Histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4. H4 'Lys-20' monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, possibly by contributing to the maintenance of proper higher-order structure of DNA and chromosome condensation during mitosis (By similarity).

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily.

691 amino acids

MIMVRRRARPAKETGGGSAAAAVASDGALSMDTAAAVAVAGGNHLLDDQYFASPKRKDCRLMKASENLKISSDVVALEEEANNKGVKPTKALTDRTIGVPLATRSQTRTIENFFKADAAAKCGITLNTHHPEPIKEQKTISTTELPLSDELGDEELERVVGDLLYDGHSTASSDSPSYQNENEHEEVMQDTFALRETSPVPVLMADFQTHRSGLRDSHSSSHSSSSSGGASATTDNIFLQEPVLTLDIDRTPTKASSIKINKSFELASAVFSSPPSVLNACRFNQIVTLNGGGQCEPQPVVVAQPQPQPQLQLPPHHNGFELDQHDSSSCDSGVACNLTISAESPAAGGGAGAAARRRKPATPHRILCPSPIKTLPRGDGGGLIVPGARKTSGIMMKGDLLSPRKSPRKLPTTTAAVAACKSRRRLNQPKPQAPYQPQQPQPPPGTQPTNEDVVAAEELENLNKIPIANSNKSNNHVKAMLKPAPAKPRAALTKGSKTKTGSKIQPGPLPLAATNGNREMTDFFPVRRSVRKTKTAVKEEWLRNLEQAVLEERSEGLQVRNFMGKGRGVVAVRHFKRNEFVVEYVGDLISISDATDRERRYALDENAGCYMYYFKHKNQQYCIDATVDTGKLGRLINHSRAGNLMTKVVVIKQRPHLVLLAKDDIAPGEELTYDYGDRSKESLLHHPWLAF

74.9 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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