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PSRC1

Gene
PSRC1
Protein
Proline/serine-rich coiled-coil protein 1
Organism
Homo sapiens
Length
363 amino acids
Function
Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.
Similarity
Belongs to the PSRC1 family.
Mass
38.796 kDa
Sequence
MEDLEEDVRFIVDETLDFGGLSPSDSREEEDITVLVTPEKPLRRGLSHRSDPNAVAPAPQGVRLSLGPLSPEKLEEILDEANRLAAQLEQCALQDRESAGEGLGPRRVKPSPRRETFVLKDSPVRDLLPTVNSLTRSTPSPSSLTPRLRSNDRKGSVRALRATSGKRPSNMKRESPTCNLFPASKSPASSPLTRSTPPVRGRAGPSGRAAASEETRAAKLRVSGSGEFVGLTLKFLHPSPPGPPTPIRSVLAPQPSTSNSQRLPRPQGAAAKSSSQLPIPSAIPRPASRMPLTSRSVPPGRGALPPDSLSTRKGLPRPSTAGHRVRESGHKVPVSQRLNLPVMGATRSNLQPPRKVAVPGPTR

Gene
Psrc1
Protein
Proline/serine-rich coiled-coil protein 1
Organism
Mus musculus
Length
329 amino acids
Function
Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression (By similarity).
Similarity
Belongs to the PSRC1 family.
Mass
34.707 kDa
Sequence
MEDLKEDIKFIVDETLDFGGLSPSDSHEEEDITVLVSPEKPLRRGLAHRSNPNEVAPALQGVRFSLGPLSPEKLEEILDEANRLAAQLEECALKDRERAGTGPGRPSPRGKPSPRRETFVLKDSPVRDLLPTVSSWSTPPPSSLAGLRSSDKKGSARAVRVASGKKPSSIKKESPTCNLFPASKSPGRSPLAQPILPPRRKTGFGARTTASPPIPVRPVPQSSASNSQCSSRLQGAAVKSSSRLPVPSAIPKPATRVPLIGRSLPPGKGALAPDSLSTQKGHPSAIGHRASVSQKTNLPTTSAARGRTTSAARGRAQPLRKAAVPGPTR

Gene
Psrc1
Protein
Proline/serine-rich coiled-coil protein 1
Organism
Rattus norvegicus
Length
329 amino acids
Function
Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression (By similarity).
Similarity
Belongs to the PSRC1 family.
Mass
34.577 kDa
Sequence
MEDLKEDIKFIVDETLDFGGLSPSDSHEEEDITVLVSPEKPLRRGLSHRSNPNAVAPALQGVRFSLGPLSPEKLEEILDEANRLAAQLEECALKDSENAAAGPGRPSPRGKPSPRRETFVLKDSPVRDLLPTVSSWSAPPPSNLTGLRSSDKKGSARAGRVTAGKKPSSIKKESPTCNLFSASKNPGRSPLAQPTLPPRRKTGSGARTVASPPIPVRPAPQSSASNSQCSSWLQGAAAKSSSRLPFPSAIPKPAIRMPLTGRSIPAGKGALAPDPLPTQKGHPSTVGHRAPVSQRTNLPTIGAARGRTSSAARGRVQPLRKAAVPGPTR

Gene
PSRC1
Protein
Proline/serine-rich coiled-coil protein 1
Organism
Bos taurus
Length
326 amino acids
Function
Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression (By similarity).
Similarity
Belongs to the PSRC1 family.
Mass
34.326 kDa
Sequence
MEDLEEDVKFIADETLDFGGLSPSDSREEEDVAVLVTPEKPLRRGLSHRSDPNAVAPTPQGLRLSLGPLSPEKLEEILHEANRLAAQLEQCALKERENTGEGSGPRRVKPSPRRETFVLKDSPVRDLLPTVSSLARSTPSPSSLTPRLRSSDRKGSIRALRATSGKKPSSVKRESPTCNLFPASKSPASSPLARSAPPVRGKAGPSGRATASPPTPVRPVLAPQPPAGSSQRPSRPQGAAAKPSSRLPVPSAVPRPGNRMPLASRSVPSSKGAPPSDSLSARKGLPRPSAAGHRVPVSQRPNLPISGAGRSNLQPPRKVAVPGSTR