Transcriptional factor that can act as an activator or repressor depending on post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription (By similarity). Required for activation of SPARC transcription.

Belongs to the Sp1 C2H2-type zinc-finger protein family.

771 amino acids

MTAPEQPVKQEEMAALDVDSSGHGEYLQHGNGNASASAAAAAPQDAQPSPLALLAATCSKIGPPSPEEDEAAAAAASHSAGATGDLASVQLAGTPNRWEVLSAAPATIKDEAGNIVQIPGAATVTSSGQYVLPIQSLQNQQIFSVAPGSDSSNGTVSNVQYQVIPQIQTADGQQVQLGFAASSDNSSINQETGQIQIIPGSNQTIIASGSPSANIQNILSQSGQVQVQGVAIGGSSFPGQAQVVANVPLGLPGNITFVPINSVDLDSLGLGSGSQTMTAGINADGHLINTGQAMDSSDNSERTGEQVSPEITETATDNDLFVPTSSSSQLPVTIDSSSILEQNANNLTTTSGQVHSSDLQGNYIQTSVSDDTQAQNIQVSTAQPIVQHIQLQESQQPTSQAQIVQGIAQQTIHGVQASQSISPQALQNLQLQLNPGTFLIQAQTVTPSGQITWQTFQVQGVQNLQNLQIQNAPGQQITLTPVQTLTLGQVAAGGALTSTPVSLSTAQLPNLQTVTVNSIDSAGIQLHQGENAGSPADIRIKEEEPDPEEWQLSGDSTLNTNDLTHLRVQVVDEEGDQPHQEGKRLRRVACTCPNCKEGGGRGSNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFVCNWMFCGKRFTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTHQNKKGIHSSSTVLASVEATSDDTLITAGGTTLILANIQQGSVSGIGTVNTSGTSNQDILTNTEIPLQLVTVSGNETME

81 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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