Description
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons. Involved in different aspects of gene regulation including promoter activation or repression. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity).
Family
Belongs to the SRY family.
Species
Arctocephalus forsteri
Sequence
MFGVLNSDDHRAAIQQRNILAFGRTSSELWTSNPTSNYWCETRGNGRDSGQNRVRRPMNAFMVWSRDQRRKVALENPQMQNSEISKQLGYQWKMLTEAEKWPFFEEAQRLQAVHREKYPDYKYRPRRKALPQKSDKLLPAASSSLLCRQVLVDKWYPFTYRDSCSRATHSHMEDQLSSSQPVNIANSLLQQEHHYSSTSLRGSPETLATHLSADPPFYPK
Simulated SDS-PAGE
(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)
Safety
Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.
Protein synthesis service