAPLYRTLELGVSEAYFAW
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Pongo pygmaeus
Length
233 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is responsible for initiating male sex determination. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Promotes DNA bending (By similarity).
Similarity
Belongs to the SRY family.
Mass
27.118 kDa
Sequence
MQSYASAMLSVFNSDDYSPAVQQNIPALRRSSSFICTESYNSKYQCETGENSKGSVQDRVKRPMNAFIVWSRDQRRKMALENPKMRNSEISKQLGYQWKMLTEAEKWPFFQEAQKLQAMHREKYPNYKYRPRRKAKMLQKSCSSLPADPASVLCSEVLQLDNRLYRDDCTKATHSRLEHQLGHLPPINTASSPQQRDRYSHSTELYDNRVTLATKTYLDAAFYDNLQPSLSYV
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Phoca largha
Length
232 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is responsible for initiating male sex determination. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Promotes DNA bending (By similarity).
Similarity
Belongs to the SRY family.
Mass
27.037 kDa
Sequence
MFGVLNSNDHRAAVQQRNIPAFGRTSFEPWTDNPTSNYRCETGGNGRDSGQNRVRRPMNAFMVWSRDQRRKVALENPQMQNSEISKQLGYQWKMLTEAEKWPFFEEAQRLQAMHREKYPDYKYRPRRKALPQKSDKLLPAASSSMLCRQVLVDEKWYPFTYRDSCSRAAHSRMEDQLSSSQPVNIANSLLQQEHHYRSTSLRDSPETLAAHLSADPPFYPKEQLGLSDAYFP
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Phoca vitulina
Length
232 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is responsible for initiating male sex determination. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Promotes DNA bending (By similarity).
Similarity
Belongs to the SRY family.
Mass
27.037 kDa
Sequence
MFGVLNSNDHRAAVQQRNIPAFGRTSFEPWTDNPTSNYRCETGGNGRDSGQNRVRRPMNAFMVWSRDQRRKVALENPQMQNSEISKQLGYQWKMLTEAEKWPFFEEAQRLQAMHREKYPDYKYRPRRKALPQKSDKLLPAASSSMLCRQVLVDEKWYPFTYRDSCSRAAHSRMEDQLSSSQPVNIANSLLQQEHHYRSTSLRDSPETLAAHLSADPPFYPKEQLGLSDAYFP
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Pusa caspica
Length
232 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is responsible for initiating male sex determination. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Promotes DNA bending (By similarity).
Similarity
Belongs to the SRY family.
Mass
26.935 kDa
Sequence
MFGVLNSNDHRAAVQQRNIPAFGRTSFEPWTDNPTSNYRCETGGNGRDSGQNRVRRPMNAFMVWSRDQRRKVALENPQMQNSEISKQLGYQWRMLTEAEKWPFFEEAQRLQAMHREKYPDYKYRPRRKALPQKSDKLLPAASSSMLCRQVLVDEKWYPFTYRDSCSRAAHSPMEDQLSSSRPVNIANSLLQQEHHYRSTSLGDSPETLAAHLSADPPFYPKEQLGLSDAYFP
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Pusa hispida
Length
232 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is responsible for initiating male sex determination. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Promotes DNA bending (By similarity).
Similarity
Belongs to the SRY family.
Mass
27.136 kDa
Sequence
MFGVLNSNDHRAAVQQRNIPAFGRTSFEPWTDNPTSNYRCETGGNGRDSGQNRVRRPMNAFMVWSRDQRRKVALENPQMQNSEISKQLGYQWKMLTEAEKWPFFEEAQRLQAMHREKYPDYKYRPRRKALPQKSDKLLPAASSSMLCRQVLVDEKWYPFTYRDSCSRAAHSRMEDQLSSSQPVNIANWLLQQEHHYRSTSLRDSPETLAAHLSADPPFYPKEQLGLSDAYFP
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Ursus arctos
Length
232 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
27.195 kDa
Sequence
MFGVLNSDDHCAAVQQRNILAFGRTFSEFWMNNPTSNYRCETEGNSRDSGQNRVRRPMNAFMLWSRDQRRKVALENPQMQNSEISKQLGYQWEMLTEAEKWPFFEEAQRLQAMHRQKYPDYKYRPRRKATPQKDDKLLPSASSSTLCRQVRVDETWYPFTYRNSHTRAAHSGMEDQLSSSQPVNVASSLLQQEQHCSSTSFRDSRETLATQLWADPPFYPKQQLGLSDAYFP
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Halichoerus grypus
Length
232 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
26.938 kDa
Sequence
MFGVLNSNDHRAAVQQRNIPAFGRTSFEPWTDNPTSNYRCETGGNGRDSGQNRVRRPMNAFMVWSRDQRRKVALENPQMQNSEISKQLGYQWKMLTEAEKWPFFEEAQRLQAMHREKYPDYKYRPRRKALPQKSDKLLPAASSSMLCRQVLVDEKWYPFTYRDSCSRAAHSRMEDQLSSSQPVNIANSLLQQEHHYRSTSLGDSPETLAAHLSADPPFYPKEQLGLSDAYFP
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Przewalskium albirostris
Length
229 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
26.796 kDa
Sequence
MFRVLNDDVYSPAEIQQQNPLAFGKASSLFTDNRSANDQCETGENVRESGQDHVKRPMNAFIVWSRERRRKVALENPKMQNSEISKQLGYEWKRLTDAEKRPFFEEAQRLLAVHRDKYPGYKYRPRRKRKRQQKLLPADSSKLCKQMHIETLQPFTYRDGCANTTGSRMESQLSLSQSVTITNSFFQNEHHSSWTNLGHNRVTLATQISADFPFYQSLQPELSCAYFQY
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Axis porcinus
Length
229 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
26.75 kDa
Sequence
MFRVLNDDVYSPAEIQQQNPLAFGKASSLFTDNRSANDQCETGENVRESGQDHVKRPMNAFIVWSRERRRKVALENPKMQNSEISKQLGYEWKRLTDAEKRPFFEEAQRLLAVHRDKYPGYKYRPRRKTKRQQKLLPADSSKLCKQMHIETLQPFIYRDGCANTTGSRMESQLSLSQSVTITNSFFQNEHHRSWTNLGHNRVTLATQISADFPFYQSLQPGLSCAYFQY
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Bison bison
Length
229 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
26.687 kDa
Sequence
MFRVLNDDVYSPAVVQQQTTLSFRKDSSLCTDSHSANDQCERGEHVRESSQDHVKRPMNAFIVWSRERRRKVALENPKMKNSDISKQLGYEWKRLTDAEKRPFFEEAQRLLAIHRDKYPGYKYRPRRRAKRPQKSLPADSSILCNPMHVETLHPFTYRDGCAKTTYSQMESQLSRSQSVIITNSLLQKEHHSSWTSLGHNKVTLATRISADFPFNKSLEPGLSCAYFQY
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Bison bonasus
Length
229 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
26.671 kDa
Sequence
MFRVLNDDVYSPAVVQQQTTLAFRKDSSLCTDSHSANDQCERGEHVRESSQDHVKRPMNAFIVWSRERRRKVALENPKMKNSDISKQLGYEWKRLTDAEKRPFFEEAQRLLAIHRDKYPGYKYRPRRRAKRPQKSLPADSSILCNPMHVETLHPFTYRDGCAKTTYSQMESQLSRSQSVIITNSLLQKEHHSSWTSLGHNKVTLATRISADFPFNKSLEPGLSCAYFQY
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Bos gaurus frontalis
Length
229 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
26.671 kDa
Sequence
MFRVLNDDVYSPAVVQQQTTLAFRKDSSLCTDSHSANDQCERGEHVRESSQDHVKRPMNAFIVWSRERRRKVALENPKMKNSDISKQLGYEWKRLTDAEKRPFFEEAQRLLAIHRDKYPGYKYRPRRRAKRPQKSLPADSSILCNPMHVETLHPFTYRDGCAKTTYSQMESQLSRSQSVIITNSLLQKEHHSSWTSLGHNKVTLATRISADFPFNKSLEPGLSCAYFQY
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Bos indicus
Length
229 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
26.671 kDa
Sequence
MFRVLNDDVYSPAVVQQQTTLAFRKDSSLCTDSHSANDQCERGEHVRESSQDHVKRPMNAFIVWSRERRRKVALENPKMKNSDISKQLGYEWKRLTDAEKRPFFEEAQRLLAIHRDKYPGYKYRPRRRAKRPQKSLPADSSILCNPMHVETLHPFTYRDGCAKTTYSQMESQLSRSQSVIITNSLLQKEHHSSWTSLGHNKVTLATRISADFPFNKSLEPGLSCAYFQY
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Bos javanicus
Length
229 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
26.645 kDa
Sequence
MFRVLNDDVYSPAVVQQQTTLAFRKDSSLCTDSHSANDQCERGEHVRESSQDHVKRPMNAFIVWSRERRRKVALENPKMKNSDISKQLGYEWKRLTDAEKRPFFEEAQRLLAIHRDKHPGYKYRPRRRAKRPQKSLPADSSILCNPMHVETLHPFTYRDGCAKTTYSQMESQLSRSQSVIITNSLLQKEHHSSWTSLGHNKVTLATRISADFPFNKSLEPGLSCAYFQY
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Bos mutus grunniens
Length
229 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
26.72 kDa
Sequence
MFRVLNDDVYSPAVVQQQTTLAFRKDSSLCTDSHSANDQCERGEHVRESSQDHVKRPMNAFIVWSRERRRKVALEYPKMKNSDISKQLGYEWKRLTDAEKRPFFEEAQRLLAIHRDKYPGYKYRPRRRAKRPQKSLPADSSILCNPMHVETLHPFTYRDGCAKTTYSQMESQLSRSQSVIITNSLLQKEHHSSWTSLGHNKVTLATRISADFPFNKSLEPGLSCAYFQY
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Bos taurus
Length
229 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
26.627 kDa
Sequence
MFRVLNDDVYSPAVVQQQTTLAFRKDSSLCTDSHSANDQCERGEHVRESSQDHVKRPMNAFIVWSRERRRKVALENPKMKNSDISKQLGYEWKRLTDAEKRPFFEEAQRLLAIHRDKYPGYKYRPRRRAKRPQKSLPADSSILCNPMHVETLHPFTYRDGCAKTTYSQMESQLSRSQSVIITNSLLQKEHHSSWTSLGHNKVTLATRISADFPCNKSLEPGLSCAYFQY
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Bubalus bubalis
Length
229 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
26.793 kDa
Sequence
MFRVLNDDVYSPAVVQQQNILAFRKDSSSCTDSHSANDQCERGENVRESSQDHIKRPMNAFILWSRERRRKLALENPKMKNSEISKQLGYEWKRLTDAEKRPFFEEAQRLLSIHRDKYPGYKYRPRRKAKRLQKSLPADSSILCNPMHVETLHPFTYRDGCAKTTYSQMESQLSRSQSVIITNSLLQKEHHSSWTSLGHNRVTLATRISEDFPFNKSLEPGLSCAYFQY
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Cervus nippon
Length
229 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
26.732 kDa
Sequence
MFRVLNDDVYSPAEIQQQNPLAFGKASSLFTDNRSANDQCETGENVRESGQDHVKRPMNAFIVWSRERRRKVALENPQMQNSEISKQLGYEWKRLTDAEKRPFFEEAQRLLAVHRDKYPGYKYRPRRKTKRQQKLLPADSSKQCKQMHIETLQPFTYRYGCANTTGSRMESQLSLSQSVTITNSFFQNEHHSSWTNLGHNRVTLATQISADFPFYQSLQPGLSCAYFQY
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Elaphurus davidianus
Length
229 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
26.669 kDa
Sequence
MFRVLNDDVYSPAEIQQQNPLAFGKASSLFTDNRSANDQCETGENVRESGQDHVKRPMNAFIVWSRERRRKVALENPKMQNSEISKQLGYEWKRLTDAEKRPFFEEAQRLLAVHRDKYPGYKYRPRRKTKRQQKLLPADSSKLCKQMHIETLQPFTYRDGCANTTGSRMESQLSLSQSVTITNSFFQNEHHSSWTNLGHNRVTLATQISADFPFYQSLQPGLSCAYFQY
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Alces alces cameloides
Length
229 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
26.828 kDa
Sequence
MFRVLNDDVYSPAEIQQQNPLAFGKASSLFTDNRSANDQCETGENVRESGQDHVKRPMNAFIVWSRERRRKVALENPKMQNSEISKQLGYEWKRLTDAEKRPFFEEAQRLLAIHRDKYPDYKYRPRRKTKRQQKLLPADSSILCKQMHVETLQPFTYRNGCAKTTCSRMESQLSLSQSVTITNSFFQKEHHNSWTNLGHNRVTLSTQISADFPFYQSLQPGLSCAYFQY
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Callithrix jacchus
Length
227 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
26.307 kDa
Sequence
MQSYASAMLRVFNSDEYNPAALQNIPDSGKSSSVIWTDNSSSKDQWQTGENSKGSVQNRVKRPMNAFIVWSRDQRRKMAVENPQMRNSEISKRLGYQWKLLTEAEKWPFFQEAQKLQAMHREKYPNYKYRPRRKANMLQNNDSLLTADPSSELCGEMQAEDRLFTFSYSDNSKKSTQSTMEHPLGLSPPVNPDSSPQQRDRCSHSTNLQDNRVTLTTKIYADSPFYR
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Moschus berezovskii
Length
227 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
26.434 kDa
Sequence
MFRVLNNDVYSPAVVQQQTTLAFGKASSLCTDNRSANDQCEMGENFRESGQDHIKRPMNAFIVWSRERRRKVALENPQMQNSEISKQLGYEWKRLTDAEKRPFFEEAQRLLAIHQDKYPGYKYRPRRKAKRPQNSLPSVSSILCNQMSVETLHPFTYRDGCAKTTYSPMESQLSRSQSMTSSLLQKEHHSSWTSLGHNRVTMATHIFADFPFYQSLEPRLSCAYFPY
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Moschus chrysogaster
Length
227 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
26.358 kDa
Sequence
MFRVLNNDVYSPAVVQQQTTLAFGKASSLCTDNRSANDQCEMGENFRESGQDHVKRPMNAFIVWSRERRRKVALENPQMQNSEISKQPGYEWKRLTDAGKRPFFEEAQRLLAIHQDKYPGYKYRPRRKAKRPQNSLPSVSSILCNQMSVETLHPFTYRDGCAKTTYSPMESQLSRLQSMTSSLLQKEHHSSWTSLGHNRVTMATHIFADFPFYQSLEPRLSCAYFPY
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Equus caballus
Length
223 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
25.353 kDa
Sequence
MSRVSNSDNYSLAGQQHTVLGSGRTSSLLWTSNPGSHFRSETRGNGRENGQDRVKRPMNAFMVWSRDHRRKVALENPQLQNSEISKRLGCQWKMLTEAEKLPFFEEAQRLRAMHQEKYPDYKYRPRRKAKMPQKSDKPLPQTPLLHCAGRRTYTSTSGCPFLIHGRLFLRATQSQTGGAVKPFAAGATAISALQQELSQQHRTLRCHSGNVGYADIRRRSLSL
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Pagophilus groenlandicus
Length
221 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is responsible for initiating male sex determination. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Promotes DNA bending (By similarity).
Similarity
Belongs to the SRY family.
Mass
25.842 kDa
Sequence
MFGVLNSNDHRAAVQQRNIPAFGRTSFEPWTDNPTSNYRCEPGGNGRDSGQNRVRRPMNAFMVWSRDQRRKVALENPQMQNSEISKQLGYQWKMLTEAEKWPFFEEAQRLQAMHREKYPDYKYRPRRKALPQKSDKLLPAASSSMLCRQVLVDEKWYPFTYRDSCSRAAHSRMEDQLSSSQPVNIANSLLQQEHHYRSTSLRDSPETLATHLSADPPFYPK
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Neomonachus schauinslandi
Length
221 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
25.791 kDa
Sequence
MFGVLNSSDHRAAVQQRNIPAFGRTSFELWTDNPTSNYRCETGGNGRDSGQNRVRRPMNAFMVWSRDQRRRVALENPQMKNSEISKQLGYQWKMLTEAEKWPFFEEAQRLQAMHREKYPDYKYRPRPKALPQKSDKLLPAASSSMLCRQVLVDEKWYPFTYRDSCSRAAHPRMEDQLSSSQPVNIANSLLQQEHHYCSTSLRDSPETLAMHLSADPPFYPK
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Cystophora cristata
Length
221 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
25.874 kDa
Sequence
MFGVLNSNDHRAAVQQRNIPAFGRTSFEPWTDNPTSNYRCETGGNGRDSGQNRVRRPMNAFMVWSRDQRRKVALENPQMQNSEISKQLGYQWKMLTEAEKWPFFEEAQRLQAMHREKYPDYKYRPRRKALPQKSDKLLPAVSSSMLCRQVLVDEKWYPFTYRDSCSRAAHSRMEDQLSSSQPVNIANSLLQQEHHYRSTSLRDSPETLATHLSADPPFYPK
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Erignathus barbatus
Length
221 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
25.91 kDa
Sequence
MFGVLNSNDHRAAVQQRNTPAFGRTSFELWTDNPTSNYRCETGGNGRDSGQNRVRRPMNAFMVWSRDQRRRVALENPQMQNSEISKQLGYQWKMLTEAEKWPFFEEAQRLQAMHREKYPDYKYRPRRKALPQKRDKLLPAASSSMLRRQVLVDEKWYPFTYRDSCSTAAHSRMEDQLSSSQPVNIANSLLQQEHHYSSTSFRDSPETLATHLSADPPFYPK
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Hydrurga leptonyx
Length
221 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
25.776 kDa
Sequence
MFGVLNSSDHRAAVQQRNIPAFGRTSFELWTDNPTSNYRCETGGNGRDSGQNRVRRPMNAFMVWSRDQRRRVALENPQMQNSEISKQLGYQWKMLTEAEKWPFFEEAQRLQAMHREKYPDYKYRPRRKALPQNSDKLLPAASSSMLCRQVLVDEKWCPFTYRDSCSRAAHPRMEDQLSSSQPVNIANSLLQQEHHYCSTSLRDSPETLAMHLSADPPFYPK
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Zalophus californianus
Length
220 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
25.549 kDa
Sequence
MFGVLNSDDHRAAIQHRNILAFGRTSSELWTSNPTSNYWCETRGNGRDSGQNRVRRPMNAFMVWSRDQRRKVALENPQMQNSEISKQLGYQWKMLTEAEKWPFFEEAQRLQAVHREKYPDYKYRPRRKALPQKSDKLLPAASSSLLCRQVLVDKSYPFTYRDSCSRATHSHMEDQLSSSQPVNIANSLLQQEHHYSSTSLRGSPETLATHLSADPPFYPK
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Arctocephalus australis
Length
220 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
25.639 kDa
Sequence
MFGVLNSDDHRAAIQQRNILAFGRTSSELWTSNPTSNYWCETRGNGRDSGQNRVRRPMNAFMVWSRDQRRKVALENPQMQNSEISKQLGYQWKMLTEAEKWPFFEEAQRLQAVHREKYPDYKYRPRRKALPQKSDKLLPAASSSLLCRQVLVDKWYPFTYRDSCSRATHSHMEDQLSSSQPVNIANSLLQQEHHYSSTSLRGSPETLATHLSADPPFYPK
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Arctocephalus forsteri
Length
220 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
25.639 kDa
Sequence
MFGVLNSDDHRAAIQQRNILAFGRTSSELWTSNPTSNYWCETRGNGRDSGQNRVRRPMNAFMVWSRDQRRKVALENPQMQNSEISKQLGYQWKMLTEAEKWPFFEEAQRLQAVHREKYPDYKYRPRRKALPQKSDKLLPAASSSLLCRQVLVDKWYPFTYRDSCSRATHSHMEDQLSSSQPVNIANSLLQQEHHYSSTSLRGSPETLATHLSADPPFYPK
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Arctocephalus gazella
Length
220 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
25.667 kDa
Sequence
MFGVLNSDDHRAAIQQRNILAFGRTSSELWTSNPTSNYWCETRGNGRDSGQNRVRRPMNAFMVWSRDQRRKVALENPQMQNSEISKQLGYQWKMLTEAEKWPFFEEAQRLQAVHREKYPDYKYRPRRKALPQKSDKLLPAASSSLLCRQVLVDKWYPFTYRDSCSRATHSHMEDQLSSSKPVNIANSLLQREHHYSSTSLRGSPETLATHLSADPPFYPK
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Callorhinus ursinus
Length
220 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
25.719 kDa
Sequence
MFGVLNSDDHRAAIQQRNILAFGRTSSELWTSNPTSNYWCETRGNGRDSGQNRVRRPMNAFMVWSRDQRRKVALENPQMQNSEISKQLGYQWKMLTEAEKWPFFEEAQRLQAMHREKYPDYKYRPRRKALPQKSDKFLPAASSTLLCRQVLVDKWYPFTYRDSCSRATHSHMEDQLSSSQPVNIANSLLQQEHHYSSTSLRGSPETLATHLSADPPFYPK
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Canis lupus familiaris
Length
220 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
25.505 kDa
Sequence
MFRALNCDDHGAAVQQNAFGFPRKSSDRWTDNSTSNYRCESGGNGRDSGRNRVRRPMNAFLVWSRDQRRKMALENPQMQNSEISKQLGYQWKMLTEAEKWPFFEEAQRLQAMHREKYPDYKYRPRRKATAQKSHKLLPAASSSMLCKQVHVDERFYPFTYTDSCSRAAHTRMEDQLSCSQPMSTARSLLQQEYHSSSASLRDSPETLAAQMSADASFYSK
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Eumetopias jubatus
Length
220 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
25.585 kDa
Sequence
MFGVLNSDDRRAAIQQPNILAFGRTSSDLWTSNPTSNYWCETRGNGRDSGQNRVRRPMNAFMVWSRDQRRKVALENPQMQNSEISKQLGYQWKMLTEAEKWPFFEEAQRLQAVHREKYPDYKYRPRRKALPQKSDKLLPAASSSLLCRQVLVDKWYPFTYRDSCSRATHSHMEDQLSSSQPVNIANSLLQQEHHYSSTSLRGSPETLATHLSADPPFYPK
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Lutra lutra
Length
219 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
25.332 kDa
Sequence
MFGVLNSDNHCAAVQQGNILAFGRTSSEFWTNNPTSSYRCETGGNRTDSGQSHIRRPMNAFMVWSRDQRRKVALENPQMQNSEISKRLGYQWKMLTEAEKRPFFEEAQRIQAMHREKYPDYKYRPRRKAVPKNSDKLLPAASSSMLCRQGNVDERWYPFTWRGGRTRASHSGTEDRLNSSQAANIVRSLLQQEHHCSSTSLRHSPETLAIQLSTDFYPK
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Enhydra lutris
Length
219 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
25.308 kDa
Sequence
MFGVLNSDNHCAAVQQGNILAFGRTSSELWTNNPTSNYRCETGGNRTDSGQSHIRRPMNAFMVWSRDQRRKVALENPQMQNSEISKQLGYQWKMLTEAEKRPFFEEAQRIQAMHREKYPDYKYRPRRKAVPQNSDKLLPAAFSSMLCRQGHVDERWYPFTCRGGRTRAAHSGTEDRLNSSQAANIVRSLLQQEHHCSSTSLRHNPETLAIQLSTDFYPK
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Mirounga angustirostris
Length
218 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
25.366 kDa
Sequence
MFGVLNSSDHRAAVQQRNIPAFGRTSFELWTDSPTSNHRCETGGNGRDSGQNRVRRPMNAFMVWSRDHRRRVALENPQMQNSEISKQLGYQWKMLTEAEKWPFFEEAQRLQATHREKYPDYKYRPRRKALPQKSDKLLPAASSSTLCRQVLVDEKWYPFTYRDSCSRAAHPRMEDHLSSSQPVNIANSLLQQEHHYCSTSLRDSPETLAMHLSADPPF
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Mirounga leonina
Length
218 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
25.396 kDa
Sequence
MFGVLNSSDHRAAVQQRNIPAFGRTSFELWTDSPTSNHRCETGGNGRDSGQNRVRRPMNAFMVWSRDHRRRVALENPQMQNSEISKQLGYQWKMLTEAEKWPFFEEAQRLQAMHREKYPDYKYRPRRKALPQKSDKLLPAASSSTLCRQVLVDEKWYPFTYRDSCSRAAHPRMEDHLSSSQPVNIANSLLQQEHHYCSTSLRDSPETLAMHLSADPPF
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Physeter macrocephalus
Length
216 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is responsible for initiating male sex determination. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Promotes DNA bending (By similarity).
Similarity
Belongs to the SRY family.
Mass
25.041 kDa
Sequence
MFRIVNGEDYSPAVQQRNILDFGKAPSLLWTDNGSSNDRCDTGGNGRESGQDRVKRPMNAFIVWSRDQRRKVALENPQMQNSEISKRLGYDWKMLTEAEKQPFFEEAQRLRAMHRDKYPGYKYHPRRKPKRPQESLPADSSVLCSRTHIEETLYPFTYKDGCAKATRSRMESQLSHSQPTNISSSLLPQEHRSSWTILRHNRVTQATQTCGRPLLL
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Kogia sima
Length
216 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
25.033 kDa
Sequence
MFRIVNGEDYSPAVQQRNILDFGKAPSLLWTDNGSSNDRCDTGGNGRESGQDRVKRPMNAFIVWSRDQRRKVALENPQMQNSEISKRLGYDWKMLTEAEKQPFFEEAQRLRAMHRDKYPGYKYRPRRKPKRPQKLLPADSSVLCSRMHIEETLYPFTYKDGCAKATRSRMESQLSNSQPTNISSSLLPQEHPSSWTILRHNRVTQATQTCGRPLLL
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Mesoplodon stejnegeri
Length
216 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
25.224 kDa
Sequence
MFRIVNGEDYSPAVQQRNIRDFGKAPSLLWTDNGSSNDRCETGGNGRESGQDRVKRPMNAFIVWSRDQRRKVALENPQMRNSEISKRLGYDWKMLTEAEKQPFFEEAQRLRAMHRDKYPGYKYRPRRKAKRPQKSLPADSSVRCSRMHIEETLYPFTYKDGCAKATRSRMESRLSHSQPTNISSSLLPQEHRSSWTSLRHNRVTQAMQTCGRPLLL
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Sminthopsis macroura
Length
208 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
24.537 kDa
Sequence
MCSFLDVEVKDRFVEGDFGMSEMVKSNLANCSSRVKRPMNAFMVWSQTQRRKVALQNPKMHNSEISKQLGVTWKLLSDSEKRPFIDEAKRLRDKHKQVSDYKYQPRRKTKSFLKNVYNHKDHLTKATDQLIKTQHLKEDSTTIYENTMKCPEISSFYCAQESTYLDNWMNLPPEQENTEFWQGLFTNETETCRSLPHGQMDCNECRSI
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Pan paniscus
Length
204 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is responsible for initiating male sex determination. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Promotes DNA bending (By similarity).
Similarity
Belongs to the SRY family.
Mass
23.86 kDa
Sequence
MQSYASAMLSVFNSDDYSPGVQQNIPALRRSSSFLCTESYNSKYQRETGENSKDSVQDRVKRPMNAFFVWSRDQRRKMALENPRMRNSEISKQLGYQWKMLTAAEKWPFFQEAQKLQAMHREKYPNYKYRPRRKANMLPKNCSLLPADPASVLCSEVQLDNRLYRDDCTKATHSTMEHQLGHLPPINAASSPQQRDRCSHWTKL
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Pan troglodytes
Length
204 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is responsible for initiating male sex determination. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Promotes DNA bending (By similarity).
Similarity
Belongs to the SRY family.
Mass
24.047 kDa
Sequence
MQSYASAMLSVFNSDDYSPAVQQNIPALRRSSSFLCTESYNSKYQRETGENSKDSVQDRVKRPMNAFFVWSRDQRRKMALENPRMRNSEISKQLGYQWKMLTEAEKWPFFQEAQKLQAMHREKYPNYKYRPRRKANMLPKNCSLLPADPASVLCSEVQLDNRLYRDDCTKATHSRMEHQLGHLPPINAASSPQQRDRYSHWTKL
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Balaenoptera acutorostrata
Length
204 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
23.726 kDa
Sequence
MFRIVNGEDYSPAVQQRNSLDFGKAPSLLWTDNGGSNDRCETGGNGRESGQDRVKRPMNAFIVWSRDQRRKVALENPQMQNSEISKRLGYDWKMLTEAEKQPFFEEAQRLRAMHRDKYPGYKYRPRRKAKRPQKLLPADSSVLCSRMHIEETLYPFTYKDGCAKATRSRMESRLSYSQPTNTTSSLLPQEHRSSWTSLSHNRVT
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Balaenoptera bonaerensis
Length
204 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
23.726 kDa
Sequence
MFRIVNGEDYSPAVQQRNSLDFGKAPSLLWTDNGGSNDRCETGGNGRESGQDRVKRPMNAFIVWSRDQRRKVALENPQMQNSEISKRLGYDWKMLTEAEKQPFFEEAQRLRAMHRDKYPGYKYRPRRKAKRPQKLLPADSSVLCSRMHIEETLYPFTYKDGCAKATRSRMESRLSYSQPTNTTSSLLPQEHRSSWTSLSHNRVT
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Balaenoptera musculus
Length
204 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
23.758 kDa
Sequence
MFRIVNGEDYSPEVQQRNSLDFGKAPSLLWTDNGGSNDRCETGGNGRESGQDRVKRPMNAFIVWSRDQRRKVALENPQMQNSEISKRLGYDWKMLTEAEKQPFFEEAQRLRAMHRDKYPGYKYRPRRKAKRPQKLLPADSSVLCSRMHIEETLYPFTYKDGCAKATRSRMESRLSHSQPTNTTSSLLPQEHRSSWTSLSHNRVT
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Balaenoptera physalus
Length
204 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
23.732 kDa
Sequence
MFRIVNGEDYSPAVQQRNSLDFGKAPSLLWTDHGGSNDRCETGGNGRESGQDRVKRPMNAFIVWSRDQRRKVALENPQMQNSEISKRLGYDWKMLTEAEKQPFFEEAQRLRAMHRDKYPGYKYRPRRKAKRSQKLLPADSSVLCSRMHIEETLYPFTYKDGCAKATRSRMESRLSRSQPTNTTSSLLPQEHRSSWTSLSHNRVT
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Macaca mulatta
Length
204 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
23.618 kDa
Sequence
MQSYASAMLSVFNTDGYSPAAQQNIPALRRSSSFICTESCSSKYQCEAGENSKGSVQDKVKRPMNAFIVWSRDQKRKMALENPKMRNSEISKQLGYQWKMLTEADKWPFFQEAQKLQAMHREKYPNYKYRPRRKAKMLQNSCSLLPADPSSVPCREVQLDNRLYRDDCTKATHSRMQHQLGHLPPINTASSPQQRDRYSHSTKL
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Megaptera novaeangliae
Length
204 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
23.702 kDa
Sequence
MFRIVNGEDYSPAVQQRNSLDFGKAPSLLWTDHGGSNDRCETGGNGRESGQDRVKRPMNAFIVWSRDQRRKVALENPQMQNSEISKRLGYDWKMLTEAEKQPFFEEAQRLRAMHRDKYPGYKYRPRRKAKRSQKLLPADSSVLCSRMHIEETLYPFTYKDGCAKATRSRMESRLSRSQPTNTASSLLPQEHRSSWTSLSHNRVT
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Eubalaena australis
Length
204 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
23.713 kDa
Sequence
MFRIVNGEDYSPAVQQRNSLDFGKAPSLLWTDNGGSNDRCETGGNGRESGQDRVKRPMNAFIVWSRDQRRKVALENPQMQNSEISKRLGYDWKMLTEAEKQPFFEEAQRLRAMHRNKYPGYKYRPRRKAERPQKLLPADSSVLCSRMHIEETLYPFTYKDGCAKATRSRMESRLSHSQPTNITSSLLPQEHRSSWTSLSHDRVT
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Gorilla gorilla gorilla
Length
204 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
23.867 kDa
Sequence
MQSYASAMLSVFNSDDYSPAVQQTIPAHRRSSSFLCTESCNSKYQCETGENSKGSVQDRVKRPMNAFIVWSRDQRRKMALENPRMRNSEISKQLGYQWKMLTEAEKWPFFQEAQKLQAMHREKYPNYKYRPRRKAKMLPKNCSLLPADPASVLCSEVQLDNRLYRDDCTKATHSRMEHQLGHLPPINAASSPQQRDRYSHWTKL
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Homo sapiens
Length
204 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression (By similarity). Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.
Similarity
Belongs to the SRY family.
Mass
23.884 kDa
Sequence
MQSYASAMLSVFNSDDYSPAVQENIPALRRSSSFLCTESCNSKYQCETGENSKGNVQDRVKRPMNAFIVWSRDQRRKMALENPRMRNSEISKQLGYQWKMLTEAEKWPFFQEAQKLQAMHREKYPNYKYRPRRKAKMLPKNCSLLPADPASVLCSEVQLDNRLYRDDCTKATHSRMEHQLGHLPPINAASSPQQRDRYSHWTKL
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Hylobates lar
Length
204 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
23.78 kDa
Sequence
MQSYASAMLSVFNSDYYSPAVQQNTPALRRSSSFICTESCNSKYPCETGENSKVSVQDRVKRPMNAFIVWSRDQRRKMALENPKMRNSEISKQLGYRWKMLTEAEKWPFFQEAQKLQAMHREKYPNYKYRPRRKAKMLQKSCSLLPADSASVLCSKVQLDNRLYRDDCTKATHSRMEHQLGHLPPINTASSPQQQDHYSHSTKL
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Peponocephala electra
Length
201 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is responsible for initiating male sex determination. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Promotes DNA bending (By similarity).
Similarity
Belongs to the SRY family.
Mass
23.096 kDa
Sequence
MFRTVNGEDYSPAVQQRNILDFGKAHSLLWTDNGSANDRCETGGNCRESGQDRVKRPMNAFIVWSRDQRRKVALENPQMQNSEISKRLGYDWKMLTEAEKQPFFEEAQRLRAMHRDKYPGYKYRPRRKAKEATEIASRRLFSTVQPNAHRGDVVPLPIQGRLRQGHTFTNGKPVKPLTAHEHKQLTPATGASQQLDKPAPQ
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Tursiops truncatus
Length
201 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
23.096 kDa
Sequence
MFRTVNGEDYSPAVQQRNILDFGKAHSLLWTDNGSANDRCETGGNCRESGQDRVKRPMNAFIVWSRDQRRKVALENPQMQNSEISKRLGYDWKMLTEAEKQPFFEEAQRLRAMHRDKYPGYKYRPRRKAKEATEIASRRLFSTVQPNAHRGDVVPLPIQGRLRQGHTFTNGKPVKPLTAHEHKQLTPATGASQQLDKPAPQ
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Lagenorhynchus obliquidens
Length
201 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
23.096 kDa
Sequence
MFRTVNGEDYSPAVQQRNILDFGKAHSLLWTDNGSANDRCETGGNCRESGQDRVKRPMNAFIVWSRDQRRKVALENPQMQNSEISKRLGYDWKMLTEAEKQPFFEEAQRLRAMHRDKYPGYKYRPRRKAKEATEIASRRLFSTVQPNAHRGDVVPLPIQGRLRQGHTFTNGKPVKPLTAHEHKQLTPATGASQQLDKPAPQ
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Orcaella brevirostris
Length
201 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is responsible for initiating male sex determination. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Promotes DNA bending (By similarity).
Similarity
Belongs to the SRY family.
Mass
23.052 kDa
Sequence
MFRTVNGEDYSPAVQQRNILDFGKAHSLLWTDNGSANDRCETGGNCRESGQDRVKRPMNAFIVWSRDQRRKVALENPQMQNSEISKRLGYDWKMLTEAEKQPFFEEAQRLRAMHRDKYPGYKYRPRRKAKEATEIASRRLFSTVQPNAHRGAVVPLPIQGRLRQGHTFTNGKPVKPLTAHEHKQLTPATGASQQLDKPAPQ
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Orcinus orca
Length
201 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is responsible for initiating male sex determination. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Promotes DNA bending (By similarity).
Similarity
Belongs to the SRY family.
Mass
23.155 kDa
Sequence
MFRTVNGEDYSPAVQQRNILDFGKSHSRLWTDNGSANDRCETGGNCRESGQDRVKRPMNAFIVWSRDQRRKVALENPQMQNSEISKRLGYDWKMLTEAEKQPFFEEAQRLRAMHRDKYPGYKYRPRRKAKEATEIASRRLFSTVQPNAHRGDVVPLPIQGRLRQGHTFTNGKPVKPLTAHEHKQLTPATGASQQLDKPAPQ
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Delphinus delphis
Length
201 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
23.096 kDa
Sequence
MFRTVNGEDYSPAVQQRNILDFGKAHSLLWTDNGSANDRCETGGNCRESGQDRVKRPMNAFIVWSRDQRRKVALENPQMQNSEISKRLGYDWKMLTEAEKQPFFEEAQRLRAMHRDKYPGYKYRPRRKAKEATEIASRRLFSTVQPNAHRGDVVPLPIQGRLRQGHTFTNGKPVKPLTAHEHKQLTPATGASQQLDKPAPQ
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Delphinapterus leucas
Length
201 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
23.108 kDa
Sequence
MFRIVNGEDYSPAVQQRNILDFGKAPSLLWTDNGSSNDRCETGGNCRESGQDRVKRPMNAFIVWSRDQRRKVALENPQMQNSEISKRLGYDWKMLTEAEKQPFFEEAQRLRAMHRDKYPGYKYRPRRKAKEATEIASRRLFSTVQPNAHRGDLVPLHIQGRLRQGHTFTNGKPVKPLAAHEHKQLTPATGASQQLDKPAPQ
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Globicephala macrorhynchus
Length
201 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
23.096 kDa
Sequence
MFRTVNGEDYSPAVQQRNILDFGKAHSLLWTDNGSANDRCETGGNCRESGQDRVKRPMNAFIVWSRDQRRKVALENPQMQNSEISKRLGYDWKMLTEAEKQPFFEEAQRLRAMHRDKYPGYKYRPRRKAKEATEIASRRLFSTVQPNAHRGDVVPLPIQGRLRQGHTFTNGKPVKPLTAHEHKQLTPATGASQQLDKPAPQ
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Grampus griseus
Length
201 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
23.086 kDa
Sequence
MFRTVNGEDYSPAVQQRNILDFGKAHSLLWTDNGSANDRCETGGNCRESGQDRVKRPMNAFIVWSRDQRRKVALENPQMQNSEISKRLGYDWKMLTEAEKQPFFEEAQRLRAMHRDKYPGYKYRPRRKAKEATEIASRRLFSTVQPNAHRGDVVSLPIQGRLRQGHTFTNGKPVKPLTAHEHKQLTPATGASQQLDKPAPQ
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Phocoena phocoena
Length
196 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is responsible for initiating male sex determination. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Promotes DNA bending (By similarity).
Similarity
Belongs to the SRY family.
Mass
22.487 kDa
Sequence
MFRIVNGEDYSPAVQQRNILDFGKAPSLLWTDNGSSNDRCDTGGNCRESGQDRVKRPMNAFIVWSRDQRRKVALENPQMQNSEISKRLGYDWKMLTEAEKQPFFEEAQRLRAMHRDKYPGYKYRPRRKAKEATEIASRRLFSTVQPNAHRGDLVPLHIQGHTFTNGKPVKPLTAHEHKQLTPATGASQQSDKPAPQ
Protein
Sex-determining region Y protein: SRY

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Neophocaena phocaenoides
Length
196 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is responsible for initiating male sex determination. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Promotes DNA bending (By similarity).
Similarity
Belongs to the SRY family.
Mass
22.487 kDa
Sequence
MFRIVNGEDYSPAVQQRNILDFGKAPSLLWTDNGSSNDRCDTGGNCRESGQDRVKRPMNAFIVWSRDQRRKVALENPQMQNSEISKRLGYDWKMLTEAEKQPFFEEAQRLRAMHRDKYPGYKYRPRRKAKEATEIASRRLFSTVQPNAHRGDLVPLHIQGHTFTNGKPVKPLTAHEHKQLTPATGASQQSDKPAPQ
Protein
Sex-determining region Y protein: SRY

Gene
Sry
Protein
Sex-determining region Y protein
Organism
Rattus norvegicus
Length
121 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression (By similarity). SRY HMG box recognizes DNA by partial intercalation in the minor groove (By similarity). Promotes DNA bending (By similarity). Also involved in pre-mRNA splicing (By similarity). Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
14.625 kDa
Fragment
single
Sequence
MEGQVKRPMNAFMVWSRGERHKLAQQNPSMQNSEISKQLGYQWKSLTEAEKRPFFQEAQRLKTLHREKYPNYKYQPHRRVKVPQRSYTLQREVASTKLYNLLQWDNNLHTIIYGQDWSRAA
Protein
Sex-determining region Y protein: Sry

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Apodemus flavicollis
Length
57 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
6.732 kDa
Fragment
single
Sequence
PMNAFMVWSCGERRKLAQQNPSMQNTQISKQLEYGWKSLTEAEKRTLFQEAQRLKTL

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Apodemus agrarius
Length
57 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
6.79 kDa
Fragment
single
Sequence
PMNAFMVWSCGERRKLAQQNPSMQNTEISKQLGYRWKSLTEAEKRPFFQEAQRLKTL

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Macaca fascicularis
Length
55 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
6.839 kDa
Fragment
single
Sequence
IVWSRDQRRKMDLENPKMRNSEISKQLGYQWKMLTEADKWPFFQEAQKLQAMHRE

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Meles meles
Length
55 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
6.706 kDa
Fragment
single
Sequence
MVWSRDQRRKVALENPQMQNSEISKQLGCQWKMLTEAEKRPFFEEAQRLQAMHRE

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Neomys anomalus
Length
52 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is responsible for initiating male sex determination. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Promotes DNA bending (By similarity).
Similarity
Belongs to the SRY family.
Mass
6.366 kDa
Fragment
single
Sequence
MVWSRDQRRKVALENPHMQNSEISKRLGYQWKMLTESEKWPFFEEAQRLQAA

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Crocidura suaveolens
Length
52 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
6.366 kDa
Fragment
single
Sequence
MVWSRDQRRKVALENPHMQNSEISKRLGYQWKMLTESEKWPFFEEAQRLQAA

Gene
SRY
Protein
Sex-determining region Y protein
Organism
Akodon azarae
Length
52 amino acids
Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Similarity
Belongs to the SRY family.
Mass
6.186 kDa
Fragment
single
Sequence
MVWSRGQRRKLALENPSMQNSEISEQLGCQWKSLREADKRPFLEEAQRLKIL