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PAN2

Gene
PAN2
Protein
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Organism
Drosophila melanogaster
Length
1241 amino acids
Function
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.
Similarity
Belongs to the peptidase C19 family. PAN2 subfamily.
Mass
138.968 kDa
Sequence
MDYVYCGTDPIGASEDILSVYDAGSAPGNGHFSPSFNGFNIGTTDPEYVELVPVLADGGEHFGVSSVAFDDYEELLWMGNQGGHVTSYYTNSMQKYTSFQVHATDIVRDISTLDSGVLALTQTSLRHQIRRGLPKFTFKSNNMKEMVSMLQLSPHRLVMAGLQDELIDFDLRTLKETRIEHVGAGGCTVLRKNSRYLFAGDQLGTVTLRDLNSLSVQHTIKTHTNILSDFSVQGNLLISCGYSGRQNNLAIDRFLMVYDLRMLRLIAPIQVMIDPQMLKFLPSLTSQLAVVSSYGQVQLVDTVELSEPRVSMYQINTNGSQCLSFDISSSSQAMAFGDQSGHINMIAAVQTPQPQFNLYSRSTEFADVVPQLPMVSITDTNFPLSSVMLPHLTTGTQWFSDWPEELLRYRYHRPKTIDPEVLSNMKMQGPIGYSPNPRTARRNQIPYVIEQGGVCSPNGNGTAAATKAENGVKIIPRRYRKVELKYTKLGTQDFDFDQHNQTCFAGLEATLPNSYCNAMLQILYFTDALRVKLLEHSCIKEFCLSCELGFLFNMLDKSTASSPCQASNFLRSFRTVPEASALGLILTDRSSNVNLISLIQNWNRFILHQMHYEIFDSSKNASTYSGSVQTSTNAENAGSSETSGSSDLYDSISDENSKEDDRERSKINAETDISKIFGTKQICINRCIKCQEEKIKESILLACNLSYPNHIKDSDQYFNFGTILKRSLSSEKSIQAFCERCKKFSPTNQSVKVTSLPQILSINCGLNNEKDITFLKRQLNRCSEKTTVDAAASLSTSKPCRYGANCSRSDCHFMHPDRKSPSHTSQPNAVNNSPNGRQKSWFPLTFTMGINDQGEVQVQTQSDASSGKSEQEEETEKPPTKGLDNNRMYALHAVVCQVDDGTQKNLVSLINVQRPYHTMKLAESADDPQSQWYIFNDFSISPVSPQESVWFTLDWKVPCILFYRHVEDDSESASTTSSTVTESEETIPSESSSGSPTNLSNPFLEEIVSPMLGNLSADATLQPLQSDEMPQSGDLVAMDAEFVTLNPEENEIRPDGKTATIKPCHMSVARISCIRGQGPAEGVPFMDDYISTQEKVVDYLTQFSGIKPGDLDANFSKKRLTALKYSYQKLKYLVDVGVIFVGHGLKNDFRVINIYVPSEQIIDTVHLFHMPHHRMVSLRFLAWHFLGTKIQSETHDSIEDARTTLQLYKHYLKLQEEKKFANALKNLYERGKQLQWKVPED

Gene
PAN2
Protein
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)
Length
1234 amino acids
Function
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
Similarity
Belongs to the peptidase C19 family. PAN2 subfamily.
Mass
141.073 kDa
Sequence
MEGWSQVALVPLKNSNNNSNSNSSSNNSSNGVLVQDPISTVTTTVFDSVQNLVWCGDTSGYVRSLSSVKTSPYSIQLYPYTKFRTNTLNQPIIQILSHREGVLSLLNDQLSIYNRRGVPRNAVNSMSFKESNGRELFKDLKTMSFNCNSFNEIVVGTELDLIKVDMNKSNLVQQFNHTGKVAMVKEAPKLLALASSTGSLELFDPTSNSSIKTFSAHNGYMSDMDIKGNYIATCGNSIRPKRYHYHQAPEYTADPLVNIFDIRTMKAVAPVAFPAGVSSVRFHPKLPNILIVTSAYGLIEFVDIFDQTNVSVYHADMSAATPPLPPAGSSAAQQQKQQQQQQQQPHLSGLEISENGDFFMFNDGFSNLHLWSITNSGTLSKNFVNFPQEIERPDIVNGPSGVLGGGSGSGDGAFIDIDADVPLSVVGMPYYKELLLSNWPNDLKFVKEKARLPEPIDPDLLSIFEKQQQQKISQTPKWIPYDSLKYGTCNIPEYYSLTSQKDTQIPKFLSEKNGGQKQRQKSIQALEDSIFQCQNDEKIPNCYSRLQIQYSKFGVKDFDFAFYNRTQEYCGLENHSDNSYINSLLQLYRFQSVFYNKVVHSLSNEWLPNDEATIETNPEGSSILNELAYLFDMMFKAKSRNVKTYNFSQVMNHDKQAAKLINLNELMNLNSHEVRELIIAFNNYLLTRLSMDFRNQFNFNFDLTELAYEIEVRGRGHSCPIYDKQMGAMFSLELITPPHNMMSKMSILVNPNTQQDQQQQQQQQQQQQQQQQPTNLANIRKNLNILTYLEYSMNQYKTIPCTQHQHFHPHTLEIRTSITKLPPVLVLNVNLTNEEFRIINSLKQWLVPDLYAVRATNNGSNRGYSFKPSMPVSGDFKKYQLLGYVCEISHQVDTSRTGGHNLVSFVKIKDEWMFFNDYLVIPIPEEEVFNLTYSWKKPVIVIYQEVDKMDKVEPFRHITHFQGNDSILYRDHFAGPIRELYQREYTLLTREKEAPQPGTLVAIDAEFVTLKPEQLEISYNGQKKLVKPKELSLARVSVLRGGREGINSNITGNNNDDNNNISGMIIDDPLFGEAFIDDYIVHKSHIYDYTTNFSGIEPNDLDIHKSSKNLVTLQTAYRKLWLLLNLGVIFVGHGLYTDFRTINLQVPEEQIRDTADFYYKSSFKRQLSLKFLAYVMLKERVQKGNHDSIEDARTALLLYKKYVELNQKSTNEFEKMLNFVYEEGNRLKYRVPEL

Gene
PAN2
Protein
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Organism
Coccidioides immitis (strain RS)
Length
1222 amino acids
Function
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
Similarity
Belongs to the peptidase C19 family. PAN2 subfamily.
Mass
135.668 kDa
Sequence
MEADWDEVSQVAVPPPGPHLLPTVASTVAFDDSQELLWVGNEFGRVSSFYGPELQRYTSVKAHASSEGQVRQFLFHDKGVISLSANSVHLASRCGLTQWHISHPEMTELRCMSFTAQPHKIIVAGLQSAMFIIDVEKGAIVDQLSTEYRYTIMKRSRYLCAATDTGSVNVLSLTDFSVVKSWKAHGAVINDMDARNDFLVTCGFSVRHAGSPIVDPLANVYDLKSLIPLPPIPFHAGAAFVRMHPRLQTTSFIASQTGQLQVVDLMNPNTINLRQANVAFMLGLEVSPSGEALAINDAECSIHLWGSPSKIHFNEIGKETEFSDIPTRPSMLDWSNDTPLNVIGMPYYHERLLSAWPSHLIFEIGNAPVPMDPAILPYLRPSEIGQYAQNPRKKRRYQVENTRLQSSTEVALAAPKFLSEKARELPNSKPEGAQEAVGALQGLKINGETKEDPLLKYSNVEIKYSKFGVDDFDFRYYNKTEFSGLETHIANSFTNSLLQLLKFIPLVRNLALHHVSTNCLCESCLLCEMGFLFDMLDKANGQNCQATNLLKTFSGFREAANLGLLEESLSNKSLSSAIQSVHRFFLNQIAHDYRTVYPNSDSLDNTLSTAAVESICCMFCRNEIVRPGNAFVTELIYPAADPKQAHRNQACRFSNILRSSIERETQNRGWCSTCRRYQQVSIRKTVQRMPLVLMLNAAINNSAHRRFWSIPGWLPEKIGVMIEDNQIQCYEGEQLRIRQQNNFEGLVVYELVGIVAEIDIVEQKKPHLVSFVDVSISAREPTKKSNWHLFNDFLVTGVSKEEVFSFNQGWKSPCTLAYQISTGRHGLDDSWKNELDTTLLFYEWSMNNRPPTDKCHILKSEEKPIAGTPIALDTEFVDLEKAEIEVKADGTQEMIRPSKSGLARVSVIRGSGNDEGVPFIDDYITIKDPIVDYVTQYSGIKPGDLDPRTSRHNLVALKVAYKKLWLLLNLGCVFVGHGLASDFRKINIQVPKAQTIDTQYLFFHPGKNRRLSLRYLAWAVFKEYIQEETTTTTSTSITTTTNPNIHDANTSTTTTTAITTTPPEGHDSIEDARMALRLWKKFKEYEDAGIVNQILEEIFREGVKVGFRPPARYPSQATPNPNNNNINNGVNPNGLSTPGSTNPISRLPLSGRNTPDFILPASASAAASVTGGPAGGGSSNGSMSGSTPSTPRQAFRRSTALTPSNGSFGGAKGLTFGGSPMR

Gene
Pan2
Protein
PAN2-PAN3 deadenylation complex catalytic subunit Pan2
Organism
Rattus norvegicus
Length
1205 amino acids
Function
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation.
Similarity
Belongs to the peptidase C19 family. PAN2 subfamily.
Mass
135.627 kDa
Sequence
MNFEGLDPGLAEFSPAMHSTLDPVLDAHLNPSLLQNVELDPEGVALEALPVQESVHIMEGVYSELHSVVAEVGVPVSVSHFDLQEEMLWVGSHGGHATSFFGPALERYSSFQVNGSDDIRQIQSLENGILFLTKNNLKYMARGGLIIFDYLLDESEDMHSLLLADNNTLLVGGLQNHVLEIDLNTVQETQKYAVETPGVTIMRQTNRFFFCGHTSGKVSLRDLRSFKVEHEFDAFSGSLSDFDVHGNLLAACGFSSRLTGLACDRFLKVYDLRMMRAITPLQVHVDPAFLRFIPTYTSRLAIISQSGQCQFCEPTGLANPADIFHVNPVGPLLMTFDVSASKQALAFGDSEGCVHLWTDSPEPSFNPYSRETEFALPCLVDSLPALDWSQDLLPLSLIPVPLTTDALLSDWPAANSAPAPRRAPPVDAEILRTMKKVGFIGYAPNPRTRLRNQIPYRLKESDHEFDNFSQVTESPTGREEEPLHTVSKKYRKVTIKYSKLGLEDFDFKHYNKTLFAGLEPHIPNAYCNCMIQVLYFLEPVRCLIQNHLCQKEFCLACELGFLFHMLDLSRGDPCQGSNFLRAFRTIPEASALGLILADSDEASGKGSLARLIQRWNRFILTQLHQDMQELEVPQAYRGAGGSFCSSGDSIIGQLFSCEMENCSLCRCGSETVRASSTLLFTLSYPEDKTGKNYDFAQVLKRSICLEQNTQAWCDSCEKYQPTIQTRNIRHLPDILVINCEVNSSKEADFWRLQAEVAFKIAVKKFGGEVKSKEFALADRKELRSPEGFLCCSSMEELKNVWLPFSIRMKMTKNKGLDVCNWADEHELSSLGTPSQWGPARAEEEHGVYVYDLMATVVHILDSRTGGSLVAHIKVGETYHQRKEGVTHQQWYLFNDFLIEPIDKYEAVQFDMNWKVPAILYYVKRNLNSRYNLNSKNPIEASVLLAEASLARKQRKTHTTFIPLMLNEMPQVGDLVGLDAEFVTLNEEEAELRSDGTKSTIKPSQMSVARITCVRGQGPNEGIPFIDDYISTQEQVVDYLTQYSGIKPGDLDAKISSKHLTTLKSTYLKLRFLIDIGVKFVGHGLQKDFRVINLMVPKDQVLDTVYLFHMPRKRMISLRFLAWYFLDLKIQGETHDSIEDARTALQLYRKYLELSKNGAEPESFHKVLKGLYEKGRKMDWKVPEPESQSSPKSKAGLRPGALGWVG

Gene
PAN2
Protein
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Organism
Homo sapiens
Length
1202 amino acids
Function
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation.
Similarity
Belongs to the peptidase C19 family. PAN2 subfamily.
Mass
135.368 kDa
Sequence
MNFEGLDPGLAEYAPAMHSALDPVLDAHLNPSLLQNVELDPEGVALEALPVQESVHIMEGVYSELHSVVAEVGVPVSVSHFDLHEEMLWVGSHGGHATSFFGPALERYSSFQVNGSDDIRQIQSLENGILFLTKNNLKYMARGGLIIFDYLLDENEDMHSLLLTDSSTLLVGGLQNHIIEIDLNTVQETQKYAVETPGVTIMRQTNRFFFCGHTSGKVSLRDLRTFKVEHEFDAFSGSLSDFDVHGNLLAACGFSSRLTGLACDRFLKVYDLRMMRAITPLQVHVDPAFLRFIPTYTSRLAIISQSGQCQFCEPTGLANPADIFHVNPVGPLLMTFDVSASKQALAFGDSEGCVHLWTDSPEPSFNPYSRETEFALPCLVDSLPPLDWSQDLLPLSLIPVPLTTDTLLSDWPAANSAPAPRRAPPVDAEILRTMKKVGFIGYAPNPRTRLRNQIPYRLKESDSEFDSFSQVTESPVGREEEPHLHMVSKKYRKVTIKYSKLGLEDFDFKHYNKTLFAGLEPHIPNAYCNCMIQVLYFLEPVRCLIQNHLCQKEFCLACELGFLFHMLDLSRGDPCQGNNFLRAFRTIPEASALGLILADSDEASGKGNLARLIQRWNRFILTQLHQDMQELEIPQAYRGAGGSSFCSSGDSVIGQLFSCEMENCSLCRCGSETVRASSTLLFTLSYPDGSKSDKTGKNYDFAQVLKRSICLDQNTQAWCDTCEKYQPTIQTRNIRHLPDILVINCEVNSSKEADFWRMQAEVAFKMAVKKHGGEISKNKEFALADWKELGSPEGVLVCPSIEELKNVWLPFSIRMKMTKNKGLDVCNWTDGDEMQWGPARAEEEHGVYVYDLMATVVHILDSRTGGSLVAHIKVGETYHQRKEGVTHQQWYLFNDFLIEPIDKHEAVQFDMNWKVPAILYYVKRNLNSRYNLNIKNPIEASVLLAEASLARKQRKTHTTFIPLMLNEMPQIGDLVGLDAEFVTLNEEEAELRSDGTKSTIKPSQMSVARITCVRGQGPNEGIPFIDDYISTQEQVVDYLTQYSGIKPGDLDAKISSKHLTTLKSTYLKLRFLIDIGVKFVGHGLQKDFRVINLMVPKDQVLDTVYLFHMPRKRMISLRFLAWYFLDLKIQGETHDSIEDARTALQLYRKYLELSKNGTEPESFHKVLKGLYEKGRKMDWKVPEPEGQTSPKNAAVFSSVLAL

Gene
Pan2
Protein
PAN2-PAN3 deadenylation complex catalytic subunit Pan2
Organism
Mus musculus
Length
1200 amino acids
Function
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1 (PubMed:16284618). Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation (By similarity).
Similarity
Belongs to the peptidase C19 family. PAN2 subfamily.
Mass
135.253 kDa
Sequence
MNFEGLDPGLAEFSPAMHSTLDPVLDAHLNPSLLQNVELDPEGVALEALPVQESVHIMEGVYSELHSVVAEVGVPVSVSHFDLHEEMLWVGSHGGHATSFFGPALERYSSFQVNGGDDIRQIQSLENGILFLTKNNLKYMARGGLIIFDYLLDENEDMHSVLLTDNSTLLVGGLQNHVLEIDLNTVQETQKYAVETPGVTIMRQTNRFFFCGHTSGKVSLRDLRSFKVEHEFDAFSGSLSDFDVHGNLLAACGFSSRLTGLACDRFLKVYDLRMMRAITPLQVHVDPAFLRFIPTYTSRLAIISQSGQCQFCEPTGLANPADIFHVNPVGPLLMTFDVSASKQALAFGDSEGCVHLWTDSPEPSFNPYSRETEFALPCLVDSLPPLDWSQDLLPLSLIPVPLTTDALLSDWPAANSAPAPRRAPPVDAEILRTMKKVGFIGYAPNPRTRLRNQIPYRLKESDHEFDNFSQVTESPTGREEEPLHTVSKKYRKVTIKYSKLGLEDFDFKHYNKTLFAGLEPHIPNAYCNCMIQVLYFLEPVRCLIQNHLCQKEFCLACELGFLFHMLDLSRGDPCQGSNFLRAFRTIPEASALGLILADSDEASGKGSLARLIQRWNRFILTQLHQDMQELEVPQAYRGAGGSFCSSGDSIIGQLFSCEMENCSLCRCGSETVRASSTLLFTLSYPEDKTGKNYDFAQVLKRSICLEQNTQAWCDNCEKYQPTIQTRNIRHLPDILVINCEVNSSKEADFWRLQAEVAFKIAVKKYGGEMKSKEFALADRKELRSPEGFLCSSIEELKNVWLPFSIRMKMTKNKGLDVCNWADEHELSSLGAPSQWGPARAEEELGVYVYDLMATVVHILDSRTGGSLVAHIKVGETYHQRKEGVTHQQWYLFNDFLIEPIDKYEAVQFDMNWKVPAILYYVKRNLNSRYNLNIKNPIEASVLLAEASLARKQRKTHTTFIPLMLNEMPQVGDLVGLDAEFVTLNEEEAELRSDGTKSTIKPSQMSVARITCVRGQGPNEGIPFIDDYISTQEQVVDYLTQYSGIKPGDLDAKISSKHLTTLKSTYLKLRFLIDIGVKFVGHGLQKDFRVINLMVPKDQVLDTVYLFHMPRKRMISLRFLAWYFLDLKIQGETHDSIEDARTALQLYRKYLELSKNGTEPESFHKVLKGLYEKGRKMDWKVPEPESQTSPKNAAVFSVLAL

Gene
PAN2
Protein
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Organism
Gallus gallus
Length
1197 amino acids
Function
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.
Similarity
Belongs to the peptidase C19 family. PAN2 subfamily.
Mass
134.863 kDa
Sequence
MNFEGLDPSLAEYAPTLHPALDPVLDPHLNPSLLQNVELDPEGVPLEGIAVPESVHIVEGMYSELHTAVSEVGVPVSVSHFDLHEEMLWVGNHGGHATSFFGPTLERYSSFQVNSSDDIRQIQSLESGVLFLTKTNLKCMSRGGLIIFDYLMDEAEDMHSLLLTDSSTLLVGGLQNHVIEIDLNTVQETQKYTVEVPGITIMRQSNRFFFCGHTSGKVSLRDLRTFVVEHEFDAYSGSLSDFDVHGNLLVTCGFSSRMNGLACDRFLKVYDLRMMRATTPLQVHIDPFFLRFIPTYTSRLAIISQTGQCQFCEPTGLANPADIFHVNTVGPLIMTFDVSASKQALAFGDSEGCVHLWADSPEVTFNTYSRETDFALPCIVDTLPHLDWNQDLVPLSLIPVPLTSETLLSDWPAANSAPAPRRAPPVDPEILRTMKKVGFIGYAPNPRTKLRNQIPYRLKEADNEFDSFSQVPESPIGREEEPHLYMVAKKYRKVTIKYSKLGLEDFDFKHYNKTLFAGLEPHIPNAYCNCMIQVLYFLEPVRCLVQNHLCQKEFCLGCELGLLFHMLDLSRGDPCQGSNFLRAFRTIPEASALGLILADSDEATGKVNLGRLIQSWNRFILTQLHQETQEQEGPQAYRGAGSSTFGSSGDSVIGQLFSCEVENCSMCRCGKETVRVSSTLLFTLSYPESAEKPVKDYEFAQILKRSICLEQNTQAWCENCEKYQPTVQTRNIRCLPDVLVINCEVNSSKEADFWKTQAEYAFQRALMKRGGFEITKGKEISLGDWKELGNPEVGHSYPSVEELKNIWIPHAIKMRLTKNKELDVCNWSESDELSPNDDPESVYVYDLMATVVHILDSRTGGSLVGHIKVGETYHQRKEGVTHQQWYLFNDFLIEPVDKCEAVQFDMSWKVPAILYYARRNLNSKYNLVIKNPIEASVLLAEASLARKQRKCHATFIPLMLSEMPQAGDLVGLDAEFVTLNEEEAELRSDGTKSTIKPSQMSVARITCVRGQGPNEGVPFIDDYISTQEQVVDYLTQYSGIKPGDLDAKISSKHLTTLKSTYLKLRFLIDVGVKFVGHGLQKDFRVINLMVPKDQVIDTVYLFHIPRKRMISLRFLAWYFLDLKIQGETHDSIEDARTALQLYRKYLELSQGGSEPDDFRKVLKALYEKGRKLDWKVPEPDSQSSPKHGAVFPPVLAL

Gene
PAN2
Protein
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
1190 amino acids
Function
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
Similarity
Belongs to the peptidase C19 family. PAN2 subfamily.
Mass
136.495 kDa
Sequence
MDGWSEVLRIPSSVFATDNYNNPTTIVNITSLQFDSVQNFIWCGDSRGYTRSFTGSFATNSLYGNLQLYPYTKFHTSDVNYNNPIKQILSHREGILSLSNNAISFNSRRGLSKLQVTSKTFNNNATTENKFNNLQAMTFNCNSFNDVVVGTDTSMMKFDLNKPNVLSSFDHQGGISLLNNLGKFLTIANSNGSLDIFDPVSNSTMKTFSAHNGFISNLDVRGNYIATCGYSIKPKRYYHNQPAEYIVDPLVNIYDTRIMRAIAPVPFPAGAASVKFHPKLPNIIIIASTSGQMQFVDIFDQTNVYLYQADLAIPTTTTTTINNKPRMSNLEISENGDFLVFNDNCDNMHLWSISPSSKDFVNFPQPVEQPDIIDSNFEIIDIDANVPLSIVGMPYYKELLLSNYPNDLRFVKETAKLPEPIDIELILENETRNNGTKKFFPYDKLKYGPGNVYKPYQSLKDNKENKEISIPKFISERSTTTTTTTKELKADNDGKFIDDSIFQYKFQGKLNKVPNCYSRLQIQYSKFGIKDFDFSYYNKTKECCGLENHTDNSYINSLLQLYRFQSSIYNQVVGSLSKEWLPNDITTIITTNNPEGSSILNELGYLFDMMFKAQSNNVKIYNLSQVLNHHPNAQKLLNNNELLNLNSQQVRDLVIEFNNFLLTTLHQDFQTQFQENFNLTELKYEIEIKGNGTSCPMYDKHQGSMFSLELITPPSNMLNKMSILINNNNNNNNPQYQPEPISSLDNIRRNLNILTYLEYSMNQYKTIPCQQHNHSYPHNLEIQTSIVHLPSVLTINVNLSNPEFKIINNFTQWLVPEFYAVKSKSISGKNGYSFKEIDHPTPNSATQESGKYKYKYELLGYVCEINHQSDIVSGAHNLVAFIKVNNNGGWYLFNDFLVMPIPEEEVFDLQPSWKKPIVIMYQQTNQPSFNYLTTTTTTTTTTTTFSNAGKYDDSILYRDHFAEGIRKGHQLEYELLTRKESPQPGSLVAIDAEFVMLKPEELEIHYDGYKKLIKPKQLSLARISVLRENGIPFIDDYIVHTSDIYDYLTNFSGIEPNDLNLTLSNRENLVTLQTAYRKLWLLLNLGVIFVGHGLYNDFRTINLQVPERQIRDTAVIYYKSDFKRQLSLKFLAYVMLKEKVQSGNHDSIEDANTALLLYKKYQNLYNKEDFESILNYIYSEGQQLRFKVPE

Gene
PAN2
Protein
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Organism
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
Length
1183 amino acids
Function
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
Similarity
Belongs to the peptidase C19 family. PAN2 subfamily.
Mass
130.525 kDa
Sequence
MNYNPLHLLPLPPTALDPKPIPTSLTLDPFSDVLWVGASSGIVSALCSPLTLARNVHFPAHGCKIGGGGFSAQGVSAVREVRVTDRDVWTLTEGGIGGRKRGGAPKWIVSDVTRSLRTMSPNPTNSHELITGGSGSLLLANTARGEVVRSIENSSPVVKLAPLHRTVLAAGLSGQVTVLDPRTGFKAAQNISPVQAHTGGLSGADVQGNIVATWGWTHMQGHPLPDPLIRLYDVRALRPLPPISFSSGPAFVLLHPSSSSHIVVSSQQGMLQTIDMSLGPSATVFQQLDVSSYITSMALSSRGDYLAFGDGDGQLHVWTTNETGENAAVDENGSIVLPPFNGYDGVKPEWPDQVDPLPTIAWEESTPLNLVGMPYYNEALLSQFPSECYATSTSPLFNPPATIPQPVLSSMKMVDFVGYAPNPKELRGKRYVLRAVPGAEGRARGKGRRDSGPRFRSEKDKKGTYKDKEEIEEELNDGEVPKYYRKVEIKYSKFGIEDFDFEFYNRTNYSGLETDILNSYTNSLLQALHYTLPLRAIATAHICVDCKKEHCLLCEAGFLFRMLEDAKGRNCQASNFSRAFSATSQAYALGLMDENTNSKSTAPYGSLIQNFNRWLLSTFSTESIVDGETFHLRPFPQKTSGLDGLSMNDGPSAIDQVLGVKIKTTNTCRHCGFVSSRDSTLHVVDLVYPKKMNPRLSFSDILRSSLIRDSTTKAICSSCKAFAPLDSRRSLSPSSGHPLPPVLSVNAMVTNSDVYGFWKDKKDVKEKDGVRRFLPKRVTIREVGKLENGQEEGVKYSIRSMVVQIQESPDAVAHLVSFVKMPSKDGSSAWIMFNDFLVRPVSEDEVLSFPDQWKVPAVIILERENAEELLNLEVLPKELDREILFKDVSIAWNRKQDMIKHKILQREEMPKRGTLVAIDAEFVALQQEEMEFRSDGTKNILRPSHMSLARVSVLRGEGEMEGKPFIDDYIHTSEAVVDYLTEFSGIKAGDLDPNNSPHTLVPLKVAYKKLRLLVDLGCIFVGHGLSKDFRTINIFVPPEQVMDTVLIYTLPGSQRKLSLRFLAWYLLHQDIQTNSHDSIEDAHFALLLCKLWMDYASESEEAFEIVMEDIFAEGKKLAFKPPSSAGNMMAEQQLSPVSFPPLSNGDQTVARAVVKSRMATPPPPTKLGLPQWASQNSPSPLRR

Gene
PAN2
Protein
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)
Length
1183 amino acids
Function
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
Similarity
Belongs to the peptidase C19 family. PAN2 subfamily.
Mass
130.525 kDa
Sequence
MNYNPLHLLPLPPTALDPKPIPTSLTLDPFSDVLWVGASSGIVSALCSPLTLARNVHFPAHGCKIGGGGFSAQGVSAVREVRVTDRDVWTLTEGGIGGRKRGGAPKWIVSDVTRSLRTMSPNPTNSHELITGGSGSLLLANTARGEVVRSIENSSPVVKLAPLHRTVLAAGLSGQVTVLDPRTGFKAAQNISPVQAHTGGLSGADVQGNIVATWGWTHMQGHPLPDPLIRLYDVRALRPLPPISFSSGPAFVLLHPSSSSHIVVSSQQGMLQTIDMSLGPSATVFQQLDVSSYITSMALSSRGDYLAFGDGDGQLHVWTTNETGENAAVDENGSIVLPPFNGYDGVKPEWPDQVDPLPTIAWEESTPLNLVGMPYYNEALLSQFPSECYATSTSPLFNPPATIPQPVLSSMKMVDFVGYAPNPKELRGKRYVLRAVPGAEGRARGKGRRDSGPRFRSEKDKKGTYKDKEEIEEELNDGEVPKYYRKVEIKYSKFGIEDFDFEFYNRTNYSGLETDILNSYTNSLLQALHYTLPLRAIATAHICVDCKKEHCLLCEAGFLFRMLEDAKGRNCQASNFSRAFSATSQAYALGLMDENTNSKSTAPYGSLIQNFNRWLLSTFSTESIVDGETFHLRPFPQKTSGLDGLSMNDGPSAIDQVLGVKIKTTNTCRHCGFVSSRDSTLHVVDLVYPKKMNPRLSFSDILRSSLIRDSTTKAICSSCKAFAPLDSRRSLSPSSGHPLPPVLSVNAMVTNSDVYGFWKDKKDVKEKDGVRRFLPKRVTIREVGKLENGQEEGVKYSIRSMVVQIQESPDAVAHLVSFVKMPSKDGSSAWIMFNDFLVRPVSEDEVLSFPDQWKVPAVIILERENAEELLNLEVLPKELDREILFKDVSIAWNRKQDMIKHKILQREEMPKRGTLVAIDAEFVALQQEEMEFRSDGTKNILRPSHMSLARVSVLRGEGEMEGKPFIDDYIHTSEAVVDYLTEFSGIKAGDLDPNNSPHTLVPLKVAYKKLRLLVDLGCIFVGHGLSKDFRTINIFVPPEQVMDTVLIYTLPGSQRKLSLRFLAWYLLHQDIQTNSHDSIEDAHFALLLCKLWMDYASESEEAFEIVMEDIFAEGKKLAFKPPSSAGNMMAEQQLSPVSFPPLSNGDQTVARAVVKSRMATPPPPTKLGLPQWASQNSPSPLRR

Gene
PAN2
Protein
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Organism
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)
Length
1183 amino acids
Function
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
Similarity
Belongs to the peptidase C19 family. PAN2 subfamily.
Mass
134.233 kDa
Sequence
MDGWTEISRIAATTQPPKGPSPHIHEPASITSLKFDSVQNLIWCGDSFGYTRSFTPGPNSNGVNPYQQSLSFLPYTKFKSSLNNNPILQHLDHKDGILSLSSNCINFNNRRGLAKLSLSSDSFVDANSVLFKNLTSLTTNCNTMNDIVVGSNLSLLKFDLNKPSHLMSFNHDGNISIVNQTSKFLTLGKANGALELFDPVSNSSIKSFQGHTGLLSDLDVQGSYIATCGYSIRPRRYNHNSQNSNNDYMVDPLVNIYDVRMMRAVAPIPFPAGASCVRFHPKLPNIVLISSNSGQLQFVDIYDQTNVFLYQADLMPTSQPRQPSQLSKAPFMTNLEISENGDFFAFSDSYATMHLWTLNNSGSTITKDFVNFPASIEQPDVIIPPATEHIGVDDLVPLSTIGMPYYKDLLLSNYASDLSFTKELAKLPDPIDHDLLVESESHVGFFPYDKSKYGPANTAKKYQSLKERSNIHSTVNVPKFISERNNALTKTMSNTSLALQNLNKEHHNEIFQYKVPLSRKKIPNCYSRLQIQYSKFGVKDFDFSYYNRTDGLYCGLENDADNSYVNPLLQLYKFQPAFHNLMVRNLTNEWLPNDFETIITQKNPQGSSILNELGYLFDMMNKAKDKNVNMSNFSQVFKENRLAQTENLINLDEGAKLNSQALRNLIIGFNKFLIAEVYKDLMNQARDSSISSLMTVSYVMEVRGTGPSCPIYDKQFGSQLSLDLLTPPSNVLNKLSILLNPQINTQQQVVTPTTTRRNHNLITYLEYTINQFKTIPCQQHQHQYPHTLEVRSSITKLPPLLSLNVNLSNEEFKLINGFKKWLVPEFYALNNNNDAPIAFKPVLTQFDQDSTRYELLGYVCEISQQSDFSLGTHNLVSYVKIDGRWFLFNDFLVMQIPEEEVFNLSYPWKKPVILVYHDSSISGIPFDLFQIETFANLPGLNDSIIYRDHFAGSIRESHKKDYELLTRQEAPSLGTLIAIDAEFVNLRPEELEVRYDGHKKLIKPKFLSLARLSALRGDNGEKQGVAFIDDYVVHTGEIYDYLTSFSGIEPGDLDPINSEKNLVTLQTVYRKLWLLLNLGVVFVGHGLYNDFRGINLQVPQNQIRDTADFYYKSDFKRQLSLKFLAYVLLKEKVQTGNHDSIEDAYTALLLYKKYIEITATGEYESTLNYIYSEGQQLRFKVPE

Gene
PAN2
Protein
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Organism
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
Length
1170 amino acids
Function
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
Similarity
Belongs to the peptidase C19 family. PAN2 subfamily.
Mass
130.569 kDa
Sequence
MDADWDEVTRIAYPAPGTNDFPRPATAVAFDPIAELLWAGFDRGRVCSFYGRDLTRYTAFKIQPASEGPVRQFLFHDKGVIVLGTRSVHMAMRRGPALWNIRHENMKDLRCMSFTSKGTQEIIVAGWQDTMLVIDVLKGDIIKQIPAQHHYSIMKKSRYICAATKTGSVDLIDPLSFKIVRSWQAHASYINDMDAQNDFIVTCGGSLKQQAAQTYMLDPYVNVFDLKNMASMKPMPFPPLAAHVRLHPRMLTTAIVTSQHGQMHVVDIMNPNSSTVRYANISSYVKLFEIAPSGEALVIGDADCNIHLWGSPTKIHFTDMAIPIELPEPEEPAPVLDWSIETPLSSIGLPYYREPLFSAWPADIISDVGAPPLQLEPSFVATLKQAEWGLYGKNTRNVRRNQVEDTRNTNKQSNALQAPKFLSERARESALSSGGDSSSDPQVDQEPEDPNEIESLKPEAPPLYRNLEIKYSKFGVDDFDFGYYNKTRYAGLENHIPNSYANSLLQLMHYTPLLRNMALQHAATACVSDLCLLCELGFVFDMLQKAEGATCQATNMFKALSGTPQAAPLGLLEEETHVPSLATMAQNLSRFLLEKIHNEYRTIPPISTALEQSLFNFPHPPTPDELVAKVLATSAVATIKCMNCRSETTRPGTTHVIDLLYPPPKTAGRGGRASKVTFSQVLKMGVERETTSKGWCSRCQRYQNLQMRKTIHSVPAVLVVNAGVSNQEHRKLWSTPGWLPEEIGIIVDQGQFFCFEGEDLKLHLQRGIHNITVYSLIGMVINIESHSPQKSHLVGIINVAHAEATPPGENKWHLFNDFSVRPVSAAEALTFNAAWKMPAVLLFQIKSANNKSNLDWKTNLDTSILYKDTNPNTEKKTYRTLDQERERPGPDTIVALDTEFVSLKQPEIQMNSDGERETIRPMSHALARVSVVRGQGENEGSAFIDDYIAIREPVVDYLTLYSGITASDLDPRTSKHNLVSLKTAYKKLWVLLNLGCKFLGHGLKQDFRVINIQVPRAQVIDTIEVFYLKSRLRKLSLAFLAWYLLKEDIQLETHDSIEDARTALKLYRKYLEFDDAGILEAMLEDIYKAGRATNFKPPRREDREKELQRQSTPPNSTAPNDCGAKPDGNGNENGGEPATPARKTGGITAPTFGAVNVFGTPSKASSPLPK

Gene
PAN2
Protein
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
1162 amino acids
Function
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
Similarity
Belongs to the peptidase C19 family. PAN2 subfamily.
Mass
131.1 kDa
Sequence
MNQWQLSYQSPVELTEHLRKSYWAYDAKEKSATKMAFDQDVNLIWVGDTYGRVSSYDPSYSLYTRHTAHIGAEPVVELLSHKQGVLSLGGESLNFANRRSVTKLHVTSADIAQLCDMRAMCYGSNSQNTVYCGGTNLASGLVAVDLVKGRLSNTVQYSSKVKLMQSSNRLMAVARQNGMLDLLDPNSNTVVKTFSGHSCMVSSMDFRDHTLVTAGKSKRFNMMYPDQFVNVYDLRIMKQLPPISFSKNTEYMGNGACYMVGADFVQLHPILPTVVVIGSVTGAFDFVDLSNPTVRTQYCHPCQSVTQLQLSPSGDYIAFIEHDNNINMWSRSNGMTGFTSTATTILEYPDYPDDGILAGATSIDDYSYPLSSVGLPYYNEKLLSAWHQTVFRSDGTIPMKVPLPPKSSAASSSHTALSTSSDSRPNTARSGNPSSGGQKYRLLPYDRHKYGHRNVAVPYRSLRERKKKLLITDEDGKDKQELMNYKPSNDREVPPAFTKLQMVYGRFGVQDFDFKAFNKTRYSGLETDIDNVYTNAVLQMYRFVPEVYNFLVSCLKMENFSDNSLLTELGSLYDMMVRANGEICRSSNFQEALASIPKSYLLGLITDSIDNALEPNTTVSGTSISDSDASGSSMTAKLESMVLGDDKTTISCHDNNDNSLTTPQKFNTFLLNRLLFEELQMKINTTQSIVLEELLGIDVQVTTRSISPCANFTRRSDIIPVLTVTSPISNNIKYVNKKLNNQTILPYIESSMSRLKHTKAMCEKCFKCETVESEKTVRNLPPLLSLNISLTSDEWATAKTVRGWLTKEFYATISKDRPILKLQPTDLKTTNAIFKYELNGYVARICDYITEPHLVAYSKIFDPTTRTYKWYMFNDFLVQEVDEEEALNISYWWKTPEIAIYSDAEELTKPFVPASFYTINYSILYRDHFANGMRESIKKEYRLLTAEEAPKPGSLVALDAEFVALSEDQVEISCKGTKTLIKPAKTALARVSVLRGEGDLAGVPFIDDYIVNTKHIEDYLTKYSGIEPGDLDPDTSSKPLVTRRVVLRKIWLLLQLGCIFVGHGLYNDFRNINIHVPKEQTRDTALYYLQGRRYLSLRYLAYALLDKDIQKGNHDSIEDAYTALVLYRKYLDLREKGIFETVLNRIYEEGRASNYRVPGDLQ

Gene
pan2
Protein
PAN2-PAN3 deadenylation complex catalytic subunit pan2
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Length
1161 amino acids
Function
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
Similarity
Belongs to the peptidase C19 family. PAN2 subfamily.
Mass
129.57 kDa
Sequence
MEADWDELSRIPVPAPSSHGLPTIATTIAFDDVSELLWAGNEFGRITSFYGPELQRYTSVRAHPVSDGPVRQILFHERGVISLSPKSVHMITRRGLSQWHIAHEEMTDLHCMSFTAQLNRIIVAGCQSAMFTIDIDKGVIVDKLQTDHNYTMMKKSRYLCAATDTGSVNALSLSDFQVVKSWKAHGTAINDMDARNDLLVTCGFSVRHLGSPIVDPLANVYDLKTLSPLPPIPFHAGAAYVRMHPKLHTTSFVASQTGQLQVVDLMNPNAINLRQANVSFMLGIDISPSGEALAINDAECAIHLWGSPSKVHFNEMSKEVEFADVVPRPPSLDWSPDTPLNMIGMPYYHERLFSAWPSHLVFEVGNPPASIDQSLIPYLRPAEMGHYAPNPKKTRRYQVENTRALTTAESALIAPKFLSEKAREQTRAKSEGSVSDTAEALAGAKLNGEAEDDPLLKYSNVEIKYSRFGVDDFDFRFYNQTIFSGLETHIANSFTNALLQLLKFIPLVRNLALHHAASTCIYETCLLCEMGYLFDMLEKANGQNCQATNLLKAFSSYREASNLGLLEENLTTKSLSSAIQSVNRFFLNQIAHDFRMILPSSDDLDHRLATIASESIRCMFCQNEIVRPGNSLANELIYPAIDIKQARRNPAFKFSNILRASIERETQNRGWCNYCRRYQQVTIRKTVHRMPLVLILNAALNNPLCRRLWSIPGWLPEEIGIVVEGGQVMCYEGDELKAQVQNKVPNLVLYDLVGLVAEIDIPEHQKAHLVSFINVSISSRETESKSRWHLFNDFLVTEVDKDEALRFNQPWKIPCVLAYQARDARHGVDDAWKDTLDTTLLFRDWSLNGGRPVESRQTLTEEEKPTPGTPVALDTEFVDLEKAEIDVKADGSQEIVRPNKSGLARVSVLRGSGIHEGVPFIDDYITIKEPIVDYVTQYSGIKPGDLDPRTSQHNLVPLKVAYKKLWLLLNLGCIFVGHGLASDFRKINIQVPKNQTVDTQYLYFHPGKNRRLSLRYLAWAVFKEYIQEESTDANQGHDSVEDARMALRLWKKFQEYEDAGIVNQILEEIFREGSRLGFRPPPRNGVATVLSRPGTAVTMQNNSGRNTPSTPDVGGAAAAAATTSAPATPRQAFRRSIALTPSNGTFGGPGTGDFFGGSPLK

Gene
pan2
Protein
PAN2-PAN3 deadenylation complex catalytic subunit pan2
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)
Length
1161 amino acids
Function
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
Similarity
Belongs to the peptidase C19 family. PAN2 subfamily.
Mass
129.833 kDa
Sequence
MEADWDELSRIPVPPPSPHGLPTAATTIAFDDVSELLWAGNEFGRITSFYGPELQRYTSVRAHPVSDGPVRQILFHERGVISLSPKSVHMITRRGLTQWHISHEEMTDLYCMSLTAQLNKIIVAGCQRAMFTIDIDKGIIVDKLHTDHNYTLMKKSRYLCAATDTGSVNALSLTDFRVVKSWKSHGTAINDMDARNDLLVTCGFSVRHLGSPIVDPLANVYDLKTLSPLPPIPFHAGAAYVRMHPKLSTTSFVASQTGQLQVVDLMNPNAINLRQANVSFMLGIDISPSGEALAINDAECSIHLWGSPSKIHFNEMSKEVEFADVVPRPPPLDWSPDTPLNMIGMPYYRERLLSAWPSHLVFEVGSPPAPIDQSLIPYLRPAEMGHYAPNPKKTRRYQVENTRALTTAEPALIAPKFLSEKAREQNKFKSEASVSDTAEALAGAKLNGEAEDDPLLKYSNVEIKYSRFGVDDFDFRFYNQTTFSGLETHIANSFTNALLQLLKFIPLVRNLALHHAASTCIYETCLLCEMGYLFDMLEKANGQNCQATNLLRTFSSYREASNLGLFEENLTTKSLSSAIQSVNRFFLNQIAHDFRMIVPSSDDLDQRLSTIASESIRCMFCQNEIVRPGNSLANELIYPAIDIKQARRNPAFRFSNILRASIERETQNRGWCNYCRRYQQVTIRKSIHRMPLVLILNAALSNPICRRLWSIPGWLPEEVGIAVDNGQVMCFEGDELKTQLQNKLPNLVVYELVGLVSEIDIPEHQKPHLVSFINVSISSRELEAKNRWHLFNDFLVTEVDKDEALRFNQPWKSPCILAYQAKDARHAVDDSWKNVLDITLLFRDWSLNGGRAVETRQTLTEEEKPTPGTPVALDTEFVDLEKAEIDVKADGSQEIVRPSKSGLARVSVLRGSGVHEGVPFIDDYITIKEPIVDYVTQYSGIKPGDLDPRTSQHNLVPLKVAYKKLWLLLNLGCVFVGHGLASDFRKINIQVPKSQTVDTQYLYFHPGKNRRLSLRYLAWAVFKEYIQEEPADNNQGHDSIEDARMALRLWKKFQEYEDAGIVNQILEEIFREGSKLGFRPPPRNGVATVLSRPGTAVTMQNSSGRNTPSTPDVGGAATATATTSAPATPRQAFRRSIALTPSNGTFGGPGAGDFFGGSPLK

Gene
pan2
Protein
PAN2-PAN3 deadenylation complex catalytic subunit pan2
Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Length
1159 amino acids
Function
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
Similarity
Belongs to the peptidase C19 family. PAN2 subfamily.
Mass
129.007 kDa
Sequence
MEADWDELSRIPVPPPSPHALPTVATTIAFDDVMELLWVGNEYGRITSFYGPELQRYTSVRAHPVAEGIVRQILFHERGVISLSSRSVHMITRRGLTQWHVAHEEMVDLRCMSFTAQLNRVIVAGCQKVMFTIDIDKGVIVDKLPTEYNYTMMKKSRYLCAATDTGSVNALSLSDFRVVKSWKAHGTAVNDMDARNDLLVTCGFSVRHLGSPIVDPLANVYDLKTLSPLPPIPFHAGAAYVRMHPKLSTTSFVASQTGQLQVVDLMNPNSINLRQANVSFMLGIDISPSGEALAINDAECMVHLWGSPAKIHFNEMSKEVELADVTHRPPPLDWSPDTPLNMIGMPYYHERLFSAWPSHLVFEVGSPPAPIDTGLIPYLRPAEIGHCAPNPKKTRRYQVENTRAVATTEPALIAPKFLSEKAREQSKKSDGSVAEAAGALAGAKLNGEAEDDPLLKYSNVEIKYSRFGVDDFDFRFYNQTNFSGLETHIANSFTNALLQLLKFIPLVRNVALHHAASSCVFENCLLCEMGYLFDMLEKANGQNCQATNLLKTFSSFREAASLGILEENLTNKSLSSAIQAVNRFFLGQIAHDFRTIMPNSDDLEQRLATIASESIQCRYCGNEIVRPGNSLVNELIYPNMDIKHTRRNPAFRFSNILRASIERETQNKGWCNYCRRYQPVGIRKSVHRMPLVMMLNAALNTPMARRLWAIPGWLPDEVGIVIDGGQTLCYEGEDLRMRVQANMPGLIVYELVGVVTEIDIPEHQKPHLVSFINVAISSPEPQPQNKWHLFNDFLVTEVDKDEALRFNQPWKVPCVLAFQVKDARHAMDDSWKDALDTTLLFRDWSLNGGRPVESRVTLSEDEKPTPGTPMALDTEFVDLEKAEIDVKADGSQEIVRPSKSGLARVSVLRGSGVREGVPFIDDYITIKEPIVDYVTQYSGIKPGDLDPRTSEHNLVPLKVAYKKLWLLLNLGCVFVGHGLASDFRKINIQVPKSQTVDTQYLFFHPGKSRRLSLRYLAWAVFKEYIQEEPADNNEGHDSIEDARMALRLWKKFLEYEDAGIVSQMLEEIFREGSKLGFRPPPRNGTAAVLSRPGTAVTMQNTNSGRNTPTVPDAAGAPAVPASAPTTPGRGFRRADALTPGDGTFSGPGAGDFFGGSPLK

Gene
pan2
Protein
PAN2-PAN3 deadenylation complex catalytic subunit pan2
Organism
Aspergillus oryzae (strain ATCC 42149 / RIB 40)
Length
1155 amino acids
Function
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
Similarity
Belongs to the peptidase C19 family. PAN2 subfamily.
Mass
129.302 kDa
Sequence
MEADWDELSRIQVPPPSPHGMPTIATAIAFDDVMELLWVGNEYGRITSFCGPELQRYTSVRAHPVSEGPVRQILFHDRGVISLSSKSVHMITRRGLTQWHITHEDMTDLRCMSFTAQLNKVIVAGCQKAMFTIDIDKGHIVDKLPTEYNYTMMKKSRYLCAATDTGSVNALSLTDFRVVKSWKAHGTAVNDMDARNDLLVTCGFSVRHLGSPIVDPLANVYDLKTLSPLPPIPFHAGAAYVRMHPKLHTTSFVASQTGQLQVVDLMNPNAINLRQANVSFMLGIDLSPSGEALAINDAECAIHLWGSPSKVHFNEMSKEVEFADVPARPPPLDWSPDTPLSMIGMPYYHERLFSAWPSHLVFEIGSPPAPIDQALIPYLRPAEIGHYAPNPKKTRRNQVENTRALANSEPALIAPKFLSEKAREQSKAKSDGLVTDAAETLAGTKLNGEAEDDPLLKYSNVEIKYSRFGVDDFDFRFYNQTKFSGLETHIANSFTNALLQLFKFIPLIRNVALQHAASACIFENCLLCEMGYLFDMLEKADGQNCQATNLLKTFGSFREASSLGLLEENLTNKSLSTSIQSVNRFFLGQISHDFRMILPSSDDLDHKLATVASESIRCMFCQKEIVRPGNSLVNELIYPAIDIKQIRRNPAYRFSNILRASIERETQNRGWCNYCRRYQQVAIRKTVHRMPLVMMLNTALNNPIYRRLWAIPGWLPEAVGLVVDAGQILCFEGEDLRMRMQNNMPGLVVYELVGVVSEIDIPEHQKAHLVSFINVSISSREPETTNKWHLFNDFLVTEVDKDEALRFNQPWKVPCVLAYQVKDARHAMDDNWKNVLDTTLLYRDWSLNGGRSVESLATLSEEEKPTPGTPVALDTEFVDLEKAEIDVKADGSQEIVRPSKSGLARVSVLRGSGTREGVPFIDDYITIKETIVDYVTQYSGIKPGDLDPRTSQHNLVPLKVAYKKLWLLLNLGCVFVGHGLASDFRKINIQVPKCQTVDTQYLFFHPGKNRRLSLRYLAWAVFKEYIQEEPTDNNQGHDSIEDARMALRLWKKFQEYEDAGVVSQILEELFREGSKLGFRPPARNGATAVLSRPGTAVTMQNNSGRNTPSTPEVTAPTASAPTTPRQGFRRSVALTPSNGSFAPGTGDFFGGSPLK

Gene
pan2
Protein
PAN2-PAN3 deadenylation complex catalytic subunit pan2
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Length
1154 amino acids
Function
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
Similarity
Belongs to the peptidase C19 family. PAN2 subfamily.
Mass
129.264 kDa
Sequence
MEADWNELLRIPLPPPNPHGLPTVATTIAFDDVSELLWAGNEYGRITSFYGPELQRYTSVRAHPVAEGPVRQILFHERGVISISSRSVHMITRRGLTQWHITHDEITDLRCMSFTAQTNKIIVAGCQKAMFTIDIDKGTIVDKLRTEHNYVLMKRSRYLCAATDTGSVNALSLTDFSVVKSWKAHGAAVNDMDARGDLLVTCGFSIRQTGSPIVDPLANVYDLKTLSPLPPIPFHAGAAYVRMHPKLQTTSFVASQSGQLQVVDLMNPNAFKLRQATVSFMLGIEISPSGEALAINDAECFIQLWGSPAKIHFNEMSKEVEFADVTPRPPQVDWSPEIPLNVIGMPYYHERLLSAWPSHLLFEVGSPPAPIDPSIVPYLRSGEMGQYAANPKKTRRYQVENTRALASTEPTLIAPKFLSEKAREQSKKADDPVGDTAASLAGARISGESEDDPLLKYSNVEIKYSRFGVDDFDFRFYNQTCFSGLETHIANSFTNSLLQLLKFIPLIRNIALHHAATSCIAESCLLCEMGYLFDMLEKANGQNCQATNLLKTFSSFREASNLGLLEENLTNKSLSSAIQAVNRFFLGQIAQDYRRIAPNSEELDMRLATIASESIRCMFCQNEIVRPGNTLVNELMYPAIDMKQARRNHTLRFSNILRASIEREAQNRGWCHICRRYQQSVMRKTAHRMPHVLMLNAAINSPACRRLWTIPGWLPEEIGIVLEGGQVLCFEGEDLRMRIQGQMPGLIIYDLVGLVAEINIPEHQKAHLVSFINVSVSSRERETRSKWHLFNDFLVTEVDKEEALRFNQSWKSPCVLAFQVRDARHMVDDTWKNFLDTTLLFRDWSLNNGRPVESRVMLSDEEKPTPGTPVALDTEFVDLEKAEINVKADGSQEIVRPSKSGLARVSVLRGSGEREGVPFIDDYISVKEPIVDYVTQYSGIKPGDLDPRTSPHNIVPLKVAYKKLWLLLNLGCVFVGHGLASDFRKVNIQVPKKQTVDTQYLFFHPSKNRRLSLRYLAWAVFKEYIQEEPADSNQGHDSIEDARMALRLWKKFQEYEDAGIVGQILEEIFREGSKLGFRPPPRNGVTTVLSRPGTAVTMQNNSGRNTPSTPDVGAAASAPTTPRQAFRRSIALTPSNGTFSGPGSGEFFTGSPLK

Gene
pan2
Protein
PAN2-PAN3 deadenylation complex catalytic subunit pan2
Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Length
1150 amino acids
Function
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
Similarity
Belongs to the peptidase C19 family. PAN2 subfamily.
Mass
128.444 kDa
Sequence
MEADWDELSRIPVPAPSVHALPTIATAIAFDDVMELLWGRITSFFGPELQRYTSVRAHPATEPVRQIIFHDRGVISLSPKSVHMITRRGLTQWHIAHEEMTDLRCMSFTAQTNRIIVAGCQKSMFTIDIDKGIIIDKLHTEYNYTIMKKSRYLCAATDTGSVNALSLNDFSVVKSWKAHGTAVNDMDARNDLLVTCGFSVRHLGSPIVDPLANVYDLKTLSPLPPIPFHAGAAYVRMHPKLHTTSFVASQTGQLQVVDLMNPNAINLRQANVSFMLGIDLSPSGEALAINDAECAIHLWGSPAKVHFNEMSKEAEFGDVAPRPPTLDWSPETPLSMIGMPYYHERLFSAWPSHLVFEVGSPPPQVDQALIPYLRPAELGHHAPNPKKTRRYQVENTRALASAEPALIAPKFLSEKAREQNKAKSEGAISDAAEALAGAKINGETDDDPLLKYSNVEIKYSRFGVDDFDFRFYNQTTFSGLETHIANSFTNALLQLFKFIPYIRNVALHHAASSCIFETCLLCEMGYLFDMLEKASGQNCQATNLLKTFSSYREASNLGLFEENLTNKSLSAAIQAVNRFFLGQISHDFRMISPSSDDLDHRLATVASESIRCMFCQNEIVRPGNSLVNELNYPAIDIKQARRNPAFRFSNILRASIEREAQNRGWCNYCRRYQQVAIRKSVHRMPQVLMLNAALTNPICRRLWAIPGWLPEEVGIVIEGGQILCFEGEDLKLRVQAKMPGLVVYDLVGLVCEIDIPEHQKAHLVSFINVSISSREPETKNKWHLFNDFLVTEVDKEEALRFNQPWKIPCVLAYQVQDGRHAMDDTWKDALDTTLLFRDWSLNGGRPVESRVTLSEEEKPTPGTPVALDTEFVDLEKAEIDVKADGSQEIVRPSKSGLARVSVLRGSGIREGVPFIDDYITIKENIVDYVTQYSGIKPGDLDPRVSQHNLVPLKVAYKKLWLLLNLGCVFVGHGLASDFRKVNIQVPKSQTVDTQYLFFHPGKNRRLSLRYLAWAVFKEYIQEEPADDSQGHDSIEDARMALRLWKKFKEYEDAGIVSQILEEIFREGSKLGFRPPPRNGVPTVLSRPGTAVTMQNNSGRNTPSTSDVAGAAASAPATPRQAFRRSIALTPSNGSFAGPGTGDFFSGSPLK

Gene
PAN2
Protein
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
Length
1150 amino acids
Function
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
Similarity
Belongs to the peptidase C19 family. PAN2 subfamily.
Mass
128.528 kDa
Sequence
MDADWGEIAQYHTQLGYRPDPTNPSAHHSAPTAVAFDTRSELLWVGKDQGRVAAYVYFLNNGIMEFQRHIAFLSHPRQQGPVHQFLFNETGVISLGSHNVHMAQRGGMCLANIGHVNMTNLRCMTFTSRGTSEILVAGDQDTMFVIDLNKKQITKEVPAPNHYFLMKKSKYICAASRNGCVDILDPITLKVINTWNTRSAQLNDMDVQHDFIVTCGASLKQGTYMADPYVNVFDLKNMRSFPPISFPPLVTYARMHPKMVTTSIVVSKTGQMHVVDIANPHNPIVRQVLGHTHLALFDVSPSGQAMVFTDTEGYIHVWGPTSKAVSFVDQGLPVEFETEQPNFASIPWSEDFPVNMVGLPHYSDALLSAWPADLSSDVGAPPAQFDQAYVDAMMPNGNVGLYGKAVAGTRRNQVVDTRSADKPQSSLQAPKFLSEKARDGFKGLTMDTSDIETSEDIVPSPIRTDIESLKSVVPNMYHLFEIKFSKFGVDDFDFGYYNKTHHSGLENHITNSYANSLLQLLRFTPILRNLALQHAATSCLDQHCLLCELGYLCDSMEKARGASCQATNMLKMLSQHPAAANLHLLDGDRIASSSAMKIQGLLRFLLDFMSRDYGKTSPGINDLENATATSSQSLIRCDQCKSETSRPQTNYVQDLAYSPVTSNGNKGVDVADSYLAAQQGVARGRMAPAKLPSFSQILKKSIEREQVTRGWCTTCRGYQPLSMRKIIKSIPQVLAANTCISSVEEKKLWATPGWLPEEVGFIIDKEHIFCYEGAELDWLIKNGKYKLYVYSLMGLVVNIEPGPTFKPHPVAIINAAHSEPQKPAKSQWHLFNDFHVKPISAREALTFNTSWKTPLVVMFQLKAANNHIDSTWLQRLDTSILYQDQSPEAEDKSYTLLDRNKEAPTPGTVIAIDAEFVLAKDFEYAVNSDGEKETIRPRIHSLGRVSVVRASGDRRGVPFIDDYINIKEPIVNYFTEFSGLTETDLDPKTSRHNLVPLKLAFKKLWLLLNLGCIFVGHGLRSDFRVINLQVPREQVHDTQELFWVEAQRRKLSLAFLAKSVLNLEIQGHMHDSIEDANTAQLLYWKYKELLESGRLHEELKKIYAFGVKHGFRPVKVAGQSAQRTETPPMVDDAQPGALLPYQPPELLQGS

Gene
PAN2
Protein
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
1144 amino acids
Function
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
Similarity
Belongs to the peptidase C19 family. PAN2 subfamily.
Mass
130.053 kDa
Sequence
MNNWQLSYQSPEDLTYHLKKPYLQYDKKEKQVTKVVFDTEANLIWAGDSYGRVSSYDPTYSLYTRHTAHIGSMPVVDLLSNKNGILSLSSDSLHFSNRRGVTQMSLTSADIAQLSDMKTMCYYTNNQNQVLCAGGNTASGIISVDLIKGTLASSTYFTSKVKHMSSNNKLVAIGKQAGSIDLFDPVSNRVIHSLSGHSASITSMDFKDNTLVTAGKSKTFGYLQSDQFINVYDVRIMKQLPPISFSKTPNFVGNHTSSKFPIGADFLQLHPVLPTVVAVASSSGSFDFIDLVNPSLRTPYIHPCKSISQFTLSPSGDYLAFLEEESMINMWNRSNSMSGFTNSAAVLEYQDYPEDSFIPYRVEVGQESYPLSSIGLPYYSETLLSAWPHTVFKTEGIISKKIEGSSSSETDNNSTKSVNRSLSHLSSSKYSLQPYNKFKYGPRNVIEPYKSLRERRKKMVSTTEDNQHRKELLEYKPSNNIDIPPAYSKLQMIYGKFGVMDFDFGGFNTTQYSGLETDIDCVYINEIIHLYRFVPEVYNFVVNCLEDEHIQEKSVLTELGFLFDMMTRANGKICRASNFVDVLESISTANELGLFTDEISTVSGHAGKPSLDEGNLSSHIYNLNLSVDADAEEIMKRSYGKYMTVAQKFNIFLLDRLISEEVERKLHSTDAIVLEELFGLNVDTEIHTLSTCGNFVRQPHLVSSLVVLSPASNNVKYSNKKLSNQTILPYIESSMCRFKQLTARCSKCEKLQNQEYESIVRNLPPLLSLNICLSPEEWTTAKTVNGWLSNHFFATISKDRPILKLQATDLKTSNAIFKYELMSYVARITDDFGEEHLVTYAKILDQKIQQYKWYMFNDFLVQEIDEDEALNISYWWKTPEIVVYSDAEEIRKPFVSVSKLKVDTDILYRDYFSEGIRKDVIRQYRLLTKDEAPGPGTLVALDAEFVSLTEPYLEINCKGMKTLLKPAKKSLARVSLLRGEGELEGVPFIDDYIINECHIEDYLTQFSGIEPGDLDPKLSKKSLVKRQVFYRKMWLLLQLGCVFVGHGLTNDFRQINIYVPESQIRDTSLYYLKGKRYLSLRYLAFAVLRKQVQTGNHDSIEDAHTALLLYRKYLELKEKGVFEMYLENIYDEGRKFGFKVPDTI

Gene
PAN2
Protein
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)
Length
1129 amino acids
Function
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
Similarity
Belongs to the peptidase C19 family. PAN2 subfamily.
Mass
126.472 kDa
Sequence
MEADWNELVTAQLSPPGSHPPAVPISTFAFDTTQELLWTGNNQGRVTSLYGPSLERYTSYRGHATSDGPVKQFLFTDKGVLSISRQSVHYSHRRGLTQWHLTSPDFKDLKCMNFTSKGTREILIAGCQEQMFKVDVEKGIVVDTLPVDAQYTIMKRAGQYLCAATKTGGIHILDSNSLSVIKVFEGHTGSISDMDAKGDFLATCGWSPRQQYAYMLDPFTNVFSLKTLKQLAPVPFHTGAAFVRMHPRMSTTAIIASQNGQMQVIDLMNPDSANLRQLNLYDSYLAGFEMAPSGEAFALADSNSNVHLWGSPAKVHFPEYSNPTEFADHVIPPASMDWSLDTPLNTIGMPYYKETLLSGWPSHMVFEVGAPPPKIDGAILSNMTRTDMGFFAKNPRTKRRNQIEVTRQTDRSSDSLTPPKFLSEKSRASLSLSEANAKAVETMETLTDLHLDDVTRKDVPAMYGNVEIKYSKFGVDDFDFAYYNQTPFSGLETHITNSYANSLLQLFRFTPLIRNLALQHTASPCLFESCLLCELGFLIDMLEKAAGLNCQASNFLKTFSGLSNAVSLNLLEEFAPNVALTSMIQNLNRFLLDKISEEFRQMLPSHGGTSLMDQVLETQARASMRCAQCANETIRGGKNFVNELVYPAKHVMKNTRIPRPTFSQILKASVERQDQTRGWCTKCNRYQQMVQRKTIQSVPGVLMLNAAIQTHEAKLLWSIPNWLPHEIGIIVDQGQFYCFEGQDLKLHLQRGVFDIMVYELVGVVADINSGEHQKPHLVATINTGPSSREPDAEDKWHLFNDFLVRPIPREEALRFEPSWKLPSVLTFQTKSARNKIDDSWKENLDTSILYRWWSSNPTPPDDKFKLLQVSTEAPRPGYPVAIDAEFIRLQAEEIEMKADGTRQTIRPDRKGLARVSVCRGEGEHAGLPFIDDYIAVTEQVVDYLTEWSGISPGDLNRETSPHAPVSLKHAYKKLWLLLNLGCVFVGHSLANDFRTINIHVPRSQVVDTSNLFFLPDFKRKLNLKFLAWCVLKEQIQQDTHDSIEDATTALKLWRKYEEFVDAGVLEPMLNDIYATGSQVKFKAPGSGNRNSMPAGMTATGAGRDTPEPMTTPKKGGAFGGVGFRSPMRR

Gene
PAN2
Protein
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
1124 amino acids
Function
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
Similarity
Belongs to the peptidase C19 family. PAN2 subfamily.
Mass
127.998 kDa
Sequence
MEGWGEISRIAATASSSVIDNSKITSLQFDNQQNLLWCGDSKGTTRSFTPQSTSIPMPYPALHLSQYSKFKTSLGTSPVKQYLNHQKGILSLSHNCVNFNNRRGLTQLSLNSESLKEPGFNNLSCMTFNSNTNNDLVIAGDSLFKVDLLKPNMTTSFNHTGKVSMIDNTLNYLTLGKSNGEIEIFDPVSNQTVKSFYGHNGLLSDIDVQGNYVASCGYSLRPRRNQASQSSYMIDPLVNIYDLRMMRSLPPIPFSAGASFVKFHPKLPNIMIIASSLGQLQFVDIYDQSNVYLYQADLSNVNASTPTTSSNTYLANLEVSGNGEFITFSDGFQNLHLWSFKNNNSKNFINFPSYLEQPDFSPPFQQNHINVDDVVPLSSIGMPYYKDLLLSNYASDLHFTKELSKLPNHLDPELLQNQYSQVLPYNTLKYGKRNLNKFYVPLQNNVSTKQKLFPKFISEKNGHDSFDNENSNIFEYKLSNKFEVPNCYSNLKIQYSKFGVEDFDFSFYNRTKYSGLENHLDNSYINSLLQLYKYSPVFQNFIIKHLLKEWLPNDLTTIIQNGNPQGSSILNELGYIFDMMNKSHGKNCKTSNFSNVLSQNQVAQMQELINKDDCKNLNAFEIRAIIGKFNKFLLSTCNNDLLNQFNTSLSEITNIGYEIEIKSNGCNINNVNYNSQLTVDLMSPPINKLSILISANSTSATKKNLNILNYLDYSMNQFKTIKCQQCNNSFPHLLEIRQSLVHLPPVISINVNFTGQEFNLIQNFPNWLVPEFYTYGMNNKVSFKLHSNDNLSNKYELLGYVCEINVGSEFLKGKHNLVSYIKIESKWYLFNDFLVMPIPESEVFDLSYHWKKPIIVMYQLANHADFGSFQQQSFAQLPDLNDSILYRDHFAGGIRDSIKREYELLTKDEAPNAGTLIAIDAEFVALNPEELEVHYGGVRNLIKPRNLSLARISVLRGDNGPKQGVPFIDDYIIHTCFIDDYLTSFSGIEPGDLDPSSSTKTLTTLQTSYRKLWLLLNLGCIFVGHGLQNDFRCINLHVPKNQIRDTADFFYLPELKRKLSLKFLAYILLKEKVQTGNHDSIEDANTALLLYKKYLELTAIGEFESTLHRIYMDGQQLRFRVPDS

Gene
PAN2
Protein
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
1115 amino acids
Function
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping by DCP1-DCP2 and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails, trimming the tails from their synthesized length to the slightly shorter, apparently messenger-specific length found on newly exported mRNAs. PAN cooperates with protein kinase DUN1 in the regulation of RAD5 mRNA levels and cell survival in response to replicational stress.
Similarity
Belongs to the peptidase C19 family. PAN2 subfamily.
Mass
127.039 kDa
Sequence
MNNWQHFFNNPVDLSEHLKKPYFRFDNRDKEITAISFDEKANLIWSGDSYGCISSYDPTFQLYTRYRGHIGGNSVKDILSHRDGILSISEDSLHFANRRGVTKLNLTSIDIAAFSELNTMCYSPHSLKNNIYCGGDNTNWGIASIDLNRGCLDSLLNYSSKVKLMCSNNKVLSIGRQTGTVDLLDPTSNRTIKSFNAHSASISAMDLRDNTLVTVGKSKRFYNLYADPFVNVYDLRTMRQLPPVSFSKGTTMGSGGADFVQLHPLLPTVMIVASSSGSFDFIDLSNPTLRTQYVHPCQSIKKLCLSPNGDVLGILEADNHLDTWRRSSNNMGMFTNTPEMLAYPDYFNDITSDGPISVDDETYPLSSVGMPYYLDKLLSAWPPVVFKSEGTIPQLTGKSPLPSSGKLKSNLAVISSQNEKLSTQEFPLLRYDRTKYGMRNAIPDYVCLRDIRKQITSGLETSDIQTYTSINKYEVPPAYSRLPLTSGRFGTDNFDFTPFNNTEYSGLDPDVDNHYTNAIIQLYRFIPEMFNFVVGCLKDENFETTLLTDLGYLFDMMERSHGKICSSSNFQASLKSLTDKRQLENGEPQEHLEEYLESLCIRESIEDFNSSESIKRNMPQKFNRFLLSQLIKEEAQTVNHNITLNQCFGLETEIRTECSCDHYDTTVKLLPSLSISGINKTVIKQLNKKSNGQNILPYIEYAMKNVTQKNSICPTCGKTETITQECTVKNLPSVLSLELSLLDTEFSNIRSSKNWLTSEFYGSIIKNKAVLRSTASELKGTSHIFKYELNGYVAKITDNNNETRLVTYVKKYNPKENCFKWLMFNDYLVVEITEEEALKMTYPWKTPEIIIYCDAEELRKPFFSVDTYSINYDILFRDYFANGIRDTARREYKLLTHDEAPKSGTLVAIDAEFVSLQSELCEIDHQGIRSIIRPKRTALARISIIRGEEGELYGVPFVDDYVVNTNHIEDYLTRYSGILPGDLDPEKSTKRLVRRNVVYRKVWLLMQLGCVFVGHGLNNDFKHININVPRNQIRDTAIYFLQGKRYLSLRYLAYVLLGMNIQEGNHDSIEDAHTALILYKKYLHLKEKAIFEKVLNSVYEEGRAHNFKVPETSKG

Gene
PAN2
Protein
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Organism
Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)
Length
1102 amino acids
Function
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
Similarity
Belongs to the peptidase C19 family. PAN2 subfamily.
Mass
123.849 kDa
Sequence
MDADWDEVTRIAFPAPGSNDYPRPATALAFDTIAELLWAGNDRGRVVSFYGRDLQRYTAFKIHPPSEGPVRQFLFHDKGVIALGTRSVHMAMRRGPTLWNIRHDEMENLQCMSFTSKGASEIIVAGFQDTMFVIDVVKGEIVKQKSKYICAATRTGCVDLLDPITFKTVRSWQAHASYINDMDAQNDFIVTCGGSLKQQAAQTYMLDPYVNVFDLKNMTSMKPMPFPPLAAHVRLHPRMLTTSIVTSQHGQMHVVDIMNPNTSNVRYANVMSFINLFEIAPSGEALAMADTECNIHLWGSPSKIHFTDMAIPIEMPKAEEPAPMLDWSPDTPLSSIGMPYYREQLFSAWPSDIISDIGAPPVQLDPSFLASLKQMEWGFYGRNSRGLRRNQVEDTRACMKPSMQPPKFLSEKARESAMSYSAAVPDPKVEQVPESSTDELESLKPEAPPIYRNLEIKYSKFGVDDFDFGYYNKTQYAGLENHIPNSYANSLLQLIHYTPLLRNMALQHAATACVTDLCLLCELGFVFDMLQKAEGSTCQATNMFKALGATPQAAPLGLLEEETHVPSLSTMSQGLSRFLFDRINHDYRSINPISTTLEQTLFNLPQPPTPDELVSRVLATSAVVTIKCMNCRSETTRPGTAQVNDLMYPPPKGSARGGRMHKTTFSQVLKTGVERETASKGWCSRCQRYQNLQMRKTIHSVPAVLAINSAISSQEHRKLWATPGWLPEEIGIIVDQGQFFCFEGEDLKLHLQRGMHNITVYSLIGMVVNIESSSPQKTHLVSVINVAHADAAPSAESKWHLFNDFSVRPISTAEALTFNAAWKLPAVLLFQVKAANNKTNMDWKTKLDTSLLYQDLTPHSDEKTYHVLDLEAEPPGPDTIVGLDTEFVSLKQPEIQMNSDGERETIRPMSHALARVSVVRGQGEHEGEAFIDDYIAIREPVVDYLTLYSGITPGDLDPRTTKHNLVSLKVAYKKLWVLLNLGCKFLGHGLRQDFRVINIQVPRAQVIDTIQVFYLKARLRKLSLAFLAWFLLKEDIQLETHDSIEDARTALKLYRKYLEFEDAGILEAMLEDIYKVGRATNFKPPRKDDQVIQRTDTPFLSR

Gene
PAN2
Protein
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)
Length
1098 amino acids
Function
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
Similarity
Belongs to the peptidase C19 family. PAN2 subfamily.
Mass
123.106 kDa
Sequence
MEGWEEVSILAAILYSFPASKDPVTSLLFDSVHNLLWCGDSSGSARSFTPNAGYPFQLYPYTKFPATTSPLPVVQQRNHSRGILSLSQNCVNLNSRRGLSQATFTAASVTDSANVLRNLSCMTTLGTGNDIIVGGTHSLGSLDMQKCVATGFDHSGNLSFVDSVAKTLVLGTTDGTVELFDTASNSSVKSFPAHSGLLSDMAVQGNYIATCGYSARRRYDHKNSSAAGGTSYITDPLVHLIDTRMMKSLSPIPFPNGASFVRFHPKLPNIVIVASSTGVLEFVDIFDQSKLNVYQVNMSPASPGISRMEISDNGEYICCSEGRSLHLWSFTSDTNFVNFPAPLEEQDIPAPLPPPFEVDDPVPLSSVGMPYYKDYLLSNYATDMVFTKELSKVPAEVDTSLGHGAFVPYDRTAHGPRNISQPYQSLREPPGSNSNAPRFISERDGESNENMIHAENSIFHLKSPTSVPHCYSRLQIQYSKFGVDDFDFDYYNKSNGACSGLENHLDNSYTNALLQLYRAAPAFYNSVVESLLPEYLPNGPEIISWNPQGSSLLIELGYLFDMMHKAEGRNVKIANFSQLLTQSASAASAGVINTDEEKSLNADGLREIIIRFNHYLLSELTSNQRERRHTNSEKIEDIMGIKLEMQIKSQCTETETHTGSQLIFDLTSPPEQYLNKLAMLRRAEKTEITILSYMDYFMDQYKSASCRECEARGRPHAVNARQRVVRLPKVLSINLSMTNFELQQIHNCRGWLVPEFHIGEDERFVDAGRGRKYELLGYVCEISHGPGVKRGAHNLVSFVKIKGQWYLFNDFLVMPIAQEEALNLSYSWKKPVIIVYSEPGQDFSYFETSTFKKIQDLDTSIIYRDHFVRAAREGHRQEYKLLTKQEAPEIGTLIAIDAEFVVSEPEQLEIRYTGTRKLIKPKKLTLARVSVLRGNGPNIGVPFIDDYIVWTGHIEDYLTSFSGIEPGDLDPEVSKKALVTLQTVYRKLWLLLNMGCVFVGHGLQNDFRCINLVVPKTQVRDTADLFYLPEFKRKLSLKFLAYVLLKEKVQTGNHDSVEDAYTALMLFQKHEELTRTGDLETVLYQVYMEGQQRRFRAP

Gene
PAN2
Protein
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
1093 amino acids
Function
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
Similarity
Belongs to the peptidase C19 family. PAN2 subfamily.
Mass
123.992 kDa
Sequence
MNNWQHSFNNARPLDEHLHKPYLQYDGIEKHLTKFIFDDHANLVWTGDTYGCVSSYDVNFQPYVRQRAHIGGSPVKDLMSHSSGVLSLSSDSLHLQDRRGTTLLNLTNIDIAAFNDLQTMCYMSADQTSKVYCAGTDIGTGLSLIDLQRGTLETNIPYFSKVNFIKSSKKLAAIGKLSGSIDLFDPGSNQVIKSFISHSSCITSMDIQDYTLVTTGQSNGFYNTFADPFVNVYDLRTMRQLPPISFSKSTSMGTVGADFVQLHPVLPTIVMIASSSGAFDFVDMANPSLRTQFANPGNGIKCIRLSSNGDHLGVLESNDMFSTWKRPNSSVNFTNMPELLTYPSYPNDGPLANISIDDYNYPLSTVGMPYYQEKLLSTWSTVIFRSPGTVPRDIDKILTDLKNSKKSKKLVADGVNFYPYSVAKYGHKDALQPYISLRDKRYQRSTGSVPDDVLITKSVDGELPPAFKNLPLVVTKYATDSFDFESVNKTPYCGLDNDVDNPFTNALIQLYRFIPEISNFLISTLKHEHFESPLLTDMAYLFDMMRNTIDGICRTTNYQMSLNDVLEKNNLSLHTISESNMLQKINSLSLNDDGGKKQLSIQELNDFLLSELCEEEVKFIDQNFVLQHCYCCEFAVKTKGCMTYGQTSGSLYKPSITIGPNACTQKNGKVSYPHSILGYIEHGLKNSIVLNKKCEQCGIKENLEEDISIQELPPILSLSLEFDDNAMKLAKTTKNWLPKEFYASIMKNKPLVRGSVNDIRTNTMIYKYELHGYIARISDPDRGDHYVTFSRIYNEESKMFRWYLFNDYLVTEVDESIVYDLGKHWLKPEVVIYGDAEELRKPFNYLKDVEIDDSILYKDYFSAAIRESIQKEYELLTRNEAPRPGSLIAIDAEFVTLKNEKYDIDCRGAKTVVQSKVSALARISVVRGNEEQFGVPFIDDYIIIEKNIDDYLTKFSGILPGDLDPKTSNKHLVPRNVAYRKIWLLMQLGCTFIGHGLQNDFKHINISVPKEQIRDTAVYFLQGKRYLSLRYLAYVLLDINVQEGNHDSIEDAYTALVLYKKYLELKSNGMMDQVLNKLYEEGRTTNYKVPLKL

Gene
pan2
Protein
PAN2-PAN3 deadenylation complex catalytic subunit pan2
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
1088 amino acids
Function
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
Similarity
Belongs to the peptidase C19 family. PAN2 subfamily.
Mass
123.874 kDa
Sequence
MDAWKEITKTTENDGVSTCSLSSIAFDPYSELVWTGHKNGQIKSSFGPSLTSYTQFIGHEGPVHQVLPQERGVFSLSSKSLRLSNRKGTIRWRYQDSDCIDYRAMFYQSRNNPEVVIGGYHQKLTVVNAERGISIHKDKNVSDIFIMRRNRLLCCGSTNGEIILRDPNSFQPVNKVVAHTGTISDIDTSGNLLLSCGYSLRHGTYMLDPFVKVWDLRNLSSLVPIPFPAGPTIIRMHPKLSTTAVVCSCSGQFHIVDTGNPLDAKLMQIPLTSYLTGMDIASTGDAMVFTDVEDNIHLWSPLENPSFSDLKLPIQLPNTSTETVQLENNDPLNSIGLPYYKDELLSSWSKYLIFDVGKPILDSNLLIAKQISENSHPVPQEIKSFHRNQIIEVPWLNRKLISEGATPKFHSERQKDIMSGNDIEGSASYFEEIEDTISGPDSIPKFYQRPVIKYSKFGIEDFDFGFYNKTKYAGLETDITNSYCNSVLQLLSYVPSFSKAAISHSLGPCDLMECLLCELGFLFAMLKESTGRNCQATNFLRAFSNSSFAQSLGIVFDDYSDGTFPDSFVIQKFTKFMLTEISRIADYEDKKDGTSFPVSFLLKSFCIPEMQTYRCGICGITSQKIKSSLYIIDLHYPSQQLESILSFEWLFKMSLDRRVDLPPGWCEYCLAHQPFLLRSFIRSLPDCLFINTQVKHHEHWKLWARKNWLPKKLHLRRVNDTMQCVSQKISNLDKDQQSLSVYVLRGIIYEIRQNGEEPHFVSTIRVSDNTSSDNPDDNRWYIFNDFLVKEVTEEEALTVHGPWKIPIIVYYEKLDTKIPQWDEVSDYTLLYQPYSLNKNPPINKIQPLTTDEMLYPKMLVGIDSEFVALQQEETEVRSDGTKSTIKPSKLSLARVSVLRGEGPNKGLPFIDDYVATDDKVTDYLTEYSGIHPGDLDPDRSPYNVVPLKVAYKKLRLLVNAGCIFVGHGLQKDFRIINLLVPPEQVVDTVDLFFLSSRQRKLSLKFLAWYLLDEEIQLTEHDSIEDALTALKLYDCYDKLKSQGKLEETLDNIYEVGRRFKFRPPSVASMSLEDRNSYGDESVISNQTN

Gene
PAN2
Protein
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
1008 amino acids
Function
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
Similarity
Belongs to the peptidase C19 family. PAN2 subfamily.
Mass
112.973 kDa
Sequence
MEGWQEPPRIPLTQICRVSHTAPVATEIGQLTDTLPLTFDLAEDLVWAGDTNGIVSSYYGETLQPYSRFRAGRGRVTSLVSHDRGLVALTTDALHYSTRGGLTRKHVTDPSLGNNLCMTFTHGPTEFVVGGNPGKLVVVNSERGDVTRVVDSPGMATHMAGSSSCVVWGTENGKLVVGDNNLKELHTFQAHQGPFSDVSVQDNVVMTCGFSAASTGHRIDPLIKVWDLRMMRAMAPISYPLAAFVCQTPDSRTLITSPSGQLEFLDHATQQIKLYQAEVALVNGVKLSPRGHHFVVSDTSGQLQLWSDEPQSSFAEFSAPTAFPTPEQSYPPVSIRDTRYPLGAVGMPYYSDTLLSAMPSSIINVGMPPEEVDEDLEVRQIDFVGHAPNYKQQKRNLAQKYSNQRRTSIAAPKFLSEKEKERARRMEDIEDESFFGDEDTCTEASMSSKKVPRLYRKLEIKYSKFGISDFDFSYYNNHTGLSGLETNPFNPLLQLFRFCSPVFNFALRSVARGTPNRLLNEVGLLFDMMHKARGHVCRASNLMHCYDGIAQTRSLAPEDATNIVLFCRFLLEQIGFEQRQTPALFDSFRQLLGATVITVNTFSCGKMAQAESVWYTLELALGSTFYECLERTLDKELHTRAWCDKCRKYQSLHVSKHVESLPQVLTLSVADGNVDVAKSFLVLDGKVSPAAETDNDAYKLVGFICQIQGNGQVAFIRVGDEWYLFNDFLVTKVSEKEAFMKTPWKRTVMMVYAVGADERFDYDSWKNDMDVSALFEERLVNGNNVSRETTDYGYELIKEVPPPKTLCAIDAEFVVLKNEETEIRSDGTKVVLAPRNLCLARVTLLNEDGHPFINDYIAINEHIVDYLTAFSGIEPGDLDPSISRKPLVSLPTSYRRLWLLLNLGCVFVGHGLANDFRTINMQVPPEQVIDTVDLYYIPSERRKLSLRFLAWCVLGKKVQSGNHDSTEDSHTALLLYKKYQDCAPEEFQVLLLDVYRQGRMCNFKVPEA

Gene
pan2
Protein
Proteasome-activating nucleotidase 2
Organism
Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)
Length
412 amino acids
Function
ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
Similarity
Belongs to the AAA ATPase family.
Mass
45.589 kDa
Sequence
MSRSPSLPERPHLDLDPEMSDAERLSALRQHFERMVDVNRELDQRLQNADDRHAELVDEVDQMKARNEALKTASYYIATVEELTDDGVIIKQHGNNQEVLTEFAPSLNIDDIEPGDRVAINDSFAVQTVLDDETDARAQAMEVVESPTVTYDDIGGIDEQVREVREAVEQPLENPEMFAEVGIDPPSGVLLYGPPGTGKTMLAKAVANETNASFIKMAGSELVQKFIGEGARLVRDLFKLAAEREPVVVFIDEIDAVASKRTDSKTSGDAEVQRTMMQLLSEMDGFDDRGDIRIIAATNRFDMLDEAILRPGRFDRLIEVPKPAVEGRRHILDIHTRDMNVADDVDLDALAEELDDYSGADIASLTTEAGMFAIRDGRTEVTGADFDAAHEKLSNVDESGTGPISGFTDYQY

Gene
pan2
Protein
Proteasome-activating nucleotidase 2
Organism
Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
Length
411 amino acids
Function
ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
Similarity
Belongs to the AAA ATPase family.
Mass
45.284 kDa
Sequence
MSRSPSLPDRPTLDVDPESTPAERLNALQDHYVDIVAVNGELQAQLDDVEARREELREEVNRLQRENETLKTASLYLATVEDLPEDGSAVIKQHGNNQEVLTELSPRLADTLEVGDRVAINDSFSVQRVLDDETDARAQAMEVDESPSVTYADIGGLDDQLREVREAVEDPLVNPEKFDAVGVEPPSGVLLHGPPGTGKTMLAKAVANQTDASFIKMAGSELVRKFIGEGSRLVRDLFELAEQKDPAIIFIDEIDAVAAKRTDSKTSGDAEVQRTMMQLLSEMDGFDERGDIRIIAATNRFDMLDSAILRPGRFDRLIEVPNPNPDARERILEIHAGEMNVADSVDFSDLAADTAEFSGAQLASLATEAGMFAIRDDRDEVHRQDFDDAYEKLVAEGDTESSGPRYPSYIQ