Protein
Subtilisin-like protease 3
Organism
Pseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21)
Function
Secreted subtilisin-like serine endopeptidase (PubMed:25944934). Mediates the degradation of collagen, the major structural protein in the mammalian host. Degrades the nonhelical regions of collagen that function in the cross-linking of the helical components (By similarity). May function as virulence factor involved in epidermal wing necrosis observed in white nose syndrome (WNS) in bats (By similarity).
Similarity
Belongs to the peptidase S8 family.
Sequence
MLFSKSLVALVACFLPLIVSATELKLRNAAATNVAADSYIVVYKDIDDSTFESEMFNVHSFLSKRDSTFRGLGHKYKMPKFKGYQIESDMDTVNRISQSPHVAYVDKDVKVSAYDLSVRIGAPWGLDRISHRNGTSPGLEEYTYDSSAGGGTTIYIIDTGVYIEHVEFEGRATFGANFIPGSPDTDEDGHGTHVAGIAAGANFGVASKAKIIAVRVLDANGDGKGSNVLAGMQWAADDAGKKNQTAKSVINMSLGADYSEAFNKATEAIIAKGIVVVAAAGNEDANASGVSPASTVDAITVGATDRNDSRAAFSNWGVALDVFAPGVDILSAWIGGKDANKTISGTSMACPHVAGLAAYFIGLEKNGTSTPSKIATKIKGVATKNVVLHPKNSRDNLAYNDDGY