Protein expression services for pan2 | PAN2-PAN3 deadenylation complex catalytic subunit pan2
Description
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
Family
Belongs to the peptidase C19 family. PAN2 subfamily.
Species
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Length
1161 amino acids
Sequence
MEADWDELSRIPVPAPSSHGLPTIATTIAFDDVSELLWAGNEFGRITSFYGPELQRYTSVRAHPVSDGPVRQILFHERGVISLSPKSVHMITRRGLSQWHIAHEEMTDLHCMSFTAQLNRIIVAGCQSAMFTIDIDKGVIVDKLQTDHNYTMMKKSRYLCAATDTGSVNALSLSDFQVVKSWKAHGTAINDMDARNDLLVTCGFSVRHLGSPIVDPLANVYDLKTLSPLPPIPFHAGAAYVRMHPKLHTTSFVASQTGQLQVVDLMNPNAINLRQANVSFMLGIDISPSGEALAINDAECAIHLWGSPSKVHFNEMSKEVEFADVVPRPPSLDWSPDTPLNMIGMPYYHERLFSAWPSHLVFEVGNPPASIDQSLIPYLRPAEMGHYAPNPKKTRRYQVENTRALTTAESALIAPKFLSEKAREQTRAKSEGSVSDTAEALAGAKLNGEAEDDPLLKYSNVEIKYSRFGVDDFDFRFYNQTIFSGLETHIANSFTNALLQLLKFIPLVRNLALHHAASTCIYETCLLCEMGYLFDMLEKANGQNCQATNLLKAFSSYREASNLGLLEENLTTKSLSSAIQSVNRFFLNQIAHDFRMILPSSDDLDHRLATIASESIRCMFCQNEIVRPGNSLANELIYPAIDIKQARRNPAFKFSNILRASIERETQNRGWCNYCRRYQQVTIRKTVHRMPLVLILNAALNNPLCRRLWSIPGWLPEEIGIVVEGGQVMCYEGDELKAQVQNKVPNLVLYDLVGLVAEIDIPEHQKAHLVSFINVSISSRETESKSRWHLFNDFLVTEVDKDEALRFNQPWKIPCVLAYQARDARHGVDDAWKDTLDTTLLFRDWSLNGGRPVESRQTLTEEEKPTPGTPVALDTEFVDLEKAEIDVKADGSQEIVRPNKSGLARVSVLRGSGIHEGVPFIDDYITIKEPIVDYVTQYSGIKPGDLDPRTSQHNLVPLKVAYKKLWLLLNLGCIFVGHGLASDFRKINIQVPKNQTVDTQYLYFHPGKNRRLSLRYLAWAVFKEYIQEESTDANQGHDSVEDARMALRLWKKFQEYEDAGIVNQILEEIFREGSRLGFRPPPRNGVATVLSRPGTAVTMQNNSGRNTPSTPDVGGAAAAAATTSAPATPRQAFRRSIALTPSNGTFGGPGTGDFFGGSPLK
Mass
129.6 kDa
Simulated SDS-PAGE
(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)Safety
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Protein synthesis service
Make pan2 using our protein expression services starting at $99 + $.30/amino acid in as fast as two weeks (includes the cost of DNA synthesis)
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