ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.

Belongs to the AAA ATPase family.

412 amino acids

MSRSPSLPERPHLDLDPEMSDAERLSALRQHFERMVDVNRELDQRLQNADDRHAELVDEVDQMKARNEALKTASYYIATVEELTDDGVIIKQHGNNQEVLTEFAPSLNIDDIEPGDRVAINDSFAVQTVLDDETDARAQAMEVVESPTVTYDDIGGIDEQVREVREAVEQPLENPEMFAEVGIDPPSGVLLYGPPGTGKTMLAKAVANETNASFIKMAGSELVQKFIGEGARLVRDLFKLAAEREPVVVFIDEIDAVASKRTDSKTSGDAEVQRTMMQLLSEMDGFDDRGDIRIIAATNRFDMLDEAILRPGRFDRLIEVPKPAVEGRRHILDIHTRDMNVADDVDLDALAEELDDYSGADIASLTTEAGMFAIRDGRTEVTGADFDAAHEKLSNVDESGTGPISGFTDYQY

45.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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