Protein
Histone-lysine N-methyltransferase PR-Set7
Organism
Drosophila pseudoobscura pseudoobscura
Function
Histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4. H4 'Lys-20' monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, possibly by contributing to the maintenance of proper higher-order structure of DNA and chromosome condensation during mitosis (By similarity).
Similarity
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily.
Sequence
MIMVRRRARPAKETGGGSAAAAVASDGALSMDTAAAVAVAGGNHLLDDQYFASPKRKDCRLMKASENLKISSDVVALEEEANNKGVKPTKALTDRTIGVPLATRSQTRTIENFFKADAAAKCGITLNTHHPEPIKEQKTISTTELPLSDELGDEELERVVGDLLYDGHSTASSDSPSYQNENEHEEVMQDTFALRETSPVPVLMADFQTHRSGLRDSHSSSHSSSSSGGASATTDNIFLQEPVLTLDIDRTPTKASSIKINKSFELASAVFSSPPSVLNACRFNQIVTLNGGGQCEPQPVVVAQPQPQPQLQLPPHHNGFELDQHDSSSCDSGVACNLTISAESPAAGGGAGAAARRRKPATPHRILCPSPIKTLPRGDGGGLIVPGARKTSGIMMKGDLLSPRKSPRKLPTTTAAVAACKSRRRLNQPKPQAPYQPQQPQPPPGTQPTNEDVVAAEELENLNKIPIANSNKSNNHVKAMLKPAPAKPRAALTKGSKTKTGSKIQPGPLPLAATNGNREMTDFFPVRRSVRKTKTAVKEEWLRNLEQAVLEERSEGLQVRNFMGKGRGVVAVRHFKRNEFVVEYVGDLISISDATDRERRYALDENAGCYMYYFKHKNQQYCIDATVDTGKLGRLINHSRAGNLMTKVVVIKQRPHLVLLAKDDIAPGEELTYDYGDRSKESLLHHPWLAF